Best TWAS P=1.43e-12 · Best GWAS P=2.75e-10 conditioned to 0.243
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REEP2 | 0.06 | 0.05 | lasso | 5 | 0.05 | 1.8e-06 | -4.0 | 5.4 | 6.2e-08 | 0.66 | 0.06 | 0.93 | FALSE |
| 2 | GTEx | Artery Aorta | REEP2 | 0.12 | 0.02 | lasso | 6 | 0.02 | 3.0e-02 | 5.3 | 5.8 | 5.8e-09 | 0.64 | 0.17 | 0.43 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | FAM53C | 0.22 | 0.01 | lasso | 10 | 0.00 | 3.4e-01 | 6.3 | 7.1 | 1.4e-12 | 0.79 | 0.02 | 0.75 | TRUE |
| 4 | GTEx | Heart Atrial Appendage | REEP2 | 0.24 | 0.15 | lasso | 6 | 0.13 | 2.0e-06 | 5.3 | 5.3 | 1.1e-07 | 0.72 | 0.41 | 0.51 | FALSE |
| 5 | GTEx | Nerve Tibial | REEP2 | 0.16 | 0.08 | lasso | 11 | 0.10 | 2.5e-07 | 5.3 | 5.6 | 1.7e-08 | 0.65 | 0.46 | 0.52 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EGR1 | 0.02 | 0.01 | blup | 41 | 0.02 | 1.9e-03 | 5.2 | 5.2 | 1.8e-07 | 0.61 | 0.08 | 0.31 | FALSE |