Hub : Genes

MAPK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.0870	0.0360	3.5e-03	0.062	NA	0.006	NA	0.015	1.3e-04	NA	1.4e-01	NA	4.2e-02
2	NTR	Blood	0.0149	0.0069	9.5e-03	0.004	0.002	0.000	0.002	0.001	1.9e-02	4.7e-02	3.7e-01	4.7e-02	1.3e-01
3	YFS	Blood	0.0710	0.0195	1.3e-11	0.038	0.043	0.052	0.049	0.046	1.4e-12	4.2e-14	1.9e-16	8.7e-16	1.0e-14
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0721	0.0305	6.8e-09	0.103	0.076	0.097	NA	0.096	1.3e-11	6.5e-09	4.6e-11	NA	6.1e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	9.1	14.4	22.7	4.8	4.4	1.1	-3.8
Bipolar Disorder or Schizophrenia	5.8	14.1	30.3	5.5	3.7	-0.7	-3.4
Depressed Affect (Nagel 2018)	0.8	1.8	3.5	-1.9	-0.7	0.7	1.6
Depression (Nagel 2018)	1.0	1.5	3.1	-1.8	-0.7	0.2	1.5
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	0.2	0.2	-0.3	-0.8
Neuroticism (Nagel 2018)	0.4	0.9	1.4	-0.5	0.9	1.0	1.2
Schizophrenia (2018)	2.0	4.1	10.5	3.2	1.1	-1.7	-1.3
Schizophrenia vs Biploar Disorder	2.3	3.0	6.2	-2.1	-1.3	0.0	2.5
Worry (Nagel 2018)	0.2	0.5	1.6	0.4	1.3	0.4	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	0.1	-0.6	0.7	-0.7
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.3	-0.6	-0.3	0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	0.1	-0.9	0.9	-0.0
Crohns Disease (2017)	1.9	4.1	13.2	0.2	3.6	1.6	-0.9
Irritable Bowel Disease (IBD)	1.3	3.2	9.9	1.0	3.2	0.4	-1.3
Ulcerative Colitis (UC)	1.4	2.5	3.4	1.8	1.8	-0.6	-1.7
Major Depression (MDD)	0.1	0.2	0.4	-0.4	0.1	0.6	-0.3
Reaction Time	3.0	5.6	10.5	-2.7	-1.8	-1.2	3.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.4	0.5	1.1	-1.2	-0.5
Breast Cancer	0.6	1.4	3.9	-2.0	-0.8	-0.4	1.0
Ovarian Cancer	0.6	0.8	1.8	1.3	0.6	-0.2	-1.1
Prostate Cancer	0.1	0.2	0.5	-0.0	0.1	-0.7	0.3
Age at First Birth	0.3	0.4	0.8	-0.1	0.9	-0.5	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.7	3.7	10.0	-2.1	0.3	0.1	3.2
Coronary Artery Disease (CAD)	0.7	0.8	1.5	-0.8	1.2	0.8	-0.6
Crohns Disease (2012)	1.4	2.3	6.6	0.4	2.6	1.5	-0.4
Mean Putamen Volume	0.2	0.2	0.5	0.1	-0.4	-0.7	-0.5
Fasting Glucose	0.8	1.0	2.7	0.9	1.6	-0.3	-0.5
HbA1C	0.0	0.1	0.2	0.0	0.4	-0.2	0.0
HDL Cholesterol	0.7	1.1	2.6	0.5	-1.6	-1.0	-0.9
LDL Cholesterol	0.4	0.6	1.8	0.9	1.3	-0.0	-0.1
Lupus	0.1	0.2	0.5	-0.2	0.3	0.7	-0.4
Neuroticism (2016)	0.7	1.1	1.7	-1.3	0.6	1.2	0.9
Primary Biliary Cirrhosis	0.2	0.2	0.5	-0.1	0.7	-0.2	0.6
Rheumatoid Arthritis	2.4	3.2	7.4	-2.7	0.1	0.8	2.2
Schizophrenia (2014)	2.4	5.4	11.3	3.4	2.2	-1.5	-1.7
Triglycerides	0.4	0.7	1.6	1.0	0.2	-0.2	-1.3
Type 2 Diabetes (T2D) (2012)	2.0	2.3	5.9	-2.4	-0.9	0.0	1.5
Ulcerative Colitis	0.5	0.7	1.6	0.7	1.3	-0.4	-0.5
Blood Eosinophil Count	0.1	0.5	1.1	0.2	1.1	-0.3	0.8
Blood Platelet Count	0.0	0.6	0.8	0.3	0.9	0.8	0.8
Blood Red Count	2.1	20.7	39.3	6.3	4.5	1.9	-4.5
Blood White Count	0.0	0.1	0.2	0.4	-0.4	0.1	0.1
Heel T-Score	0.2	1.8	5.3	2.3	0.4	-0.6	-1.2
BMI	0.3	1.8	3.8	-1.3	1.9	1.0	0.8
Height	1.3	25.6	53.9	-4.9	-7.3	-2.4	4.3
Waist Hip Ratio (WHR)	0.7	3.3	7.4	2.7	0.9	-0.2	-2.2
Systolic Blood Pressure	1.0	5.0	7.8	-1.4	-2.8	-2.0	2.5
Smoking Status	0.1	0.3	0.9	0.6	1.0	-0.3	0.0
Allergy or Eczema	0.6	1.7	5.9	0.2	2.4	0.8	-0.3
Cardiovascular Disease	0.2	0.7	2.1	0.4	1.5	0.5	0.4
Hypothyroidism (self reported)	3.8	8.6	12.2	2.6	2.9	2.6	-3.5
Respiratory disease	0.5	1.2	3.5	1.9	0.9	0.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.2	-0.8	0.7	-1.5	-0.0
Lung FEV1/FVC ratio	0.1	0.5	1.3	-0.6	-1.1	0.1	0.5
Lung FVC	0.3	1.7	3.4	1.8	-0.6	-0.8	-1.5
Neuroticism	0.3	0.6	1.3	-1.0	-0.1	1.2	0.6
Chronotype (morning person)	2.0	4.5	8.6	1.7	2.1	1.5	-2.9
Hair Pigment	0.3	7.6	13.9	3.0	2.5	-1.2	-3.7
Tanning	0.2	2.9	5.3	2.3	-0.1	1.0	-2.3
Hand grip strength (left)	0.4	1.2	3.8	-0.3	-1.9	0.3	-0.8
Number of treatments/medications taken	1.4	2.5	5.2	1.4	2.3	-1.1	-1.3
Average weekly spirits intake	0.1	0.1	0.4	0.2	0.1	0.6	-0.1
Sensitivity / hurt feelings	1.6	2.7	9.1	-1.1	-0.2	0.6	3.0
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.3	-1.8	-0.9	1.2	1.1
Hearing difficulty/problems: Yes	0.7	1.1	3.3	0.9	0.4	-1.8	-0.1
Relative age of first facial hair	0.3	0.6	2.0	0.3	-0.6	1.4	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.0	1.4	1.3	0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	1.0	-0.5	-0.4	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.2	0.4	-0.6	0.4
Systolic blood pressure, automated reading	1.6	4.6	5.9	-1.4	-2.4	-2.2	2.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.6	0.4	0.3	-0.3	-1.3
Angina	2.6	3.4	6.3	2.5	1.0	1.4	-2.1
Medication for hormone replacement therapy	0.5	0.5	1.4	0.2	-0.7	1.2	-0.4
Vitamin and mineral supplements	1.1	1.5	2.4	1.4	1.0	0.9	-1.5
Supplements: Zinc	0.5	0.6	1.2	0.4	1.1	0.5	-0.8
Medication: Co-codamol	3.1	3.6	6.3	1.4	0.3	2.5	-2.5
Medication: Metformin	0.4	0.6	2.1	0.0	0.6	0.0	-1.5
Diabetes (father)	1.0	1.3	3.1	-1.8	-0.8	0.1	1.1
Diabetes (mother)	0.3	0.4	0.9	0.9	0.7	0.5	-0.3
Severe depression (siblings)	0.5	0.6	1.6	-0.6	-0.0	-1.3	0.6
Pack years adult smoking proportion	0.5	0.7	1.3	1.1	-0.3	0.9	-0.7
Impedance of leg (right)	1.3	6.4	15.7	4.0	-1.8	-0.9	-2.4
Leg fat-free mass (left)	0.9	4.7	11.6	-3.4	-0.9	1.1	2.3
Trunk fat percentage	0.0	0.1	0.2	-0.5	0.4	-0.0	-0.1
Hand grip strength (right)	0.6	1.7	5.5	-0.4	-2.4	-1.0	-0.3
Townsend deprivation index at recruitment	0.4	0.5	1.0	-0.6	-1.0	0.3	0.9
Current tobacco smoking	0.1	0.1	0.1	0.3	0.2	-0.4	-0.3
Average weekly fortified wine intake	0.4	0.5	1.2	0.8	-0.5	-0.1	1.1
Maternal smoking around birth	0.4	0.6	2.0	0.6	0.1	-1.4	-0.1
Fed-up feelings	1.2	2.1	2.9	-1.7	-1.2	1.2	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.0	-1.7	-0.6	0.5	1.0
Relative age voice broke	0.3	0.5	1.8	-0.0	0.1	0.4	1.3
Taking other prescription medications	1.2	1.8	4.0	1.4	2.0	0.1	-1.1
Age when periods started (menarche)	5.2	12.5	24.6	5.0	1.9	1.3	-4.5
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.1	1.5	1.8	0.8	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	0.4	0.5	-0.2	0.3
Tinnitus: Yes, but not now, but have in the past	3.2	3.5	6.8	-2.1	-1.4	-0.9	2.6
Qualifications: CSEs or equivalent	0.5	0.6	1.4	0.7	0.6	1.2	-0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.5	1.2	0.5	-0.8	0.3
High blood pressure	0.1	0.3	0.6	0.2	0.8	-0.1	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.6	-0.2	1.6	0.8	0.3
Multivitamins +/- minerals	0.4	0.5	0.6	-0.7	-0.7	-0.8	0.5
Stomach or abdominal pain in last month	0.3	0.3	0.6	-0.5	0.5	0.2	0.8
Supplements: Glucosamine	0.5	0.6	0.9	-0.9	-0.9	-0.9	0.3
Diverticular disease/diverticulitis (self-reported)	4.4	5.2	9.2	3.0	2.3	0.9	-2.4
Medication: Atenolol	1.0	1.3	2.1	1.3	1.5	-0.3	-1.1
Medication: Levothyroxine sodium	2.6	4.3	4.9	2.1	2.0	2.0	-2.2
Sitting height	1.1	7.8	26.4	-1.8	-5.1	-0.7	0.9
Chronic bronchitis/emphysema (father)	0.9	1.1	1.7	1.3	1.0	-1.1	-0.7
High blood pressure (mother)	0.3	0.4	1.1	0.8	1.1	-0.1	-0.1
Body mass index (BMI)	0.3	1.2	3.8	-0.4	1.9	0.9	-0.4
Impedance of leg (left)	1.1	5.3	11.4	3.4	-1.9	-1.3	-2.2
Leg predicted mass (left)	0.9	4.6	11.4	-3.4	-0.8	1.2	2.2
Trunk fat mass	0.1	0.3	1.2	-1.1	-0.2	0.2	0.3
Waist circumference	0.0	0.2	0.3	-0.2	0.6	0.5	-0.2
Number of incorrect matches in round	0.3	0.4	0.7	-0.8	-0.6	-0.7	0.4
Past tobacco smoking	0.9	1.6	2.3	-1.4	-1.5	0.2	1.5
Alcohol usually taken with meals	0.8	1.2	2.4	1.3	0.3	0.8	-1.6
Nervous feelings	0.4	0.7	1.5	-0.8	0.6	0.5	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.6	0.7	1.3	-0.7	0.1
Hair/balding pattern: Pattern 2	0.6	0.7	2.5	0.3	1.6	-0.3	-0.5
Had menopause	3.1	3.8	7.1	-0.6	-2.7	-2.5	1.2
Had other major operations	1.0	1.2	2.4	1.4	-0.8	0.2	-1.5
Forced vital capacity (FVC)	0.1	0.3	0.6	0.4	-0.7	-0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.9	1.4	0.9	-1.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.9	-1.1	0.1	-0.5	1.4
Qualifications: None of the above	0.2	0.5	0.7	0.8	0.8	0.2	-0.8
Financial difficulties in last 2 years	0.8	1.1	1.9	0.9	-1.4	-1.4	0.0
Mouth/teeth dental problems	1.7	2.5	6.9	-1.6	-2.6	-0.0	0.9
Heart attack	3.0	3.8	5.6	2.3	2.1	-0.1	-2.4
Allergy	0.4	1.0	2.8	-0.4	-1.7	-1.1	0.2
Pain all over the body in last month	0.9	1.0	3.1	-0.5	1.8	-0.2	0.7
Diabetes (self-reported)	0.5	0.7	1.7	-0.6	1.3	-0.8	-0.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.5	0.9	2.3	-0.3	-0.1
Medication: Ramipril	2.2	2.8	4.1	1.1	1.9	2.0	-1.5
Medication: Simvastatin	1.9	2.8	6.1	2.5	1.8	0.4	-1.3
Fluid intelligence score	0.3	0.5	1.6	-0.3	1.3	-0.6	-0.0
Illnesses of siblings	1.1	1.6	5.5	-0.0	0.6	2.3	-0.7
Neuroticism score	0.5	1.1	3.0	-0.8	-0.5	0.7	1.7
Weight	0.2	1.1	3.0	-1.7	-0.6	0.6	0.7
Impedance of arm (right)	0.2	0.8	2.0	1.0	-1.4	-0.3	-0.5
Arm fat percentage (right)	0.4	1.5	3.5	-0.0	1.9	1.2	-1.0
Trunk fat-free mass	0.7	3.9	7.2	-2.7	-1.9	1.3	1.8
Hip circumference	0.1	0.6	1.2	-1.1	-0.7	0.5	0.6
Time employed in main current job	1.8	2.0	4.6	2.1	-0.7	0.1	-1.7
Alcohol intake versus 10 years previously	0.2	0.4	0.9	0.5	0.5	-0.9	-0.2
Father’s age at death	1.0	1.3	2.5	0.3	-1.6	1.6	0.1
Worrier / anxious feelings	0.6	1.1	2.5	0.0	-1.6	-0.6	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.6	0.6	1.3	0.7	-0.4
Falls in the last year	0.4	0.6	2.0	1.4	-0.0	0.1	-0.6
Hair/balding pattern: Pattern 3	1.2	1.9	4.1	-1.0	-2.0	-0.5	1.4
Number of live births	2.5	3.5	7.2	2.7	1.2	0.5	-2.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.9	0.4	-0.8	-0.0	-1.0
Pulse rate	1.8	3.0	5.2	2.3	1.8	1.1	-1.6
Happiness	1.0	1.2	3.3	-1.1	-0.4	-0.3	1.8
Noisy workplace	1.0	1.2	3.9	2.0	0.1	-0.9	-0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.1	0.2	-1.8	0.3	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.4	-0.5	0.6	-0.4
Mouth/teeth dental problems: Dentures	0.6	0.9	2.3	0.5	0.9	-1.5	-0.5
Asthma	0.5	0.9	1.5	1.2	1.1	0.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	-0.2	1.0	0.2	-0.7
Medication: Cholesterol lowering	1.2	1.9	3.6	1.9	1.4	-0.8	-1.2
Depression (self-reported)	0.1	0.1	0.4	0.1	-0.1	0.6	-0.1
Medication: Lansoprazole	1.9	2.1	5.6	0.8	2.4	0.9	-1.2
Prospective memory result	2.0	2.5	6.2	-1.0	-0.6	-2.5	1.6
Lung cancer (father)	0.1	0.1	0.4	-0.3	0.1	-0.2	0.6
Illnesses of mother	0.4	0.5	1.2	-0.8	-0.4	-0.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.5	0.2	-1.9	-1.1	-0.4
Pulse wave Arterial Stiffness index	0.3	0.4	1.4	0.2	1.2	0.1	-0.3
Impedance of arm (left)	0.2	0.8	2.4	0.7	-1.6	-0.6	0.2
Arm fat mass (right)	0.2	0.6	1.1	-0.6	1.0	1.0	-0.3
Trunk predicted mass	0.6	3.5	6.2	-2.5	-1.8	1.5	1.6
Standing height	1.1	11.1	28.7	-2.9	-5.4	-0.8	2.6
Length of working week for main job	0.6	0.7	2.2	-0.5	-1.5	0.5	0.3
Exposure to tobacco smoke at home	4.5	5.1	9.1	2.2	1.4	2.0	-3.0
Breastfed as a baby	0.7	0.8	1.5	-0.8	0.3	-1.1	1.2
Tense / ‘highly strung’	0.2	0.3	0.6	0.7	0.2	-0.8	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	0.3	0.7	-0.5	-0.8
Hair/balding pattern: Pattern 4	0.4	0.9	1.7	1.2	-0.2	-1.3	-0.8
Birth weight of first child	0.2	0.4	0.6	0.8	-0.5	0.6	-0.7
Peak expiratory flow (PEF)	0.8	1.8	4.0	2.0	1.2	0.2	-1.2
Pulse wave reflection index	0.3	0.4	1.1	-0.0	1.0	0.3	-0.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	0.2	0.0	-1.0	0.9
Loud music exposure frequency	0.6	0.7	2.0	1.4	-0.7	-0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.3	-0.2	-0.6	-1.5	-0.3
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.2	1.8	0.9	1.0	-1.0
Blood clot in the leg (DVT)	0.7	0.9	2.5	-0.3	1.0	-0.4	1.6
Medication: Paracetamol	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2
Headache pain in last month	7.2	12.4	14.8	3.5	3.7	2.9	-3.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.7	-1.6	-1.3	-0.1	1.1
Glaucoma (self-reported)	0.0	0.1	0.1	0.0	-0.2	-0.4	0.2
Gout (self-reported)	0.4	0.5	1.6	-1.3	-0.3	0.6	0.1
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	4.5	1.6	2.0	2.0	-2.1
Medication: Amlodipine	0.3	0.4	1.0	0.2	-0.7	-1.0	0.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	0.3	0.4	-1.1	1.4
Birth weight	1.0	2.1	4.8	0.3	-0.2	2.2	-1.8
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	-0.2	0.2	0.7	0.2
High blood pressure (siblings)	1.4	2.0	7.4	0.3	-0.7	-2.7	0.0
Forced vital capacity (FVC), Best measure	0.5	1.7	4.7	0.0	-2.2	-1.5	0.1
Body fat percentage	0.1	0.3	0.7	-0.0	0.8	0.2	-0.7
Leg fat percentage (right)	0.5	1.9	4.0	1.5	1.1	0.4	-2.0
Arm fat-free mass (right)	0.5	2.3	5.2	-2.3	-1.1	0.4	1.7
Exposure to tobacco smoke outside home	1.6	2.2	5.4	0.6	2.3	1.0	-1.5
Comparative body size at age 10	4.4	12.1	24.8	-5.0	-0.2	0.3	4.8
Number of full brothers	0.0	0.1	0.2	-0.1	-0.2	-0.4	0.1
Worry too long after embarrassment	0.6	1.0	2.3	1.5	1.2	0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.8	0.8	1.7	1.0	-0.6
Wheeze or whistling in the chest in last year	1.0	1.8	5.8	0.8	2.4	1.0	-0.0
Number of children fathered	0.4	0.4	0.7	0.7	-0.5	-0.8	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-0.7	0.4	1.1	0.1
Age at first live birth	0.1	0.2	0.6	-0.0	0.2	-0.8	-0.3
Pulse wave peak to peak time	0.6	0.7	2.6	-0.2	-1.6	-0.3	0.4
Health satisfaction	0.8	1.1	1.9	0.8	1.4	0.8	-1.0
Shortness of breath walking on level ground	1.8	2.2	3.9	0.8	1.7	2.0	-1.1
Qualifications: College or University degree	0.4	1.4	2.7	-1.6	-1.0	0.6	1.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.3	0.4	0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	1.0	1.3	0.7	-0.2
Emphysema/chronic bronchitis	0.3	0.4	0.8	0.6	-0.1	0.9	-0.7
Medication for pain relief, constipation, heartburn	1.2	2.0	5.9	-0.4	-2.4	0.3	1.4
Neck or shoulder pain in last month	2.6	3.7	4.7	2.0	1.6	2.2	-1.8
Medication: Blood pressure	0.7	1.3	1.8	1.4	1.2	0.8	-1.0
Angina (self-reported)	2.9	3.8	6.8	2.6	1.2	1.3	-2.3
Migraine (self-reported)	0.4	0.5	1.2	-0.4	-0.7	-0.4	1.1
Medication: Ibuprofen	0.5	0.5	1.8	0.2	1.3	0.3	-0.6
Medication: Allopurinol	0.5	0.7	1.5	-1.2	0.3	0.8	0.8
Medication: Omeprazole	2.0	2.4	5.7	0.7	2.4	0.7	-1.7
Medication: Seretide 50 evohaler	1.3	1.5	2.5	-0.9	1.4	1.6	0.9
Mean time to correctly identify matches	4.6	8.8	11.3	-3.4	-2.8	-2.2	3.3
Heart disease (mother)	1.2	1.4	3.4	1.4	0.7	0.2	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	-0.8	0.1	1.0	0.1
Whole body fat mass	0.1	0.3	0.7	-0.8	0.4	0.7	-0.0
Leg fat mass (right)	0.1	0.2	0.5	-0.0	0.5	0.4	-0.7
Arm predicted mass (right)	0.4	2.2	4.9	-2.2	-1.0	0.7	1.6
Pulse rate, automated reading	0.8	2.5	4.0	1.7	1.7	0.3	-2.0
Alcohol intake frequency.	0.3	0.7	2.0	-0.7	-0.4	-0.4	1.4
Comparative height size at age 10	2.9	15.8	23.2	-4.3	-4.8	-1.6	4.4
Number of full sisters	0.5	0.7	2.6	-0.1	-1.6	0.1	0.2
Suffer from ‘nerves’	1.0	1.6	4.1	1.2	2.0	0.2	-0.7
Overall health rating	1.6	3.3	4.5	2.0	2.1	1.6	-1.6
Chest pain or discomfort	2.3	3.3	6.1	2.5	1.8	0.2	-1.9
Had major operations	0.7	0.8	2.2	0.5	0.7	0.4	-1.5
Age at last live birth	0.3	0.4	1.0	1.0	0.3	-0.0	-0.8
Family relationship satisfaction	1.0	1.2	2.4	-0.6	1.4	-0.1	1.5
Leg pain on walking	1.3	1.7	3.1	1.7	0.4	0.8	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.1	-0.4	-1.1	-0.6	0.4
Commuting to job workplace: Car/motor vehicle	2.5	2.9	3.8	1.9	1.9	1.4	-1.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.6	0.1	1.1	1.3	0.1
Medication: Aspirin	1.4	1.8	3.7	0.9	1.9	-0.7	-1.6
Supplements: Vitamin C	0.7	0.8	2.2	-0.9	-0.2	-0.4	1.5
Knee pain experienced in last month	0.3	0.5	1.2	0.8	-1.1	-0.3	0.3
Hypertension (Self-reported)	0.1	0.4	0.6	0.0	0.7	0.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.3	0.7	0.4	-0.0	-2.1
Illnesses of father: Heart disease	1.4	1.9	6.3	0.4	-1.0	-2.5	-0.5
Illnesses of siblings: Diabetes	1.6	2.0	4.6	-1.7	-0.7	-0.2	2.1
Smoking status: Previous	0.4	0.6	1.3	0.7	1.1	0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	0.5	-1.1	-0.8	0.1
Whole body fat-free mass	0.7	4.2	9.1	-3.0	-1.5	1.2	2.0
Leg fat-free mass (right)	1.1	5.6	14.4	-3.8	-1.0	0.9	2.5
Arm fat percentage (left)	0.3	1.1	3.1	-0.4	1.8	0.9	-0.6
Average weekly red wine intake	0.4	0.6	1.6	0.9	-0.2	-1.3	-0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.8	0.5	1.4	-0.1	-0.5
Mood swings	1.3	2.3	3.6	-1.6	-1.0	1.9	1.4
Loneliness, isolation	0.3	0.5	1.0	0.7	0.2	0.6	-1.0
Long-standing illness, disability or infirmity	0.5	0.8	2.7	0.5	1.6	-0.6	0.2
Ever had bowel cancer screening	1.2	1.5	2.5	1.1	1.0	-1.0	-1.6
Diabetes diagnosed by doctor	0.8	1.3	3.2	0.4	1.8	-0.9	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.4	-0.9	0.2	1.6	1.1
Friendships satisfaction	0.8	1.0	2.0	-0.5	1.3	0.1	1.4
Qualifications: nursing, teaching	0.3	0.5	1.1	-0.6	-1.0	-0.5	0.6
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.3	-0.9	0.3	0.5
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.7	-1.1	-0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	5.5	-0.2	2.4	-0.5	0.5
Medication for cholesterol	0.2	0.3	0.8	-0.6	0.9	0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.1	-0.7	0.0	-1.5	0.5
Back pain experienced in last month	0.2	0.3	0.6	0.8	-0.1	-0.7	-0.6
Mineral and other dietary supplements	1.1	1.5	3.5	1.9	1.2	0.7	-0.9
Breast cancer (self-reported)	2.0	2.4	6.3	2.5	0.7	-0.6	-1.6
Asthma (self-reported)	0.5	1.0	2.3	1.5	1.1	0.0	-0.6
Osteoporosis (self-reported)	0.5	0.7	2.1	-0.2	-1.5	-0.7	0.1
Osteoarthritis (self-reported)	0.3	0.4	0.5	-0.7	0.6	-0.5	-0.6
Medication: Aspirin	0.7	1.0	2.4	0.5	1.5	-0.5	-1.0
Medication: Gliclazide	0.5	0.6	2.2	-0.3	1.5	0.2	-0.3
Illnesses of father: None of the above (group 1)	1.3	1.5	4.0	-0.1	1.5	2.0	-0.1
Smoking status: Current	0.1	0.2	0.3	0.4	0.3	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.1	1.5	0.1	-0.8	-0.5
Whole body water mass	0.7	3.9	8.5	-2.9	-1.4	1.2	1.9
Leg predicted mass (right)	1.0	5.5	14.1	-3.7	-1.0	0.9	2.4
Arm fat mass (left)	0.2	0.7	1.2	-0.9	1.1	0.9	0.0
Number of self-reported non-cancer illnesses	1.2	2.1	6.2	1.4	2.5	-0.2	0.2
Average weekly champagne plus white wine intake	1.4	1.9	3.7	-1.1	-0.6	-1.5	1.9
Miserableness	2.7	4.7	13.7	-2.1	-0.8	-0.2	3.7
Guilty feelings	0.9	1.3	4.7	-0.3	-0.0	2.2	0.7
Wears glasses or contact lenses	3.0	3.4	4.4	-1.9	-1.4	-2.1	1.9
Ever taken oral contraceptive pill	0.8	0.9	2.5	0.9	1.6	-0.1	-0.2
Hearing aid user	1.0	1.1	1.7	1.3	1.2	-1.1	-0.0
Mother’s age at death	0.5	0.7	1.9	0.5	-0.2	-0.7	-1.4
Financial situation satisfaction	0.4	0.5	1.3	0.0	-0.7	-0.4	1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	0.8	-0.8	-0.9	-1.1
Commuting to job workplace: Public transport	0.5	0.5	1.6	-1.3	0.1	0.8	-0.1
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	0.4	0.9	-0.5	-0.4
Medication: Blood pressure	0.2	0.3	0.9	1.0	0.1	-0.1	0.5
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.7	-1.0	-0.4	-1.0	1.3
Supplements: Fish oil (including cod liver oil)	2.2	2.8	6.0	-1.9	-2.5	-0.5	1.2
High cholesterol (Self-reported)	1.9	3.4	7.2	2.7	2.2	-0.7	-1.1
Medication: Bendroflumethiazide	0.5	0.8	2.3	-0.7	-0.4	0.2	1.5
Medication: Paracetamol	0.1	0.2	0.4	-0.3	0.5	0.6	0.1
Medication: Lisinopril	1.9	2.5	5.9	2.4	0.2	0.1	-2.0
Medication: Atorvastatin	0.5	0.7	1.7	0.5	-0.1	-1.3	-0.8
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.3	0.8	-0.4	-0.9
Alcohol drinker status: Never	0.9	1.0	2.2	-1.5	-0.1	1.3	0.4
Ever smoked	1.4	2.5	4.8	1.8	1.4	0.0	-2.2
Basal metabolic rate	0.6	3.4	7.7	-2.8	-1.2	1.2	1.7
Leg fat percentage (left)	0.4	1.4	3.3	1.0	1.2	0.2	-1.8
Arm fat-free mass (left)	0.3	1.6	3.5	-1.9	-0.8	1.1	1.0
Number of operations (self-reported)	2.2	3.2	6.1	2.4	1.0	0.4	-2.5
Average weekly beer plus cider intake	0.9	1.3	4.6	0.6	0.2	2.1	-0.5
Irritability	0.2	0.3	1.1	-0.0	0.1	1.1	0.1
Risk taking	0.5	0.8	2.6	1.6	-0.5	0.1	-0.5
Ever had prostate specific antigen (PSA) test	1.9	2.2	5.1	0.8	2.3	-0.4	-1.8
Fractured/broken bones in last 5 years	0.6	0.8	1.2	-0.3	-1.1	-1.0	0.9
Age started oral contraceptive pill	0.7	0.8	2.5	0.6	-0.7	-1.6	0.1
Diastolic blood pressure, automated reading	0.2	0.6	1.2	0.9	0.6	-1.1	0.0
Ever depressed for a whole week	0.1	0.1	0.3	0.1	-0.1	-0.4	0.5
Unable to work because of sickness or disability	3.7	4.8	9.9	3.1	2.0	1.6	-1.8
Commuting to job workplace: Cycle	0.2	0.3	0.7	-0.1	0.8	0.6	-0.2
Myopia	1.3	1.8	2.9	-1.5	0.3	-1.5	1.7
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	0.0	-0.7	0.2	-0.7
Cholesterol lowering medication	1.5	2.3	4.2	1.7	2.1	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	6.3	0.4	2.5	0.9	-1.1
Pain experienced in last month	1.6	2.7	3.8	-1.9	-1.9	0.0	1.9
Supplements: Calcium	0.6	0.6	2.1	0.1	1.5	0.6	-0.2
Basal cell carcinoma (self-reported)	0.9	1.1	2.2	1.5	1.1	-0.0	-1.0
Heart attack/myocardial infarction (self-reported)	3.3	4.3	6.0	2.4	2.3	0.1	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	-0.3	0.9	-0.3	1.6
Heart disease (siblings)	1.2	1.4	2.8	1.6	-0.0	0.6	-1.7
Alcohol drinker status: Previous	1.5	1.7	5.1	0.1	-1.2	-2.3	0.5
Pack years of smoking	0.4	0.6	1.4	1.2	-0.4	0.4	-0.8
Impedance of whole body	0.5	2.8	4.8	2.2	-1.8	-1.4	-1.0
Leg fat mass (left)	0.1	0.3	0.4	-0.3	0.6	0.5	-0.7
Arm predicted mass (left)	0.5	2.3	5.0	-2.2	-1.0	1.0	1.5