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chr15:90,718,541-92,135,418

Best TWAS P=4.93e-15 · Best GWAS P=2.5e-13 conditioned to 0.041

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FURIN	0.12	0.14	lasso	2	0.13	1.2e-15	7.3	-7.3	3.3e-13	-1.00	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	FES	0.21	0.09	lasso	5	0.05	1.3e-03	-5.7	5.8	5.0e-09	0.60	0.47	0.07	FALSE
3	GTEx	Artery Tibial	FES	0.16	0.04	lasso	5	0.05	4.8e-05	-5.4	5.2	1.5e-07	0.58	0.56	0.38	FALSE
4	GTEx	Cells Transformed fibroblasts	FES	0.28	0.17	enet	21	0.20	2.8e-15	-5.7	6.7	2.6e-11	0.77	0.09	0.91	FALSE
5	GTEx	Lung	FES	0.24	0.07	lasso	6	0.05	5.1e-05	-5.4	6.1	1.1e-09	0.64	0.23	0.73	FALSE
6	GTEx	Thyroid	FES	0.33	0.19	lasso	6	0.18	4.3e-14	-5.1	5.5	3.4e-08	0.60	0.99	0.01	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FES	0.06	0.05	blup	46	0.06	1.9e-05	-6.9	6.4	1.2e-10	0.74	0.01	0.98	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	FES	0.06	0.05	blup	46	0.07	7.4e-14	-5.7	7.8	4.9e-15	0.77	0.05	0.95	TRUE
9	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FES	0.06	0.02	blup	46	0.02	2.4e-02	-5.7	6.6	4.0e-11	0.64	0.01	0.79	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	FES	0.08	0.07	blup	46	0.06	3.4e-04	-7.0	6.6	3.2e-11	0.82	0.00	0.99	FALSE
11	The Cancer Genome Atlas	Glioblastoma Multiforme	FES	0.12	0.06	enet	6	0.06	5.7e-03	-7.0	6.4	1.9e-10	0.84	0.01	0.88	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	-7.0	7.0	3.1e-12	0.71	0.02	0.97	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FES	0.10	0.07	enet	5	0.05	2.8e-06	-6.9	7.1	1.3e-12	0.88	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HDDC3	0.16	0.10	enet	9	0.12	2.1e-07	-2.9	6.0	1.5e-09	0.56	0.29	0.65	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	FES	0.05	0.04	lasso	2	0.04	2.2e-05	-5.7	6.7	2.4e-11	0.76	0.02	0.97	FALSE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FES	0.08	0.07	enet	7	0.08	4.2e-09	-5.7	6.5	1.1e-10	0.66	0.33	0.67	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FES	0.13	0.16	lasso	2	0.14	6.1e-10	-5.7	5.5	3.1e-08	0.61	0.80	0.20	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	FES	0.12	0.09	lasso	5	0.08	4.1e-09	-5.7	6.1	1.0e-09	0.65	0.37	0.63	FALSE
19	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	-6.9	7.5	5.1e-14	0.63	0.01	0.49	FALSE
20	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FES	0.32	0.26	lasso	2	0.25	2.0e-09	-5.8	5.8	5.5e-09	0.62	0.70	0.28	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	FES	0.30	0.30	lasso	7	0.32	1.3e-31	-5.8	6.5	8.1e-11	0.72	0.97	0.03	FALSE