Best TWAS P=4.84e-12 · Best GWAS P=1.2e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | ARHGEF5 | 0.33 | 0.23 | lasso | 4 | 0.21 | 1.1e-06 | 6.8 | 6.9 | 4.8e-12 | 0.98 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Brain Cortex | ARHGEF5 | 0.27 | 0.00 | lasso | 7 | 0.03 | 4.4e-02 | -2.0 | 5.7 | 1.5e-08 | 0.73 | 0.02 | 0.71 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARHGEF5 | 0.14 | 0.08 | lasso | 1 | 0.08 | 4.3e-09 | 6.8 | 6.8 | 1.2e-11 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARHGEF5 | 0.10 | 0.07 | enet | 17 | 0.07 | 4.2e-08 | 6.8 | 5.3 | 1.0e-07 | 0.88 | 0.00 | 1.00 | FALSE |