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chr15:67,138,238-68,789,191

Best TWAS P=2.65e-11 · Best GWAS P=1.15e-10 conditioned to 0.132

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAP2K5	0.11	0.07	bslmm	474	0.08	1.2e-09	-5.7	5.6	1.7e-08	-0.72	0.35	0.65	FALSE
2	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	-5.6	5.6	1.8e-08	-0.77	0.42	0.58	FALSE
3	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	-5.3	5.6	2.6e-08	-0.79	0.04	0.94	FALSE
4	GTEx	Artery Aorta	MAP2K5	0.06	0.05	enet	6	0.05	7.7e-04	-5.6	5.6	2.0e-08	-0.78	0.18	0.72	FALSE
5	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	-5.7	5.6	2.4e-08	-0.76	0.39	0.61	FALSE
6	GTEx	Breast Mammary Tissue	MAP2K5	0.14	0.07	lasso	5	0.09	2.8e-05	-5.8	5.7	1.5e-08	-0.87	0.04	0.96	FALSE
7	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	-5.6	5.5	3.8e-08	-0.77	0.46	0.54	FALSE
8	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	-5.7	5.7	1.2e-08	-0.76	0.20	0.80	FALSE
9	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	-5.6	5.7	1.0e-08	-0.80	0.33	0.64	FALSE
10	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	3.9	5.2	1.7e-07	-0.69	0.42	0.58	FALSE
11	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	-5.7	5.7	1.1e-08	-0.77	0.36	0.64	FALSE
12	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	-5.6	5.5	2.9e-08	-0.77	0.09	0.78	FALSE
13	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	3.7	5.3	9.8e-08	-0.66	0.70	0.29	FALSE
14	GTEx	Spleen	MAP2K5	0.25	0.19	lasso	3	0.18	2.1e-05	-5.7	5.2	1.7e-07	-0.76	0.06	0.88	FALSE
15	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	-5.6	5.6	2.7e-08	-0.78	0.39	0.61	FALSE
16	GTEx	Whole Blood	MAP2K5	0.09	0.06	lasso	6	0.06	8.1e-06	-5.7	5.2	2.2e-07	-0.75	0.32	0.62	FALSE
17	METSIM	Adipose	MAP2K5	0.07	0.05	enet	19	0.06	2.8e-09	-5.9	6.7	2.6e-11	-0.85	0.04	0.96	TRUE
18	YFS	Blood	MAP2K5	0.05	0.07	lasso	4	0.07	1.2e-21	-5.6	5.6	2.1e-08	-0.77	0.37	0.63	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K5	0.03	0.03	blup	142	0.02	1.6e-03	-5.7	5.6	2.1e-08	-0.90	0.04	0.93	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	-5.7	5.8	7.4e-09	-0.79	0.07	0.91	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	-5.7	5.8	6.6e-09	-0.82	0.26	0.72	FALSE