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chr15:90,776,375-92,225,560

Best TWAS P=9.5e-16 · Best GWAS P=1.87e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RCCD1	0.37	0.31	bslmm	474	0.35	1.4e-43	7.7	7.5	6.0e-14	0.91	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RCCD1	0.34	0.34	lasso	5	0.35	1.7e-29	8.0	7.9	2.4e-15	1.00	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	RCCD1	0.20	0.14	lasso	4	0.13	4.2e-07	7.7	7.5	4.5e-14	0.95	0.00	1.00	FALSE
4	GTEx	Artery Aorta	RCCD1	0.25	0.22	lasso	3	0.22	3.4e-12	8.0	8.0	1.3e-15	1.00	0.00	1.00	FALSE
5	GTEx	Artery Tibial	RCCD1	0.34	0.30	lasso	6	0.31	2.2e-24	8.0	7.8	5.7e-15	0.99	0.00	1.00	FALSE
6	GTEx	Brain Caudate basal ganglia	RCCD1	0.33	0.28	lasso	2	0.27	2.1e-08	7.7	7.8	4.9e-15	0.99	0.00	1.00	FALSE
7	GTEx	Brain Cerebellar Hemisphere	RCCD1	0.43	0.41	lasso	3	0.38	1.1e-10	7.7	8.0	1.8e-15	0.99	0.00	1.00	FALSE
8	GTEx	Brain Cerebellum	RCCD1	0.45	0.29	lasso	6	0.31	8.9e-10	6.9	7.5	7.8e-14	0.96	0.00	1.00	FALSE
9	GTEx	Brain Cortex	RCCD1	0.38	0.36	lasso	3	0.40	2.8e-12	7.7	7.9	2.3e-15	0.95	0.00	1.00	FALSE
10	GTEx	Brain Frontal Cortex BA9	RCCD1	0.43	0.29	lasso	6	0.28	5.7e-08	7.7	7.3	3.4e-13	0.95	0.00	1.00	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	RCCD1	0.39	0.23	lasso	3	0.24	5.3e-07	7.7	7.5	5.1e-14	0.95	0.00	0.99	FALSE
12	GTEx	Breast Mammary Tissue	RCCD1	0.16	0.16	lasso	2	0.14	1.8e-07	8.0	8.0	1.3e-15	1.00	0.00	1.00	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RCCD1	0.11	0.01	lasso	6	0.02	7.7e-02	6.9	5.2	1.9e-07	0.58	0.02	0.62	TRUE
14	GTEx	Colon Sigmoid	RCCD1	0.36	0.30	lasso	4	0.27	5.6e-10	8.0	7.9	2.4e-15	0.99	0.00	1.00	FALSE
15	GTEx	Colon Transverse	RCCD1	0.39	0.30	enet	7	0.30	8.1e-15	7.7	7.8	8.2e-15	0.99	0.00	1.00	FALSE
16	GTEx	Esophagus Mucosa	RCCD1	0.25	0.24	lasso	3	0.24	4.0e-16	8.0	7.9	2.5e-15	1.00	0.00	1.00	FALSE
17	GTEx	Esophagus Muscularis	RCCD1	0.31	0.28	lasso	3	0.25	4.2e-15	8.0	7.9	4.1e-15	0.99	0.00	1.00	TRUE
18	GTEx	Lung	RCCD1	0.14	0.09	lasso	3	0.06	1.2e-05	8.0	7.9	2.5e-15	0.98	0.00	1.00	FALSE
19	GTEx	Muscle Skeletal	RCCD1	0.16	0.15	lasso	5	0.14	6.4e-14	8.0	7.8	6.8e-15	0.96	0.00	1.00	FALSE
20	GTEx	Nerve Tibial	RCCD1	0.21	0.18	lasso	1	0.18	1.3e-12	8.0	8.0	1.9e-15	1.00	0.00	1.00	FALSE
21	GTEx	Pancreas	RCCD1	0.48	0.27	lasso	13	0.31	1.7e-13	7.7	6.9	6.1e-12	0.91	0.00	1.00	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	RCCD1	0.33	0.37	lasso	2	0.38	5.7e-22	7.7	7.9	3.7e-15	1.00	0.00	1.00	FALSE
23	GTEx	Skin Sun Exposed Lower leg	RCCD1	0.45	0.50	lasso	4	0.50	3.4e-47	8.0	7.9	3.7e-15	1.00	0.00	1.00	FALSE
24	GTEx	Stomach	RCCD1	0.29	0.16	lasso	6	0.16	2.9e-08	7.7	7.6	3.2e-14	0.95	0.00	1.00	FALSE
25	GTEx	Testis	RCCD1	0.60	0.52	lasso	4	0.52	2.6e-26	8.0	7.9	3.7e-15	0.99	0.00	1.00	FALSE
26	GTEx	Testis	AC068831.6	0.26	0.28	lasso	4	0.26	9.4e-12	5.5	-5.5	3.9e-08	-0.67	0.96	0.04	TRUE
27	GTEx	Testis	PRC1-AS1	0.21	0.05	enet	12	0.05	4.4e-03	5.5	-6.4	1.7e-10	-0.72	0.06	0.90	FALSE
28	GTEx	Thyroid	RCCD1	0.27	0.20	lasso	3	0.18	1.3e-13	8.0	8.0	1.5e-15	1.00	0.00	1.00	FALSE
29	GTEx	Thyroid	HDDC3	0.08	0.06	lasso	2	0.06	2.4e-05	5.3	-5.3	1.2e-07	-0.55	0.77	0.07	FALSE
30	METSIM	Adipose	RCCD1	0.19	0.16	bslmm	481	0.17	2.4e-25	8.0	7.3	2.8e-13	0.95	0.00	1.00	FALSE
31	NTR	Blood	RCCD1	0.02	0.02	lasso	2	0.01	1.2e-05	8.0	7.8	4.6e-15	0.99	0.00	1.00	FALSE
32	YFS	Blood	RCCD1	0.27	0.27	bslmm	473	0.29	8.3e-96	8.0	8.0	9.5e-16	0.95	0.00	1.00	TRUE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	HDDC3	0.07	0.07	lasso	4	0.06	2.3e-04	5.2	-5.4	6.5e-08	-0.57	0.24	0.65	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	4.7	-5.1	3.1e-07	-0.20	0.13	0.83	TRUE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HDDC3	0.02	0.01	enet	3	0.02	1.8e-03	5.5	-5.4	7.8e-08	-0.65	0.09	0.28	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RCCD1	0.16	0.11	lasso	2	0.11	6.5e-12	7.7	7.6	2.8e-14	0.97	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HDDC3	0.16	0.10	enet	9	0.12	2.1e-07	5.2	-7.9	1.9e-15	-0.71	0.12	0.86	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	RCCD1	0.18	0.12	lasso	3	0.12	1.1e-13	7.7	7.7	1.7e-14	0.98	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RCCD1	0.09	0.02	blup	65	0.02	3.2e-02	5.6	7.1	1.3e-12	0.81	0.01	0.83	TRUE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	RCCD1	0.13	0.07	enet	7	0.08	2.0e-08	7.7	6.7	2.1e-11	0.91	0.00	1.00	TRUE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	4.6	-5.6	2.1e-08	-0.28	0.02	0.17	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	HDDC3	0.12	0.13	lasso	4	0.14	2.5e-13	5.2	-5.3	9.5e-08	-0.60	0.51	0.49	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	RCCD1	0.09	0.05	lasso	1	0.04	1.9e-04	7.7	7.7	1.2e-14	0.98	0.00	1.00	FALSE