Best TWAS P=6.48e-09 · Best GWAS P=2.88e-07 conditioned to 0.353
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAN2C1 | 0.13 | 0.17 | lasso | 5 | 0.18 | 2.5e-21 | 5.0 | 5.6 | 2.8e-08 | 0.05 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | NEIL1 | 0.09 | 0.03 | lasso | 3 | 0.05 | 2.0e-03 | 5.0 | 5.1 | 2.8e-07 | -0.02 | 0.03 | 0.93 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | ULK3 | 0.15 | 0.11 | lasso | 3 | 0.09 | 1.6e-05 | 5.1 | 5.2 | 2.1e-07 | 1.00 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Colon Transverse | CTD-2323K18.1 | 0.13 | 0.04 | lasso | 11 | 0.05 | 1.8e-03 | 4.9 | 5.5 | 4.8e-08 | 0.09 | 0.03 | 0.91 | FALSE |
| 5 | GTEx | Lung | SNUPN | 0.14 | 0.06 | lasso | 2 | 0.07 | 2.7e-06 | 4.5 | 5.3 | 1.5e-07 | 0.05 | 0.04 | 0.96 | FALSE |
| 6 | GTEx | Muscle Skeletal | MAN2C1 | 0.05 | 0.01 | enet | 6 | 0.03 | 5.6e-04 | 4.5 | 5.8 | 6.5e-09 | 0.09 | 0.04 | 0.93 | TRUE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | MAN2C1 | 0.39 | 0.44 | lasso | 4 | 0.44 | 1.2e-26 | 4.9 | 5.2 | 2.4e-07 | -0.04 | 0.02 | 0.97 | FALSE |
| 8 | GTEx | Thyroid | SNUPN | 0.15 | 0.10 | lasso | 7 | 0.16 | 6.2e-12 | -4.1 | 5.4 | 8.5e-08 | 0.10 | 0.08 | 0.91 | FALSE |
| 9 | GTEx | Uterus | ULK3 | 0.40 | 0.16 | lasso | 16 | 0.12 | 2.2e-03 | 4.9 | 5.4 | 6.1e-08 | 0.91 | 0.02 | 0.77 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNUPN | 0.04 | 0.02 | lasso | 3 | 0.03 | 3.3e-06 | -4.1 | 5.3 | 9.0e-08 | 0.12 | 0.02 | 0.93 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MAN2C1 | 0.12 | 0.11 | blup | 14 | 0.12 | 1.4e-06 | 4.9 | 5.3 | 8.8e-08 | 0.10 | 0.00 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ULK3 | 0.21 | 0.02 | enet | 8 | 0.07 | 1.9e-04 | 4.5 | 5.3 | 1.2e-07 | 0.77 | 0.02 | 0.53 | FALSE |
| 13 | The Cancer Genome Atlas | Esophageal Carcinoma | SNUPN | 0.18 | 0.11 | lasso | 5 | 0.07 | 2.6e-03 | 4.9 | 5.2 | 1.9e-07 | -0.04 | 0.00 | 0.88 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SNUPN | 0.05 | 0.03 | blup | 38 | 0.05 | 4.0e-06 | 5.0 | 5.7 | 1.2e-08 | 0.09 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MAN2C1 | 0.11 | 0.05 | lasso | 5 | 0.09 | 1.2e-05 | -3.9 | 5.3 | 9.7e-08 | 0.12 | 0.00 | 0.87 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAN2C1 | 0.08 | 0.06 | blup | 14 | 0.09 | 2.0e-10 | 4.9 | 5.5 | 3.8e-08 | 0.13 | 0.00 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNUPN | 0.03 | 0.03 | enet | 8 | 0.02 | 9.9e-04 | 4.6 | 5.5 | 3.8e-08 | 0.00 | 0.00 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MAN2C1 | 0.08 | 0.02 | blup | 14 | 0.04 | 1.3e-02 | 4.9 | 5.2 | 1.7e-07 | 0.08 | 0.00 | 0.60 | FALSE |