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chr22:21,798,199-23,032,448

Best TWAS P=1.61e-09 · Best GWAS P=3.73e-08 conditioned to 0.946

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Brain Hippocampus	LL22NC03-86G7.1	0.40	0.40	enet	22	0.29	1.4e-07	-5.5	6.0	1.6e-09	-0.91	0.01	0.99	TRUE
28	GTEx	Pancreas	LL22NC03-86G7.1	0.35	0.40	lasso	5	0.39	1.4e-17	-5.5	5.8	7.2e-09	-0.99	0.00	1.00	FALSE
34	GTEx	Stomach	LL22NC03-86G7.1	0.29	0.37	enet	13	0.28	5.9e-14	-5.5	5.8	8.3e-09	-0.99	0.00	1.00	FALSE
33	GTEx	Spleen	LL22NC03-86G7.1	0.44	0.27	lasso	8	0.31	9.9e-09	4.9	5.7	1.1e-08	-0.90	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	LL22NC03-86G7.1	0.33	0.41	enet	22	0.37	2.9e-20	-5.5	5.7	1.5e-08	-0.98	0.00	1.00	FALSE
11	GTEx	Brain Hypothalamus	LL22NC03-86G7.1	0.45	0.52	enet	10	0.47	1.8e-12	-5.5	5.6	1.8e-08	-0.99	0.01	0.99	FALSE
17	GTEx	Cells Transformed fibroblasts	LL22NC03-86G7.1	0.25	0.32	lasso	3	0.33	2.3e-25	-5.5	5.6	1.8e-08	-1.00	0.00	1.00	FALSE
19	GTEx	Colon Transverse	LL22NC03-86G7.1	0.46	0.49	enet	39	0.44	5.6e-23	-5.5	5.6	2.1e-08	-0.94	0.00	1.00	FALSE
8	GTEx	Brain Cortex	LL22NC03-86G7.1	0.50	0.52	lasso	3	0.58	1.2e-19	-5.5	5.6	2.2e-08	-0.98	0.01	0.99	FALSE
5	GTEx	Brain Caudate basal ganglia	LL22NC03-86G7.1	0.47	0.50	enet	12	0.49	6.3e-16	-5.5	5.6	2.4e-08	-0.97	0.01	0.99	FALSE
29	GTEx	Pituitary	LL22NC03-86G7.1	0.50	0.56	lasso	5	0.55	2.1e-16	-5.5	5.5	3.1e-08	-1.00	0.01	0.99	FALSE
3	GTEx	Artery Aorta	LL22NC03-86G7.1	0.26	0.38	lasso	1	0.37	1.7e-21	-5.5	5.5	3.7e-08	-1.00	0.00	1.00	FALSE
22	GTEx	Esophagus Muscularis	MAPK1	0.09	0.06	lasso	1	0.01	4.2e-02	-5.5	5.5	3.7e-08	-1.00	0.01	0.93	FALSE
30	GTEx	Prostate	LL22NC03-86G7.1	0.32	0.34	lasso	7	0.32	6.5e-09	-5.3	5.5	3.7e-08	-0.98	0.01	0.99	FALSE
24	GTEx	Heart Atrial Appendage	LL22NC03-86G7.1	0.44	0.52	enet	8	0.51	7.3e-26	-5.5	5.5	4.0e-08	-1.00	0.00	1.00	FALSE
36	GTEx	Thyroid	LL22NC03-86G7.1	0.33	0.45	lasso	2	0.46	1.6e-38	-5.5	5.5	4.1e-08	-1.00	0.00	1.00	FALSE
37	GTEx	Uterus	LL22NC03-86G7.1	0.30	0.46	lasso	1	0.43	5.2e-10	-5.5	5.5	4.1e-08	-1.00	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	LL22NC03-86G7.1	0.37	0.54	lasso	3	0.53	3.6e-50	-5.5	5.5	4.3e-08	-1.00	0.00	1.00	FALSE
4	GTEx	Artery Tibial	LL22NC03-86G7.1	0.23	0.32	enet	24	0.33	9.7e-27	-5.5	5.5	4.3e-08	-0.96	0.01	0.99	FALSE
26	GTEx	Muscle Skeletal	LL22NC03-86G7.1	0.16	0.19	lasso	2	0.20	3.0e-19	-5.5	5.5	4.3e-08	-1.00	0.00	1.00	FALSE
18	GTEx	Colon Sigmoid	LL22NC03-86G7.1	0.20	0.29	lasso	2	0.18	4.7e-07	-5.5	-5.5	4.7e-08	1.00	0.00	1.00	FALSE
13	GTEx	Breast Mammary Tissue	LL22NC03-86G7.1	0.37	0.44	lasso	3	0.42	1.4e-23	-5.5	5.4	5.1e-08	-1.00	0.00	1.00	FALSE
23	GTEx	Esophagus Muscularis	LL22NC03-86G7.1	0.22	0.24	enet	16	0.18	6.1e-11	-5.5	5.4	5.1e-08	-0.99	0.00	1.00	FALSE
35	GTEx	Testis	LL22NC03-86G7.1	0.20	0.11	lasso	8	0.12	9.0e-06	-5.5	5.4	5.6e-08	-0.97	0.01	0.99	FALSE
25	GTEx	Lung	LL22NC03-86G7.1	0.19	0.26	enet	14	0.26	5.9e-20	-5.5	5.4	5.9e-08	-0.97	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PPM1F	0.14	0.09	lasso	3	0.10	7.7e-05	-5.4	5.4	6.8e-08	-0.81	0.01	0.93	FALSE
15	GTEx	Breast Mammary Tissue (Female)	LL22NC03-86G7.1	0.37	0.40	lasso	4	0.38	3.9e-12	-5.5	5.4	6.9e-08	-1.00	0.01	0.99	FALSE
16	GTEx	Cells Transformed fibroblasts	PPM1F	0.06	0.05	lasso	2	0.04	6.3e-04	-5.5	5.4	7.2e-08	-0.96	0.02	0.97	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	LL22NC03-86G7.1	0.61	0.50	enet	32	0.56	7.3e-18	-5.5	5.3	9.3e-08	-0.94	0.01	0.98	FALSE
21	GTEx	Esophagus Mucosa	LL22NC03-86G7.1	0.21	0.26	lasso	3	0.24	3.3e-16	-5.5	5.3	9.6e-08	-0.99	0.00	1.00	FALSE
14	GTEx	Breast Mammary Tissue (Male)	LL22NC03-86G7.1	0.41	0.31	lasso	4	0.31	5.0e-08	-5.5	5.3	1.0e-07	-0.97	0.01	0.98	FALSE
31	GTEx	Skin Sun Exposed Lower leg	LL22NC03-86G7.1	0.30	0.43	enet	9	0.43	7.8e-39	-5.5	5.3	1.2e-07	-0.99	0.00	1.00	FALSE
38	GTEx	Vagina	LL22NC03-86G7.1	0.35	0.34	lasso	3	0.30	1.5e-07	-5.5	5.3	1.3e-07	-0.99	0.01	0.98	FALSE
32	GTEx	Spleen	TOP3B	0.20	0.03	lasso	5	0.06	1.5e-02	-5.4	5.2	1.6e-07	-0.91	0.02	0.91	FALSE
7	GTEx	Brain Cerebellum	LL22NC03-86G7.1	0.50	0.50	enet	18	0.54	9.6e-19	-5.5	5.2	1.7e-07	-0.98	0.01	0.99	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	LL22NC03-86G7.1	0.36	0.40	enet	18	0.24	4.3e-09	-5.5	5.2	1.7e-07	-0.98	0.01	0.99	FALSE
6	GTEx	Brain Cerebellar Hemisphere	LL22NC03-86G7.1	0.48	0.40	enet	32	0.41	1.3e-11	-5.3	5.2	2.3e-07	-0.93	0.01	0.99	FALSE
10	GTEx	Brain Hypothalamus	TOP3B	0.20	0.17	lasso	2	0.11	1.3e-03	-5.3	5.2	2.3e-07	-0.86	0.02	0.91	FALSE
27	GTEx	Nerve Tibial	LL22NC03-86G7.1	0.34	0.48	enet	27	0.52	2.0e-42	-5.5	5.1	3.0e-07	-0.98	0.00	1.00	FALSE