[Hub]/) : Traits : Bipolar Disorder or Schizophrenia : ←

chr22:39,192,995-43,232,818

Best TWAS P=1.05e-11 · Best GWAS P=1.6e-10 conditioned to 0.00026

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Nerve Tibial	XPNPEP3	0.18	0.02	lasso	14	0.05	9.8e-05	-4.7	6.8	1.0e-11	-0.04	0.39	0.55	TRUE
17	GTEx	Skin Not Sun Exposed Suprapubic	NAGA	0.13	0.06	lasso	3	0.07	1.4e-04	5.3	6.0	2.2e-09	0.01	0.02	0.89	TRUE
10	GTEx	Esophagus Muscularis	MGAT3	0.09	0.02	enet	15	0.02	1.3e-02	5.5	-5.8	6.8e-09	-0.70	0.10	0.53	TRUE
2	CommonMind	Brain Pre-frontal Cortex	MCHR1	0.15	0.07	lasso	7	0.14	7.5e-17	5.1	-6.6	3.3e-11	0.05	0.09	0.91	FALSE
6	GTEx	Artery Aorta	L3MBTL2	0.14	0.01	lasso	6	0.04	1.8e-03	-5.1	6.2	6.6e-10	-0.11	0.03	0.88	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	NAGA	0.09	0.09	enet	7	0.11	7.0e-07	5.0	6.0	2.7e-09	0.00	0.01	0.98	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC25A17	0.17	0.05	lasso	4	0.05	5.0e-04	-4.6	5.9	3.4e-09	0.00	0.03	0.41	FALSE
9	GTEx	Cells Transformed fibroblasts	SLC25A17	0.09	0.03	enet	10	0.06	4.2e-05	5.0	5.8	6.7e-09	-0.09	0.08	0.91	FALSE
5	CommonMind	Brain Pre-frontal Cortex	XPNPEP3	0.06	0.04	lasso	4	0.04	3.9e-06	-5.3	5.8	7.6e-09	-0.11	0.06	0.94	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	XPNPEP3	0.07	0.05	enet	6	0.07	1.2e-06	4.8	5.8	7.8e-09	-0.09	0.01	0.99	FALSE
25	GTEx	Vagina	CYP2D6	0.19	0.08	enet	14	0.08	6.8e-03	5.3	-5.7	9.6e-09	-0.04	0.04	0.77	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	NAGA	0.02	0.00	blup	18	0.01	1.5e-02	-5.1	5.7	1.0e-08	0.01	0.01	0.73	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NAGA	0.09	0.09	blup	336	0.13	1.2e-15	-5.1	5.7	1.3e-08	0.04	0.09	0.91	FALSE
21	GTEx	Stomach	CYP2D7P1	0.22	0.10	lasso	14	0.07	2.7e-04	-4.9	5.6	2.4e-08	0.05	0.06	0.88	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM109B	0.06	0.02	blup	337	0.03	7.4e-05	-5.1	5.6	2.6e-08	0.01	0.10	0.90	FALSE
24	GTEx	Thyroid	NAGA	0.10	0.17	lasso	5	0.17	9.8e-13	5.3	5.5	3.5e-08	0.04	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NAGA	0.01	0.00	blup	18	0.01	5.4e-02	-5.1	5.5	4.2e-08	0.01	0.01	0.61	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	NAGA	0.03	0.03	lasso	2	0.03	1.2e-07	5.0	5.5	4.9e-08	0.01	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NAGA	0.04	0.07	enet	3	0.07	1.1e-06	-5.0	5.4	6.1e-08	0.00	0.01	0.98	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	XPNPEP3	0.18	0.15	enet	7	0.15	4.4e-15	-5.3	5.4	6.2e-08	-0.10	0.00	1.00	FALSE
19	GTEx	Spleen	CYP2D6	0.60	0.50	lasso	12	0.56	2.7e-17	4.7	-5.4	6.7e-08	-0.04	0.07	0.92	FALSE
18	GTEx	Skin Sun Exposed Lower leg	CYP2D6	0.38	0.45	lasso	9	0.46	5.8e-42	5.3	-5.4	7.2e-08	-0.04	0.03	0.97	FALSE
11	GTEx	Liver	OLA1P1	0.37	0.40	lasso	1	0.35	1.7e-10	5.3	5.3	8.9e-08	0.04	0.02	0.98	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	NAGA	0.04	0.03	enet	16	0.05	6.3e-06	4.7	5.3	9.5e-08	0.02	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	XPNPEP3	0.10	0.06	lasso	3	0.06	1.4e-04	-5.1	5.3	1.0e-07	-0.07	0.00	0.97	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	XPNPEP3	0.23	0.26	lasso	2	0.26	3.2e-29	-5.3	5.3	1.0e-07	-0.10	0.00	1.00	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ST13	0.06	0.05	enet	1	0.02	9.3e-02	-5.3	5.3	1.1e-07	-0.10	0.04	0.25	FALSE
22	GTEx	Testis	RP4-669P10.16	0.35	0.33	enet	28	0.36	8.9e-17	-5.0	5.3	1.1e-07	0.01	0.09	0.91	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	XPNPEP3	0.21	0.19	lasso	1	0.19	7.2e-08	-5.3	5.3	1.1e-07	-0.10	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	RANGAP1	0.19	0.04	enet	10	0.05	2.8e-04	5.3	5.3	1.1e-07	-0.06	0.00	0.92	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	XPNPEP3	0.33	0.38	lasso	4	0.40	7.4e-41	-5.3	5.3	1.3e-07	-0.09	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	XPNPEP3	0.10	0.11	lasso	4	0.10	1.2e-11	-5.3	5.2	1.5e-07	-0.10	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	NAGA	0.07	0.07	blup	18	0.10	2.0e-10	4.7	5.2	1.6e-07	0.03	0.02	0.98	FALSE
14	GTEx	Muscle Skeletal	SMDT1	0.17	0.26	enet	17	0.28	1.3e-27	-5.0	5.2	1.7e-07	0.02	0.09	0.90	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	NAGA	0.08	0.10	lasso	4	0.09	7.3e-12	5.1	5.2	1.7e-07	0.02	0.05	0.94	FALSE
13	GTEx	Lung	CYP2D7P1	0.20	0.00	lasso	8	0.00	4.2e-01	4.7	5.2	2.2e-07	0.07	0.06	0.26	FALSE
16	GTEx	Pituitary	NAGA	0.25	0.16	lasso	4	0.08	4.6e-03	5.0	5.2	2.2e-07	0.02	0.04	0.78	FALSE
12	GTEx	Liver	NDUFA6-AS1	0.38	0.25	enet	12	0.28	2.0e-08	5.3	5.2	2.3e-07	0.04	0.03	0.96	FALSE
20	GTEx	Spleen	CYP2D7P1	0.17	0.00	lasso	3	0.03	4.8e-02	3.3	5.2	2.3e-07	0.08	0.05	0.41	FALSE
26	GTEx	Whole Blood	FAM109B	0.04	0.06	lasso	2	0.06	3.9e-06	-4.9	5.2	2.4e-07	-0.02	0.11	0.88	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	XPNPEP3	0.10	0.10	lasso	3	0.10	1.9e-11	-5.3	5.2	2.4e-07	-0.10	0.00	1.00	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	CYP2D6	0.25	0.16	lasso	7	0.12	7.7e-05	4.8	-5.2	2.5e-07	-0.05	0.06	0.92	FALSE
38	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	XPNPEP3	0.12	0.10	lasso	3	0.09	7.5e-05	-5.3	5.2	2.5e-07	-0.11	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FAM109B	0.03	0.03	enet	3	0.02	5.4e-03	-5.0	5.2	2.6e-07	-0.01	0.01	0.82	FALSE
23	GTEx	Thyroid	FAM109B	0.07	0.06	lasso	9	0.05	2.1e-04	-5.0	5.1	2.9e-07	0.01	0.10	0.89	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SLC25A17	0.03	0.01	blup	301	0.01	9.6e-03	5.4	-5.1	3.1e-07	0.11	0.07	0.66	FALSE