Best TWAS P=7.44e-09 · Best GWAS P=5.89e-08 conditioned to 0.91
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SIVA1 | 0.15 | 0.14 | enet | 10 | 0.15 | 6.9e-12 | -4.9 | 5.4 | 5.3e-08 | -0.98 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ADSSL1 | 0.13 | 0.05 | enet | 9 | 0.05 | 1.2e-04 | -5.4 | 5.3 | 1.1e-07 | -0.92 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SIVA1 | 0.11 | 0.09 | enet | 3 | 0.03 | 6.2e-03 | -5.4 | 5.4 | 6.8e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ADSSL1 | 0.27 | 0.22 | lasso | 3 | 0.21 | 6.0e-14 | -4.9 | 5.2 | 1.8e-07 | -0.98 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Esophagus Muscularis | ADSSL1 | 0.14 | 0.10 | lasso | 4 | 0.09 | 3.0e-06 | -4.9 | 5.5 | 3.2e-08 | -0.98 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | ADSSL1 | 0.32 | 0.16 | enet | 24 | 0.20 | 1.8e-11 | -4.4 | 5.3 | 1.1e-07 | -0.88 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | SIVA1 | 0.08 | 0.03 | lasso | 1 | 0.00 | 1.7e-01 | -5.4 | 5.4 | 7.4e-08 | -0.99 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | ADSSL1 | 0.23 | 0.22 | enet | 3 | 0.18 | 2.0e-14 | -5.4 | 5.4 | 8.4e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Thyroid | AKT1 | 0.40 | 0.34 | lasso | 8 | 0.34 | 4.3e-27 | -5.4 | -5.2 | 1.7e-07 | 0.97 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Thyroid | ZBTB42 | 0.16 | 0.11 | enet | 11 | 0.08 | 5.0e-07 | -5.3 | -5.4 | 5.8e-08 | 0.98 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Thyroid | RP11-982M15.2 | 0.38 | 0.25 | enet | 40 | 0.27 | 7.0e-21 | -5.4 | -5.8 | 7.4e-09 | 0.94 | 0.01 | 0.99 | TRUE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | AKT1 | 0.08 | 0.08 | lasso | 2 | 0.12 | 1.5e-11 | -5.1 | -5.2 | 1.6e-07 | 0.84 | 0.02 | 0.98 | FALSE |