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chr16:28,825,605-31,026,427

Best TWAS P=2.7e-11 · Best GWAS P=6.85e-11 conditioned to 0.0615

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
42	GTEx	Whole Blood	MAPK3	0.09	0.05	enet	30	0.09	7.8e-09	6.52	6.7	2.7e-11	0.82	0.01	0.99	TRUE
13	GTEx	Cells Transformed fibroblasts	MAPK3	0.12	0.05	lasso	10	0.04	3.7e-04	6.34	6.6	3.0e-11	0.94	0.02	0.98	FALSE
21	GTEx	Esophagus Muscularis	INO80E	0.10	0.11	enet	20	0.07	4.6e-05	-6.22	6.5	6.4e-11	0.83	0.04	0.96	FALSE
24	GTEx	Heart Left Ventricle	INO80E	0.06	0.07	lasso	7	0.08	6.1e-05	-6.19	6.4	1.6e-10	0.91	0.04	0.94	FALSE
11	GTEx	Breast Mammary Tissue	INO80E	0.17	0.12	enet	14	0.13	2.3e-07	4.54	6.4	2.1e-10	0.84	0.04	0.96	FALSE
33	GTEx	Prostate	INO80E	0.18	0.23	lasso	2	0.23	1.6e-06	-6.27	6.3	2.7e-10	0.84	0.04	0.94	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD13	0.02	0.02	lasso	2	0.02	3.9e-03	6.34	-6.3	3.3e-10	-0.99	0.01	0.85	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	TAOK2	0.04	0.02	blup	188	0.03	1.7e-04	6.22	6.3	3.9e-10	0.86	0.02	0.97	FALSE
39	GTEx	Stomach	RP11-231C14.4	0.09	0.09	enet	7	0.05	1.5e-03	6.32	-6.3	4.1e-10	-0.96	0.02	0.88	FALSE
16	GTEx	Colon Transverse	RP11-231C14.4	0.07	0.04	enet	8	0.06	8.0e-04	-6.19	-6.2	4.9e-10	-0.79	0.03	0.88	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	INO80E	0.08	0.13	lasso	2	0.12	1.6e-15	-6.19	6.2	5.8e-10	0.83	0.04	0.96	FALSE
8	GTEx	Artery Aorta	SLX1A-SULT1A3	0.07	0.00	enet	17	0.00	2.6e-01	-4.07	-6.2	7.4e-10	-0.77	0.04	0.72	FALSE
40	GTEx	Testis	INO80E	0.15	0.20	lasso	3	0.19	8.3e-09	-6.15	6.1	8.1e-10	0.84	0.04	0.96	FALSE
14	GTEx	Cells Transformed fibroblasts	PPP4C	0.04	0.06	lasso	1	0.05	8.0e-05	-6.13	6.1	8.8e-10	0.83	0.05	0.93	FALSE
9	GTEx	Artery Tibial	RP11-231C14.4	0.04	0.04	enet	4	0.02	9.2e-03	6.22	-6.1	1.2e-09	-0.98	0.02	0.89	FALSE
5	GTEx	Adipose Visceral Omentum	SEZ6L2	0.05	0.01	enet	10	0.01	9.4e-02	5.99	-6.1	1.3e-09	-0.95	0.03	0.82	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	DOC2A	0.03	0.02	blup	48	0.03	6.1e-04	-6.19	6.0	1.8e-09	0.80	0.02	0.87	FALSE
6	GTEx	Adipose Visceral Omentum	AC009133.12	0.05	0.01	lasso	2	0.00	2.3e-01	-6.27	-6.0	2.0e-09	-0.79	0.04	0.57	FALSE
10	GTEx	Artery Tibial	INO80E	0.23	0.15	enet	21	0.19	6.7e-15	-6.15	6.0	2.0e-09	0.83	0.05	0.95	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	MAPK3	0.23	0.12	enet	8	0.08	1.5e-03	6.21	6.0	2.1e-09	0.94	0.02	0.98	FALSE
36	GTEx	Small Intestine Terminal Ileum	MAPK3	0.17	0.01	lasso	5	0.04	5.4e-02	-6.19	6.0	2.3e-09	0.79	0.04	0.66	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	INO80E	0.06	0.01	blup	49	0.02	2.8e-03	3.26	5.9	2.8e-09	0.60	0.02	0.25	FALSE
32	GTEx	Pituitary	INO80E	0.27	0.29	lasso	8	0.27	1.9e-07	-6.19	5.9	2.9e-09	0.83	0.04	0.95	FALSE
30	GTEx	Ovary	RP11-231C14.4	0.22	0.12	lasso	5	0.11	1.1e-03	6.52	-5.9	3.0e-09	-0.87	0.02	0.80	FALSE
3	GTEx	Adipose Subcutaneous	INO80E	0.10	0.16	enet	19	0.15	4.5e-12	-6.19	5.9	3.1e-09	0.80	0.05	0.95	FALSE
2	GTEx	Adipose Subcutaneous	RP11-231C14.4	0.06	0.07	enet	5	0.07	4.7e-06	6.52	-5.9	3.5e-09	-0.93	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DOC2A	0.08	0.01	bslmm	213	0.05	2.4e-06	3.26	5.9	4.1e-09	0.64	0.10	0.89	FALSE
23	GTEx	Heart Atrial Appendage	INO80E	0.14	0.17	lasso	3	0.19	5.7e-09	-6.25	5.8	4.9e-09	0.82	0.04	0.95	FALSE
29	GTEx	Nerve Tibial	INO80E	0.26	0.34	enet	30	0.38	3.5e-28	-6.19	5.8	5.1e-09	0.81	0.04	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	INO80E	0.14	0.14	enet	17	0.19	3.7e-10	-6.25	5.8	5.2e-09	0.77	0.05	0.95	FALSE
19	GTEx	Esophagus Mucosa	RP11-231C14.4	0.07	0.00	enet	11	0.00	4.9e-01	-6.19	-5.8	5.8e-09	-0.84	0.02	0.75	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALDOA	0.02	0.01	enet	9	0.02	9.2e-05	-4.77	-5.8	6.1e-09	-0.85	0.01	0.98	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	RP11-231C14.4	0.08	0.05	lasso	5	0.04	7.3e-06	6.21	-5.8	6.5e-09	-0.96	0.01	0.99	FALSE
37	GTEx	Small Intestine Terminal Ileum	INO80E	0.20	0.14	lasso	17	0.08	6.2e-03	-4.68	5.8	6.9e-09	0.84	0.04	0.86	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	INO80E	0.15	0.00	lasso	6	0.02	4.3e-02	-6.27	5.7	1.1e-08	0.74	0.05	0.77	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOC2A	0.03	0.01	blup	47	0.02	3.8e-03	-4.98	5.7	1.2e-08	0.80	0.02	0.63	FALSE
15	GTEx	Cells Transformed fibroblasts	TMEM219	0.10	0.05	enet	28	0.06	1.6e-05	-6.15	5.6	1.6e-08	0.79	0.04	0.95	FALSE
38	GTEx	Spleen	INO80E	0.23	0.20	enet	13	0.26	2.6e-07	4.56	5.7	1.6e-08	0.76	0.12	0.86	FALSE
7	GTEx	Artery Aorta	INO80E	0.12	0.17	enet	11	0.17	1.9e-09	4.54	5.6	2.1e-08	0.78	0.06	0.94	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RP11-231C14.4	0.06	0.05	enet	17	0.03	9.6e-04	-6.19	-5.6	2.1e-08	-0.84	0.02	0.96	FALSE
20	GTEx	Esophagus Mucosa	INO80E	0.12	0.16	enet	14	0.20	4.6e-13	4.54	5.6	2.2e-08	0.81	0.08	0.92	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM57B	0.04	0.01	blup	46	0.03	2.6e-07	-6.12	-5.6	2.8e-08	-0.71	0.02	0.98	FALSE
25	GTEx	Lung	INO80E	0.18	0.17	lasso	8	0.19	1.0e-14	4.54	5.5	3.0e-08	0.82	0.15	0.85	FALSE
35	GTEx	Skin Sun Exposed Lower leg	INO80E	0.11	0.10	lasso	5	0.10	1.4e-08	-6.19	5.5	3.3e-08	0.77	0.05	0.95	FALSE
26	GTEx	Lung	RP11-347C12.2	0.04	0.03	enet	11	0.04	8.8e-04	4.43	-5.5	3.6e-08	-0.79	0.05	0.88	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	ASPHD1	0.03	0.03	lasso	4	0.02	5.0e-04	6.28	-5.5	3.6e-08	-0.92	0.02	0.96	FALSE
17	GTEx	Colon Transverse	INO80E	0.14	0.17	enet	16	0.19	3.3e-09	4.54	5.5	3.9e-08	0.78	0.10	0.90	FALSE
41	GTEx	Thyroid	RP11-231C14.4	0.06	0.00	lasso	3	0.02	1.9e-02	6.52	-5.4	8.5e-08	-0.84	0.02	0.77	FALSE
22	GTEx	Esophagus Muscularis	RP11-347C12.1	0.07	0.05	lasso	4	0.07	2.8e-05	3.02	-5.3	1.0e-07	-0.82	0.03	0.95	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	RP11-345J4.8	0.02	0.00	blup	192	0.01	1.9e-02	-0.59	-5.3	1.0e-07	-0.70	0.02	0.26	FALSE
28	GTEx	Nerve Tibial	RP11-231C14.4	0.06	0.08	enet	18	0.10	1.9e-07	6.22	-5.3	1.2e-07	-0.84	0.02	0.97	FALSE
31	GTEx	Ovary	INO80E	0.16	0.06	lasso	14	0.13	5.1e-04	-6.19	5.2	1.7e-07	0.76	0.05	0.82	FALSE
27	GTEx	Muscle Skeletal	RP11-347C12.1	0.04	0.02	enet	7	0.04	1.8e-04	3.02	-5.2	2.0e-07	-0.72	0.06	0.91	FALSE