Hub : Genes

CCDC88C

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1490 0.0380 1.3e-07 0.086 0.069 0.114 0.094 0.108 1.2e-10 9.4e-09 9.3e-14 1.5e-11 4.5e-13
2 GTEx Skin Not Sun Exposed Suprapubic 0.1260 0.0560 9.5e-03 0.033 NA 0.059 NA 0.037 6.6e-03 NA 3.8e-04 NA 4.3e-03
3 GTEx Testis 0.3040 0.0900 7.7e-04 0.071 NA 0.151 NA 0.178 4.4e-04 NA 3.1e-07 NA 2.4e-08
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0511 0.0222 2.9e-03 -0.001 0.025 -0.001 NA -0.001 4.0e-01 7.4e-04 5.0e-01 NA 3.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.4 2.2 5.6 2.4 1.0 1.1 1.0
Bipolar Disorder or Schizophrenia 0.7 1.7 4.0 2.0 1.2 0.3 1.2
Depressed Affect (Nagel 2018) 0.8 1.7 2.7 1.1 0.9 -1.6 1.5
Depression (Nagel 2018) 0.1 0.1 0.3 0.2 0.6 -0.3 0.2
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.2 -0.5 0.3 1.0 1.5
Neuroticism (Nagel 2018) 0.6 1.5 1.7 1.3 1.1 -1.3 1.2
Schizophrenia (2018) 0.2 0.4 0.5 0.6 0.7 -0.5 0.7
Schizophrenia vs Biploar Disorder 1.4 1.9 4.6 -2.1 -1.0 0.4 -1.3
Worry (Nagel 2018) 0.4 0.8 2.8 0.6 0.1 0.4 1.7
Alzheimer’s Disease (in mother) 1.6 1.9 4.9 -0.7 -1.5 2.2 0.2
Alzheimer’s Disease (in father) 0.5 0.5 1.0 0.2 -0.9 1.0 -0.5
Alzheimer’s Disease (including proxy) 2.1 3.1 7.6 -0.5 -2.0 2.8 -0.5
Crohns Disease (2017) 1.0 2.2 7.3 2.7 0.8 -0.2 1.0
Irritable Bowel Disease (IBD) 0.8 1.8 4.4 2.1 0.6 -1.6 -0.3
Ulcerative Colitis (UC) 0.7 1.4 2.7 1.2 0.5 -1.7 -1.1
Major Depression (MDD) 0.4 0.5 1.5 1.2 -0.2 0.7 -0.4
Reaction Time 0.1 0.2 0.3 0.2 -0.6 0.4 0.6
Verbal and Numeric Reasoning (VNR) 1.2 2.9 6.2 1.2 0.8 2.5 1.8
Breast Cancer 4.9 11.7 32.5 -3.0 -5.7 2.2 -0.6
Ovarian Cancer 1.7 2.3 4.0 -1.2 -2.0 -1.8 0.5
Prostate Cancer 0.5 0.7 1.2 -0.8 1.1 1.0 -0.0
Age at First Birth 0.8 1.1 2.0 0.1 1.4 0.6 1.4
Bipolar Disorder (2011) 0.3 0.3 0.6 0.7 -0.6 -0.3 -0.5
Body Mass Index (BMI) (2010) 0.6 0.8 2.7 -0.0 -1.6 0.1 0.5
Coronary Artery Disease (CAD) 0.8 1.0 1.5 1.2 0.8 1.2 0.6
Crohns Disease (2012) 0.1 0.1 0.3 0.5 -0.5 0.2 0.1
Mean Putamen Volume 1.3 1.4 2.9 -1.7 -0.5 1.6 -0.2
Fasting Glucose 3.6 4.4 8.3 1.6 2.5 0.0 2.9
HbA1C 0.0 0.1 0.1 0.1 0.0 -0.4 -0.2
HDL Cholesterol 0.5 0.8 1.3 -1.0 0.8 -1.1 0.4
LDL Cholesterol 1.1 1.7 5.8 -0.5 -0.8 -0.3 -2.4
Lupus 1.0 1.6 4.1 1.0 2.0 0.3 1.1
Neuroticism (2016) 1.0 1.4 2.5 0.9 1.5 -1.6 0.2
Primary Biliary Cirrhosis 1.5 2.1 4.5 0.8 1.0 2.1 1.5
Rheumatoid Arthritis 0.8 1.1 1.9 -1.4 1.4 0.2 -0.7
Schizophrenia (2014) 0.5 1.2 2.6 1.0 1.6 -0.7 0.7
Triglycerides 0.2 0.4 0.6 0.8 0.7 0.6 0.2
Type 2 Diabetes (T2D) (2012) 6.8 7.8 16.5 2.8 4.1 0.2 2.6
Ulcerative Colitis 0.5 0.8 1.7 1.0 0.4 -0.5 -1.3
Blood Eosinophil Count 0.0 0.4 0.6 -0.6 -0.8 -0.3 0.7
Blood Platelet Count 0.2 1.8 4.6 0.9 1.2 2.1 0.4
Blood Red Count 0.5 5.1 11.3 -2.5 0.2 1.8 -3.4
Blood White Count 0.2 1.7 3.1 -0.6 1.4 -1.8 -1.3
Heel T-Score 0.2 1.7 3.6 -1.9 -1.8 0.2 0.1
BMI 1.0 5.6 8.6 2.9 -2.3 -0.5 2.9
Height 0.0 0.8 3.1 0.1 1.8 0.1 0.5
Waist Hip Ratio (WHR) 0.2 0.8 1.9 -0.3 1.4 -1.1 -0.3
Systolic Blood Pressure 0.0 0.1 0.3 0.6 -0.2 0.1 -0.1
Smoking Status 0.3 0.8 1.9 -1.4 -0.8 0.7 -0.0
Allergy or Eczema 0.8 2.0 6.2 1.1 0.2 -2.5 0.8
Cardiovascular Disease 0.2 0.8 1.9 0.3 -0.5 1.4 -0.9
Hypothyroidism (self reported) 0.3 0.7 1.0 0.9 -0.6 0.7 1.0
Respiratory disease 0.7 1.6 3.2 0.6 -0.7 -1.8 1.5
Type 2 Diabetes (T2D) (2018) 1.7 3.3 5.4 2.3 2.1 -0.7 1.6
Lung FEV1/FVC ratio 0.2 0.8 2.2 1.5 1.1 0.1 0.1
Lung FVC 0.7 3.5 10.0 -1.4 3.2 1.2 0.8
Neuroticism 0.9 2.2 3.2 1.2 1.8 -1.1 1.8
Chronotype (morning person) 2.0 4.7 11.2 3.3 1.8 1.4 1.5
Hair Pigment 0.2 4.8 14.3 3.8 1.3 0.8 1.6
Tanning 0.2 2.2 4.1 -1.2 -1.8 0.1 -2.0
Hand grip strength (left) 0.3 0.9 2.1 -0.2 -0.8 0.9 1.5
Number of treatments/medications taken 0.3 0.5 0.8 0.9 -0.4 -0.7 0.7
Average weekly spirits intake 1.2 1.5 5.1 -0.3 -2.2 0.5 -0.8
Sensitivity / hurt feelings 0.2 0.4 0.8 -0.3 -0.4 -0.8 -0.9
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.6 0.4 0.8 -0.7 -0.2
Hearing difficulty/problems: Yes 0.8 1.2 3.2 0.6 1.0 -1.8 -0.5
Relative age of first facial hair 0.4 0.8 1.7 -0.8 0.8 -1.3 -0.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.0 -0.3 -1.0 0.3 0.2
Ever used hormone-replacement therapy (HRT) 2.0 2.5 6.5 -1.2 -1.2 -0.8 -2.5
Ever had hysterectomy (womb removed) 1.7 1.9 4.5 1.2 1.0 -0.8 2.1
Systolic blood pressure, automated reading 0.9 2.6 8.8 -0.7 -3.0 -0.1 -1.0
Eye problems/disorders: Diabetes related eye disease 3.7 4.0 8.3 1.4 2.4 -2.9 0.3
Angina 3.0 3.9 6.3 -2.5 -2.0 -1.3 -1.8
Medication for hormone replacement therapy 1.8 2.1 5.4 -2.3 0.0 -1.1 -1.3
Vitamin and mineral supplements 1.1 1.4 2.8 -1.0 1.7 -0.3 -1.3
Supplements: Zinc 1.7 1.9 3.9 0.3 -2.0 1.4 1.2
Medication: Co-codamol 1.0 1.2 3.2 0.7 -1.8 0.5 0.9
Medication: Metformin 3.1 4.3 9.4 3.1 2.6 0.3 0.9
Diabetes (father) 0.9 1.2 2.7 0.6 0.6 -1.2 1.6
Diabetes (mother) 1.1 1.4 2.2 1.5 1.3 0.9 0.9
Severe depression (siblings) 0.6 0.6 1.2 0.5 -1.1 0.4 0.9
Pack years adult smoking proportion 0.4 0.6 1.1 0.9 -0.3 0.7 1.1
Impedance of leg (right) 0.9 4.6 10.2 -3.2 2.5 1.0 -0.9
Leg fat-free mass (left) 0.6 3.3 8.6 2.9 -0.8 -0.9 1.8
Trunk fat percentage 0.1 0.6 0.9 0.8 -0.9 -0.8 -0.1
Hand grip strength (right) 0.2 0.5 1.6 0.0 0.1 1.3 0.7
Townsend deprivation index at recruitment 1.1 1.6 3.7 -0.5 -1.6 0.2 -1.9
Current tobacco smoking 0.4 0.7 1.3 -0.4 0.6 1.1 -0.9
Average weekly fortified wine intake 1.0 1.2 3.2 -1.8 -1.3 0.1 0.2
Maternal smoking around birth 0.7 0.9 2.0 1.4 -0.3 0.4 1.2
Fed-up feelings 1.0 1.9 3.8 1.9 0.7 -1.6 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 0.9 1.0 0.6 -0.9 0.9
Relative age voice broke 0.4 0.5 1.8 -1.3 0.6 -0.1 -0.1
Taking other prescription medications 0.5 0.8 2.7 -0.2 0.1 -1.6 -0.5
Age when periods started (menarche) 2.5 6.0 9.4 -3.0 -1.1 -2.1 -3.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 1.5 -0.6 -0.5 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 2.1 1.4 -1.3 -0.5 0.3
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 4.0 -0.4 -2.0 -1.2 -1.5
Qualifications: CSEs or equivalent 0.9 1.2 3.2 0.0 1.8 -0.1 1.2
Serious illness, injury or assault to yourself 0.4 0.4 1.4 -0.5 -1.2 -0.2 0.4
High blood pressure 0.5 1.4 3.8 -0.9 -0.8 0.4 -2.0
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.1 1.3 0.6 -1.4 1.0
Multivitamins +/- minerals 2.1 2.6 7.1 1.2 -1.2 0.8 2.7
Stomach or abdominal pain in last month 0.2 0.3 0.4 0.4 -0.5 -0.5 0.6
Supplements: Glucosamine 0.4 0.5 1.0 -0.2 -0.9 -1.0 -0.4
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 2.0 1.3 -1.4 -1.1 1.4
Medication: Atenolol 0.1 0.1 0.4 -0.1 0.7 -0.3 -0.2
Medication: Levothyroxine sodium 0.0 0.1 0.2 0.4 0.1 0.3 0.2
Sitting height 0.3 1.8 2.6 1.5 1.6 0.9 1.2
Chronic bronchitis/emphysema (father) 0.1 0.2 0.3 0.2 -0.6 -0.1 -0.5
High blood pressure (mother) 1.5 2.1 7.0 0.6 -2.6 0.8 -0.4
Body mass index (BMI) 0.9 3.8 7.8 2.0 -2.8 -1.4 1.1
Impedance of leg (left) 0.9 4.2 7.7 -2.8 2.5 1.4 -1.1
Leg predicted mass (left) 0.6 3.4 8.7 3.0 -0.8 -0.9 1.8
Trunk fat mass 0.3 1.2 2.2 1.5 -1.0 -1.1 0.5
Waist circumference 0.6 2.2 3.0 1.7 -1.6 -1.2 1.2
Number of incorrect matches in round 1.0 1.7 4.3 -0.2 1.4 -2.1 -0.4
Past tobacco smoking 0.3 0.5 1.3 1.1 0.6 -0.7 0.2
Alcohol usually taken with meals 0.5 0.8 2.0 -1.4 -1.0 -0.3 0.3
Nervous feelings 0.1 0.2 0.4 0.2 0.4 0.4 0.6
Frequency of tenseness / restlessness in last 2 weeks 1.9 2.9 7.4 2.7 0.8 -0.8 1.7
Hearing difficulty/problems with background noise 0.6 0.9 1.9 1.2 1.4 0.2 -0.4
Hair/balding pattern: Pattern 2 0.3 0.4 1.0 0.5 0.5 -1.0 0.0
Had menopause 0.5 0.7 1.3 -0.6 0.5 -0.9 -1.1
Had other major operations 0.5 0.6 1.5 0.5 -0.4 -1.2 -0.8
Forced vital capacity (FVC) 0.8 3.0 7.7 -0.7 2.8 0.8 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 3.1 1.8 -1.6 -0.7 0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 1.5 0.4 -1.2 0.5 0.8
Qualifications: None of the above 0.3 0.6 1.3 1.0 -1.1 0.0 0.1
Financial difficulties in last 2 years 0.3 0.4 0.8 -0.8 -0.9 -0.3 -0.2
Mouth/teeth dental problems 0.5 0.8 1.9 1.0 1.4 0.4 0.5
Heart attack 0.2 0.2 0.7 -0.8 -0.1 -0.0 0.3
Allergy 0.8 1.7 3.3 -1.1 0.5 1.8 -1.5
Pain all over the body in last month 0.1 0.1 0.1 -0.2 -0.3 -0.0 -0.3
Diabetes (self-reported) 1.5 2.4 4.2 2.0 2.1 -1.0 0.7
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.9 0.9 0.5 -1.4 -0.1
Medication: Ramipril 0.2 0.3 1.0 0.0 1.0 -0.5 0.1
Medication: Simvastatin 0.6 0.9 3.2 -0.6 -0.1 0.1 -1.8
Fluid intelligence score 1.0 2.1 4.7 1.9 -0.0 0.5 2.2
Illnesses of siblings 0.4 0.6 1.1 1.0 1.0 0.5 0.4
Neuroticism score 1.2 2.6 4.4 1.4 1.7 -1.1 2.1
Weight 0.6 3.0 5.2 2.3 -1.6 -1.4 1.5
Impedance of arm (right) 0.9 4.3 7.8 -2.8 2.5 0.8 -1.5
Arm fat percentage (right) 0.4 1.6 3.5 0.7 -1.9 -1.1 1.0
Trunk fat-free mass 0.5 3.1 6.0 2.5 -0.9 -1.1 2.1
Hip circumference 0.7 3.1 5.5 2.3 -2.3 -0.5 1.1
Time employed in main current job 1.2 1.4 3.0 1.4 1.7 0.9 -0.0
Alcohol intake versus 10 years previously 0.6 0.9 2.6 0.9 -1.6 0.5 0.3
Father’s age at death 1.6 2.2 6.7 -2.6 0.6 -0.5 -1.1
Worrier / anxious feelings 0.4 0.8 1.7 1.3 1.3 0.1 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 3.1 0.7 -0.0 -1.1 1.7
Falls in the last year 0.5 0.6 1.1 -0.9 -1.1 -0.6 0.5
Hair/balding pattern: Pattern 3 0.8 1.3 2.3 -1.5 -1.5 -0.6 -0.5
Number of live births 1.3 1.8 5.1 -0.7 -1.2 -0.7 -2.2
Forced expiratory volume in 1-second (FEV1) 1.2 4.1 14.5 -0.1 3.8 0.5 1.3
Pulse rate 0.8 1.3 4.1 -2.0 -0.4 0.4 -1.0
Happiness 0.4 0.5 1.4 0.4 1.2 -0.5 -0.5
Noisy workplace 2.3 2.8 5.3 -1.5 -1.8 -0.6 -2.3
Qualifications: A levels/AS levels or equivalent 1.9 4.1 7.8 2.1 2.8 0.4 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.9 -0.5 -1.0 -0.8 -0.2
Mouth/teeth dental problems: Dentures 0.2 0.3 0.7 -0.5 -0.8 0.5 0.4
Asthma 0.7 1.5 2.2 1.3 -1.0 -1.5 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.5 -0.0 -0.3 -1.2 1.2
Medication: Cholesterol lowering 0.8 1.3 4.2 -1.0 0.1 0.2 -2.1
Depression (self-reported) 0.0 0.0 0.1 -0.3 0.2 0.1 0.1
Medication: Lansoprazole 0.7 0.8 2.5 -1.6 0.3 -0.1 -0.8
Prospective memory result 0.8 1.0 2.0 -0.4 1.3 -1.4 -0.1
Lung cancer (father) 2.1 2.4 7.3 2.7 1.2 -0.1 0.9
Illnesses of mother 0.7 0.9 2.3 -0.9 1.5 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.3 17.1 0.0 4.1 0.3 2.0
Pulse wave Arterial Stiffness index 0.7 0.9 1.4 1.2 -0.9 0.5 -1.0
Impedance of arm (left) 0.8 3.9 6.2 -2.5 2.2 1.0 -1.9
Arm fat mass (right) 0.6 2.4 3.1 1.8 -1.8 -1.4 1.1
Trunk predicted mass 0.5 3.1 6.2 2.5 -0.8 -1.1 2.1
Standing height 0.2 2.2 6.5 1.1 2.5 -0.3 1.0
Length of working week for main job 0.9 1.0 2.3 -1.5 -0.8 -1.1 -0.1
Exposure to tobacco smoke at home 0.5 0.6 1.6 -0.1 -1.3 0.8 -0.2
Breastfed as a baby 0.3 0.4 0.7 -0.4 0.8 0.3 0.8
Tense / ‘highly strung’ 0.6 0.9 2.0 1.0 0.9 -1.4 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 2.4 1.5 -1.3 -0.1 1.5
Hair/balding pattern: Pattern 4 0.2 0.5 2.1 -0.1 0.0 1.4 -0.3
Birth weight of first child 1.2 2.1 5.6 2.4 0.3 -0.5 1.6
Peak expiratory flow (PEF) 0.2 0.6 1.8 -0.5 1.3 0.4 -0.3
Pulse wave reflection index 0.8 1.0 2.4 1.2 0.4 1.6 0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 -0.5 0.6 -0.5 0.3
Loud music exposure frequency 0.5 0.6 1.8 0.6 -0.1 -0.3 -1.4
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.5 0.1 1.4 0.8 1.6
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.1 -1.6 -1.8 -1.0 0.8
Blood clot in the leg (DVT) 1.5 1.9 3.3 1.7 -0.3 -1.2 1.8
Medication: Paracetamol 0.4 0.7 1.0 1.0 -0.8 -0.3 1.0
Headache pain in last month 0.3 0.5 0.8 -0.9 -0.0 -0.8 -0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.6 0.5 -0.4 0.2 1.6
Glaucoma (self-reported) 0.3 0.3 0.6 0.8 0.7 0.1 0.4
Gout (self-reported) 0.4 0.6 1.3 -0.6 -0.1 1.1 0.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 0.7 -0.2 0.4 0.4
Medication: Amlodipine 0.6 0.8 1.7 0.5 1.1 -0.3 1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 0.5 0.7 -0.9 -0.3
Birth weight 0.4 0.9 3.5 0.1 1.9 -0.0 -0.2
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.5 0.5 -0.5 -0.7 -0.4
High blood pressure (siblings) 0.1 0.2 0.4 0.5 -0.0 -0.6 0.3
Forced vital capacity (FVC), Best measure 1.3 4.7 13.0 -0.3 3.6 0.7 2.3
Body fat percentage 0.2 0.7 1.7 0.8 -1.3 -0.6 0.5
Leg fat percentage (right) 0.3 1.0 2.5 0.3 -1.6 -0.6 0.9
Arm fat-free mass (right) 0.8 4.2 12.3 3.5 -0.7 -0.9 1.7
Exposure to tobacco smoke outside home 0.0 0.1 0.1 0.3 -0.3 -0.3 -0.1
Comparative body size at age 10 0.5 1.3 2.8 1.4 -0.7 -0.1 1.7
Number of full brothers 0.6 0.8 1.6 -1.3 -1.0 0.6 -0.3
Worry too long after embarrassment 1.5 2.4 5.7 2.4 1.8 -0.1 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.1 -0.3 -0.8 0.9 1.1
Wheeze or whistling in the chest in last year 0.9 1.6 2.9 0.8 -1.5 -0.7 -1.7
Number of children fathered 2.3 2.6 5.9 -2.4 1.5 0.3 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 0.7 -0.2 0.1 0.1
Age at first live birth 1.2 2.1 4.4 0.4 1.8 -0.9 2.1
Pulse wave peak to peak time 0.8 0.9 1.2 -1.0 1.1 -0.6 1.1
Health satisfaction 0.4 0.6 1.1 1.1 0.8 -0.7 0.3
Shortness of breath walking on level ground 0.8 1.0 2.5 1.1 1.6 -0.2 0.2
Qualifications: College or University degree 0.9 2.8 5.7 1.3 1.9 -0.3 2.4
Eye problems/disorders: None of the above 0.6 0.6 1.9 -0.3 0.1 1.4 0.8
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.2 0.3 0.6 1.5 0.6
Emphysema/chronic bronchitis 0.9 1.0 2.4 1.2 0.2 0.2 1.6
Medication for pain relief, constipation, heartburn 0.0 0.0 0.1 0.3 0.2 0.2 -0.1
Neck or shoulder pain in last month 0.8 1.2 3.6 -0.7 0.1 -1.9 -0.9
Medication: Blood pressure 0.4 0.7 1.4 -0.2 0.7 -1.0 -1.2
Angina (self-reported) 2.4 3.1 4.6 -2.1 -1.8 -1.6 -1.6
Migraine (self-reported) 0.5 0.6 1.3 -0.7 -1.1 0.3 -0.7
Medication: Ibuprofen 0.8 1.0 2.6 0.5 -0.0 -1.6 1.0
Medication: Allopurinol 0.3 0.5 1.5 -1.2 0.3 -0.2 0.4
Medication: Omeprazole 1.1 1.3 2.1 -1.1 -1.5 -0.9 -1.1
Medication: Seretide 50 evohaler 0.2 0.2 0.4 -0.0 0.2 -0.6 0.7
Mean time to correctly identify matches 0.1 0.3 0.5 0.3 -0.6 -0.5 -0.7
Heart disease (mother) 1.4 1.7 5.6 2.4 0.7 -0.8 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.2 1.8 0.3 0.5 1.2
Whole body fat mass 0.4 1.6 2.7 1.6 -1.2 -0.9 1.1
Leg fat mass (right) 0.5 1.9 2.7 1.6 -1.2 -1.1 1.4
Arm predicted mass (right) 0.8 4.1 10.9 3.3 -0.8 -1.0 2.0
Pulse rate, automated reading 0.7 2.3 5.5 -2.4 -0.8 0.9 -1.4
Alcohol intake frequency. 0.6 1.3 2.5 -1.3 -1.6 0.6 -0.8
Comparative height size at age 10 0.1 0.8 2.2 -0.9 -0.2 -1.5 0.2
Number of full sisters 0.9 1.0 3.1 -1.0 0.2 0.1 -1.8
Suffer from ‘nerves’ 0.2 0.3 0.8 -0.1 0.1 -0.9 0.8
Overall health rating 0.4 0.8 2.9 0.5 -0.0 -1.7 0.0
Chest pain or discomfort 0.5 0.7 2.0 0.6 0.6 -1.4 -0.1
Had major operations 1.4 1.7 5.3 1.1 -0.1 -2.3 0.5
Age at last live birth 0.2 0.3 1.0 -0.2 1.0 -0.6 0.1
Family relationship satisfaction 0.6 0.7 1.8 -0.9 1.4 -0.2 -0.1
Leg pain on walking 0.2 0.3 0.6 0.4 -0.4 -0.5 0.7
Qualifications: NVQ or HND or HNC or equivalent 3.4 4.1 9.7 -2.5 -0.5 -0.5 -3.1
Commuting to job workplace: Car/motor vehicle 1.1 1.2 4.2 -2.0 -0.0 0.1 -0.9
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.9 0.8 1.7 -0.1 0.5
Medication: Aspirin 0.5 0.7 1.7 -0.3 1.3 0.1 -0.9
Supplements: Vitamin C 0.2 0.2 0.5 -0.2 -0.7 -0.4 -0.4
Knee pain experienced in last month 0.7 1.0 2.5 -1.2 -1.6 0.4 -0.1
Hypertension (Self-reported) 0.4 1.1 3.8 -0.3 -0.7 0.3 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.4 3.4 -1.8 -1.6 0.4 -1.9
Illnesses of father: Heart disease 0.3 0.4 1.6 -0.4 0.0 -0.1 1.2
Illnesses of siblings: Diabetes 0.4 0.5 0.8 0.7 -0.4 -0.8 0.9
Smoking status: Previous 0.2 0.3 0.6 -0.8 -0.4 0.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 1.4 -0.8 1.1 0.6 1.2
Whole body fat-free mass 0.6 3.6 8.5 2.9 -0.9 -1.0 2.0
Leg fat-free mass (right) 0.6 3.2 9.0 3.0 -0.9 -0.6 1.7
Arm fat percentage (left) 0.4 1.6 3.8 1.0 -1.9 -1.0 0.7
Average weekly red wine intake 0.3 0.5 0.9 1.0 0.9 -0.4 -0.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.5 0.3 0.2 0.2
Mood swings 1.9 3.5 5.1 2.3 1.7 -1.4 2.0
Loneliness, isolation 0.8 1.1 3.1 0.9 -0.4 -1.8 -0.4
Long-standing illness, disability or infirmity 0.9 1.3 4.3 1.0 0.3 -2.1 0.1
Ever had bowel cancer screening 0.1 0.2 0.5 -0.0 0.4 -0.7 -0.2
Diabetes diagnosed by doctor 1.6 2.6 4.6 2.1 1.9 -1.2 0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.7 6.7 -1.7 -2.6 0.5 -1.0
Friendships satisfaction 0.7 0.9 2.4 -1.5 0.4 0.8 -0.4
Qualifications: nursing, teaching 0.3 0.5 0.7 -0.8 -0.8 -0.8 -0.3
Commuting to job workplace: Walk 0.9 0.9 2.7 1.7 0.5 0.8 -0.3
Eye problems/disorders: Cataract 1.6 1.9 6.2 -0.4 -0.7 -2.5 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.0 -0.8 -1.0 -0.2 -0.6
Medication for cholesterol 0.2 0.2 0.7 0.8 0.1 0.2 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.2 0.9 1.5 -0.8 -0.4
Back pain experienced in last month 0.5 0.8 1.9 0.0 -1.4 -1.0 0.4
Mineral and other dietary supplements 1.2 1.6 2.6 -1.3 1.4 0.3 -1.6
Breast cancer (self-reported) 0.8 1.0 1.5 1.1 1.1 -1.2 -0.2
Asthma (self-reported) 0.7 1.4 2.1 1.5 -0.1 -1.5 1.1
Osteoporosis (self-reported) 0.3 0.4 1.3 0.2 0.2 -1.2 -0.4
Osteoarthritis (self-reported) 0.7 0.9 2.9 -0.3 0.6 1.7 0.4
Medication: Aspirin 0.8 1.0 2.1 -0.0 1.4 -0.3 -1.4
Medication: Gliclazide 3.1 3.5 7.9 2.8 1.2 1.2 1.7
Illnesses of father: None of the above (group 1) 0.4 0.5 1.5 0.5 -0.0 1.2 -0.3
Smoking status: Current 0.5 0.9 1.5 -0.5 0.5 1.2 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 10.1 0.4 3.2 -0.2 0.6
Whole body water mass 0.7 3.9 9.5 3.1 -0.8 -1.0 2.1
Leg predicted mass (right) 0.6 3.3 9.1 3.0 -0.8 -0.7 1.6
Arm fat mass (left) 0.6 2.4 3.4 1.8 -1.8 -1.0 1.4
Number of self-reported non-cancer illnesses 0.1 0.1 0.3 0.2 0.5 -0.5 -0.1
Average weekly champagne plus white wine intake 0.9 1.2 2.2 1.5 1.5 0.3 0.7
Miserableness 0.9 1.5 3.1 0.9 -0.2 -1.5 1.8
Guilty feelings 1.1 1.7 3.0 1.1 1.7 -0.6 1.4
Wears glasses or contact lenses 1.0 1.1 3.0 -0.6 0.2 -1.7 -1.0
Ever taken oral contraceptive pill 0.7 0.8 1.9 -0.9 -0.6 -1.4 0.3
Hearing aid user 0.3 0.4 0.7 0.1 0.7 -0.6 -0.8
Mother’s age at death 0.8 1.0 3.4 0.5 -1.8 -0.0 -0.7
Financial situation satisfaction 0.4 0.4 1.6 0.4 -0.1 0.0 -1.3
Tinnitus: Yes, now most or all of the time 3.3 3.9 6.6 -2.5 -1.5 0.5 -2.6
Commuting to job workplace: Public transport 0.3 0.4 1.6 0.0 -0.1 -0.0 1.3
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 0.2 0.7 -0.1 0.0
Medication: Blood pressure 0.2 0.4 0.7 0.8 0.6 -0.7 -0.3
Pain type(s) experienced in last month: Hip pain 1.5 1.9 7.7 0.2 -2.8 0.0 -0.3
Supplements: Fish oil (including cod liver oil) 0.7 1.0 2.2 0.6 -1.5 0.1 1.1
High cholesterol (Self-reported) 1.5 2.7 5.4 -1.2 -0.0 2.3 -2.0
Medication: Bendroflumethiazide 0.1 0.2 0.6 -0.8 0.0 -0.1 -0.3
Medication: Paracetamol 0.2 0.3 0.8 0.5 -0.9 -0.4 0.4
Medication: Lisinopril 1.7 2.3 3.0 1.7 1.6 -1.4 -1.1
Medication: Atorvastatin 0.1 0.1 0.2 -0.1 -0.1 -0.4 -0.5
Illnesses of father: High blood pressure 2.1 2.6 4.9 -1.5 -1.7 -2.2 -0.7
Alcohol drinker status: Never 0.7 0.8 2.5 -0.6 -0.6 1.6 -0.2
Ever smoked 0.1 0.2 0.4 -0.6 0.0 0.6 -0.4
Basal metabolic rate 0.7 3.6 8.2 2.9 -1.1 -1.0 2.0
Leg fat percentage (left) 0.3 1.1 3.1 0.5 -1.8 -0.3 0.9
Arm fat-free mass (left) 0.9 4.4 11.3 3.4 -0.9 -0.9 2.2
Number of operations (self-reported) 2.1 3.1 11.8 0.6 0.2 -3.4 -0.3
Average weekly beer plus cider intake 0.2 0.3 0.8 0.3 0.9 -0.0 0.5
Irritability 1.6 2.8 7.4 1.4 1.0 -0.8 2.7
Risk taking 0.2 0.4 1.0 -0.2 -0.5 -1.0 -0.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 -0.7 -0.4 -0.1 -0.2
Fractured/broken bones in last 5 years 0.2 0.2 0.6 0.2 0.2 -0.2 0.8
Age started oral contraceptive pill 0.2 0.3 0.5 -0.6 -0.2 0.4 -0.7
Diastolic blood pressure, automated reading 0.6 1.8 5.0 -1.4 -2.2 -0.4 -0.6
Ever depressed for a whole week 0.2 0.2 0.6 -0.5 -0.4 -0.8 0.0
Unable to work because of sickness or disability 0.9 1.2 2.9 1.1 1.7 0.5 0.7
Commuting to job workplace: Cycle 3.8 4.6 6.9 2.2 2.6 1.8 1.9
Myopia 0.8 1.1 2.1 1.4 1.4 0.7 0.1
Vascular/heart problems diagnosed by doctor 0.4 1.2 3.4 0.7 0.9 -0.2 1.8
Cholesterol lowering medication 0.4 0.5 1.1 1.0 0.9 0.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 3.7 -1.9 -1.9 -0.2 -1.3
Pain experienced in last month 0.4 0.7 1.3 0.3 1.2 1.1 0.6
Supplements: Calcium 2.1 2.3 5.8 -1.1 -2.4 1.1 -0.9
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.2 -0.2 -0.3 0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.9 -0.9 -0.0 -0.1 0.1
Deep venous thrombosis (DVT) (self-reported) 1.9 2.5 4.1 1.9 -0.2 -1.5 2.0
Heart disease (siblings) 1.8 2.2 4.4 -1.8 -2.1 0.4 -1.0
Alcohol drinker status: Previous 0.6 0.7 1.5 1.2 0.2 -0.1 1.0
Pack years of smoking 0.2 0.3 0.5 0.7 -0.6 0.2 0.7
Impedance of whole body 1.0 5.0 8.1 -2.7 2.8 1.2 -1.8
Leg fat mass (left) 0.5 1.8 2.8 1.7 -1.3 -0.9 1.4
Arm predicted mass (left) 0.9 4.4 10.1 3.2 -0.9 -1.0 2.3