Best TWAS P=4.43e-09 · Best GWAS P=4.43e-11 conditioned to 0.0027
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | PHTF1 | 0.22 | 0.09 | lasso | 5 | 0.19 | 2.2e-14 | -4.9 | 5.5 | 3.5e-08 | -0.57 | 0.82 | 0.18 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | DCLRE1B | 0.08 | 0.04 | enet | 14 | 0.05 | 2.6e-07 | -6.6 | 5.9 | 4.4e-09 | -0.88 | 0.00 | 1.00 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHTF1 | 0.05 | 0.02 | enet | 7 | 0.03 | 3.1e-07 | -4.9 | 5.2 | 2.5e-07 | -0.56 | 0.03 | 0.94 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PTPN22 | 0.02 | 0.01 | blup | 67 | 0.01 | 9.6e-03 | -6.6 | -5.7 | 1.5e-08 | 0.83 | 0.00 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | DCLRE1B | 0.06 | 0.04 | enet | 11 | 0.04 | 4.3e-05 | -6.6 | 5.5 | 3.9e-08 | -0.82 | 0.00 | 0.99 | FALSE |