[Hub]/) : Traits : Bipolar Disorder or Schizophrenia :

chr22:39,192,995-43,232,818

Best TWAS P=1.05e-11 · Best GWAS P=1.6e-10 conditioned to 0.00026

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM109B 0.06 0.02 blup 337 0.03 7.4e-05 -5.1 5.6 2.6e-08 0.01 0.10 0.90 FALSE
2 CommonMind Brain Pre-frontal Cortex MCHR1 0.15 0.07 lasso 7 0.14 7.5e-17 5.1 -6.6 3.3e-11 0.05 0.09 0.91 FALSE
3 CommonMind Brain Pre-frontal Cortex NAGA 0.09 0.09 blup 336 0.13 1.2e-15 -5.1 5.7 1.3e-08 0.04 0.09 0.91 FALSE
4 CommonMind Brain Pre-frontal Cortex SLC25A17 0.03 0.01 blup 301 0.01 9.6e-03 5.4 -5.1 3.1e-07 0.11 0.07 0.66 FALSE
5 CommonMind Brain Pre-frontal Cortex XPNPEP3 0.06 0.04 lasso 4 0.04 3.9e-06 -5.3 5.8 7.6e-09 -0.11 0.06 0.94 FALSE
6 GTEx Artery Aorta L3MBTL2 0.14 0.01 lasso 6 0.04 1.8e-03 -5.1 6.2 6.6e-10 -0.11 0.03 0.88 FALSE
7 GTEx Breast Mammary Tissue (Female) ST13 0.06 0.05 enet 1 0.02 9.3e-02 -5.3 5.3 1.1e-07 -0.10 0.04 0.25 FALSE
8 GTEx Cells EBV-transformed lymphocytes CYP2D6 0.25 0.16 lasso 7 0.12 7.7e-05 4.8 -5.2 2.5e-07 -0.05 0.06 0.92 FALSE
9 GTEx Cells Transformed fibroblasts SLC25A17 0.09 0.03 enet 10 0.06 4.2e-05 5.0 5.8 6.7e-09 -0.09 0.08 0.91 FALSE
10 GTEx Esophagus Muscularis MGAT3 0.09 0.02 enet 15 0.02 1.3e-02 5.5 -5.8 6.8e-09 -0.70 0.10 0.53 TRUE
11 GTEx Liver OLA1P1 0.37 0.40 lasso 1 0.35 1.7e-10 5.3 5.3 8.9e-08 0.04 0.02 0.98 FALSE
12 GTEx Liver NDUFA6-AS1 0.38 0.25 enet 12 0.28 2.0e-08 5.3 5.2 2.3e-07 0.04 0.03 0.96 FALSE
13 GTEx Lung CYP2D7P1 0.20 0.00 lasso 8 0.00 4.2e-01 4.7 5.2 2.2e-07 0.07 0.06 0.26 FALSE
14 GTEx Muscle Skeletal SMDT1 0.17 0.26 enet 17 0.28 1.3e-27 -5.0 5.2 1.7e-07 0.02 0.09 0.90 FALSE
15 GTEx Nerve Tibial XPNPEP3 0.18 0.02 lasso 14 0.05 9.8e-05 -4.7 6.8 1.0e-11 -0.04 0.39 0.55 TRUE
16 GTEx Pituitary NAGA 0.25 0.16 lasso 4 0.08 4.6e-03 5.0 5.2 2.2e-07 0.02 0.04 0.78 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic NAGA 0.13 0.06 lasso 3 0.07 1.4e-04 5.3 6.0 2.2e-09 0.01 0.02 0.89 TRUE
18 GTEx Skin Sun Exposed Lower leg CYP2D6 0.38 0.45 lasso 9 0.46 5.8e-42 5.3 -5.4 7.2e-08 -0.04 0.03 0.97 FALSE
19 GTEx Spleen CYP2D6 0.60 0.50 lasso 12 0.56 2.7e-17 4.7 -5.4 6.7e-08 -0.04 0.07 0.92 FALSE
20 GTEx Spleen CYP2D7P1 0.17 0.00 lasso 3 0.03 4.8e-02 3.3 5.2 2.3e-07 0.08 0.05 0.41 FALSE
21 GTEx Stomach CYP2D7P1 0.22 0.10 lasso 14 0.07 2.7e-04 -4.9 5.6 2.4e-08 0.05 0.06 0.88 FALSE
22 GTEx Testis RP4-669P10.16 0.35 0.33 enet 28 0.36 8.9e-17 -5.0 5.3 1.1e-07 0.01 0.09 0.91 FALSE
23 GTEx Thyroid FAM109B 0.07 0.06 lasso 9 0.05 2.1e-04 -5.0 5.1 2.9e-07 0.01 0.10 0.89 FALSE
24 GTEx Thyroid NAGA 0.10 0.17 lasso 5 0.17 9.8e-13 5.3 5.5 3.5e-08 0.04 0.02 0.98 FALSE
25 GTEx Vagina CYP2D6 0.19 0.08 enet 14 0.08 6.8e-03 5.3 -5.7 9.6e-09 -0.04 0.04 0.77 FALSE
26 GTEx Whole Blood FAM109B 0.04 0.06 lasso 2 0.06 3.9e-06 -4.9 5.2 2.4e-07 -0.02 0.11 0.88 FALSE
27 ROSMAP Brain Pre-frontal Cortex NAGA 0.08 0.10 lasso 4 0.09 7.3e-12 5.1 5.2 1.7e-07 0.02 0.05 0.94 FALSE
28 The Cancer Genome Atlas Bladder Urothelial Carcinoma FAM109B 0.03 0.03 enet 3 0.02 5.4e-03 -5.0 5.2 2.6e-07 -0.01 0.01 0.82 FALSE
29 The Cancer Genome Atlas Bladder Urothelial Carcinoma NAGA 0.04 0.07 enet 3 0.07 1.1e-06 -5.0 5.4 6.1e-08 0.00 0.01 0.98 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma XPNPEP3 0.07 0.05 enet 6 0.07 1.2e-06 4.8 5.8 7.8e-09 -0.09 0.01 0.99 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma NAGA 0.03 0.03 lasso 2 0.03 1.2e-07 5.0 5.5 4.9e-08 0.01 0.01 0.99 FALSE
32 The Cancer Genome Atlas Colon Adenocarcinoma NAGA 0.09 0.09 enet 7 0.11 7.0e-07 5.0 6.0 2.7e-09 0.00 0.01 0.98 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma XPNPEP3 0.10 0.06 lasso 3 0.06 1.4e-04 -5.1 5.3 1.0e-07 -0.07 0.00 0.97 FALSE
34 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma XPNPEP3 0.10 0.10 lasso 3 0.10 1.9e-11 -5.3 5.2 2.4e-07 -0.10 0.00 1.00 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NAGA 0.01 0.00 blup 18 0.01 5.4e-02 -5.1 5.5 4.2e-08 0.01 0.01 0.61 FALSE
36 The Cancer Genome Atlas Brain Lower Grade Glioma NAGA 0.04 0.03 enet 16 0.05 6.3e-06 4.7 5.3 9.5e-08 0.02 0.02 0.98 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma XPNPEP3 0.23 0.26 lasso 2 0.26 3.2e-29 -5.3 5.3 1.0e-07 -0.10 0.00 1.00 FALSE
38 The Cancer Genome Atlas Liver Hepatocellular Carcinoma XPNPEP3 0.12 0.10 lasso 3 0.09 7.5e-05 -5.3 5.2 2.5e-07 -0.11 0.00 1.00 FALSE
39 The Cancer Genome Atlas Lung Adenocarcinoma NAGA 0.02 0.00 blup 18 0.01 1.5e-02 -5.1 5.7 1.0e-08 0.01 0.01 0.73 FALSE
40 The Cancer Genome Atlas Lung Adenocarcinoma XPNPEP3 0.10 0.11 lasso 4 0.10 1.2e-11 -5.3 5.2 1.5e-07 -0.10 0.00 1.00 FALSE
41 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SLC25A17 0.17 0.05 lasso 4 0.05 5.0e-04 -4.6 5.9 3.4e-09 0.00 0.03 0.41 FALSE
42 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma XPNPEP3 0.21 0.19 lasso 1 0.19 7.2e-08 -5.3 5.3 1.1e-07 -0.10 0.00 1.00 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma NAGA 0.07 0.07 blup 18 0.10 2.0e-10 4.7 5.2 1.6e-07 0.03 0.02 0.98 FALSE
44 The Cancer Genome Atlas Prostate Adenocarcinoma XPNPEP3 0.18 0.15 enet 7 0.15 4.4e-15 -5.3 5.4 6.2e-08 -0.10 0.00 1.00 FALSE
45 The Cancer Genome Atlas Stomach Adenocarcinoma RANGAP1 0.19 0.04 enet 10 0.05 2.8e-04 5.3 5.3 1.1e-07 -0.06 0.00 0.92 FALSE
46 The Cancer Genome Atlas Thyroid Carcinoma XPNPEP3 0.33 0.38 lasso 4 0.40 7.4e-41 -5.3 5.3 1.3e-07 -0.09 0.00 1.00 FALSE