Hub : Genes

CCDC88C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1490	0.0380	1.3e-07	0.086	0.069	0.114	0.094	0.108	1.2e-10	9.4e-09	9.3e-14	1.5e-11	4.5e-13
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1260	0.0560	9.5e-03	0.033	NA	0.059	NA	0.037	6.6e-03	NA	3.8e-04	NA	4.3e-03
3	GTEx	Testis	0.3040	0.0900	7.7e-04	0.071	NA	0.151	NA	0.178	4.4e-04	NA	3.1e-07	NA	2.4e-08
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0511	0.0222	2.9e-03	-0.001	0.025	-0.001	NA	-0.001	4.0e-01	7.4e-04	5.0e-01	NA	3.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.4	2.2	5.6	2.4	1.0	1.1	1.0
Bipolar Disorder or Schizophrenia	0.7	1.7	4.0	2.0	1.2	0.3	1.2
Depressed Affect (Nagel 2018)	0.8	1.7	2.7	1.1	0.9	-1.6	1.5
Depression (Nagel 2018)	0.1	0.1	0.3	0.2	0.6	-0.3	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	-0.5	0.3	1.0	1.5
Neuroticism (Nagel 2018)	0.6	1.5	1.7	1.3	1.1	-1.3	1.2
Schizophrenia (2018)	0.2	0.4	0.5	0.6	0.7	-0.5	0.7
Schizophrenia vs Biploar Disorder	1.4	1.9	4.6	-2.1	-1.0	0.4	-1.3
Worry (Nagel 2018)	0.4	0.8	2.8	0.6	0.1	0.4	1.7
Alzheimer’s Disease (in mother)	1.6	1.9	4.9	-0.7	-1.5	2.2	0.2
Alzheimer’s Disease (in father)	0.5	0.5	1.0	0.2	-0.9	1.0	-0.5
Alzheimer’s Disease (including proxy)	2.1	3.1	7.6	-0.5	-2.0	2.8	-0.5
Crohns Disease (2017)	1.0	2.2	7.3	2.7	0.8	-0.2	1.0
Irritable Bowel Disease (IBD)	0.8	1.8	4.4	2.1	0.6	-1.6	-0.3
Ulcerative Colitis (UC)	0.7	1.4	2.7	1.2	0.5	-1.7	-1.1
Major Depression (MDD)	0.4	0.5	1.5	1.2	-0.2	0.7	-0.4
Reaction Time	0.1	0.2	0.3	0.2	-0.6	0.4	0.6
Verbal and Numeric Reasoning (VNR)	1.2	2.9	6.2	1.2	0.8	2.5	1.8
Breast Cancer	4.9	11.7	32.5	-3.0	-5.7	2.2	-0.6
Ovarian Cancer	1.7	2.3	4.0	-1.2	-2.0	-1.8	0.5
Prostate Cancer	0.5	0.7	1.2	-0.8	1.1	1.0	-0.0
Age at First Birth	0.8	1.1	2.0	0.1	1.4	0.6	1.4
Bipolar Disorder (2011)	0.3	0.3	0.6	0.7	-0.6	-0.3	-0.5
Body Mass Index (BMI) (2010)	0.6	0.8	2.7	-0.0	-1.6	0.1	0.5
Coronary Artery Disease (CAD)	0.8	1.0	1.5	1.2	0.8	1.2	0.6
Crohns Disease (2012)	0.1	0.1	0.3	0.5	-0.5	0.2	0.1
Mean Putamen Volume	1.3	1.4	2.9	-1.7	-0.5	1.6	-0.2
Fasting Glucose	3.6	4.4	8.3	1.6	2.5	0.0	2.9
HbA1C	0.0	0.1	0.1	0.1	0.0	-0.4	-0.2
HDL Cholesterol	0.5	0.8	1.3	-1.0	0.8	-1.1	0.4
LDL Cholesterol	1.1	1.7	5.8	-0.5	-0.8	-0.3	-2.4
Lupus	1.0	1.6	4.1	1.0	2.0	0.3	1.1
Neuroticism (2016)	1.0	1.4	2.5	0.9	1.5	-1.6	0.2
Primary Biliary Cirrhosis	1.5	2.1	4.5	0.8	1.0	2.1	1.5
Rheumatoid Arthritis	0.8	1.1	1.9	-1.4	1.4	0.2	-0.7
Schizophrenia (2014)	0.5	1.2	2.6	1.0	1.6	-0.7	0.7
Triglycerides	0.2	0.4	0.6	0.8	0.7	0.6	0.2
Type 2 Diabetes (T2D) (2012)	6.8	7.8	16.5	2.8	4.1	0.2	2.6
Ulcerative Colitis	0.5	0.8	1.7	1.0	0.4	-0.5	-1.3
Blood Eosinophil Count	0.0	0.4	0.6	-0.6	-0.8	-0.3	0.7
Blood Platelet Count	0.2	1.8	4.6	0.9	1.2	2.1	0.4
Blood Red Count	0.5	5.1	11.3	-2.5	0.2	1.8	-3.4
Blood White Count	0.2	1.7	3.1	-0.6	1.4	-1.8	-1.3
Heel T-Score	0.2	1.7	3.6	-1.9	-1.8	0.2	0.1
BMI	1.0	5.6	8.6	2.9	-2.3	-0.5	2.9
Height	0.0	0.8	3.1	0.1	1.8	0.1	0.5
Waist Hip Ratio (WHR)	0.2	0.8	1.9	-0.3	1.4	-1.1	-0.3
Systolic Blood Pressure	0.0	0.1	0.3	0.6	-0.2	0.1	-0.1
Smoking Status	0.3	0.8	1.9	-1.4	-0.8	0.7	-0.0
Allergy or Eczema	0.8	2.0	6.2	1.1	0.2	-2.5	0.8
Cardiovascular Disease	0.2	0.8	1.9	0.3	-0.5	1.4	-0.9
Hypothyroidism (self reported)	0.3	0.7	1.0	0.9	-0.6	0.7	1.0
Respiratory disease	0.7	1.6	3.2	0.6	-0.7	-1.8	1.5
Type 2 Diabetes (T2D) (2018)	1.7	3.3	5.4	2.3	2.1	-0.7	1.6
Lung FEV1/FVC ratio	0.2	0.8	2.2	1.5	1.1	0.1	0.1
Lung FVC	0.7	3.5	10.0	-1.4	3.2	1.2	0.8
Neuroticism	0.9	2.2	3.2	1.2	1.8	-1.1	1.8
Chronotype (morning person)	2.0	4.7	11.2	3.3	1.8	1.4	1.5
Hair Pigment	0.2	4.8	14.3	3.8	1.3	0.8	1.6
Tanning	0.2	2.2	4.1	-1.2	-1.8	0.1	-2.0
Hand grip strength (left)	0.3	0.9	2.1	-0.2	-0.8	0.9	1.5
Number of treatments/medications taken	0.3	0.5	0.8	0.9	-0.4	-0.7	0.7
Average weekly spirits intake	1.2	1.5	5.1	-0.3	-2.2	0.5	-0.8
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.3	-0.4	-0.8	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.4	0.8	-0.7	-0.2
Hearing difficulty/problems: Yes	0.8	1.2	3.2	0.6	1.0	-1.8	-0.5
Relative age of first facial hair	0.4	0.8	1.7	-0.8	0.8	-1.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	-0.3	-1.0	0.3	0.2
Ever used hormone-replacement therapy (HRT)	2.0	2.5	6.5	-1.2	-1.2	-0.8	-2.5
Ever had hysterectomy (womb removed)	1.7	1.9	4.5	1.2	1.0	-0.8	2.1
Systolic blood pressure, automated reading	0.9	2.6	8.8	-0.7	-3.0	-0.1	-1.0
Eye problems/disorders: Diabetes related eye disease	3.7	4.0	8.3	1.4	2.4	-2.9	0.3
Angina	3.0	3.9	6.3	-2.5	-2.0	-1.3	-1.8
Medication for hormone replacement therapy	1.8	2.1	5.4	-2.3	0.0	-1.1	-1.3
Vitamin and mineral supplements	1.1	1.4	2.8	-1.0	1.7	-0.3	-1.3
Supplements: Zinc	1.7	1.9	3.9	0.3	-2.0	1.4	1.2
Medication: Co-codamol	1.0	1.2	3.2	0.7	-1.8	0.5	0.9
Medication: Metformin	3.1	4.3	9.4	3.1	2.6	0.3	0.9
Diabetes (father)	0.9	1.2	2.7	0.6	0.6	-1.2	1.6
Diabetes (mother)	1.1	1.4	2.2	1.5	1.3	0.9	0.9
Severe depression (siblings)	0.6	0.6	1.2	0.5	-1.1	0.4	0.9
Pack years adult smoking proportion	0.4	0.6	1.1	0.9	-0.3	0.7	1.1
Impedance of leg (right)	0.9	4.6	10.2	-3.2	2.5	1.0	-0.9
Leg fat-free mass (left)	0.6	3.3	8.6	2.9	-0.8	-0.9	1.8
Trunk fat percentage	0.1	0.6	0.9	0.8	-0.9	-0.8	-0.1
Hand grip strength (right)	0.2	0.5	1.6	0.0	0.1	1.3	0.7
Townsend deprivation index at recruitment	1.1	1.6	3.7	-0.5	-1.6	0.2	-1.9
Current tobacco smoking	0.4	0.7	1.3	-0.4	0.6	1.1	-0.9
Average weekly fortified wine intake	1.0	1.2	3.2	-1.8	-1.3	0.1	0.2
Maternal smoking around birth	0.7	0.9	2.0	1.4	-0.3	0.4	1.2
Fed-up feelings	1.0	1.9	3.8	1.9	0.7	-1.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	0.9	1.0	0.6	-0.9	0.9
Relative age voice broke	0.4	0.5	1.8	-1.3	0.6	-0.1	-0.1
Taking other prescription medications	0.5	0.8	2.7	-0.2	0.1	-1.6	-0.5
Age when periods started (menarche)	2.5	6.0	9.4	-3.0	-1.1	-2.1	-3.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	1.5	-0.6	-0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.1	1.4	-1.3	-0.5	0.3
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.0	-0.4	-2.0	-1.2	-1.5
Qualifications: CSEs or equivalent	0.9	1.2	3.2	0.0	1.8	-0.1	1.2
Serious illness, injury or assault to yourself	0.4	0.4	1.4	-0.5	-1.2	-0.2	0.4
High blood pressure	0.5	1.4	3.8	-0.9	-0.8	0.4	-2.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.1	1.3	0.6	-1.4	1.0
Multivitamins +/- minerals	2.1	2.6	7.1	1.2	-1.2	0.8	2.7
Stomach or abdominal pain in last month	0.2	0.3	0.4	0.4	-0.5	-0.5	0.6
Supplements: Glucosamine	0.4	0.5	1.0	-0.2	-0.9	-1.0	-0.4
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	2.0	1.3	-1.4	-1.1	1.4
Medication: Atenolol	0.1	0.1	0.4	-0.1	0.7	-0.3	-0.2
Medication: Levothyroxine sodium	0.0	0.1	0.2	0.4	0.1	0.3	0.2
Sitting height	0.3	1.8	2.6	1.5	1.6	0.9	1.2
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.2	-0.6	-0.1	-0.5
High blood pressure (mother)	1.5	2.1	7.0	0.6	-2.6	0.8	-0.4
Body mass index (BMI)	0.9	3.8	7.8	2.0	-2.8	-1.4	1.1
Impedance of leg (left)	0.9	4.2	7.7	-2.8	2.5	1.4	-1.1
Leg predicted mass (left)	0.6	3.4	8.7	3.0	-0.8	-0.9	1.8
Trunk fat mass	0.3	1.2	2.2	1.5	-1.0	-1.1	0.5
Waist circumference	0.6	2.2	3.0	1.7	-1.6	-1.2	1.2
Number of incorrect matches in round	1.0	1.7	4.3	-0.2	1.4	-2.1	-0.4
Past tobacco smoking	0.3	0.5	1.3	1.1	0.6	-0.7	0.2
Alcohol usually taken with meals	0.5	0.8	2.0	-1.4	-1.0	-0.3	0.3
Nervous feelings	0.1	0.2	0.4	0.2	0.4	0.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	7.4	2.7	0.8	-0.8	1.7
Hearing difficulty/problems with background noise	0.6	0.9	1.9	1.2	1.4	0.2	-0.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	0.5	0.5	-1.0	0.0
Had menopause	0.5	0.7	1.3	-0.6	0.5	-0.9	-1.1
Had other major operations	0.5	0.6	1.5	0.5	-0.4	-1.2	-0.8
Forced vital capacity (FVC)	0.8	3.0	7.7	-0.7	2.8	0.8	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.1	1.8	-1.6	-0.7	0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.5	0.4	-1.2	0.5	0.8
Qualifications: None of the above	0.3	0.6	1.3	1.0	-1.1	0.0	0.1
Financial difficulties in last 2 years	0.3	0.4	0.8	-0.8	-0.9	-0.3	-0.2
Mouth/teeth dental problems	0.5	0.8	1.9	1.0	1.4	0.4	0.5
Heart attack	0.2	0.2	0.7	-0.8	-0.1	-0.0	0.3
Allergy	0.8	1.7	3.3	-1.1	0.5	1.8	-1.5
Pain all over the body in last month	0.1	0.1	0.1	-0.2	-0.3	-0.0	-0.3
Diabetes (self-reported)	1.5	2.4	4.2	2.0	2.1	-1.0	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.9	0.9	0.5	-1.4	-0.1
Medication: Ramipril	0.2	0.3	1.0	0.0	1.0	-0.5	0.1
Medication: Simvastatin	0.6	0.9	3.2	-0.6	-0.1	0.1	-1.8
Fluid intelligence score	1.0	2.1	4.7	1.9	-0.0	0.5	2.2
Illnesses of siblings	0.4	0.6	1.1	1.0	1.0	0.5	0.4
Neuroticism score	1.2	2.6	4.4	1.4	1.7	-1.1	2.1
Weight	0.6	3.0	5.2	2.3	-1.6	-1.4	1.5
Impedance of arm (right)	0.9	4.3	7.8	-2.8	2.5	0.8	-1.5
Arm fat percentage (right)	0.4	1.6	3.5	0.7	-1.9	-1.1	1.0
Trunk fat-free mass	0.5	3.1	6.0	2.5	-0.9	-1.1	2.1
Hip circumference	0.7	3.1	5.5	2.3	-2.3	-0.5	1.1
Time employed in main current job	1.2	1.4	3.0	1.4	1.7	0.9	-0.0
Alcohol intake versus 10 years previously	0.6	0.9	2.6	0.9	-1.6	0.5	0.3
Father’s age at death	1.6	2.2	6.7	-2.6	0.6	-0.5	-1.1
Worrier / anxious feelings	0.4	0.8	1.7	1.3	1.3	0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.1	0.7	-0.0	-1.1	1.7
Falls in the last year	0.5	0.6	1.1	-0.9	-1.1	-0.6	0.5
Hair/balding pattern: Pattern 3	0.8	1.3	2.3	-1.5	-1.5	-0.6	-0.5
Number of live births	1.3	1.8	5.1	-0.7	-1.2	-0.7	-2.2
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	14.5	-0.1	3.8	0.5	1.3
Pulse rate	0.8	1.3	4.1	-2.0	-0.4	0.4	-1.0
Happiness	0.4	0.5	1.4	0.4	1.2	-0.5	-0.5
Noisy workplace	2.3	2.8	5.3	-1.5	-1.8	-0.6	-2.3
Qualifications: A levels/AS levels or equivalent	1.9	4.1	7.8	2.1	2.8	0.4	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	-0.5	-1.0	-0.8	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.5	-0.8	0.5	0.4
Asthma	0.7	1.5	2.2	1.3	-1.0	-1.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	-0.0	-0.3	-1.2	1.2
Medication: Cholesterol lowering	0.8	1.3	4.2	-1.0	0.1	0.2	-2.1
Depression (self-reported)	0.0	0.0	0.1	-0.3	0.2	0.1	0.1
Medication: Lansoprazole	0.7	0.8	2.5	-1.6	0.3	-0.1	-0.8
Prospective memory result	0.8	1.0	2.0	-0.4	1.3	-1.4	-0.1
Lung cancer (father)	2.1	2.4	7.3	2.7	1.2	-0.1	0.9
Illnesses of mother	0.7	0.9	2.3	-0.9	1.5	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	17.1	0.0	4.1	0.3	2.0
Pulse wave Arterial Stiffness index	0.7	0.9	1.4	1.2	-0.9	0.5	-1.0
Impedance of arm (left)	0.8	3.9	6.2	-2.5	2.2	1.0	-1.9
Arm fat mass (right)	0.6	2.4	3.1	1.8	-1.8	-1.4	1.1
Trunk predicted mass	0.5	3.1	6.2	2.5	-0.8	-1.1	2.1
Standing height	0.2	2.2	6.5	1.1	2.5	-0.3	1.0
Length of working week for main job	0.9	1.0	2.3	-1.5	-0.8	-1.1	-0.1
Exposure to tobacco smoke at home	0.5	0.6	1.6	-0.1	-1.3	0.8	-0.2
Breastfed as a baby	0.3	0.4	0.7	-0.4	0.8	0.3	0.8
Tense / ‘highly strung’	0.6	0.9	2.0	1.0	0.9	-1.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	2.4	1.5	-1.3	-0.1	1.5
Hair/balding pattern: Pattern 4	0.2	0.5	2.1	-0.1	0.0	1.4	-0.3
Birth weight of first child	1.2	2.1	5.6	2.4	0.3	-0.5	1.6
Peak expiratory flow (PEF)	0.2	0.6	1.8	-0.5	1.3	0.4	-0.3
Pulse wave reflection index	0.8	1.0	2.4	1.2	0.4	1.6	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.5	0.6	-0.5	0.3
Loud music exposure frequency	0.5	0.6	1.8	0.6	-0.1	-0.3	-1.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.5	0.1	1.4	0.8	1.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.1	-1.6	-1.8	-1.0	0.8
Blood clot in the leg (DVT)	1.5	1.9	3.3	1.7	-0.3	-1.2	1.8
Medication: Paracetamol	0.4	0.7	1.0	1.0	-0.8	-0.3	1.0
Headache pain in last month	0.3	0.5	0.8	-0.9	-0.0	-0.8	-0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.6	0.5	-0.4	0.2	1.6
Glaucoma (self-reported)	0.3	0.3	0.6	0.8	0.7	0.1	0.4
Gout (self-reported)	0.4	0.6	1.3	-0.6	-0.1	1.1	0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.7	-0.2	0.4	0.4
Medication: Amlodipine	0.6	0.8	1.7	0.5	1.1	-0.3	1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.5	0.7	-0.9	-0.3
Birth weight	0.4	0.9	3.5	0.1	1.9	-0.0	-0.2
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.5	-0.5	-0.7	-0.4
High blood pressure (siblings)	0.1	0.2	0.4	0.5	-0.0	-0.6	0.3
Forced vital capacity (FVC), Best measure	1.3	4.7	13.0	-0.3	3.6	0.7	2.3
Body fat percentage	0.2	0.7	1.7	0.8	-1.3	-0.6	0.5
Leg fat percentage (right)	0.3	1.0	2.5	0.3	-1.6	-0.6	0.9
Arm fat-free mass (right)	0.8	4.2	12.3	3.5	-0.7	-0.9	1.7
Exposure to tobacco smoke outside home	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.1
Comparative body size at age 10	0.5	1.3	2.8	1.4	-0.7	-0.1	1.7
Number of full brothers	0.6	0.8	1.6	-1.3	-1.0	0.6	-0.3
Worry too long after embarrassment	1.5	2.4	5.7	2.4	1.8	-0.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	-0.3	-0.8	0.9	1.1
Wheeze or whistling in the chest in last year	0.9	1.6	2.9	0.8	-1.5	-0.7	-1.7
Number of children fathered	2.3	2.6	5.9	-2.4	1.5	0.3	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	0.7	-0.2	0.1	0.1
Age at first live birth	1.2	2.1	4.4	0.4	1.8	-0.9	2.1
Pulse wave peak to peak time	0.8	0.9	1.2	-1.0	1.1	-0.6	1.1
Health satisfaction	0.4	0.6	1.1	1.1	0.8	-0.7	0.3
Shortness of breath walking on level ground	0.8	1.0	2.5	1.1	1.6	-0.2	0.2
Qualifications: College or University degree	0.9	2.8	5.7	1.3	1.9	-0.3	2.4
Eye problems/disorders: None of the above	0.6	0.6	1.9	-0.3	0.1	1.4	0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.2	0.3	0.6	1.5	0.6
Emphysema/chronic bronchitis	0.9	1.0	2.4	1.2	0.2	0.2	1.6
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	0.3	0.2	0.2	-0.1
Neck or shoulder pain in last month	0.8	1.2	3.6	-0.7	0.1	-1.9	-0.9
Medication: Blood pressure	0.4	0.7	1.4	-0.2	0.7	-1.0	-1.2
Angina (self-reported)	2.4	3.1	4.6	-2.1	-1.8	-1.6	-1.6
Migraine (self-reported)	0.5	0.6	1.3	-0.7	-1.1	0.3	-0.7
Medication: Ibuprofen	0.8	1.0	2.6	0.5	-0.0	-1.6	1.0
Medication: Allopurinol	0.3	0.5	1.5	-1.2	0.3	-0.2	0.4
Medication: Omeprazole	1.1	1.3	2.1	-1.1	-1.5	-0.9	-1.1
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.0	0.2	-0.6	0.7
Mean time to correctly identify matches	0.1	0.3	0.5	0.3	-0.6	-0.5	-0.7
Heart disease (mother)	1.4	1.7	5.6	2.4	0.7	-0.8	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.2	1.8	0.3	0.5	1.2
Whole body fat mass	0.4	1.6	2.7	1.6	-1.2	-0.9	1.1
Leg fat mass (right)	0.5	1.9	2.7	1.6	-1.2	-1.1	1.4
Arm predicted mass (right)	0.8	4.1	10.9	3.3	-0.8	-1.0	2.0
Pulse rate, automated reading	0.7	2.3	5.5	-2.4	-0.8	0.9	-1.4
Alcohol intake frequency.	0.6	1.3	2.5	-1.3	-1.6	0.6	-0.8
Comparative height size at age 10	0.1	0.8	2.2	-0.9	-0.2	-1.5	0.2
Number of full sisters	0.9	1.0	3.1	-1.0	0.2	0.1	-1.8
Suffer from ‘nerves’	0.2	0.3	0.8	-0.1	0.1	-0.9	0.8
Overall health rating	0.4	0.8	2.9	0.5	-0.0	-1.7	0.0
Chest pain or discomfort	0.5	0.7	2.0	0.6	0.6	-1.4	-0.1
Had major operations	1.4	1.7	5.3	1.1	-0.1	-2.3	0.5
Age at last live birth	0.2	0.3	1.0	-0.2	1.0	-0.6	0.1
Family relationship satisfaction	0.6	0.7	1.8	-0.9	1.4	-0.2	-0.1
Leg pain on walking	0.2	0.3	0.6	0.4	-0.4	-0.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	3.4	4.1	9.7	-2.5	-0.5	-0.5	-3.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.2	-2.0	-0.0	0.1	-0.9
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.9	0.8	1.7	-0.1	0.5
Medication: Aspirin	0.5	0.7	1.7	-0.3	1.3	0.1	-0.9
Supplements: Vitamin C	0.2	0.2	0.5	-0.2	-0.7	-0.4	-0.4
Knee pain experienced in last month	0.7	1.0	2.5	-1.2	-1.6	0.4	-0.1
Hypertension (Self-reported)	0.4	1.1	3.8	-0.3	-0.7	0.3	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	3.4	-1.8	-1.6	0.4	-1.9
Illnesses of father: Heart disease	0.3	0.4	1.6	-0.4	0.0	-0.1	1.2
Illnesses of siblings: Diabetes	0.4	0.5	0.8	0.7	-0.4	-0.8	0.9
Smoking status: Previous	0.2	0.3	0.6	-0.8	-0.4	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.4	-0.8	1.1	0.6	1.2
Whole body fat-free mass	0.6	3.6	8.5	2.9	-0.9	-1.0	2.0
Leg fat-free mass (right)	0.6	3.2	9.0	3.0	-0.9	-0.6	1.7
Arm fat percentage (left)	0.4	1.6	3.8	1.0	-1.9	-1.0	0.7
Average weekly red wine intake	0.3	0.5	0.9	1.0	0.9	-0.4	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.5	0.3	0.2	0.2
Mood swings	1.9	3.5	5.1	2.3	1.7	-1.4	2.0
Loneliness, isolation	0.8	1.1	3.1	0.9	-0.4	-1.8	-0.4
Long-standing illness, disability or infirmity	0.9	1.3	4.3	1.0	0.3	-2.1	0.1
Ever had bowel cancer screening	0.1	0.2	0.5	-0.0	0.4	-0.7	-0.2
Diabetes diagnosed by doctor	1.6	2.6	4.6	2.1	1.9	-1.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	6.7	-1.7	-2.6	0.5	-1.0
Friendships satisfaction	0.7	0.9	2.4	-1.5	0.4	0.8	-0.4
Qualifications: nursing, teaching	0.3	0.5	0.7	-0.8	-0.8	-0.8	-0.3
Commuting to job workplace: Walk	0.9	0.9	2.7	1.7	0.5	0.8	-0.3
Eye problems/disorders: Cataract	1.6	1.9	6.2	-0.4	-0.7	-2.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-0.8	-1.0	-0.2	-0.6
Medication for cholesterol	0.2	0.2	0.7	0.8	0.1	0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.2	0.9	1.5	-0.8	-0.4
Back pain experienced in last month	0.5	0.8	1.9	0.0	-1.4	-1.0	0.4
Mineral and other dietary supplements	1.2	1.6	2.6	-1.3	1.4	0.3	-1.6
Breast cancer (self-reported)	0.8	1.0	1.5	1.1	1.1	-1.2	-0.2
Asthma (self-reported)	0.7	1.4	2.1	1.5	-0.1	-1.5	1.1
Osteoporosis (self-reported)	0.3	0.4	1.3	0.2	0.2	-1.2	-0.4
Osteoarthritis (self-reported)	0.7	0.9	2.9	-0.3	0.6	1.7	0.4
Medication: Aspirin	0.8	1.0	2.1	-0.0	1.4	-0.3	-1.4
Medication: Gliclazide	3.1	3.5	7.9	2.8	1.2	1.2	1.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	0.5	-0.0	1.2	-0.3
Smoking status: Current	0.5	0.9	1.5	-0.5	0.5	1.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	10.1	0.4	3.2	-0.2	0.6
Whole body water mass	0.7	3.9	9.5	3.1	-0.8	-1.0	2.1
Leg predicted mass (right)	0.6	3.3	9.1	3.0	-0.8	-0.7	1.6
Arm fat mass (left)	0.6	2.4	3.4	1.8	-1.8	-1.0	1.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.2	0.5	-0.5	-0.1
Average weekly champagne plus white wine intake	0.9	1.2	2.2	1.5	1.5	0.3	0.7
Miserableness	0.9	1.5	3.1	0.9	-0.2	-1.5	1.8
Guilty feelings	1.1	1.7	3.0	1.1	1.7	-0.6	1.4
Wears glasses or contact lenses	1.0	1.1	3.0	-0.6	0.2	-1.7	-1.0
Ever taken oral contraceptive pill	0.7	0.8	1.9	-0.9	-0.6	-1.4	0.3
Hearing aid user	0.3	0.4	0.7	0.1	0.7	-0.6	-0.8
Mother’s age at death	0.8	1.0	3.4	0.5	-1.8	-0.0	-0.7
Financial situation satisfaction	0.4	0.4	1.6	0.4	-0.1	0.0	-1.3
Tinnitus: Yes, now most or all of the time	3.3	3.9	6.6	-2.5	-1.5	0.5	-2.6
Commuting to job workplace: Public transport	0.3	0.4	1.6	0.0	-0.1	-0.0	1.3
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	0.2	0.7	-0.1	0.0
Medication: Blood pressure	0.2	0.4	0.7	0.8	0.6	-0.7	-0.3
Pain type(s) experienced in last month: Hip pain	1.5	1.9	7.7	0.2	-2.8	0.0	-0.3
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.2	0.6	-1.5	0.1	1.1
High cholesterol (Self-reported)	1.5	2.7	5.4	-1.2	-0.0	2.3	-2.0
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.8	0.0	-0.1	-0.3
Medication: Paracetamol	0.2	0.3	0.8	0.5	-0.9	-0.4	0.4
Medication: Lisinopril	1.7	2.3	3.0	1.7	1.6	-1.4	-1.1
Medication: Atorvastatin	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.5
Illnesses of father: High blood pressure	2.1	2.6	4.9	-1.5	-1.7	-2.2	-0.7
Alcohol drinker status: Never	0.7	0.8	2.5	-0.6	-0.6	1.6	-0.2
Ever smoked	0.1	0.2	0.4	-0.6	0.0	0.6	-0.4
Basal metabolic rate	0.7	3.6	8.2	2.9	-1.1	-1.0	2.0
Leg fat percentage (left)	0.3	1.1	3.1	0.5	-1.8	-0.3	0.9
Arm fat-free mass (left)	0.9	4.4	11.3	3.4	-0.9	-0.9	2.2
Number of operations (self-reported)	2.1	3.1	11.8	0.6	0.2	-3.4	-0.3
Average weekly beer plus cider intake	0.2	0.3	0.8	0.3	0.9	-0.0	0.5
Irritability	1.6	2.8	7.4	1.4	1.0	-0.8	2.7
Risk taking	0.2	0.4	1.0	-0.2	-0.5	-1.0	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.7	-0.4	-0.1	-0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.2	0.2	-0.2	0.8
Age started oral contraceptive pill	0.2	0.3	0.5	-0.6	-0.2	0.4	-0.7
Diastolic blood pressure, automated reading	0.6	1.8	5.0	-1.4	-2.2	-0.4	-0.6
Ever depressed for a whole week	0.2	0.2	0.6	-0.5	-0.4	-0.8	0.0
Unable to work because of sickness or disability	0.9	1.2	2.9	1.1	1.7	0.5	0.7
Commuting to job workplace: Cycle	3.8	4.6	6.9	2.2	2.6	1.8	1.9
Myopia	0.8	1.1	2.1	1.4	1.4	0.7	0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.4	0.7	0.9	-0.2	1.8
Cholesterol lowering medication	0.4	0.5	1.1	1.0	0.9	0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.7	-1.9	-1.9	-0.2	-1.3
Pain experienced in last month	0.4	0.7	1.3	0.3	1.2	1.1	0.6
Supplements: Calcium	2.1	2.3	5.8	-1.1	-2.4	1.1	-0.9
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.2	-0.2	-0.3	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.9	-0.9	-0.0	-0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.1	1.9	-0.2	-1.5	2.0
Heart disease (siblings)	1.8	2.2	4.4	-1.8	-2.1	0.4	-1.0
Alcohol drinker status: Previous	0.6	0.7	1.5	1.2	0.2	-0.1	1.0
Pack years of smoking	0.2	0.3	0.5	0.7	-0.6	0.2	0.7
Impedance of whole body	1.0	5.0	8.1	-2.7	2.8	1.2	-1.8
Leg fat mass (left)	0.5	1.8	2.8	1.7	-1.3	-0.9	1.4
Arm predicted mass (left)	0.9	4.4	10.1	3.2	-0.9	-1.0	2.3