Best TWAS P=1.85e-12 · Best GWAS P=8.19e-13 conditioned to 4.79e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | 6.9 | -7.0 | 1.8e-12 | 0.01 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | 5.4 | -5.4 | 8.5e-08 | 0.00 | 0.09 | 0.67 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | CCDC88C | 0.13 | 0.03 | enet | 10 | 0.06 | 3.8e-04 | -2.8 | -5.7 | 1.2e-08 | 0.40 | 0.07 | 0.28 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPR68 | 0.06 | 0.05 | lasso | 4 | 0.04 | 1.6e-09 | 7.0 | -6.7 | 2.1e-11 | 0.17 | 0.00 | 1.00 | TRUE |