Hub : Genes

MIER3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.5530	0.1420	0.0095	-0.007	NA	-0.012	NA	-0.001	5.1e-01	NA	0.810	NA	0.3400
2	TCGA	Brain Lower Grade Glioma	0.0509	0.0275	0.0067	-0.002	0.006	0.000	NA	0.002	6.0e-01	0.062	0.300	NA	0.1600
3	TCGA	Testicular Germ Cell Tumors	0.1690	0.0860	0.0092	0.122	0.044	0.017	NA	0.072	4.5e-05	0.012	0.078	NA	0.0016

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.7	2.6	1.6	-0.7	1.4
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	0.6	-1.2	-0.2
Depressed Affect (Nagel 2018)	0.9	1.9	4.5	-0.6	2.1	0.8
Depression (Nagel 2018)	0.5	0.7	1.5	-0.8	1.2	0.0
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.2	1.1	-1.1	1.0
Neuroticism (Nagel 2018)	0.3	0.6	1.3	1.1	0.7	0.1
Schizophrenia (2018)	0.6	1.3	2.1	0.9	-1.1	-1.5
Schizophrenia vs Biploar Disorder	2.7	3.5	6.7	-0.6	1.8	-2.6
Worry (Nagel 2018)	1.1	2.4	5.9	2.4	0.7	-0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.4	-0.3	1.0
Alzheimer’s Disease (in father)	1.2	1.4	3.5	-0.1	0.7	-1.9
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.2	0.1	-0.9
Crohns Disease (2017)	0.1	0.3	0.6	0.1	0.6	0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.7	-0.6	-0.2
Ulcerative Colitis (UC)	1.0	1.8	2.0	-1.3	-1.3	-1.4
Major Depression (MDD)	0.3	0.4	0.9	-0.9	0.2	0.5
Reaction Time	0.4	0.7	1.1	-1.0	1.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.2	0.5	-1.1	1.1
Breast Cancer	27.6	66.4	134.6	-0.4	-8.0	-11.6
Ovarian Cancer	0.1	0.1	0.2	0.1	0.3	-0.5
Prostate Cancer	0.0	0.0	0.1	-0.3	0.0	0.0
Age at First Birth	0.7	1.0	1.7	0.2	-1.3	-1.2
Bipolar Disorder (2011)	0.2	0.2	0.5	0.0	-0.4	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	-1.0	-0.4	0.5
Coronary Artery Disease (CAD)	2.4	2.8	7.8	0.2	-0.8	2.8
Crohns Disease (2012)	0.0	0.1	0.1	-0.2	-0.4	0.2
Mean Putamen Volume	1.0	1.2	2.2	0.4	1.5	-1.1
Fasting Glucose	1.0	1.2	1.6	-1.3	-1.0	1.0
HbA1C	0.2	0.2	0.3	-0.5	0.6	0.4
HDL Cholesterol	0.1	0.2	0.5	0.1	0.7	-0.3
LDL Cholesterol	0.3	0.4	1.3	1.1	-0.2	0.1
Lupus	1.2	1.9	4.6	-2.1	0.5	0.9
Neuroticism (2016)	1.5	2.1	5.0	-2.2	1.0	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.3	1.1	-0.7	-0.6
Rheumatoid Arthritis	1.7	2.3	3.6	1.9	-1.0	-1.6
Schizophrenia (2014)	0.7	1.6	2.0	1.3	-1.0	-1.4
Triglycerides	0.5	0.8	2.2	0.0	-0.6	1.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	-0.4	-0.5	-0.7
Ulcerative Colitis	1.3	1.9	5.3	-0.4	-0.5	-2.3
Blood Eosinophil Count	0.1	0.8	2.0	0.5	1.4	-0.5
Blood Platelet Count	0.5	5.7	14.4	-1.6	3.8	-0.1
Blood Red Count	0.4	3.8	8.3	-1.0	1.4	-2.9
Blood White Count	0.1	0.6	1.2	0.7	1.1	-0.3
Heel T-Score	0.6	4.5	13.0	0.5	-3.6	-0.4
BMI	0.2	1.3	2.6	-0.4	-1.1	1.6
Height	0.3	6.2	11.8	0.9	2.4	-3.4
Waist Hip Ratio (WHR)	0.8	3.7	6.8	2.1	-2.6	-0.1
Systolic Blood Pressure	0.2	1.2	2.8	-1.7	0.8	0.5
Smoking Status	0.2	0.4	1.0	0.4	-0.3	1.0
Allergy or Eczema	0.8	2.0	3.9	2.0	-1.4	-0.5
Cardiovascular Disease	0.6	2.0	5.4	-0.8	2.3	0.2
Hypothyroidism (self reported)	0.1	0.3	0.9	0.3	0.9	0.2
Respiratory disease	0.4	0.9	1.8	0.5	-1.4	0.7
Type 2 Diabetes (T2D) (2018)	1.8	3.3	8.2	-1.2	-2.9	0.4
Lung FEV1/FVC ratio	0.5	2.4	3.5	-1.0	1.6	-1.9
Lung FVC	0.3	1.4	3.9	-0.4	0.5	-2.0
Neuroticism	0.5	1.2	2.7	1.6	0.6	0.7
Chronotype (morning person)	0.2	0.5	0.7	0.4	-0.7	0.9
Hair Pigment	0.9	25.1	56.6	1.4	-7.5	-4.1
Tanning	0.0	0.2	0.3	0.2	-0.6	-0.5
Hand grip strength (left)	0.5	1.2	2.1	-1.4	0.3	-1.2
Number of treatments/medications taken	1.2	2.1	3.8	-0.4	2.0	1.5
Average weekly spirits intake	0.6	0.7	1.5	-0.1	-0.8	-1.2
Sensitivity / hurt feelings	0.8	1.3	3.0	1.7	-0.4	0.9
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.8	-1.7	0.2	1.3
Hearing difficulty/problems: Yes	0.7	1.0	2.2	1.5	0.9	-0.2
Relative age of first facial hair	1.1	2.2	4.6	-0.3	-1.4	2.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.2	0.2	0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	-0.7	0.2	0.7
Ever had hysterectomy (womb removed)	1.5	1.7	3.7	1.9	1.2	0.3
Systolic blood pressure, automated reading	1.7	5.0	8.8	-3.0	2.5	-0.1
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	5.2	0.1	-2.3	-0.6
Angina	1.4	1.8	4.4	-0.3	-0.9	2.1
Medication for hormone replacement therapy	2.2	2.5	4.2	-0.4	-2.0	1.8
Vitamin and mineral supplements	0.1	0.2	0.3	0.2	0.4	-0.5
Supplements: Zinc	1.7	1.8	2.9	1.6	0.2	1.7
Medication: Co-codamol	0.2	0.3	0.5	-0.7	0.6	-0.1
Medication: Metformin	0.8	1.1	3.1	-0.4	-1.8	0.5
Diabetes (father)	0.9	1.1	1.8	-0.4	-1.3	-1.2
Diabetes (mother)	2.2	2.8	7.8	-0.4	-0.7	2.8
Severe depression (siblings)	0.7	0.8	2.1	-0.3	0.5	-1.4
Pack years adult smoking proportion	1.4	2.1	3.2	-1.8	1.7	-0.1
Impedance of leg (right)	1.2	5.9	9.1	1.0	2.8	-3.0
Leg fat-free mass (left)	0.2	1.2	2.2	-1.1	-0.3	1.5
Trunk fat percentage	0.5	2.0	5.8	-0.3	2.4	-0.4
Hand grip strength (right)	0.3	0.8	1.8	-0.5	0.7	-1.3
Townsend deprivation index at recruitment	1.1	1.6	2.6	-1.6	-1.4	0.4
Current tobacco smoking	1.7	2.8	7.7	-0.4	0.8	2.8
Average weekly fortified wine intake	1.9	2.2	5.6	-0.4	-2.4	-0.8
Maternal smoking around birth	0.1	0.1	0.4	0.1	0.0	-0.7
Fed-up feelings	0.9	1.6	2.4	-0.8	1.6	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-0.0	1.1	0.3
Relative age voice broke	0.1	0.2	0.3	-0.4	-0.1	-0.6
Taking other prescription medications	1.6	2.4	3.5	-0.7	1.8	1.9
Age when periods started (menarche)	1.2	2.8	5.9	2.4	0.8	1.3
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	5.1	-1.3	2.3	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.8	-0.8	-1.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.5	0.1	0.3
Qualifications: CSEs or equivalent	1.5	2.0	4.1	0.8	-1.1	2.0
Serious illness, injury or assault to yourself	3.5	4.2	6.5	-1.3	2.1	2.5
High blood pressure	1.4	4.0	11.0	-1.0	3.3	-0.1
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.7	2.2	-1.0	0.6
Multivitamins +/- minerals	0.6	0.8	2.0	-1.4	0.1	-0.6
Stomach or abdominal pain in last month	0.3	0.4	1.1	1.0	0.1	0.3
Supplements: Glucosamine	0.4	0.6	1.5	-0.4	0.3	-1.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.2	-0.2	0.4
Medication: Atenolol	1.2	1.5	3.6	-1.9	0.8	-0.5
Medication: Levothyroxine sodium	1.2	2.1	3.2	-1.6	1.8	-0.7
Sitting height	0.6	4.1	7.7	-0.5	2.1	-2.8
Chronic bronchitis/emphysema (father)	0.7	0.9	1.8	-1.3	0.3	0.8
High blood pressure (mother)	2.3	3.3	6.7	-0.8	1.6	-2.6
Body mass index (BMI)	0.5	2.2	4.0	-2.0	0.1	1.6
Impedance of leg (left)	1.2	5.7	9.3	1.1	2.5	-3.0
Leg predicted mass (left)	0.2	1.1	2.1	-1.1	-0.3	1.5
Trunk fat mass	0.3	1.4	3.7	-0.8	1.9	-0.1
Waist circumference	0.2	0.6	1.0	-0.9	0.0	1.0
Number of incorrect matches in round	0.4	0.6	0.9	-0.9	-0.4	1.0
Past tobacco smoking	0.9	1.7	2.8	-0.7	1.4	-1.7
Alcohol usually taken with meals	2.6	4.3	4.6	2.1	-2.1	-2.0
Nervous feelings	0.8	1.6	3.8	1.9	0.9	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.1	0.4	-0.6
Hearing difficulty/problems with background noise	0.3	0.4	0.8	0.9	0.2	0.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	-0.9	-1.2	0.5
Had menopause	0.7	0.9	1.8	-0.6	1.4	-0.6
Had other major operations	1.1	1.3	2.6	-1.0	0.7	1.6
Forced vital capacity (FVC)	1.1	4.3	12.4	-0.1	0.8	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	5.0	-0.4	-2.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.1	-1.0	0.8
Qualifications: None of the above	0.5	1.1	2.1	-1.0	1.4	0.4
Financial difficulties in last 2 years	1.1	1.5	4.1	-0.6	2.0	-0.1
Mouth/teeth dental problems	0.6	0.9	1.0	0.9	-0.9	-1.0
Heart attack	0.6	0.8	2.3	1.5	0.2	-0.0
Allergy	0.9	2.0	2.5	-1.4	1.3	-1.6
Pain all over the body in last month	0.5	0.6	1.4	1.2	0.4	-0.5
Diabetes (self-reported)	1.6	2.4	4.8	-0.7	-2.2	1.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.0	0.6	-1.7	0.6
Medication: Ramipril	1.7	2.1	4.3	-1.2	-0.8	2.1
Medication: Simvastatin	0.8	1.1	2.3	0.3	1.5	1.0
Fluid intelligence score	0.4	0.7	1.7	0.2	-1.3	0.7
Illnesses of siblings	0.1	0.2	0.3	0.4	-0.3	-0.6
Neuroticism score	0.9	1.9	2.2	1.5	1.3	1.4
Weight	0.3	1.4	2.6	-1.6	1.1	0.7
Impedance of arm (right)	1.1	5.3	7.0	2.7	2.2	-2.1
Arm fat percentage (right)	0.2	0.9	1.0	-1.0	1.0	0.9
Trunk fat-free mass	0.3	1.7	2.7	-1.6	-0.9	1.2
Hip circumference	0.2	0.8	2.0	-1.4	0.5	0.5
Time employed in main current job	0.8	0.9	1.1	-1.1	1.0	-0.8
Alcohol intake versus 10 years previously	0.2	0.4	0.8	-0.0	0.5	0.9
Father’s age at death	1.6	2.1	6.0	0.5	-2.5	0.5
Worrier / anxious feelings	1.2	2.3	5.5	1.1	2.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.6	-0.1	2.1	1.3
Falls in the last year	1.3	1.7	2.5	-1.5	0.6	1.6
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.1	0.0	-0.0
Number of live births	0.1	0.1	0.4	-0.6	-0.1	0.1
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	11.7	-0.5	1.0	-3.4
Pulse rate	0.1	0.2	0.3	-0.2	0.6	0.5
Happiness	0.3	0.3	0.8	-0.1	-0.3	0.9
Noisy workplace	0.2	0.2	0.5	0.3	0.7	-0.3
Qualifications: A levels/AS levels or equivalent	1.4	3.1	4.6	0.7	-2.1	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.2	-1.8	-1.0	0.3
Mouth/teeth dental problems: Dentures	0.3	0.6	0.9	-0.9	0.9	0.1
Asthma	0.6	1.2	2.7	0.5	-1.6	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.1	-0.3	-2.2	-0.4
Medication: Cholesterol lowering	1.4	2.1	4.4	1.2	0.7	2.1
Depression (self-reported)	1.5	1.8	5.3	-2.3	-0.4	-0.0
Medication: Lansoprazole	1.4	1.6	4.0	2.0	-0.2	-0.9
Prospective memory result	0.5	0.6	1.7	1.3	-0.5	0.1
Lung cancer (father)	3.3	3.9	6.0	1.3	2.0	2.5
Illnesses of mother	0.1	0.1	0.3	0.0	0.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.2	-0.2	1.6	-1.8
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	0.4	-0.9	0.1
Impedance of arm (left)	1.8	8.2	10.0	2.8	2.5	-3.2
Arm fat mass (right)	0.3	1.2	1.6	-1.3	0.8	1.1
Trunk predicted mass	0.3	1.7	2.5	-1.6	-1.0	1.3
Standing height	0.4	3.5	6.5	0.7	2.6	-1.9
Length of working week for main job	0.7	0.8	0.9	1.0	1.0	-0.8
Exposure to tobacco smoke at home	2.0	2.2	3.5	1.7	-1.9	-0.5
Breastfed as a baby	0.2	0.2	0.5	0.2	-0.7	0.2
Tense / ‘highly strung’	0.6	0.9	1.6	1.0	1.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.0	-1.7	0.4	1.7
Hair/balding pattern: Pattern 4	1.2	2.8	8.2	-0.4	2.9	0.3
Birth weight of first child	0.3	0.5	1.2	0.4	0.5	1.1
Peak expiratory flow (PEF)	0.6	1.4	1.6	-1.3	1.3	-1.0
Pulse wave reflection index	0.2	0.2	0.4	0.7	0.4	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.9	0.6	-0.9	-0.3
Loud music exposure frequency	1.4	1.6	4.5	0.2	-2.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	0.4	-0.4	-1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.6	-0.5	0.8
Blood clot in the leg (DVT)	1.1	1.4	3.5	-1.9	-0.7	0.4
Medication: Paracetamol	0.4	0.6	0.9	-0.9	1.0	0.4
Headache pain in last month	0.1	0.1	0.2	0.4	-0.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-1.1	-0.2	-0.7
Glaucoma (self-reported)	1.6	1.8	4.9	-0.3	-0.7	-2.2
Gout (self-reported)	0.8	1.2	1.8	-1.2	-0.5	1.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.3	-0.8	2.1	-0.0
Medication: Amlodipine	1.2	1.7	4.6	-0.2	2.1	0.8
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.1	-1.8	0.9	1.1
Birth weight	0.3	0.8	0.9	0.9	0.7	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.0	-0.1	-0.5	1.0
High blood pressure (siblings)	0.5	0.8	1.8	-0.5	0.5	-1.3
Forced vital capacity (FVC), Best measure	0.4	1.6	2.8	0.0	1.5	-1.7
Body fat percentage	0.5	1.9	5.0	-0.9	2.2	-0.2
Leg fat percentage (right)	0.6	2.2	3.3	-1.8	1.8	-0.0
Arm fat-free mass (right)	0.3	1.7	4.0	-2.0	0.2	1.1
Exposure to tobacco smoke outside home	1.0	1.4	3.2	-1.8	0.9	0.3
Comparative body size at age 10	0.9	2.6	4.1	2.0	-1.9	-0.5
Number of full brothers	0.1	0.1	0.2	-0.4	0.1	-0.3
Worry too long after embarrassment	0.5	0.8	1.7	1.3	0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	2.8	-1.7	-1.5	1.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.1	0.6	0.6
Number of children fathered	1.0	1.1	2.5	-0.8	1.6	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.0	0.5	0.0	1.0
Age at first live birth	0.6	1.0	2.7	0.6	0.3	-1.6
Pulse wave peak to peak time	0.3	0.4	1.0	-0.1	1.0	-0.2
Health satisfaction	0.8	1.0	2.5	1.6	-0.3	0.6
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.5	0.3	-0.9
Qualifications: College or University degree	0.9	3.0	6.5	0.1	-2.6	-1.6
Eye problems/disorders: None of the above	0.4	0.5	0.7	0.8	-0.5	0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.5	-1.6	-0.2	0.0
Emphysema/chronic bronchitis	1.0	1.1	2.8	-0.7	-0.1	1.7
Medication for pain relief, constipation, heartburn	1.0	1.7	4.2	0.9	-0.4	-2.0
Neck or shoulder pain in last month	1.2	1.8	3.8	0.4	1.9	1.1
Medication: Blood pressure	0.5	0.9	2.4	0.6	0.3	1.6
Angina (self-reported)	1.1	1.4	3.4	-0.2	-0.9	1.8
Migraine (self-reported)	0.0	0.0	0.1	0.0	-0.3	0.1
Medication: Ibuprofen	0.9	1.1	2.9	0.3	-1.7	-0.6
Medication: Allopurinol	1.4	1.9	3.2	-1.8	-1.0	1.2
Medication: Omeprazole	2.4	2.8	3.4	-1.5	1.7	1.8
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.6	0.3	0.1
Mean time to correctly identify matches	0.0	0.1	0.1	0.2	0.2	0.3
Heart disease (mother)	0.2	0.3	0.6	0.7	-0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.5	-1.0	-0.1	-1.9
Whole body fat mass	0.3	1.4	3.1	-1.0	1.8	0.4
Leg fat mass (right)	0.5	1.7	2.3	-1.5	1.4	0.9
Arm predicted mass (right)	0.3	1.6	3.6	-1.9	0.1	1.0
Pulse rate, automated reading	1.0	3.4	8.1	-1.3	2.8	0.4
Alcohol intake frequency.	0.9	2.1	4.3	-0.7	2.1	1.2
Comparative height size at age 10	0.5	3.0	4.7	0.7	2.2	-2.0
Number of full sisters	0.7	0.8	2.4	-0.1	-0.2	1.6
Suffer from ‘nerves’	1.2	1.9	4.5	2.1	0.4	1.1
Overall health rating	1.6	3.5	5.6	0.4	2.4	2.2
Chest pain or discomfort	2.1	3.0	4.7	-0.9	1.8	2.2
Had major operations	0.2	0.3	0.5	0.7	0.4	0.4
Age at last live birth	0.0	0.0	0.1	0.2	0.2	-0.1
Family relationship satisfaction	0.4	0.4	0.8	-0.3	-0.9	0.7
Leg pain on walking	0.1	0.2	0.3	-0.5	0.4	0.1
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	6.3	-1.4	2.5	0.2
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.2	-0.2	1.8	1.3
Illness, injury, bereavement, stress in last 2 years	4.9	6.0	11.0	3.3	-2.0	-1.7
Medication: Aspirin	0.5	0.7	1.0	1.0	0.6	0.8
Supplements: Vitamin C	1.8	2.1	5.3	0.2	-0.9	2.3
Knee pain experienced in last month	1.0	1.5	3.1	-1.2	-0.0	1.8
Hypertension (Self-reported)	1.6	4.4	12.0	-1.0	3.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-0.3	-0.7	1.2
Illnesses of father: Heart disease	1.1	1.5	4.2	2.0	-0.5	-0.2
Illnesses of siblings: Diabetes	0.8	1.0	2.0	-0.9	0.5	1.4
Smoking status: Previous	1.1	1.7	3.7	1.0	-1.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.8	0.9	0.6	0.7
Whole body fat-free mass	0.3	1.8	2.5	-1.6	-0.7	1.5
Leg fat-free mass (right)	0.2	1.3	2.6	-1.0	-0.5	1.6
Arm fat percentage (left)	0.2	0.9	1.6	-1.1	1.3	0.2
Average weekly red wine intake	2.2	3.3	6.1	0.3	-2.5	-1.9
Handedness (chirality/laterality): Left-handed	0.5	0.7	1.3	-0.8	-1.1	-0.1
Mood swings	1.6	2.9	5.1	-0.7	2.3	1.8
Loneliness, isolation	0.3	0.5	1.0	-1.0	0.1	0.6
Long-standing illness, disability or infirmity	0.6	1.0	1.4	-1.2	-0.6	1.1
Ever had bowel cancer screening	0.5	0.6	1.2	0.7	-0.1	-1.1
Diabetes diagnosed by doctor	1.7	2.8	6.4	-1.0	-2.5	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.3	-0.4	0.2	1.5
Friendships satisfaction	0.8	1.0	1.5	-1.2	-1.1	0.5
Qualifications: nursing, teaching	0.8	1.2	1.7	1.1	-0.9	-1.3
Commuting to job workplace: Walk	1.1	1.2	2.4	-0.2	-1.6	-1.1
Eye problems/disorders: Cataract	0.2	0.3	0.3	-0.4	0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.3	-0.4	-0.5	1.8
Medication for cholesterol	2.3	3.4	5.1	2.3	-2.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	2.6	-1.2	1.1	1.6
Back pain experienced in last month	1.1	1.6	4.2	-0.7	2.1	0.1
Mineral and other dietary supplements	0.4	0.5	1.2	-0.2	-0.5	-1.1
Breast cancer (self-reported)	11.2	13.3	20.7	1.3	4.2	4.6
Asthma (self-reported)	0.8	1.5	3.3	0.9	-1.8	0.7
Osteoporosis (self-reported)	1.2	1.5	2.5	1.4	-0.1	1.6
Osteoarthritis (self-reported)	0.6	0.7	2.2	0.2	0.0	1.5
Medication: Aspirin	0.6	0.8	1.1	1.1	0.5	1.0
Medication: Gliclazide	0.1	0.1	0.3	-0.6	-0.2	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.0	-0.3	0.1
Smoking status: Current	1.4	2.3	5.6	-0.6	0.9	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.7	-0.8	0.8	-0.7
Whole body water mass	0.3	1.7	2.4	-1.6	-0.6	1.5
Leg predicted mass (right)	0.2	1.3	2.7	-1.0	-0.4	1.6
Arm fat mass (left)	0.3	1.1	1.7	-1.3	1.1	0.7
Number of self-reported non-cancer illnesses	0.8	1.5	2.5	0.2	1.4	1.6
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.5	-0.8	0.0
Miserableness	0.4	0.8	1.7	-0.5	0.6	1.3
Guilty feelings	0.8	1.2	2.5	0.8	0.7	1.6
Wears glasses or contact lenses	1.4	1.7	3.6	1.9	0.8	0.8
Ever taken oral contraceptive pill	0.0	0.0	0.1	0.0	-0.3	0.0
Hearing aid user	0.5	0.5	1.5	1.2	0.2	0.1
Mother’s age at death	1.5	1.9	3.8	-1.3	0.1	-2.0
Financial situation satisfaction	0.7	0.9	2.1	-0.8	0.1	1.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	0.7	1.3	0.0
Commuting to job workplace: Public transport	2.1	2.5	4.4	0.1	-1.8	-2.1
Eye problems/disorders: Glaucoma	1.5	1.8	4.3	-1.1	-0.3	-2.1
Medication: Blood pressure	3.5	6.6	15.8	-2.0	4.0	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.8	0.9	0.8	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.8	0.9	0.1	0.9
High cholesterol (Self-reported)	0.9	1.6	3.7	0.1	1.9	1.0
Medication: Bendroflumethiazide	2.8	4.3	11.3	-1.2	3.4	0.4
Medication: Paracetamol	0.1	0.2	0.4	-0.4	0.6	0.3
Medication: Lisinopril	1.1	1.4	2.4	1.6	0.8	-1.0
Medication: Atorvastatin	0.7	0.9	2.5	-0.2	0.1	1.6
Illnesses of father: High blood pressure	2.8	3.4	8.6	-0.4	2.9	-1.2
Alcohol drinker status: Never	0.8	1.0	1.4	-1.2	-1.1	0.7
Ever smoked	0.9	1.5	2.1	1.2	-1.0	1.4
Basal metabolic rate	0.3	1.4	2.6	-1.6	-0.3	1.2
Leg fat percentage (left)	0.5	1.8	2.9	-1.7	1.6	-0.2
Arm fat-free mass (left)	0.5	2.4	5.0	-2.2	0.1	1.5
Number of operations (self-reported)	0.4	0.6	1.0	-0.5	1.0	0.9
Average weekly beer plus cider intake	0.8	1.2	2.7	-1.0	-0.3	1.6
Irritability	0.4	0.7	1.6	0.8	-0.1	-1.3
Risk taking	0.1	0.1	0.4	-0.6	0.2	-0.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.5	-0.5	0.5	-1.9
Fractured/broken bones in last 5 years	1.8	2.3	4.3	-2.1	1.6	0.3
Age started oral contraceptive pill	1.7	2.1	3.7	-1.5	1.9	0.5
Diastolic blood pressure, automated reading	3.2	9.9	22.2	-2.7	4.7	-0.4
Ever depressed for a whole week	1.6	1.9	2.6	-1.6	-0.9	1.5
Unable to work because of sickness or disability	0.2	0.3	0.4	-0.4	-0.6	-0.6
Commuting to job workplace: Cycle	0.4	0.4	1.2	0.4	-1.1	0.1
Myopia	0.1	0.2	0.3	-0.5	-0.5	0.3
Vascular/heart problems diagnosed by doctor	1.3	3.6	9.2	1.2	-3.0	-0.5
Cholesterol lowering medication	1.0	1.5	2.7	-1.3	1.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.5	-1.3	2.1	0.5
Pain experienced in last month	0.5	0.9	1.9	0.4	-1.4	-0.8
Supplements: Calcium	1.1	1.2	1.9	1.2	0.5	1.4
Basal cell carcinoma (self-reported)	2.4	2.9	5.0	1.9	2.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.1	1.8	0.1	0.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.6	-1.6	-0.8	0.2
Heart disease (siblings)	1.7	2.1	6.4	0.0	-0.0	2.5
Alcohol drinker status: Previous	0.4	0.5	1.0	1.0	0.5	-0.5
Pack years of smoking	1.2	1.8	2.9	-1.6	1.7	0.0
Impedance of whole body	1.7	8.4	10.5	2.3	3.1	-3.2
Leg fat mass (left)	0.4	1.5	2.0	-1.4	1.4	0.7
Arm predicted mass (left)	0.4	2.1	4.1	-2.0	-0.1	1.5