TWAS
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Usage
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Genes
Traits
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Traits
:
Crohns Disease (2012)
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chr9:4,415,824-5,811,733
Best TWAS P=2.17e-08 · Best GWAS P=4.52e-11 conditioned to 0.00011
4.4M
4.6M
4.8M
5M
5.2M
5.4M
5.6M
5.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
IGHEP2
0.08
0.07
enet
12
0.08
3.7e-10
5.4
-5.6
2.2e-08
-0.65
0.48
0.52
TRUE