TWAS hub - ANP32E

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.0760	0.0390	0.0089	0.002	NA	0.007	NA	0.005	0.2200	NA	0.086	NA	0.120
2	NTR	Blood	0.0083	0.0048	0.0096	0.007	0	0.004	0.002	0.002	0.0024	0.21	0.013	0.082	0.055

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of arm (right)	13.5	62.9	125.4	11.2	0.5
Impedance of arm (left)	13.1	60.8	121.0	11.0	0.7
Trunk fat percentage	11.1	44.5	82.1	9.1	2.6
Impedance of whole body	8.6	43.8	86.9	9.3	0.9
Body fat percentage	8.3	32.7	58.1	7.6	2.7
Trunk fat mass	7.3	31.4	53.5	7.3	3.1
Prostate Cancer	6.8	9.6	11.8	-3.4	2.7
Lung FVC	6.8	34.8	53.4	-4.0	-7.3
Bipolar Disorder or Schizophrenia	6.7	16.2	31.3	-1.1	-5.6
Bipolar Disorder (2018)	6.4	10.2	20.2	-0.4	-4.5
Arm fat percentage (right)	6.1	24.0	44.6	6.7	1.9
Arm fat percentage (left)	5.9	23.5	43.4	6.6	1.9
Medication for cholesterol	5.9	8.9	13.0	3.6	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.4	11.4	20.0	-1.7	-4.5
Bipolar Disorder (2011)	5.2	5.1	9.9	-0.4	-3.2
Whole body fat mass	5.0	20.9	34.3	5.9	2.8
Schizophrenia (2014)	4.9	10.7	20.5	-1.0	-4.5
Comparative height size at age 10	4.6	25.4	38.1	6.2	3.6
Stomach or abdominal pain in last month	4.5	5.6	9.7	1.2	-3.1
Qualifications: CSEs or equivalent	4.3	5.7	11.2	3.4	0.4
Breast cancer (self-reported)	3.9	4.6	6.4	1.7	2.5
Allergy or Eczema	3.8	9.9	17.6	4.2	1.5
Blood Platelet Count	3.7	43.0	71.4	-8.4	-3.8
Medication for hormone replacement therapy	3.7	4.1	6.2	-1.4	-2.5
Medication: Blood pressure	3.7	7.1	12.4	-3.5	-1.3
Hayfever, allergic rhinitis or eczema	3.6	7.8	15.0	3.9	0.8
Allergy	3.6	8.2	15.2	-3.9	-1.1
Depression (Nagel 2018)	3.5	5.2	10.4	-0.1	-3.2
Hip circumference	3.5	15.2	20.2	4.5	3.2
Arm fat mass (right)	3.5	14.3	24.0	4.9	2.1
Schizophrenia (2018)	3.4	7.0	12.7	-1.2	-3.6
Relative age of first facial hair	3.4	6.9	8.7	3.0	2.3
Ever used hormone-replacement therapy (HRT)	3.3	4.2	8.2	-2.9	0.3
Impedance of leg (right)	3.3	15.8	29.4	5.4	1.5
Arm fat mass (left)	3.3	13.5	22.0	4.7	2.3
Pack years adult smoking proportion	3.1	4.8	7.2	-1.5	2.7
Relative age voice broke	3.0	4.6	5.6	2.4	1.9
Birth weight	3.0	6.4	9.1	-3.0	1.9
Leg fat percentage (right)	3.0	11.0	14.5	3.8	2.7
Migraine (self-reported)	2.9	3.6	5.1	-1.5	-2.3
Osteoporosis (self-reported)	2.9	3.6	6.9	2.6	-0.6
Commuting to job workplace: Cycle	2.9	3.5	6.0	-1.1	2.4
Basal cell carcinoma (self-reported)	2.9	3.4	4.9	2.2	1.4
Average weekly fortified wine intake	2.8	3.3	3.7	-1.7	1.9
Leg fat mass (right)	2.8	11.0	13.6	3.7	2.9
Myopia	2.8	4.1	4.8	-1.9	-2.2
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	3.3	1.8	-1.6
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	4.9	2.2	1.4
Pack years of smoking	2.7	4.0	5.5	-1.6	2.3
Coronary Artery Disease (CAD)	2.6	3.1	6.0	2.5	0.4
Frequency of depressed mood in last 2 weeks	2.6	3.7	6.6	-0.9	-2.6
Number of full sisters	2.6	3.2	3.3	1.8	1.8
Standing height	2.5	25.2	26.8	5.2	4.8
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	4.0	1.4	2.0
Leg fat mass (left)	2.5	9.7	11.4	3.4	2.8
Ulcerative Colitis	2.4	3.5	6.7	0.7	-2.6
Impedance of leg (left)	2.4	11.6	21.8	4.7	1.1
Qualifications: A levels/AS levels or equivalent	2.4	5.4	8.9	-1.4	3.0
Average weekly red wine intake	2.4	3.5	6.0	2.5	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	3.5	1.9	-1.4
Hearing aid user	2.4	2.7	4.8	0.9	2.2
Fasting Glucose	2.3	2.8	5.4	2.3	-0.3
Medication: Ventolin 100micrograms inhaler	2.3	2.9	5.5	2.3	0.6
Tinnitus: Yes, now most or all of the time	2.3	2.7	4.1	2.0	-1.1
Reaction Time	2.2	4.2	6.6	1.3	-2.6
Heel T-Score	2.2	17.3	20.9	4.6	-3.7
Type 2 Diabetes (T2D) (2018)	2.2	4.1	8.2	2.9	-0.1
Angina (self-reported)	2.2	2.9	5.5	2.4	0.4
Leg fat percentage (left)	2.2	8.1	10.1	3.2	2.5
Hypothyroidism (self reported)	2.1	4.8	7.7	2.8	-1.4
Angina	2.1	2.7	5.2	2.3	0.5
Had other major operations	2.1	2.6	4.7	-2.2	0.7
Medication: Omeprazole	2.1	2.5	3.6	1.2	1.9
Exposure to tobacco smoke outside home	2.0	2.7	4.0	1.1	2.0
Hearing difficulty/problems: Yes	1.9	2.9	3.3	1.6	1.8
Weight	1.9	9.5	10.1	3.0	3.2
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	4.3	-1.4	-2.1
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	4.9	2.2	0.1
Hypothyroidism/myxoedema (self-reported)	1.9	3.8	5.7	2.4	-1.4
Breast Cancer	1.8	4.3	6.9	-2.6	-1.4
Serious illness, injury or assault to yourself	1.8	2.2	4.0	2.0	0.6
Sitting height	1.8	12.8	25.6	-0.0	5.1
Hearing difficulty/problems with background noise	1.8	2.8	3.9	2.0	1.3
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.0	1.7	-1.0
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.5	2.1	0.2
Alcohol drinker status: Previous	1.8	2.0	4.0	0.0	-2.0
Alzheimer’s Disease (in mother)	1.7	2.0	3.8	2.0	-0.3
Supplements: Glucosamine	1.7	2.3	3.1	1.2	1.7
Falls in the last year	1.7	2.3	4.5	2.1	-0.3
Comparative body size at age 10	1.7	4.8	8.6	-2.9	-1.0
Family relationship satisfaction	1.7	2.1	4.0	-2.0	-0.4
Diabetes diagnosed by doctor	1.7	2.7	5.4	2.3	0.3
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	4.8	-2.2	-0.7
Illnesses of father: None of the above (group 1)	1.7	2.1	3.8	0.7	-1.9
Alcohol drinker status: Never	1.7	2.0	2.4	-1.6	-1.3
Worry (Nagel 2018)	1.6	3.4	4.4	1.6	-2.1
Verbal and Numeric Reasoning (VNR)	1.6	3.9	4.7	-1.8	2.2
Blood White Count	1.6	12.2	13.4	-3.3	3.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	9.9	0.3	-3.1
Blood clot in the leg (DVT)	1.6	2.1	2.4	1.5	1.3
Asthma (self-reported)	1.6	3.2	3.7	1.9	1.6
Diabetes (self-reported)	1.5	2.3	4.0	2.0	0.7
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	9.9	0.5	-3.2
Chest pain or discomfort	1.5	2.2	4.1	2.0	0.6
Number of operations (self-reported)	1.5	2.2	4.2	-2.1	-0.5
Lupus	1.4	2.1	3.8	0.5	-2.0
Type 2 Diabetes (T2D) (2012)	1.4	1.7	3.1	1.8	-0.5
Height	1.4	27.0	34.5	4.4	5.9
Supplements: Zinc	1.4	1.5	2.6	-0.6	-1.6
Waist circumference	1.4	5.3	5.7	2.2	2.4
Trunk fat-free mass	1.4	7.8	10.2	-3.2	2.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.2	-1.8	0.1
Trunk predicted mass	1.4	7.9	10.2	-3.2	2.4
Arm fat-free mass (right)	1.4	7.0	8.1	-2.8	2.4
Arm predicted mass (right)	1.4	7.3	8.0	-2.8	2.6
Supplements: Vitamin C	1.4	1.7	3.1	0.5	-1.8
Medication: Gliclazide	1.4	1.6	3.0	1.7	0.5
Alzheimer’s Disease (in father)	1.3	1.4	2.6	0.4	1.6
Lung FEV1/FVC ratio	1.3	6.4	9.7	3.1	-1.8
Medication: Metformin	1.3	1.9	3.0	1.7	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	4.1	2.0	-1.4
Number of incorrect matches in round	1.3	2.2	4.3	0.3	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.0	0.0	-2.0
Hypertension (Self-reported)	1.3	3.6	6.5	-2.5	-0.9
Illnesses of siblings: Diabetes	1.3	1.6	2.5	1.6	-0.8
Mood swings	1.3	2.4	2.5	-1.5	-1.6
Ever taken oral contraceptive pill	1.3	1.5	2.5	1.6	0.7
Medication: Bendroflumethiazide	1.3	1.9	3.8	-2.0	-0.1
Fractured/broken bones in last 5 years	1.3	1.7	3.2	1.8	-0.4
Blood Eosinophil Count	1.2	9.1	12.0	-2.5	3.5
Respiratory disease	1.2	2.8	4.3	2.1	1.1
Mean time to correctly identify matches	1.2	2.3	4.0	0.9	-2.0
Friendships satisfaction	1.2	1.5	3.0	-1.7	0.1
Osteoarthritis (self-reported)	1.2	1.5	2.4	-0.8	1.5
Eye problems/disorders: Glaucoma	1.2	1.4	2.4	-0.6	1.6
Arm fat-free mass (left)	1.2	6.0	7.1	-2.2	2.7
Mean Putamen Volume	1.1	1.2	2.4	1.6	0.1
High blood pressure	1.1	3.1	5.7	-2.4	-0.7
Had menopause	1.1	1.4	2.7	-1.6	-0.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.7	1.6	0.4
Asthma	1.1	2.2	2.7	1.6	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.8	1.0	1.3
Medication: Cholesterol lowering	1.1	1.6	2.8	1.7	0.7
Headache pain in last month	1.1	2.0	3.8	0.4	-1.9
Medication: Allopurinol	1.1	1.5	2.8	-0.5	1.7
Knee pain experienced in last month	1.1	1.7	1.8	1.2	1.4
Arm predicted mass (left)	1.1	5.7	6.5	-2.2	2.5
Neuroticism (2016)	1.0	1.5	2.9	1.7	-0.3
Forced vital capacity (FVC)	1.0	3.9	7.8	-0.1	-2.8
Qualifications: None of the above	1.0	2.1	2.4	-1.4	-1.6
Depression (self-reported)	1.0	1.2	2.0	-1.4	-0.7
Peak expiratory flow (PEF)	1.0	2.3	3.6	1.9	-1.0
Glaucoma (self-reported)	1.0	1.2	2.3	-0.0	1.5
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.2	1.0	-1.1
Medication: Ibuprofen	1.0	1.2	1.5	1.2	0.9
Smoking status: Previous	1.0	1.5	2.7	1.6	0.5
Eye problems/disorders: Cataract	1.0	1.1	2.2	1.5	0.3
Primary Biliary Cirrhosis	0.9	1.2	1.6	-0.9	-1.3
Medication: Levothyroxine sodium	0.9	1.6	3.1	0.4	-1.8
Past tobacco smoking	0.9	1.7	3.0	-1.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	2.1	1.5	-1.4
Illnesses of siblings	0.9	1.3	1.6	-1.0	1.2
Worrier / anxious feelings	0.9	1.7	3.5	-0.1	-1.9
Prospective memory result	0.9	1.1	1.9	1.4	-0.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.9	-1.4	-0.5
Forced vital capacity (FVC), Best measure	0.9	3.2	6.4	-0.4	-2.5
Shortness of breath walking on level ground	0.9	1.0	1.5	1.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.7	1.9	0.1
Guilty feelings	0.9	1.4	2.6	-1.6	-0.4
Wears glasses or contact lenses	0.9	1.0	1.8	0.4	1.3
Pain experienced in last month	0.9	1.6	2.4	0.9	1.5
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.8	-0.3	2.2
Neuroticism (Nagel 2018)	0.8	1.9	3.2	0.8	-1.8
Ovarian Cancer	0.8	1.0	1.4	0.8	1.2
Medication: Co-codamol	0.8	0.9	1.7	1.3	0.2
High blood pressure (mother)	0.8	1.1	2.3	-1.5	-0.1
Fluid intelligence score	0.8	1.6	2.3	-0.9	1.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.4	-1.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.3	-1.5	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.1	-1.1	-0.9
Number of children fathered	0.8	0.9	1.7	1.3	0.2
Health satisfaction	0.8	1.0	1.4	0.8	-1.2
Overall health rating	0.8	1.8	2.4	1.5	-1.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.1	2.0	0.6
Depressed Affect (Nagel 2018)	0.7	1.5	2.9	-0.4	-1.7
Schizophrenia vs Biploar Disorder	0.7	0.9	1.6	-1.3	0.4
Ulcerative Colitis (UC)	0.7	1.3	2.5	0.3	-1.6
Cardiovascular Disease	0.7	2.2	2.8	-1.7	-1.3
Neuroticism	0.7	1.6	2.8	0.6	-1.7
Diabetes (father)	0.7	0.8	1.0	0.8	-1.0
Leg fat-free mass (left)	0.7	3.8	5.4	1.5	2.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	-1.3	0.3
Multivitamins +/- minerals	0.7	0.8	1.0	1.0	-0.8
Leg predicted mass (left)	0.7	3.7	5.5	1.4	2.4
Father’s age at death	0.7	1.0	1.3	-1.1	0.8
Happiness	0.7	0.8	1.1	-1.0	-0.7
Length of working week for main job	0.7	0.8	1.0	-0.8	1.0
Pulse wave reflection index	0.7	0.9	1.3	-1.1	0.7
Illnesses of father: Heart disease	0.7	1.0	1.9	0.3	1.4
Whole body fat-free mass	0.7	3.8	5.2	-1.5	2.3
Whole body water mass	0.7	4.0	5.7	-1.5	2.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	-0.6	-1.1
Supplements: Calcium	0.7	0.7	1.2	1.1	0.5
HbA1C	0.6	0.7	0.8	0.8	-0.9
Sensitivity / hurt feelings	0.6	1.0	1.8	0.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	-0.3	-1.2
Medication: Atenolol	0.6	0.7	1.3	-1.1	-0.4
Alcohol usually taken with meals	0.6	1.0	2.0	0.0	-1.4
Financial difficulties in last 2 years	0.6	0.8	0.9	-0.9	1.0
Medication: Simvastatin	0.6	0.9	1.6	0.3	-1.3
Medication: Lansoprazole	0.6	0.7	1.4	0.2	-1.2
Medication: Amlodipine	0.6	0.9	1.6	-0.4	1.2
Age at first live birth	0.6	1.1	2.2	1.5	-0.0
Neck or shoulder pain in last month	0.6	0.8	1.6	-0.0	-1.3
Medication: Seretide 50 evohaler	0.6	0.7	1.3	0.1	1.1
Alcohol intake frequency.	0.6	1.5	2.3	-0.8	-1.5
Suffer from ‘nerves’	0.6	1.0	1.4	1.2	-0.8
Age at last live birth	0.6	0.9	1.0	0.9	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	0.8	-0.9	0.7
Basal metabolic rate	0.6	3.3	6.5	-0.2	2.5
Ever depressed for a whole week	0.6	0.8	1.4	0.4	-1.2
Unable to work because of sickness or disability	0.6	0.8	1.6	-0.0	-1.2
Crohns Disease (2017)	0.5	1.1	1.8	0.6	1.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	0.4	1.1
Blood Red Count	0.5	5.1	9.0	1.1	3.0
Average weekly spirits intake	0.5	0.6	0.9	-0.6	1.0
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	-1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	-1.1	-0.2
Mouth/teeth dental problems: Dentures	0.5	0.8	1.0	-1.0	-0.7
Worry too long after embarrassment	0.5	0.9	1.6	-1.3	0.5
Medication: Blood pressure	0.5	0.9	1.3	0.7	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	-0.9	-0.7
Medication: Aspirin	0.5	0.7	1.2	0.5	1.1
Long-standing illness, disability or infirmity	0.5	0.8	1.5	1.2	0.3
Mineral and other dietary supplements	0.5	0.7	1.4	-1.2	0.2
Medication: Aspirin	0.5	0.6	0.6	0.8	0.7
Number of self-reported non-cancer illnesses	0.5	0.9	1.5	1.2	-0.4
Cholesterol lowering medication	0.5	0.8	1.0	-0.8	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	1.1	0.0
Triglycerides	0.4	0.6	0.6	0.8	-0.8
BMI	0.4	2.2	3.5	1.9	1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.5	-0.9
Vitamin and mineral supplements	0.4	0.6	0.9	-0.5	1.0
Diabetes (mother)	0.4	0.5	0.8	0.4	-0.9
Current tobacco smoking	0.4	0.6	0.9	0.9	0.6
Hair/balding pattern: Pattern 4	0.4	1.0	1.7	-1.3	0.5
Gout (self-reported)	0.4	0.5	0.9	0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.7	0.9	-0.5
Leg fat-free mass (right)	0.4	2.4	4.4	0.6	2.1
Leg predicted mass (right)	0.4	2.3	4.3	0.6	2.1
Average weekly champagne plus white wine intake	0.4	0.6	1.0	-1.0	-0.4
Mother’s age at death	0.4	0.5	1.0	-0.2	-1.0
Financial situation satisfaction	0.4	0.5	1.1	-0.1	1.0
Commuting to job workplace: Public transport	0.4	0.5	0.8	-0.9	0.4
Medication: Atorvastatin	0.4	0.5	0.8	-0.4	0.9
Ever smoked	0.4	0.7	1.5	1.2	0.1
Smoking Status	0.3	0.6	1.2	1.1	0.2
Chronotype (morning person)	0.3	0.7	1.3	-0.3	-1.2
Hair Pigment	0.3	9.3	13.9	-2.2	3.7
Number of treatments/medications taken	0.3	0.5	0.6	0.8	-0.6
Fed-up feelings	0.3	0.5	0.6	-0.5	-0.8
Taking other prescription medications	0.3	0.4	0.8	0.9	0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.1	-0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.4	-0.7	0.6
Neuroticism score	0.3	0.7	0.7	-0.8	-0.8
Pulse wave Arterial Stiffness index	0.3	0.4	0.4	-0.7	0.6
Tense / ‘highly strung’	0.3	0.5	0.5	0.7	-0.7
Loud music exposure frequency	0.3	0.4	0.7	0.9	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	0.2	0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.2	0.8
Emphysema/chronic bronchitis	0.3	0.3	0.6	0.3	0.8
Medication for pain relief, constipation, heartburn	0.3	0.6	0.8	-0.9	-0.6
Pulse rate, automated reading	0.3	0.8	1.5	1.2	-0.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.9	0.0
Smoking status: Current	0.3	0.5	1.0	1.0	0.2
High cholesterol (Self-reported)	0.3	0.4	0.9	0.0	-0.9
Risk taking	0.3	0.5	0.9	-1.0	-0.0
Age at First Birth	0.2	0.3	0.5	0.7	-0.4
Crohns Disease (2012)	0.2	0.4	0.5	0.7	0.5
Tanning	0.2	3.0	5.9	-2.4	0.0
Hand grip strength (right)	0.2	0.6	0.8	0.6	0.9
Age when periods started (menarche)	0.2	0.4	0.9	-0.9	0.2
Body mass index (BMI)	0.2	0.6	0.8	0.7	0.9
Mouth/teeth dental problems	0.2	0.3	0.5	0.7	0.2
Lung cancer (father)	0.2	0.2	0.4	0.6	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.0	-0.8
Birth weight of first child	0.2	0.4	0.6	-0.8	-0.5
High blood pressure (siblings)	0.2	0.3	0.5	-0.7	-0.3
Pulse wave peak to peak time	0.2	0.3	0.5	0.7	-0.2
Eye problems/disorders: None of the above	0.2	0.3	0.4	-0.6	-0.4
Leg pain on walking	0.2	0.2	0.4	0.3	0.6
Miserableness	0.2	0.4	0.7	-0.4	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.2	-0.7
Illnesses of father: High blood pressure	0.2	0.2	0.3	-0.6	-0.3
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.3	-0.7
Age started oral contraceptive pill	0.2	0.2	0.4	0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.7	1.1	-0.5	-1.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.5	-0.2
Major Depression (MDD)	0.1	0.1	0.1	-0.3	-0.3
HDL Cholesterol	0.1	0.1	0.3	-0.5	-0.1
Rheumatoid Arthritis	0.1	0.2	0.4	0.1	0.6
Waist Hip Ratio (WHR)	0.1	0.6	0.9	-1.0	-0.5
Systolic Blood Pressure	0.1	0.7	1.4	-1.2	-0.1
Hand grip strength (left)	0.1	0.2	0.3	0.3	0.6
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.5	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.2	-0.5	-0.3
Nervous feelings	0.1	0.3	0.5	0.2	-0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.1	-0.4
Heart attack	0.1	0.1	0.2	-0.3	-0.4
Time employed in main current job	0.1	0.2	0.2	-0.3	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.2	-0.4	0.5
Pulse rate	0.1	0.2	0.2	0.4	-0.4
Noisy workplace	0.1	0.1	0.3	0.5	-0.0
Illnesses of mother	0.1	0.1	0.3	-0.1	0.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	0.3
Breastfed as a baby	0.1	0.1	0.2	0.4	0.3
Number of full brothers	0.1	0.1	0.1	0.2	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.2	0.7
Qualifications: College or University degree	0.1	0.4	0.7	-0.1	0.9
Heart disease (mother)	0.1	0.1	0.2	-0.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	0.6	-0.1
Had major operations	0.1	0.2	0.2	-0.4	-0.5
Loneliness, isolation	0.1	0.2	0.3	0.1	-0.6
Qualifications: nursing, teaching	0.1	0.1	0.1	0.2	0.4
Commuting to job workplace: Walk	0.1	0.1	0.1	0.2	0.3
Back pain experienced in last month	0.1	0.1	0.1	-0.3	-0.3
Medication: Lisinopril	0.1	0.2	0.3	-0.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.1	-0.5
LDL Cholesterol	0.0	0.0	0.0	-0.1	-0.2
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.4	-0.0
Severe depression (siblings)	0.0	0.0	0.0	0.2	-0.0
Maternal smoking around birth	0.0	0.0	0.1	-0.3	0.1
Pain all over the body in last month	0.0	0.0	0.0	0.1	0.2
Medication: Ramipril	0.0	0.0	0.0	-0.1	-0.2
Number of live births	0.0	0.0	0.0	0.1	0.1
Medication: Paracetamol	0.0	0.0	0.1	0.0	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.1	0.3
Ever had bowel cancer screening	0.0	0.1	0.1	0.3	0.1
Medication: Paracetamol	0.0	0.1	0.1	0.2	0.3
Irritability	0.0	0.1	0.1	0.2	-0.3
Heart disease (siblings)	0.0	0.0	0.1	-0.1	0.2

Hub : Genes

ANP32E

Models

Trait associations