Best TWAS P=2.15e-12 · Best GWAS P=2.99e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | THOC7 | 0.27 | 0.10 | lasso | 3 | 0.12 | 1.9e-04 | -4.7 | 6.3 | 3.6e-10 | -0.84 | 0.03 | 0.90 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | ATXN7 | 0.30 | 0.14 | lasso | 4 | 0.12 | 1.4e-04 | -7.0 | 7.0 | 2.1e-12 | -0.99 | 0.00 | 0.99 | TRUE |
| 3 | GTEx | Pancreas | ATXN7 | 0.25 | 0.09 | lasso | 6 | 0.09 | 1.1e-04 | -6.8 | 6.7 | 1.8e-11 | -0.94 | 0.01 | 0.98 | FALSE |
| 4 | METSIM | Adipose | RP11-245J9.5 | 0.07 | 0.02 | bslmm | 563 | 0.03 | 4.0e-05 | -6.8 | 6.3 | 2.6e-10 | -0.95 | 0.01 | 0.99 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ATXN7 | 0.09 | 0.06 | lasso | 9 | 0.07 | 2.2e-09 | -6.6 | 6.4 | 1.8e-10 | -0.86 | 0.03 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PSMD6 | 0.02 | 0.01 | blup | 56 | 0.01 | 8.3e-03 | 3.6 | 6.7 | 2.0e-11 | -0.70 | 0.02 | 0.49 | FALSE |