Best TWAS P=1.8e-10 · Best GWAS P=5.17e-10 conditioned to 0.115
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Coronary | LNP1 | 0.15 | 0.00 | lasso | 3 | -0.01 | 5.7e-01 | 2.4 | -5.5 | 4.5e-08 | 0.72 | 0.04 | 0.41 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | FILIP1L | 0.15 | 0.21 | enet | 19 | 0.20 | 5.5e-15 | -5.3 | 5.5 | 5.2e-08 | -0.68 | 0.78 | 0.22 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | CMSS1 | 0.08 | 0.02 | enet | 17 | 0.05 | 1.5e-04 | 5.4 | -5.2 | 1.9e-07 | 0.48 | 0.54 | 0.28 | FALSE |
4 | GTEx | Esophagus Mucosa | CMSS1 | 0.06 | 0.08 | lasso | 4 | 0.08 | 4.2e-06 | 5.6 | -5.8 | 5.7e-09 | 0.49 | 0.42 | 0.48 | FALSE |
5 | GTEx | Esophagus Muscularis | NIT2 | 0.12 | 0.01 | enet | 12 | 0.03 | 9.7e-03 | -2.2 | -5.2 | 2.0e-07 | 0.61 | 0.13 | 0.64 | FALSE |
6 | GTEx | Spleen | NIT2 | 0.26 | 0.00 | enet | 41 | 0.10 | 2.0e-03 | -2.8 | -6.0 | 2.6e-09 | 0.68 | 0.08 | 0.62 | FALSE |
7 | GTEx | Stomach | TBC1D23 | 0.08 | 0.02 | lasso | 3 | 0.02 | 3.5e-02 | -4.7 | -5.3 | 1.2e-07 | 0.59 | 0.10 | 0.39 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf26 | 0.03 | 0.02 | blup | 163 | 0.02 | 5.8e-06 | 5.4 | -6.1 | 1.2e-09 | 0.65 | 0.50 | 0.47 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C3orf26 | 0.02 | 0.01 | blup | 163 | 0.01 | 3.4e-02 | -5.2 | -6.1 | 1.1e-09 | 0.83 | 0.09 | 0.60 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | COL8A1 | 0.03 | 0.03 | enet | 6 | 0.01 | 9.2e-03 | -5.8 | 5.3 | 1.3e-07 | -0.87 | 0.01 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | C3orf26 | 0.05 | 0.01 | blup | 163 | 0.03 | 2.2e-04 | 5.4 | -6.4 | 1.8e-10 | 0.84 | 0.06 | 0.87 | TRUE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C3orf26 | 0.10 | 0.02 | blup | 163 | 0.05 | 4.6e-03 | -4.9 | -6.2 | 6.5e-10 | 0.78 | 0.07 | 0.66 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf26 | 0.03 | 0.01 | blup | 163 | 0.02 | 2.2e-03 | -4.3 | -5.5 | 4.9e-08 | 0.69 | 0.22 | 0.25 | FALSE |