Hub : Genes

FAM53C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.049	0.0230	4.9e-04	0.022	0.024	0.007	0.025	0.015	1.0e-03	6.3e-04	4.7e-02	4.1e-04	4.7e-03
2	GTEx	Cells EBV-transformed lymphocytes	0.216	0.0930	1.8e-03	0.012	NA	-0.008	NA	-0.001	1.3e-01	NA	7.5e-01	NA	3.4e-01
3	GTEx	Pituitary	0.283	0.0930	3.2e-04	0.089	NA	-0.012	NA	0.024	3.1e-03	NA	8.9e-01	NA	8.2e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.132	0.0427	1.4e-05	0.060	0.041	0.049	0.045	0.050	3.1e-08	5.0e-06	6.2e-07	1.5e-06	4.6e-07
5	TCGA	Testicular Germ Cell Tumors	0.112	0.0630	2.4e-03	0.021	0.064	0.055	NA	0.046	6.1e-02	2.8e-03	5.1e-03	NA	9.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	4.1	6.4	12.6	-2.2	3.5	-2.1	3.2	-0.4
Bipolar Disorder or Schizophrenia	8.7	21.3	50.1	-4.7	7.1	-3.9	4.4	-0.8
Depressed Affect (Nagel 2018)	1.0	2.2	7.7	1.5	-2.8	-0.4	-0.7	0.5
Depression (Nagel 2018)	0.9	1.3	3.4	-0.4	-0.9	-1.8	-0.4	-1.5
Intelligence (Savage-Jansen 2018)	0.9	2.8	8.9	1.4	-1.1	1.1	-0.7	3.0
Neuroticism (Nagel 2018)	0.8	1.9	4.5	-0.8	-1.5	-1.3	-2.1	0.8
Schizophrenia (2018)	7.4	15.3	38.6	-4.2	6.2	-3.2	3.1	-0.7
Schizophrenia vs Biploar Disorder	3.5	4.7	11.2	-3.3	2.8	-1.5	-0.6	-1.4
Worry (Nagel 2018)	1.1	2.4	7.4	-0.6	-1.8	-0.3	-2.7	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.4	0.1	-0.7	-0.5	0.9
Alzheimer’s Disease (in father)	0.7	0.7	2.2	-1.5	0.6	-0.1	-0.9	-0.4
Alzheimer’s Disease (including proxy)	1.3	1.9	3.4	-1.5	1.5	-1.8	-1.1	0.6
Crohns Disease (2017)	0.6	1.3	2.7	1.6	-1.3	-0.3	1.2	-0.7
Irritable Bowel Disease (IBD)	0.7	1.6	5.0	0.6	0.4	0.3	2.2	-1.5
Ulcerative Colitis (UC)	0.7	1.4	2.6	-0.4	1.3	0.1	1.5	-1.6
Major Depression (MDD)	1.4	1.7	3.6	-0.4	-1.8	-0.7	-1.9	-1.0
Reaction Time	1.0	2.0	4.1	-0.6	1.2	-1.0	1.7	-2.0
Verbal and Numeric Reasoning (VNR)	1.7	4.1	7.1	1.8	-2.0	2.7	-0.6	2.4
Breast Cancer	0.1	0.2	0.6	-0.8	0.2	0.8	-0.1	-0.1
Ovarian Cancer	2.3	3.0	4.3	1.9	-2.1	2.1	0.8	1.5
Prostate Cancer	0.7	0.9	2.2	0.8	-1.3	0.4	-0.4	1.5
Age at First Birth	1.3	1.9	3.3	-0.6	1.8	-1.8	0.8	1.4
Bipolar Disorder (2011)	4.0	3.9	8.5	-2.1	2.9	-2.0	1.2	-1.1
Body Mass Index (BMI) (2010)	4.0	5.5	13.1	2.2	-1.9	3.6	2.4	0.3
Coronary Artery Disease (CAD)	1.2	1.5	5.7	-0.8	0.4	-1.0	0.2	-2.4
Crohns Disease (2012)	0.8	1.3	3.8	1.7	-1.9	-0.3	-0.0	-0.1
Mean Putamen Volume	1.3	1.5	3.7	0.6	-1.0	-1.6	0.0	-1.9
Fasting Glucose	1.1	1.4	3.4	-1.6	1.8	-0.8	0.5	-0.3
HbA1C	0.3	0.3	0.7	0.3	0.5	-0.6	0.8	0.5
HDL Cholesterol	0.6	1.1	2.7	-0.5	1.6	-0.0	0.5	1.4
LDL Cholesterol	0.7	1.2	3.1	-1.1	0.8	-0.8	-0.5	-1.8
Lupus	1.1	1.7	4.4	-1.1	1.1	-0.5	1.1	-2.1
Neuroticism (2016)	1.0	1.4	4.9	-0.7	-0.7	1.0	-2.2	-0.1
Primary Biliary Cirrhosis	0.1	0.2	0.6	0.2	-0.3	0.3	0.8	-0.1
Rheumatoid Arthritis	0.1	0.1	0.2	-0.2	0.4	0.2	-0.2	-0.5
Schizophrenia (2014)	7.8	17.1	43.7	-4.8	6.6	-3.4	2.6	-1.0
Triglycerides	1.4	2.3	5.7	-1.3	-0.8	-0.2	-1.8	-2.4
Type 2 Diabetes (T2D) (2012)	1.3	1.6	4.1	1.5	-2.0	0.9	-0.7	-0.4
Ulcerative Colitis	1.2	1.8	4.9	-0.6	1.2	-0.4	1.4	-2.2
Blood Eosinophil Count	0.8	6.2	25.7	0.8	-0.8	-0.5	1.9	-5.1
Blood Platelet Count	0.2	1.8	3.8	-1.8	1.9	-0.5	-1.1	1.0
Blood Red Count	0.9	8.2	31.2	-0.4	-0.5	3.0	0.5	-5.6
Blood White Count	0.0	0.2	0.3	0.4	-0.1	-0.5	-0.6	-0.5
Heel T-Score	0.0	0.2	0.5	0.7	-0.0	0.1	0.2	0.5
BMI	1.7	10.1	22.1	3.5	-2.1	3.2	4.7	-1.4
Height	0.8	14.7	45.1	3.3	0.6	3.8	6.7	1.6
Waist Hip Ratio (WHR)	2.3	10.4	21.5	-3.5	4.6	-4.1	0.8	1.0
Systolic Blood Pressure	0.2	1.0	2.5	1.3	-0.4	-0.4	-0.8	1.6
Smoking Status	2.9	6.9	17.0	-2.9	2.7	-1.4	-0.1	-4.1
Allergy or Eczema	1.2	3.1	7.2	1.2	-1.2	2.3	0.3	-2.7
Cardiovascular Disease	0.2	0.6	1.1	1.0	-1.0	-0.2	-0.3	1.0
Hypothyroidism (self reported)	0.5	1.1	2.2	0.8	-1.5	-0.6	-0.6	-1.3
Respiratory disease	2.2	5.0	10.3	3.2	-2.2	1.7	1.1	-2.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.2	1.0	-1.1	0.0	0.2	1.0
Lung FEV1/FVC ratio	0.7	3.3	8.8	1.3	-1.2	-0.4	-2.1	3.0
Lung FVC	0.6	3.1	4.7	-1.8	2.2	-2.0	0.8	1.6
Neuroticism	0.4	1.0	1.5	-0.6	-1.2	-1.2	-1.2	-0.4
Chronotype (morning person)	1.9	4.4	13.2	-0.5	2.0	-2.1	3.6	0.0
Hair Pigment	0.3	9.1	19.7	-2.1	4.1	-1.6	4.4	-1.5
Tanning	0.3	3.2	9.7	2.0	-1.4	3.1	0.3	0.7
Hand grip strength (left)	1.0	2.6	5.5	1.8	-2.4	1.9	0.6	-0.5
Number of treatments/medications taken	0.5	0.9	2.8	0.8	-0.1	-0.4	0.9	-1.7
Average weekly spirits intake	0.9	1.1	2.9	0.8	0.6	-0.5	1.1	1.7
Sensitivity / hurt feelings	0.7	1.2	3.2	-1.8	0.6	-1.3	-0.4	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.8	-0.1	-0.9	-1.0	-0.3	-1.3
Hearing difficulty/problems: Yes	0.4	0.6	0.9	-0.8	0.7	-0.9	-1.0	0.2
Relative age of first facial hair	0.8	1.6	4.2	-1.2	0.7	-1.4	0.1	-2.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.3	1.1	1.0	0.7	2.1	0.5
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.1	-1.6	1.2	-2.0	-1.7	-0.5
Ever had hysterectomy (womb removed)	0.9	1.0	4.1	0.7	0.7	-0.0	2.0	0.2
Systolic blood pressure, automated reading	0.4	1.1	1.5	1.2	-0.5	-1.1	-1.1	1.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.5	0.7	-0.1	-0.8	0.9	1.6
Angina	0.2	0.3	0.7	-0.7	0.2	-0.2	-0.4	-0.8
Medication for hormone replacement therapy	0.6	0.6	1.6	-0.8	1.2	0.6	0.6	-0.6
Vitamin and mineral supplements	0.3	0.4	0.6	-0.7	-0.7	-0.5	-0.4	-0.8
Supplements: Zinc	0.4	0.4	0.8	0.9	-0.1	-0.6	0.2	0.8
Medication: Co-codamol	1.2	1.4	4.8	-2.2	1.1	-0.7	-0.6	-0.5
Medication: Metformin	0.6	0.9	1.9	1.1	-0.2	-0.5	1.4	1.1
Diabetes (father)	0.6	0.7	1.5	1.0	-1.2	0.4	0.7	-0.5
Diabetes (mother)	0.2	0.3	0.7	-0.8	-0.0	0.8	0.2	0.4
Severe depression (siblings)	0.4	0.4	1.6	0.5	-0.1	-1.3	0.3	0.4
Pack years adult smoking proportion	0.5	0.8	2.4	-0.7	-0.9	-0.2	-1.6	0.3
Impedance of leg (right)	1.9	9.1	21.7	-3.6	2.1	-2.0	-4.7	-1.5
Leg fat-free mass (left)	3.6	18.8	35.8	5.6	-3.4	4.0	6.0	0.5
Trunk fat percentage	0.8	3.2	7.4	1.4	-0.1	0.0	2.7	-2.6
Hand grip strength (right)	1.0	2.6	3.7	1.9	-1.9	1.8	1.5	-0.4
Townsend deprivation index at recruitment	0.8	1.1	2.7	-0.5	1.1	-1.6	0.7	-0.9
Current tobacco smoking	3.1	5.0	11.5	-2.1	2.0	-3.4	0.5	-2.2
Average weekly fortified wine intake	1.6	1.9	3.4	1.7	-1.5	1.9	0.2	0.9
Maternal smoking around birth	3.3	4.7	9.0	-2.4	2.0	-3.0	-0.5	-2.2
Fed-up feelings	1.3	2.4	5.3	0.5	-2.3	-1.7	-1.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.7	0.5	-0.9	-0.2	1.0	-1.3
Relative age voice broke	2.2	3.3	7.5	-2.0	1.6	-2.7	-1.3	-0.8
Taking other prescription medications	1.0	1.5	4.5	1.4	0.0	1.0	2.1	-0.5
Age when periods started (menarche)	0.3	0.8	3.3	0.7	0.2	-1.8	-0.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.9	1.4	-0.3	1.1	0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	0.1	0.5	-0.8	0.8	0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.8	0.6	-0.8	0.6	0.5	-0.9
Qualifications: CSEs or equivalent	1.8	2.4	9.3	0.4	-1.3	-0.2	-0.9	-3.1
Serious illness, injury or assault to yourself	1.1	1.4	3.7	0.0	1.5	-0.9	1.9	0.3
High blood pressure	0.6	1.7	3.8	1.9	-1.9	1.1	-0.4	0.0
Hayfever, allergic rhinitis or eczema	1.5	3.2	8.6	1.1	-1.2	2.1	0.3	-2.9
Multivitamins +/- minerals	0.6	0.8	2.2	0.7	-0.0	1.2	0.1	1.5
Stomach or abdominal pain in last month	1.4	1.8	3.1	-0.6	1.4	-1.8	1.6	-1.0
Supplements: Glucosamine	1.9	2.5	4.9	2.2	-1.7	1.4	0.3	-1.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.5	-1.9	1.7	-1.0	0.4	-0.7
Medication: Atenolol	0.5	0.6	2.3	-0.8	0.3	0.5	-0.1	1.5
Medication: Levothyroxine sodium	0.7	1.1	2.0	1.4	-1.3	1.1	0.8	0.2
Sitting height	2.4	17.0	26.6	5.2	-5.0	4.2	1.4	3.8
Chronic bronchitis/emphysema (father)	1.0	1.2	3.4	-0.3	-0.7	-1.8	-1.3	-0.3
High blood pressure (mother)	0.7	1.0	2.2	1.5	-1.3	-0.2	1.0	-0.2
Body mass index (BMI)	1.1	4.8	10.2	2.4	-1.5	1.8	3.2	-1.6
Impedance of leg (left)	2.1	10.4	22.9	-3.8	2.5	-2.5	-4.8	-1.3
Leg predicted mass (left)	3.5	18.6	35.6	5.5	-3.3	4.0	6.0	0.4
Trunk fat mass	1.3	5.6	13.5	2.7	-1.1	1.5	3.7	-1.8
Waist circumference	0.7	2.5	8.9	0.9	0.6	0.3	3.0	-1.4
Number of incorrect matches in round	0.9	1.5	3.6	0.2	-1.4	0.8	-1.9	-1.1
Past tobacco smoking	1.2	2.1	3.7	1.8	-1.9	0.4	-0.2	1.8
Alcohol usually taken with meals	1.1	1.8	4.1	0.8	-1.2	2.0	-0.4	1.5
Nervous feelings	1.4	2.6	7.6	-1.6	-0.6	-1.5	-2.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.9	0.5	-2.0	-0.0	-0.6	-0.2
Hearing difficulty/problems with background noise	1.1	1.8	4.7	-1.3	0.5	0.3	-1.4	-2.2
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	-0.3	0.2	0.6	-0.9	1.3
Had menopause	0.6	0.8	1.6	-0.8	1.0	-1.3	-0.4	0.7
Had other major operations	0.7	0.9	2.0	-0.4	1.4	-0.7	1.2	-0.3
Forced vital capacity (FVC)	1.1	4.2	15.3	0.7	0.7	1.3	3.9	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.5	-0.0	0.3	0.7	0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.6	0.3	-0.7	-0.8	0.4	-1.6
Qualifications: None of the above	2.3	4.9	12.8	-2.4	1.2	-3.6	-0.3	-2.1
Financial difficulties in last 2 years	0.8	1.1	2.9	1.1	-0.9	1.7	0.7	0.3
Mouth/teeth dental problems	1.5	2.2	3.5	1.9	-1.4	1.6	1.6	0.8
Heart attack	0.8	1.1	2.3	-0.9	1.0	-0.9	0.7	-1.5
Allergy	2.6	6.0	8.8	-3.0	2.8	-2.2	-0.9	2.8
Pain all over the body in last month	0.2	0.2	0.3	0.0	-0.6	-0.6	0.0	0.5
Diabetes (self-reported)	1.4	2.1	4.4	1.5	-1.0	0.8	1.5	2.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.2	-0.6	0.4	1.0	1.0	-1.1
Medication: Ramipril	1.8	2.3	5.5	1.3	-2.3	1.6	-1.2	-0.8
Medication: Simvastatin	0.6	0.8	1.7	-0.1	0.9	-1.3	1.2	-0.6
Fluid intelligence score	1.2	2.4	5.9	1.6	-1.0	1.5	0.8	2.4
Illnesses of siblings	0.6	0.9	1.8	1.1	-1.2	1.3	0.2	0.2
Neuroticism score	0.5	1.0	2.1	-0.6	-1.4	-1.0	-1.4	0.0
Weight	2.4	11.6	24.9	4.1	-2.2	3.3	5.0	-0.6
Impedance of arm (right)	2.3	10.6	18.1	-4.1	4.3	-3.7	-1.2	-1.6
Arm fat percentage (right)	0.8	3.1	8.3	0.6	0.3	0.3	2.9	-2.6
Trunk fat-free mass	3.5	20.3	31.5	5.6	-4.1	5.4	4.7	1.4
Hip circumference	2.0	8.8	20.1	3.2	-1.3	3.0	4.5	-1.8
Time employed in main current job	0.4	0.5	1.2	-0.0	0.6	-0.6	0.6	1.1
Alcohol intake versus 10 years previously	0.6	0.9	2.2	-0.6	1.1	-0.5	0.7	-1.5
Father’s age at death	0.4	0.6	2.3	1.5	0.0	-0.1	-0.0	0.8
Worrier / anxious feelings	1.0	1.8	5.8	-1.8	-0.2	-0.1	-2.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	-0.2	0.7	-0.6	1.2	0.4
Falls in the last year	0.5	0.7	2.8	-0.3	1.7	0.1	0.4	-0.8
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	-0.3	1.1	-1.3	0.5	0.2
Number of live births	2.2	3.1	5.2	-1.8	-0.1	-1.7	-2.3	-2.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	8.1	1.4	-0.3	2.2	2.8	2.8
Pulse rate	1.9	3.3	10.0	1.5	1.1	-1.2	3.2	1.1
Happiness	1.8	2.2	5.9	-1.6	-0.5	-0.8	-2.4	-1.3
Noisy workplace	0.2	0.3	0.5	-0.7	-0.4	-0.7	0.0	0.3
Qualifications: A levels/AS levels or equivalent	2.9	6.4	17.5	3.1	-0.2	1.3	1.8	4.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.5	0.3	1.2	0.8	1.0	-0.3
Mouth/teeth dental problems: Dentures	1.7	2.9	5.7	-2.4	1.1	-1.0	-1.4	-2.2
Asthma	2.8	5.4	11.1	3.3	-2.7	1.8	1.0	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.6	-0.5	1.2	-0.7	1.3	-0.6
Medication: Cholesterol lowering	0.2	0.3	0.9	1.0	-0.0	-0.2	0.6	0.3
Depression (self-reported)	0.5	0.6	1.6	-1.0	0.4	-0.6	0.3	1.2
Medication: Lansoprazole	1.0	1.2	5.4	-0.2	-0.1	-0.5	0.1	-2.3
Prospective memory result	0.4	0.5	1.3	-0.3	-0.6	-0.7	0.2	1.1
Lung cancer (father)	0.1	0.1	0.3	0.2	0.3	0.1	0.5	-0.5
Illnesses of mother	1.2	1.4	2.6	1.1	-0.8	1.6	-0.5	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	11.9	2.1	-1.1	2.5	1.9	3.5
Pulse wave Arterial Stiffness index	0.8	1.0	2.9	0.0	1.2	-0.5	1.7	-0.3
Impedance of arm (left)	2.0	9.5	15.0	-3.8	3.9	-3.9	-1.2	-1.3
Arm fat mass (right)	1.3	5.5	13.2	2.3	-1.2	1.8	3.6	-2.0
Trunk predicted mass	3.5	19.9	30.9	5.6	-4.0	5.2	4.8	1.4
Standing height	1.1	11.3	20.2	4.1	-1.9	3.5	4.5	1.8
Length of working week for main job	1.1	1.2	3.0	1.5	0.1	0.7	1.7	-0.2
Exposure to tobacco smoke at home	2.0	2.2	3.5	-1.8	1.8	-1.9	0.3	0.9
Breastfed as a baby	0.2	0.3	0.6	0.8	-0.8	0.3	-0.2	-0.2
Tense / ‘highly strung’	1.0	1.7	5.5	0.7	-2.3	-0.2	-1.4	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	-1.0	-0.0	-0.6	0.3	-0.1
Hair/balding pattern: Pattern 4	0.8	1.8	4.6	2.1	-1.8	1.0	0.4	0.4
Birth weight of first child	0.6	1.0	2.7	1.6	-0.5	0.7	0.9	-1.0
Peak expiratory flow (PEF)	3.8	8.7	13.1	3.6	-2.8	3.2	2.5	2.6
Pulse wave reflection index	0.5	0.6	1.0	-1.0	0.5	0.3	-0.8	-1.0
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.0	-0.9	2.0	-1.6	1.4	0.0
Loud music exposure frequency	1.9	2.1	5.2	-2.3	1.5	-0.6	-1.6	-0.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.1	1.0	1.0	0.1	1.4	0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	0.4	-0.7	-0.5	-1.2	0.4
Blood clot in the leg (DVT)	0.5	0.6	1.2	0.5	-0.9	1.1	0.9	-0.2
Medication: Paracetamol	0.5	0.9	3.6	0.7	-0.1	-0.5	-0.0	-1.9
Headache pain in last month	1.0	1.8	3.7	-0.1	1.3	-1.8	1.9	0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.0	-1.7	1.0	-0.5	-0.8	-1.2
Glaucoma (self-reported)	1.1	1.3	2.9	0.6	-1.1	1.4	-1.7	-0.4
Gout (self-reported)	0.1	0.2	0.6	-0.3	0.0	0.8	-0.4	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.0	0.3	-1.0	-0.2	0.1	-0.8
Medication: Amlodipine	0.3	0.4	0.9	-1.0	0.9	0.1	-0.6	0.1
Medication: Ventolin 100micrograms inhaler	1.7	2.1	7.6	0.8	-0.8	1.3	0.4	-2.8
Birth weight	0.6	1.4	3.5	-0.2	0.9	0.3	1.9	-1.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.5	-0.1	0.4	-1.0	0.7	-1.6
High blood pressure (siblings)	0.7	1.1	4.5	-0.4	0.4	-2.1	-0.7	-0.4
Forced vital capacity (FVC), Best measure	0.9	3.5	8.7	0.9	0.2	1.7	3.0	2.2
Body fat percentage	0.7	2.8	8.0	1.3	-0.3	0.2	2.1	-2.8
Leg fat percentage (right)	0.6	2.2	8.8	0.7	-0.5	0.8	1.0	-3.0
Arm fat-free mass (right)	3.8	19.6	33.2	5.8	-4.2	5.1	4.5	0.7
Exposure to tobacco smoke outside home	1.5	2.0	6.9	-0.5	1.5	-2.6	0.6	0.7
Comparative body size at age 10	2.0	5.5	18.2	2.4	-1.0	1.4	4.3	-0.6
Number of full brothers	0.6	0.8	1.9	-0.7	-0.1	1.4	-0.3	-1.2
Worry too long after embarrassment	1.7	2.8	8.0	-1.7	-0.9	-1.5	-2.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	-0.6	1.2	-0.1	0.8	0.1
Wheeze or whistling in the chest in last year	1.5	2.7	5.4	2.3	-0.7	0.4	1.5	-2.3
Number of children fathered	1.6	1.8	4.1	0.6	-2.0	1.5	-1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.8	-0.7	-0.8	1.2	-1.3	-0.1
Age at first live birth	1.4	2.4	8.4	0.8	0.8	1.5	2.9	0.5
Pulse wave peak to peak time	0.8	0.9	2.3	0.1	-1.4	0.5	-1.5	0.4
Health satisfaction	0.6	0.7	1.2	0.8	-1.1	-1.1	-0.3	-0.7
Shortness of breath walking on level ground	1.3	1.5	3.6	-1.0	1.9	-1.0	0.9	1.0
Qualifications: College or University degree	1.2	3.6	9.9	2.2	-1.0	1.6	-0.2	3.1
Eye problems/disorders: None of the above	1.8	2.1	4.2	1.4	-1.1	1.5	0.9	2.0
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	0.0	-0.1	0.3	-0.7	0.5
Emphysema/chronic bronchitis	4.7	5.3	16.1	-2.1	1.6	-1.7	0.8	-4.0
Medication for pain relief, constipation, heartburn	0.7	1.3	4.8	-0.5	-0.6	0.2	-0.9	2.2
Neck or shoulder pain in last month	1.0	1.5	4.5	-0.7	1.6	-2.1	0.0	-0.3
Medication: Blood pressure	0.9	1.5	3.3	1.5	-1.0	1.8	0.9	0.2
Angina (self-reported)	0.3	0.4	0.7	-0.9	0.4	-0.5	-0.3	-0.8
Migraine (self-reported)	1.5	1.9	7.4	1.1	0.4	-0.5	2.7	0.6
Medication: Ibuprofen	0.5	0.5	1.5	-0.6	1.2	-0.1	0.9	-0.3
Medication: Allopurinol	0.6	0.7	1.5	-0.4	0.8	1.2	0.1	-1.2
Medication: Omeprazole	3.1	3.7	7.4	-0.4	2.0	-0.7	2.5	-2.7
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.3	-0.3	-0.5	-0.8	-0.8
Mean time to correctly identify matches	2.2	4.2	7.5	-2.0	2.7	-1.8	1.3	-2.2
Heart disease (mother)	1.7	2.1	6.3	-1.6	1.0	-0.7	-0.2	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.6	-0.1	0.0	0.2	-0.9
Whole body fat mass	1.3	5.5	10.9	2.6	-1.3	1.8	3.3	-2.2
Leg fat mass (right)	1.3	4.9	8.5	2.4	-1.3	1.9	2.9	-2.2
Arm predicted mass (right)	3.5	18.0	29.7	5.5	-4.0	5.0	4.4	0.7
Pulse rate, automated reading	2.0	6.6	13.9	1.6	1.8	0.2	3.6	3.7
Alcohol intake frequency.	2.1	4.8	11.4	-1.5	1.1	-3.4	2.2	-2.0
Comparative height size at age 10	1.8	9.7	22.0	3.1	-1.5	4.7	3.5	1.5
Number of full sisters	1.4	1.7	5.4	-1.4	1.1	-2.3	0.1	0.0
Suffer from ‘nerves’	1.1	1.7	4.9	-0.0	-2.2	-0.1	-1.9	0.1
Overall health rating	0.8	1.8	4.2	-0.3	1.0	-2.0	1.3	-1.4
Chest pain or discomfort	0.4	0.6	1.8	1.4	0.0	0.9	0.8	-0.2
Had major operations	0.2	0.3	0.5	0.5	-0.3	-0.7	0.6	0.3
Age at last live birth	0.4	0.6	1.5	0.2	0.1	1.2	1.1	-0.5
Family relationship satisfaction	3.2	4.0	8.3	-2.9	2.3	-1.3	-0.1	-2.1
Leg pain on walking	0.6	0.7	2.7	0.8	-0.6	-1.6	0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.5	1.4	-1.3	0.9	0.1	-1.6
Commuting to job workplace: Car/motor vehicle	2.2	2.5	6.2	2.5	-2.4	-0.1	0.6	-0.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.8	-1.4	-0.3	-1.3	-1.9	-0.7
Medication: Aspirin	0.1	0.2	0.6	0.4	-0.2	-0.8	0.0	0.1
Supplements: Vitamin C	0.5	0.6	1.5	0.9	0.5	-0.5	1.2	0.0
Knee pain experienced in last month	0.7	1.1	3.3	1.8	-1.1	-0.3	-0.8	-0.7
Hypertension (Self-reported)	0.5	1.5	3.5	1.9	-1.5	1.2	0.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	11.9	-1.2	1.6	-1.1	1.0	-3.4
Illnesses of father: Heart disease	0.6	0.8	2.6	-1.6	0.8	-0.2	-0.7	-0.1
Illnesses of siblings: Diabetes	0.5	0.6	2.0	-0.4	-0.1	-0.9	0.1	1.4
Smoking status: Previous	0.4	0.5	2.0	-0.3	0.3	1.4	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	6.2	1.3	-0.6	0.7	2.5	0.4
Whole body fat-free mass	3.6	20.7	33.6	5.8	-3.9	4.9	5.4	1.1
Leg fat-free mass (right)	3.4	18.1	36.0	5.4	-3.1	3.8	6.0	0.8
Arm fat percentage (left)	0.8	3.1	7.8	0.9	0.1	0.5	2.8	-2.6
Average weekly red wine intake	1.0	1.5	4.7	1.0	-0.3	2.2	0.3	1.3
Handedness (chirality/laterality): Left-handed	3.1	3.7	9.2	0.4	1.4	-2.1	3.0	1.8
Mood swings	0.7	1.3	3.0	0.7	-1.6	-1.7	-0.1	0.5
Loneliness, isolation	0.9	1.2	3.1	0.7	-1.8	1.5	-0.2	-0.5
Long-standing illness, disability or infirmity	1.4	2.2	4.6	-0.2	1.6	-0.4	2.1	-1.8
Ever had bowel cancer screening	0.7	0.8	2.4	-0.6	0.0	-1.6	-1.0	-0.6
Diabetes diagnosed by doctor	1.1	1.8	4.7	1.4	-1.0	0.7	1.0	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.8	0.4	-1.5	1.3	-2.0	0.6
Friendships satisfaction	2.6	3.3	5.3	-2.3	1.0	-1.7	-1.7	-2.1
Qualifications: nursing, teaching	0.8	1.2	2.2	1.0	0.1	1.5	1.0	1.3
Commuting to job workplace: Walk	1.2	1.3	3.4	-0.1	1.8	-0.2	1.0	1.5
Eye problems/disorders: Cataract	2.0	2.3	6.3	-1.5	0.9	-1.3	-0.9	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	-0.7	1.2	-0.3	-0.6	-0.2
Medication for cholesterol	1.1	1.7	4.8	2.2	-1.4	-0.0	-0.1	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-0.8	1.1	0.3	0.9	-0.6
Back pain experienced in last month	0.4	0.6	2.2	-0.4	0.0	-0.2	-1.5	-0.8
Mineral and other dietary supplements	1.4	1.9	5.5	-1.2	1.0	-1.2	-0.3	2.3
Breast cancer (self-reported)	1.5	1.7	3.6	0.4	-1.7	1.0	-1.9	1.1
Asthma (self-reported)	2.8	5.5	11.0	3.3	-2.7	1.8	1.0	-2.3
Osteoporosis (self-reported)	0.2	0.3	0.5	-0.5	0.2	0.2	-0.7	-0.7
Osteoarthritis (self-reported)	0.4	0.6	1.6	1.0	-0.4	0.1	1.2	-0.1
Medication: Aspirin	0.2	0.2	0.6	0.2	0.2	-0.8	0.6	-0.3
Medication: Gliclazide	1.0	1.2	3.2	1.5	-0.2	0.4	0.6	1.8
Illnesses of father: None of the above (group 1)	0.6	0.8	1.9	0.2	1.2	0.5	1.4	0.3
Smoking status: Current	3.2	5.0	11.1	-2.1	2.3	-3.3	0.7	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	8.8	0.8	-1.0	0.3	-0.4	3.0
Whole body water mass	3.5	20.2	32.6	5.7	-3.9	4.9	5.3	1.0
Leg predicted mass (right)	3.4	18.4	36.5	5.5	-3.2	3.8	6.0	0.9
Arm fat mass (left)	1.4	5.9	14.1	2.5	-1.3	1.9	3.8	-1.9
Number of self-reported non-cancer illnesses	1.3	2.3	4.0	2.0	-1.0	1.6	1.7	-0.9
Average weekly champagne plus white wine intake	1.1	1.4	1.9	1.2	-1.2	1.4	-0.7	1.3
Miserableness	0.6	1.0	2.4	0.6	-1.6	-0.1	-0.0	-1.6
Guilty feelings	1.6	2.5	6.8	-1.7	1.3	-2.6	0.9	0.2
Wears glasses or contact lenses	0.5	0.6	1.1	0.9	-1.0	1.1	-0.2	-0.4
Ever taken oral contraceptive pill	1.6	1.8	3.8	1.5	-2.0	0.3	-1.0	1.3
Hearing aid user	0.2	0.2	0.7	0.1	-0.1	-0.2	-0.5	0.9
Mother’s age at death	0.7	0.9	2.1	-0.1	1.4	0.0	1.1	1.1
Financial situation satisfaction	0.7	0.9	2.4	0.7	-0.5	1.5	0.4	-1.0
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.6	1.7	-2.2	-0.8	-0.6	0.4
Commuting to job workplace: Public transport	1.7	2.1	3.5	-0.7	1.9	1.7	1.5	1.1
Eye problems/disorders: Glaucoma	1.1	1.2	4.9	0.3	-1.1	0.2	-2.2	0.0
Medication: Blood pressure	0.1	0.2	0.3	-0.2	-0.5	0.4	-0.4	-0.5
Pain type(s) experienced in last month: Hip pain	0.8	1.0	4.7	0.3	-0.3	-0.0	-0.1	-2.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.7	1.3	-0.8	0.7	0.5	-1.0
High cholesterol (Self-reported)	1.2	2.2	3.7	-1.9	1.7	-1.9	-0.8	-0.4
Medication: Bendroflumethiazide	0.3	0.5	1.2	0.9	-1.1	-0.0	-0.4	0.3
Medication: Paracetamol	0.5	0.8	3.7	0.1	0.4	-0.6	-0.0	-1.9
Medication: Lisinopril	0.6	0.8	1.9	0.6	-0.8	1.4	-0.0	1.0
Medication: Atorvastatin	0.3	0.3	0.9	-0.1	0.7	1.0	0.4	0.3
Illnesses of father: High blood pressure	1.6	1.9	3.7	1.7	-1.9	1.5	0.7	-0.5
Alcohol drinker status: Never	0.4	0.4	0.8	0.9	-0.6	-0.1	0.9	0.5
Ever smoked	1.2	2.2	3.4	-1.2	1.8	-1.3	1.1	-1.8
Basal metabolic rate	3.4	19.0	30.7	5.5	-3.7	4.7	5.3	0.6
Leg fat percentage (left)	0.5	1.9	7.6	0.7	-0.2	0.4	1.0	-2.8
Arm fat-free mass (left)	3.7	18.9	31.1	5.6	-3.9	5.0	4.8	0.8
Number of operations (self-reported)	0.3	0.4	1.0	1.0	0.1	-0.1	0.9	-0.4
Average weekly beer plus cider intake	0.3	0.5	1.2	-0.4	0.1	-1.1	-0.9	0.3
Irritability	0.4	0.7	2.5	-0.8	-0.0	-1.6	-0.6	0.3
Risk taking	0.5	0.7	1.4	0.8	0.7	-1.0	-0.0	1.2
Ever had prostate specific antigen (PSA) test	3.0	3.5	8.6	2.9	-2.1	1.4	0.5	1.4
Fractured/broken bones in last 5 years	1.5	1.9	6.4	0.3	1.3	-1.2	2.5	-0.5
Age started oral contraceptive pill	1.6	2.0	4.1	-2.0	0.9	-1.1	-1.4	-1.4
Diastolic blood pressure, automated reading	0.3	0.9	2.3	1.5	-0.2	-1.2	0.9	-0.0
Ever depressed for a whole week	0.8	1.0	2.8	0.9	-1.0	-0.5	-0.0	-1.7
Unable to work because of sickness or disability	1.9	2.4	6.7	-0.7	1.8	-0.2	2.6	-1.3
Commuting to job workplace: Cycle	0.7	0.8	2.2	-0.3	1.3	-0.1	1.5	0.5
Myopia	0.6	0.8	1.6	0.2	-0.2	1.2	0.9	-1.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.8	-1.2	1.3	-0.6	0.6	0.6
Cholesterol lowering medication	2.3	3.4	6.2	-2.5	2.3	-2.0	0.7	-1.1
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	6.3	-0.1	1.4	-0.4	2.0	-2.5
Pain experienced in last month	0.4	0.7	2.5	-0.8	0.6	1.6	-0.2	-0.3
Supplements: Calcium	0.4	0.4	1.1	0.1	1.0	-0.2	1.0	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	-0.2	-0.3	-1.2	-0.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.2	-0.9	1.1	-0.9	0.7	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.3	0.7	-1.1	1.2	1.0	-0.5
Heart disease (siblings)	0.7	0.9	2.0	-0.9	1.4	-1.0	0.8	0.2
Alcohol drinker status: Previous	1.1	1.3	5.5	-0.7	0.1	-2.4	-0.6	-0.4
Pack years of smoking	0.6	0.9	2.7	-0.8	-0.8	-0.5	-1.6	0.5
Impedance of whole body	2.1	10.8	16.0	-4.0	3.4	-3.6	-3.4	-1.4
Leg fat mass (left)	1.2	4.8	9.2	2.4	-1.1	1.8	3.0	-2.1
Arm predicted mass (left)	3.2	16.3	26.9	5.2	-3.4	4.4	4.8	0.5