Best TWAS P=5.07e-08 · Best GWAS P=9.2e-07 conditioned to 0.000941
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GSTM1 | 0.34 | 0.16 | enet | 15 | 0.16 | 2.6e-09 | 3.3 | 5.2 | 1.5e-07 | 0.51 | 0.25 | 0.24 | FALSE |
| 2 | GTEx | Artery Aorta | AC000032.2 | 0.33 | 0.16 | enet | 22 | 0.16 | 4.8e-09 | 3.3 | 5.2 | 2.6e-07 | 0.46 | 0.26 | 0.20 | FALSE |
| 3 | GTEx | Muscle Skeletal | GSTM2 | 0.16 | 0.00 | lasso | 8 | 0.01 | 7.1e-02 | 1.6 | 5.2 | 2.7e-07 | 0.48 | 0.02 | 0.60 | FALSE |
| 4 | GTEx | Whole Blood | AC000032.2 | 0.24 | 0.00 | enet | 20 | 0.03 | 1.1e-03 | 3.3 | 5.3 | 1.3e-07 | 0.54 | 0.05 | 0.68 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | GSTM2 | 0.15 | 0.00 | lasso | 3 | 0.04 | 2.9e-03 | 4.9 | 5.2 | 1.8e-07 | 0.84 | 0.00 | 0.82 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GSTM2 | 0.06 | 0.01 | blup | 41 | 0.04 | 7.4e-05 | 2.9 | 5.2 | 2.5e-07 | 0.54 | 0.00 | 0.03 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | GSTM2 | 0.09 | 0.00 | blup | 38 | 0.04 | 6.0e-06 | 1.7 | 5.1 | 2.7e-07 | 0.46 | 0.01 | 0.21 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GSTM1 | 0.13 | 0.03 | blup | 32 | 0.05 | 4.0e-04 | -3.9 | 5.3 | 1.1e-07 | 0.57 | 0.00 | 0.06 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GSTM1 | 0.18 | 0.03 | enet | 7 | 0.04 | 4.2e-04 | 3.1 | 5.5 | 5.1e-08 | 0.33 | 0.00 | 0.00 | TRUE |