[Hub]/) : Traits : Breast Cancer :

chr5:55,509,554-56,923,759

Best TWAS P=7.53e-67 · Best GWAS P=8.81e-98 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous SETD9 0.15 0.14 lasso 10 0.16 3.0e-13 -7.576 5.3 1.1e-07 -0.04 1.00 0.00 FALSE
2 GTEx Brain Putamen basal ganglia SETD9 0.23 0.15 lasso 3 0.14 2.9e-04 -9.515 8.9 5.7e-19 -0.19 0.22 0.04 FALSE
3 GTEx Breast Mammary Tissue CTD-2310F14.1 0.14 -0.01 enet 23 0.01 6.7e-02 6.303 -7.2 6.6e-13 0.27 0.07 0.31 TRUE
4 GTEx Breast Mammary Tissue (Female) SETD9 0.21 0.12 lasso 11 0.16 1.4e-05 -14.260 11.2 4.9e-29 -0.33 0.57 0.04 TRUE
5 GTEx Breast Mammary Tissue (Female) CTD-2310F14.1 0.21 0.01 lasso 6 0.02 9.4e-02 4.875 -6.0 2.2e-09 0.26 0.05 0.55 TRUE
6 GTEx Cells Transformed fibroblasts SETD9 0.31 0.42 lasso 6 0.47 5.7e-39 0.440 5.7 1.3e-08 -0.06 1.00 0.00 FALSE
7 GTEx Spleen CTD-2310F14.1 0.38 0.00 enet 21 0.01 2.0e-01 -16.491 -17.3 7.5e-67 0.60 0.04 0.50 TRUE
8 GTEx Stomach SETD9 0.35 0.31 lasso 8 0.38 1.9e-19 0.440 5.7 1.6e-08 -0.07 1.00 0.00 TRUE
9 GTEx Testis SETD9 0.18 0.05 lasso 6 0.11 1.9e-05 -7.301 8.0 1.3e-15 -0.12 0.73 0.01 FALSE
10 GTEx Testis CTD-2310F14.1 0.35 0.14 lasso 8 0.15 2.9e-07 -0.064 -8.1 7.8e-16 0.12 0.94 0.00 FALSE
11 METSIM Adipose SETD9 0.10 0.14 lasso 17 0.16 9.6e-23 -7.310 5.4 5.5e-08 -0.04 1.00 0.00 FALSE
12 The Cancer Genome Atlas Breast Invasive Carcinoma C5orf35 0.29 0.42 lasso 8 0.46 3.0e-107 0.440 5.2 1.8e-07 -0.07 1.00 0.00 FALSE
13 The Cancer Genome Atlas Esophageal Carcinoma C5orf35 0.19 0.20 lasso 4 0.18 1.9e-06 -7.301 6.4 1.2e-10 -0.07 0.81 0.01 FALSE
14 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C5orf35 0.27 0.30 lasso 6 0.36 1.4e-21 0.440 5.6 2.5e-08 -0.07 1.00 0.00 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma MIER3 0.05 0.00 blup 81 0.01 6.2e-02 -0.117 -8.0 1.0e-15 0.31 0.03 0.12 TRUE
16 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C5orf35 0.23 0.39 lasso 11 0.37 1.9e-18 -7.301 7.6 2.4e-14 -0.12 1.00 0.00 FALSE
17 The Cancer Genome Atlas Lung Adenocarcinoma C5orf35 0.42 0.45 enet 17 0.50 3.2e-67 0.440 5.2 2.6e-07 -0.07 1.00 0.00 FALSE
18 The Cancer Genome Atlas Lung Adenocarcinoma MAP3K1 0.02 0.01 blup 83 0.01 9.1e-03 -13.795 -14.2 8.8e-46 0.64 0.06 0.44 TRUE
19 The Cancer Genome Atlas Skin Cutaneous Melanoma C5orf35 0.23 0.08 blup 58 0.17 2.5e-05 -15.283 10.2 1.3e-24 -0.27 0.52 0.05 FALSE
20 The Cancer Genome Atlas Testicular Germ Cell Tumors MIER3 0.17 0.12 lasso 3 0.07 1.6e-03 -10.660 -11.6 2.5e-31 0.62 0.02 0.54 TRUE
21 The Cancer Genome Atlas Thyroid Carcinoma MAP3K1 0.04 0.03 lasso 2 0.03 4.4e-04 -12.627 -13.4 5.6e-41 0.62 0.09 0.63 TRUE
22 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma C5orf35 0.38 0.05 blup 58 0.06 7.0e-03 -0.117 6.5 7.9e-11 -0.09 0.13 0.04 TRUE