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chr16:19,022,448-20,596,558

Best TWAS P=9.76e-11 · Best GWAS P=4.61e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	GPRC5B	0.07	0.04	lasso	4	0.03	1.3e-03	-6.4	6.5	9.8e-11	-0.96	0.01	0.97	TRUE
2	GTEx	Artery Aorta	KNOP1	0.50	0.48	lasso	8	0.49	4.0e-30	-4.7	-5.2	2.0e-07	0.76	0.99	0.01	FALSE
3	GTEx	Artery Coronary	KNOP1	0.28	0.25	lasso	7	0.32	2.5e-11	-4.6	-5.4	7.2e-08	0.82	0.08	0.92	FALSE
4	GTEx	Artery Coronary	AC002550.5	0.30	0.34	enet	11	0.37	1.5e-13	-4.7	-5.2	2.5e-07	0.79	0.43	0.57	FALSE
5	GTEx	Breast Mammary Tissue	AC002550.5	0.37	0.49	enet	13	0.50	3.3e-29	-4.7	-5.3	1.1e-07	0.80	0.86	0.14	FALSE
6	GTEx	Breast Mammary Tissue (Male)	AC002550.5	0.37	0.29	lasso	3	0.35	4.8e-09	-5.7	-5.7	1.2e-08	0.90	0.06	0.94	FALSE
7	GTEx	Colon Sigmoid	KNOP1	0.32	0.35	lasso	6	0.32	4.9e-12	-4.7	-5.4	7.9e-08	0.80	0.15	0.85	FALSE
8	GTEx	Colon Transverse	KNOP1	0.22	0.23	enet	19	0.24	9.8e-12	-4.7	-5.4	7.5e-08	0.81	0.47	0.53	FALSE
9	GTEx	Colon Transverse	AC002550.5	0.35	0.36	enet	15	0.41	5.0e-21	-4.7	-5.4	5.2e-08	0.81	0.85	0.15	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	KNOP1	0.51	0.44	enet	22	0.56	5.3e-24	-5.2	-5.7	9.3e-09	0.84	0.11	0.89	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	AC002550.5	0.62	0.54	enet	35	0.63	4.4e-29	-4.7	-5.7	1.3e-08	0.77	0.82	0.18	FALSE
12	GTEx	Liver	KNOP1	0.23	0.21	lasso	7	0.25	1.4e-07	-4.6	-5.6	1.9e-08	0.81	0.25	0.70	FALSE
13	GTEx	Liver	AC002550.5	0.43	0.42	enet	13	0.47	1.1e-14	-4.7	-5.4	6.6e-08	0.85	0.31	0.69	FALSE
14	GTEx	Ovary	KNOP1	0.61	0.64	lasso	7	0.57	4.4e-17	-4.7	-5.1	3.0e-07	0.77	0.78	0.22	FALSE
15	GTEx	Pancreas	KNOP1	0.42	0.37	lasso	11	0.40	4.2e-18	-4.6	-5.6	2.6e-08	0.84	0.62	0.38	FALSE
16	GTEx	Pancreas	AC002550.5	0.37	0.36	lasso	12	0.36	3.2e-16	-4.7	-5.2	2.2e-07	0.76	0.92	0.08	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	AC002550.5	0.44	0.43	enet	24	0.43	1.2e-25	-4.7	-5.3	8.8e-08	0.79	0.97	0.03	FALSE
18	GTEx	Stomach	KNOP1	0.28	0.21	lasso	6	0.21	1.8e-10	-4.1	-5.4	8.3e-08	0.77	0.11	0.89	FALSE
19	GTEx	Testis	AC002550.5	0.49	0.57	lasso	5	0.56	7.7e-30	-4.7	-5.2	2.0e-07	0.77	0.99	0.01	FALSE
20	GTEx	Vagina	KNOP1	0.43	0.35	lasso	5	0.36	4.2e-09	-4.7	-5.2	1.9e-07	0.74	0.47	0.52	FALSE
21	GTEx	Whole Blood	KNOP1	0.08	0.04	lasso	3	0.04	1.7e-04	-4.7	-5.6	2.9e-08	0.86	0.24	0.74	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCK	0.05	0.02	blup	73	0.03	1.0e-03	-6.0	-5.5	3.1e-08	0.84	0.01	0.97	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCK	0.03	0.03	blup	73	0.03	1.6e-07	-4.6	-5.4	5.8e-08	0.81	0.16	0.84	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf88	0.22	0.08	lasso	3	0.08	2.0e-09	-5.2	-5.1	2.6e-07	0.82	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf88	0.07	0.05	lasso	2	0.05	7.7e-04	-5.2	-5.2	1.8e-07	0.83	0.00	0.90	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	IQCK	0.09	0.04	lasso	6	0.04	4.9e-05	-4.6	-5.1	2.8e-07	0.73	0.15	0.84	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf88	0.10	0.10	lasso	3	0.13	3.7e-14	-5.2	-5.2	2.1e-07	0.80	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCK	0.03	0.03	lasso	3	0.02	7.2e-04	-5.6	-5.8	5.5e-09	0.94	0.00	0.99	FALSE
29	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C16orf88	0.34	0.21	lasso	4	0.17	3.1e-07	-5.2	-5.2	2.0e-07	0.82	0.00	1.00	FALSE