Best TWAS P=2.49e-08 · Best GWAS P=2.96e-08 conditioned to 0.0154
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TESK2 | 0.06 | 0.02 | bslmm | 327 | 0.04 | 2.3e-05 | 4.5 | 5.3 | 1.4e-07 | 0.31 | 0.18 | 0.79 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-767N6.2 | 0.03 | 0.03 | enet | 6 | 0.04 | 3.0e-04 | 4.1 | 5.3 | 1.4e-07 | 0.77 | 0.10 | 0.73 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-767N6.2 | 0.04 | 0.02 | enet | 5 | 0.04 | 6.9e-04 | 4.5 | 5.5 | 2.9e-08 | 0.59 | 0.16 | 0.70 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | MMACHC | 0.10 | 0.06 | enet | 11 | 0.10 | 3.3e-05 | 4.3 | 5.4 | 6.9e-08 | 0.60 | 0.09 | 0.86 | FALSE |
| 5 | GTEx | Muscle Skeletal | GPBP1L1 | 0.03 | 0.02 | enet | 19 | 0.03 | 7.2e-04 | 4.2 | -5.6 | 2.5e-08 | -0.67 | 0.36 | 0.38 | TRUE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | GPBP1L1 | 0.09 | 0.02 | enet | 11 | 0.02 | 3.5e-02 | 4.5 | -5.3 | 1.5e-07 | -0.66 | 0.27 | 0.66 | FALSE |
| 7 | GTEx | Stomach | MUTYH | 0.08 | 0.02 | lasso | 4 | 0.02 | 4.1e-02 | 4.0 | -5.3 | 9.9e-08 | -0.61 | 0.08 | 0.45 | FALSE |
| 8 | METSIM | Adipose | EIF2B3 | 0.04 | 0.00 | bslmm | 366 | 0.01 | 2.2e-03 | 2.2 | 5.3 | 9.2e-08 | 0.40 | 0.12 | 0.35 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MUTYH | 0.12 | 0.00 | blup | 36 | 0.04 | 1.2e-02 | 4.5 | -5.3 | 1.0e-07 | -0.44 | 0.01 | 0.26 | FALSE |