TWAS hub - IL23R

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Papillary Cell Carcinoma	0.063	0.031	0.0028	0.028	0.031	0.027	NA	0.030	0.0094	0.00700	0.0110	NA	0.0073
2	TCGA	Rectum Adenocarcinoma	0.169	0.074	0.0020	0.027	0.150	0.091	NA	0.032	0.0780	0.00023	0.0037	NA	0.0600
3	TCGA	Testicular Germ Cell Tumors	0.252	0.096	0.0022	0.067	0.018	-0.005	NA	0.046	0.0023	0.07400	0.5400	NA	0.0100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Crohns Disease (2017)	92.2	202.4	309.8	17.6	16.3	5.6
Irritable Bowel Disease (IBD)	62.1	147.8	219.0	14.8	14.0	5.3
Crohns Disease (2012)	51.0	82.1	130.0	11.4	10.2	3.5
Ulcerative Colitis (UC)	13.1	24.6	36.7	5.7	6.1	2.1
Ulcerative Colitis	10.3	14.9	23.4	4.8	4.5	1.1
Bilateral oophorectomy (both ovaries removed)	6.9	8.0	12.7	3.2	3.6	-0.8
Supplements: Calcium	4.1	4.6	8.1	-2.8	-2.3	-0.5
Hypothyroidism (self reported)	3.0	6.9	11.0	-3.0	-3.3	1.0
Ever had prostate specific antigen (PSA) test	3.0	3.5	5.2	-2.1	-2.3	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	5.9	-1.7	-2.4	1.2
Illnesses of siblings: Diabetes	2.8	3.4	5.2	1.6	1.6	2.3
Number of operations (self-reported)	2.8	4.1	4.7	2.1	1.8	-2.2
Ever had hysterectomy (womb removed)	2.7	3.1	4.8	2.0	2.2	-0.7
Townsend deprivation index at recruitment	2.7	3.8	3.9	-1.9	-2.0	2.0
Maternal smoking around birth	2.7	4.0	6.4	2.5	2.1	1.0
Number of children fathered	2.6	2.9	3.8	-1.8	-1.9	-1.2
Hair/balding pattern: Pattern 2	2.5	3.2	6.0	1.9	2.4	-0.2
Medication: Simvastatin	2.5	3.6	5.1	1.8	2.2	-1.6
Friendships satisfaction	2.5	3.1	5.2	2.3	1.9	-0.7
Illnesses of father: None of the above (group 1)	2.4	2.9	3.9	-1.9	-2.0	1.2
Alzheimer’s Disease (in father)	2.3	2.5	3.4	1.8	1.1	-1.6
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	4.4	1.7	2.1	1.1
High cholesterol (Self-reported)	2.3	4.0	6.5	2.2	2.5	-0.7
Medication: Lisinopril	2.2	2.9	3.5	1.9	1.5	-1.7
Had major operations	2.1	2.4	3.9	1.2	1.4	-2.0
Medication: Levothyroxine sodium	1.9	3.2	5.4	-2.3	-1.7	1.2
Rheumatoid Arthritis	1.8	2.4	4.4	-1.4	-2.1	0.8
Loneliness, isolation	1.7	2.3	4.9	-1.0	-0.9	2.2
Hand grip strength (right)	1.6	4.2	9.2	-1.4	-1.3	-3.0
Illnesses of siblings	1.5	2.1	3.0	-1.4	-1.7	-1.1
Medication: Lansoprazole	1.5	1.8	2.4	-1.2	-1.2	1.5
Hypothyroidism/myxoedema (self-reported)	1.5	2.8	4.2	-1.7	-2.0	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.0	-0.9	-1.7	0.9
Breast cancer (self-reported)	1.5	1.8	2.9	1.5	1.7	0.5
Pack years of smoking	1.5	2.2	3.3	1.6	1.8	-0.7
Fasting Glucose	1.4	1.7	3.8	0.8	0.9	-1.9
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.9	1.7	1.6	0.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.1	-1.1	-0.5	1.8
Supplements: Zinc	1.4	1.6	2.9	1.7	0.9	-1.0
Had other major operations	1.4	1.7	4.3	-0.8	-0.5	-2.1
Length of working week for main job	1.4	1.5	3.7	0.8	0.4	1.9
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	6.3	0.3	-0.5	-2.5
Financial situation satisfaction	1.4	1.7	5.0	-0.3	0.4	2.2
Pain type(s) experienced in last month: Hip pain	1.4	1.7	5.0	0.1	-0.4	-2.2
Ever smoked	1.4	2.5	4.9	-2.2	-1.3	-0.9
Medication: Atenolol	1.3	1.7	3.3	-1.8	-1.2	0.5
Diabetes (self-reported)	1.3	2.0	3.5	-1.9	-1.2	1.1
Exposure to tobacco smoke outside home	1.3	1.7	3.2	1.2	1.8	0.5
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.4	-1.5	-0.5	-1.6
Mean time to correctly identify matches	1.3	2.5	4.7	2.2	1.5	-0.5
Alcohol intake frequency.	1.3	2.9	3.9	2.0	1.7	-1.5
Diabetes diagnosed by doctor	1.3	2.2	3.2	-1.8	-1.3	1.3
Ever depressed for a whole week	1.3	1.6	2.8	1.7	1.2	-0.8
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.2	1.8	1.4	0.3
Triglycerides	1.2	2.0	5.5	0.5	0.5	2.3
Systolic blood pressure, automated reading	1.2	3.5	10.5	0.2	0.2	-3.2
Number of live births	1.2	1.6	2.7	-1.6	-1.5	-0.3
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.2	-0.5	-1.8	1.6
Birth weight	1.2	2.6	5.7	-1.2	-0.8	2.4
Hypertension (Self-reported)	1.2	3.4	9.5	-0.1	0.7	-3.1
Wears glasses or contact lenses	1.2	1.3	1.7	-1.3	-1.0	-1.1
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.7	-1.2	-1.6	-0.6
Body Mass Index (BMI) (2010)	1.1	1.5	2.8	-0.9	-0.9	1.7
LDL Cholesterol	1.1	1.7	2.9	-1.7	-1.4	0.3
Hand grip strength (left)	1.1	2.9	8.1	-0.4	-0.7	-2.8
Average weekly spirits intake	1.1	1.3	2.3	1.1	0.7	-1.5
Number of incorrect matches in round	1.1	1.9	3.3	1.5	1.8	0.4
Medication: Cholesterol lowering	1.1	1.7	3.8	1.1	1.9	-0.4
Asthma (self-reported)	1.1	2.3	2.4	1.5	1.6	-1.5
Average weekly champagne plus white wine intake	1.1	1.5	3.3	1.1	1.8	0.2
Myopia	1.1	1.5	2.5	1.6	0.6	-1.3
Worry (Nagel 2018)	1.0	2.2	6.1	-0.4	0.5	-2.5
Major Depression (MDD)	1.0	1.2	2.1	-1.2	-1.5	-0.1
Sensitivity / hurt feelings	1.0	1.8	4.8	-0.5	-0.5	2.2
Pack years adult smoking proportion	1.0	1.5	1.7	1.3	1.3	-1.1
High blood pressure	1.0	2.7	7.3	-0.1	0.8	-2.7
Nervous feelings	1.0	1.9	3.6	0.5	1.3	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	5.2	-0.7	-1.2	2.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	2.1	1.1	1.3	-1.5
Mouth/teeth dental problems: Dentures	1.0	1.6	2.7	0.8	1.3	-1.6
Exposure to tobacco smoke at home	1.0	1.1	1.6	0.6	1.3	1.2
Primary Biliary Cirrhosis	0.9	1.3	1.6	1.3	1.0	-1.1
Blood White Count	0.9	6.5	7.3	2.5	2.5	2.7
Heart attack	0.9	1.1	2.0	1.4	1.1	0.2
Allergy	0.9	2.0	3.4	-1.8	-1.1	1.1
Number of full brothers	0.9	1.1	3.3	-0.3	-0.0	1.8
Emphysema/chronic bronchitis	0.9	1.0	2.4	0.6	1.6	-0.4
Migraine (self-reported)	0.9	1.2	1.7	-1.0	-1.3	0.9
Overall health rating	0.9	2.0	3.4	1.8	1.4	0.7
Commuting to job workplace: Car/motor vehicle	0.9	1.1	1.6	-1.2	-1.3	-0.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.9	-1.4	-1.0	0.7
Long-standing illness, disability or infirmity	0.9	1.3	2.6	1.0	1.6	-0.6
Ever had bowel cancer screening	0.9	1.1	1.8	1.1	1.3	0.5
Bipolar Disorder (2018)	0.8	1.3	2.3	-1.5	-0.9	-0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	2.7	-0.7	-1.6	0.1
Allergy or Eczema	0.8	2.1	4.9	2.2	1.1	-0.5
Respiratory disease	0.8	1.8	2.2	1.1	1.4	-1.5
Medication: Co-codamol	0.8	1.0	1.7	1.3	1.1	-0.1
Age when periods started (menarche)	0.8	1.9	3.3	-1.6	-1.8	-0.1
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.8	2.0	1.2	-0.3
Past tobacco smoking	0.8	1.4	2.3	1.5	0.5	1.3
Medication: Ramipril	0.8	1.0	2.5	-1.6	-0.7	0.3
Pulse rate	0.8	1.3	2.0	1.4	1.3	-0.4
Breastfed as a baby	0.8	0.9	1.3	-1.0	-1.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.5	-0.1	0.5	-1.9
Medication: Blood pressure	0.8	1.4	2.9	0.9	1.7	-0.6
Pulse rate, automated reading	0.8	2.7	3.3	1.8	1.8	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.8	-2.0	0.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.1	0.2	-0.7	-1.4
Mineral and other dietary supplements	0.8	1.1	2.2	0.4	1.0	1.5
Medication: Bendroflumethiazide	0.8	1.2	3.2	0.4	1.8	-0.6
Fractured/broken bones in last 5 years	0.8	1.0	2.6	0.6	0.4	-1.6
Breast Cancer	0.7	1.6	3.1	-0.6	-1.8	-1.1
HDL Cholesterol	0.7	1.2	3.0	-0.7	-0.3	-1.7
Systolic Blood Pressure	0.7	3.7	11.0	-0.1	0.0	-3.3
Angina	0.7	0.9	2.6	0.1	0.3	1.6
Qualifications: CSEs or equivalent	0.7	0.9	1.0	1.0	0.9	1.0
Stomach or abdominal pain in last month	0.7	0.8	2.2	-1.5	-0.5	-0.2
Qualifications: None of the above	0.7	1.5	2.5	1.4	1.6	0.3
Asthma	0.7	1.3	1.5	1.1	1.2	-1.2
Lung cancer (father)	0.7	0.8	1.2	-0.1	-1.1	-1.1
Headache pain in last month	0.7	1.1	1.7	-0.7	-1.3	1.1
Eye problems/disorders: None of the above	0.7	0.8	2.1	0.4	-0.2	-1.4
Angina (self-reported)	0.7	0.9	2.8	0.1	0.2	1.7
Heart disease (mother)	0.7	0.9	2.0	-0.2	-1.4	-0.8
Number of self-reported non-cancer illnesses	0.7	1.2	1.3	1.0	1.2	-1.0
Medication: Atorvastatin	0.7	0.8	1.9	-1.4	-0.7	0.2
Illnesses of father: High blood pressure	0.7	0.9	1.9	0.2	-0.8	-1.4
Diastolic blood pressure, automated reading	0.7	2.3	6.2	0.6	0.6	-2.5
Vascular/heart problems diagnosed by doctor	0.7	2.0	5.1	-0.0	-0.9	2.3
Basal cell carcinoma (self-reported)	0.7	0.8	1.1	-0.9	-1.1	-0.6
Reaction Time	0.6	1.1	2.0	1.4	0.6	-0.9
Age at First Birth	0.6	0.9	2.4	0.1	-0.6	1.5
Coronary Artery Disease (CAD)	0.6	0.7	1.0	-0.2	-1.0	-1.0
Cardiovascular Disease	0.6	2.1	6.1	0.2	0.6	-2.5
Average weekly fortified wine intake	0.6	0.7	1.8	-0.1	-0.6	1.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	0.9	0.5	0.9	0.9
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	-1.2	-0.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.1	0.6	0.4	-1.5
Hearing difficulty/problems with background noise	0.6	1.0	2.2	0.5	0.7	-1.5
Alcohol intake versus 10 years previously	0.6	0.8	1.5	1.2	-0.1	1.0
Prospective memory result	0.6	0.7	1.1	-1.1	-0.6	-0.8
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.5	1.2	0.2	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	1.1	0.9	-0.1
Comparative body size at age 10	0.6	1.7	3.5	-0.8	-1.0	1.9
Neck or shoulder pain in last month	0.6	0.8	1.7	0.8	1.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	-0.2	0.1	-1.4
Knee pain experienced in last month	0.6	1.0	2.0	-1.4	-0.9	0.1
Eye problems/disorders: Cataract	0.6	0.7	2.1	-0.0	0.2	1.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.0	-0.8	-1.0	-0.5
Risk taking	0.6	0.9	1.8	-1.4	-0.9	-0.3
Age started oral contraceptive pill	0.6	0.8	2.2	-0.3	-0.2	-1.5
Unable to work because of sickness or disability	0.6	0.7	1.5	-1.2	-0.7	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	1.2	0.2	0.7
Bipolar Disorder (2011)	0.5	0.4	0.8	-0.9	-0.7	0.1
Lupus	0.5	0.7	1.6	-0.7	-1.2	0.2
Height	0.5	9.1	26.5	-0.7	-0.7	-5.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.7	-1.3	-0.8	0.8
Taking other prescription medications	0.5	0.7	1.5	-0.8	-1.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.3	-0.1	0.6	1.1
High blood pressure (mother)	0.5	0.6	1.5	0.5	0.4	-1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	0.9	1.1	-0.1
Trunk fat-free mass	0.5	3.0	4.7	-1.5	-1.4	-2.2
Noisy workplace	0.5	0.6	1.7	-0.4	-1.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	1.6	-1.0	-1.0	-1.3
Trunk predicted mass	0.5	2.8	4.5	-1.5	-1.4	-2.1
Loud music exposure frequency	0.5	0.5	0.8	-0.9	-0.7	0.6
Gout (self-reported)	0.5	0.6	1.0	0.9	1.0	0.3
High blood pressure (siblings)	0.5	0.8	1.2	1.1	1.0	0.2
Arm fat-free mass (right)	0.5	2.8	3.7	-1.4	-1.7	-1.9
Worry too long after embarrassment	0.5	0.8	1.0	0.8	1.0	0.8
Wheeze or whistling in the chest in last year	0.5	0.9	1.7	0.9	1.3	-0.1
Health satisfaction	0.5	0.6	1.0	0.5	0.8	-1.0
Arm predicted mass (right)	0.5	2.8	3.3	-1.5	-1.7	-1.8
Number of full sisters	0.5	0.6	1.0	-1.0	-0.9	0.2
Suffer from ‘nerves’	0.5	0.8	2.1	0.3	0.5	-1.5
Chest pain or discomfort	0.5	0.6	1.6	-0.3	-0.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-0.9	-0.6	0.9
Illnesses of father: Heart disease	0.5	0.7	1.2	1.1	0.9	-0.3
Smoking status: Previous	0.5	0.8	1.9	-0.7	0.1	-1.4
Whole body fat-free mass	0.5	2.9	5.1	-1.2	-1.5	-2.2
Whole body water mass	0.5	2.7	4.3	-1.3	-1.4	-2.1
Mother’s age at death	0.5	0.6	0.8	0.5	0.8	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.7	-1.1	0.2
Alcohol drinker status: Never	0.5	0.6	1.2	1.1	0.5	-0.5
Basal metabolic rate	0.5	2.5	4.4	-1.1	-1.4	-2.1
Ovarian Cancer	0.4	0.5	0.7	0.8	0.6	-0.7
Blood Eosinophil Count	0.4	2.9	3.9	-1.9	-2.0	1.0
Waist Hip Ratio (WHR)	0.4	1.6	4.2	-0.7	-0.2	2.0
Smoking Status	0.4	1.0	2.2	-1.5	-0.9	-0.2
Hearing difficulty/problems: Yes	0.4	0.6	1.4	0.4	1.2	-0.4
Leg fat-free mass (left)	0.4	2.2	3.7	-0.9	-1.5	-1.9
Current tobacco smoking	0.4	0.6	1.1	-1.1	-0.7	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	0.1	-0.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.5	-0.5	-0.8	1.2
Serious illness, injury or assault to yourself	0.4	0.5	1.1	0.5	0.3	-1.0
Sitting height	0.4	3.2	4.0	-1.7	-1.6	-2.0
Leg predicted mass (left)	0.4	2.2	4.0	-0.8	-1.4	-2.0
Mouth/teeth dental problems	0.4	0.6	1.2	0.7	-0.4	1.1
Impedance of arm (right)	0.4	2.0	3.1	1.8	1.7	0.2
Father’s age at death	0.4	0.6	0.9	-0.4	-0.9	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	-0.3	-1.2	0.2
Tense / ‘highly strung’	0.4	0.6	1.4	0.2	0.7	-1.2
Birth weight of first child	0.4	0.7	2.2	0.2	-0.0	1.5
Pulse wave reflection index	0.4	0.4	0.8	0.0	0.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.4	-1.1	-1.2	-0.1
Leg fat-free mass (right)	0.4	2.1	3.6	-0.8	-1.4	-1.9
Back pain experienced in last month	0.4	0.6	1.6	0.3	0.3	-1.3
Smoking status: Current	0.4	0.7	1.3	-1.1	-0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.2	0.9	0.6	-1.1
Leg predicted mass (right)	0.4	2.2	3.7	-0.8	-1.5	-1.9
Medication: Blood pressure	0.4	0.7	1.5	-1.2	-0.4	-0.7
Average weekly beer plus cider intake	0.4	0.5	1.3	-0.2	-0.4	1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.0	-1.0	-1.4	-0.3
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	0.7	0.2	0.7
Neuroticism (2016)	0.3	0.5	1.3	0.1	0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	0.3	0.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.7	-0.3	0.5	0.8
Diabetes (father)	0.3	0.3	0.9	0.3	-0.1	1.0
Severe depression (siblings)	0.3	0.4	0.6	-0.8	-0.7	0.1
Impedance of leg (left)	0.3	1.4	2.1	1.5	1.4	-0.1
Trunk fat mass	0.3	1.1	3.1	-0.1	-0.4	-1.8
Alcohol usually taken with meals	0.3	0.5	0.8	0.3	0.9	0.8
Financial difficulties in last 2 years	0.3	0.4	1.0	-0.3	-0.4	1.0
Weight	0.3	1.3	3.3	-0.5	-0.7	-1.8
Hip circumference	0.3	1.4	4.0	-0.1	0.1	-2.0
Worrier / anxious feelings	0.3	0.6	1.2	-0.8	0.1	-1.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.5	-1.2	-1.2	-0.6
Illnesses of mother	0.3	0.3	0.8	-0.4	0.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	1.4	-0.8	-1.1	-1.2
Standing height	0.3	3.0	7.6	-0.6	-0.9	-2.8
Peak expiratory flow (PEF)	0.3	0.8	2.3	-0.2	0.0	-1.5
Medication: Paracetamol	0.3	0.5	0.7	0.8	0.2	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	1.6	-1.1	-0.9	-1.3
Shortness of breath walking on level ground	0.3	0.3	0.9	-0.3	0.0	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.6	1.1	-1.1	-0.7	0.4
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-0.1	-0.1	0.9
Medication: Aspirin	0.3	0.4	1.1	0.1	0.3	1.0
Average weekly red wine intake	0.3	0.5	0.5	-0.7	-0.6	-0.7
Medication for cholesterol	0.3	0.5	0.9	1.0	-0.0	0.7
Osteoporosis (self-reported)	0.3	0.4	0.9	0.5	1.0	-0.2
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.8	-0.2	0.8
Ever taken oral contraceptive pill	0.3	0.4	0.9	0.4	1.0	-0.2
Commuting to job workplace: Public transport	0.3	0.3	0.8	0.4	-0.1	0.9
Medication: Paracetamol	0.3	0.5	0.9	0.7	0.4	-1.0
Arm fat-free mass (left)	0.3	1.6	3.2	-0.9	-1.0	-1.8
Pain experienced in last month	0.3	0.5	0.8	0.6	0.9	-0.4
Alcohol drinker status: Previous	0.3	0.4	0.8	0.6	0.9	-0.3
Impedance of whole body	0.3	1.7	2.8	1.7	1.6	0.1
Arm predicted mass (left)	0.3	1.8	4.1	-0.7	-0.8	-2.0
Bipolar Disorder or Schizophrenia	0.2	0.5	0.9	-0.7	-0.3	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	-0.3	-0.4	-1.1
Heel T-Score	0.2	1.6	3.1	-0.6	-1.2	1.8
Relative age of first facial hair	0.2	0.5	1.1	-0.2	0.6	1.0
Medication for hormone replacement therapy	0.2	0.2	0.2	0.3	0.5	0.5
Medication: Metformin	0.2	0.3	0.8	-0.9	-0.0	-0.4
Diabetes (mother)	0.2	0.2	0.5	-0.4	-0.7	0.0
Impedance of leg (right)	0.2	0.8	1.4	0.9	1.2	0.1
Trunk fat percentage	0.2	0.6	1.7	0.4	0.0	-1.3
Forced vital capacity (FVC)	0.2	0.7	1.0	-1.0	-0.7	-0.9
Falls in the last year	0.2	0.3	0.5	-0.5	-0.7	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.5	0.4	0.7
Happiness	0.2	0.3	0.6	0.3	0.8	-0.3
Impedance of arm (left)	0.2	0.9	1.5	1.2	1.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.5	-0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	0.4	0.8	0.2
Body fat percentage	0.2	0.6	1.5	0.6	0.2	-1.2
Age at first live birth	0.2	0.4	0.7	-0.0	-0.8	-0.6
Whole body fat mass	0.2	0.9	2.5	-0.0	-0.2	-1.6
Leg fat mass (right)	0.2	0.8	2.2	-0.3	-0.2	-1.5
Comparative height size at age 10	0.2	1.0	2.6	0.3	-0.5	-1.6
Leg pain on walking	0.2	0.2	0.6	-0.2	-0.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.3	0.8	0.1
Supplements: Vitamin C	0.2	0.2	0.5	0.7	0.3	-0.0
Mood swings	0.2	0.4	1.1	-0.3	-0.3	-1.1
Qualifications: nursing, teaching	0.2	0.3	0.8	0.3	-0.9	0.2
Commuting to job workplace: Walk	0.2	0.3	0.4	0.1	0.6	-0.6
Medication: Aspirin	0.2	0.3	0.8	-0.3	0.2	0.9
Guilty feelings	0.2	0.3	0.4	-0.6	0.6	0.6
Cholesterol lowering medication	0.2	0.2	0.5	0.4	0.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	0.0	-0.2	0.7
Leg fat mass (left)	0.2	0.8	2.4	-0.1	-0.1	-1.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.6	0.1	-0.2
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.4	0.3	-0.7
Schizophrenia (2018)	0.1	0.2	0.2	0.3	0.4	-0.5
Prostate Cancer	0.1	0.1	0.2	0.4	0.4	-0.1
Mean Putamen Volume	0.1	0.1	0.2	-0.0	0.3	-0.4
HbA1C	0.1	0.1	0.2	0.3	0.0	-0.4
Schizophrenia (2014)	0.1	0.1	0.1	0.3	0.4	-0.4
Blood Red Count	0.1	0.9	1.7	0.9	1.3	-0.4
BMI	0.1	0.5	1.0	-1.0	-0.7	-0.1
Lung FEV1/FVC ratio	0.1	0.6	1.8	-0.3	-1.4	0.0
Lung FVC	0.1	0.5	0.8	0.4	0.7	-0.9
Neuroticism	0.1	0.3	0.8	-0.2	0.5	-0.9
Chronotype (morning person)	0.1	0.2	0.3	0.1	-0.6	0.5
Tanning	0.1	0.7	2.0	0.2	-0.2	1.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.2	-0.2	-0.7
Vitamin and mineral supplements	0.1	0.2	0.3	-0.5	0.4	-0.2
Fed-up feelings	0.1	0.2	0.4	0.1	0.6	0.3
Relative age voice broke	0.1	0.1	0.3	-0.2	0.2	0.5
Body mass index (BMI)	0.1	0.3	0.6	-0.3	-0.3	-0.8
Waist circumference	0.1	0.4	1.0	-0.2	-0.1	-1.0
Had menopause	0.1	0.1	0.4	-0.6	-0.2	-0.1
Fluid intelligence score	0.1	0.2	0.3	-0.4	-0.5	-0.5
Neuroticism score	0.1	0.1	0.3	-0.1	0.5	-0.3
Arm fat percentage (right)	0.1	0.4	0.7	0.5	0.5	-0.8
Time employed in main current job	0.1	0.1	0.2	0.4	0.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.3	0.0	-0.5
Depression (self-reported)	0.1	0.1	0.1	-0.4	-0.2	0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.3	0.3	-0.3
Arm fat mass (right)	0.1	0.5	1.6	-0.0	-0.0	-1.2
Glaucoma (self-reported)	0.1	0.1	0.3	-0.2	-0.5	0.2
Leg fat percentage (right)	0.1	0.3	0.6	0.3	0.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.7	-0.3	-0.0
Qualifications: College or University degree	0.1	0.2	0.2	-0.5	-0.5	0.3
Medication: Ibuprofen	0.1	0.1	0.3	0.3	-0.1	-0.5
Medication: Allopurinol	0.1	0.1	0.2	-0.5	-0.2	0.3
Medication: Omeprazole	0.1	0.1	0.2	0.4	0.2	-0.3
Age at last live birth	0.1	0.1	0.2	0.4	0.0	-0.3
Family relationship satisfaction	0.1	0.1	0.2	-0.1	-0.4	0.1
Medication: Gliclazide	0.1	0.1	0.4	-0.3	0.1	0.6
Arm fat mass (left)	0.1	0.5	1.3	-0.3	-0.3	-1.2
Miserableness	0.1	0.2	0.4	-0.6	0.2	-0.5
Hearing aid user	0.1	0.1	0.2	-0.1	0.3	0.5
Leg fat percentage (left)	0.1	0.3	0.6	0.4	0.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.3	-0.1	-0.5
Heart disease (siblings)	0.1	0.1	0.2	-0.3	0.5	-0.0
Depression (Nagel 2018)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Blood Platelet Count	0.0	0.3	0.5	0.3	0.7	-0.6
Hair Pigment	0.0	0.8	1.0	-0.8	-1.0	0.8
Number of treatments/medications taken	0.0	0.1	0.2	-0.1	0.1	0.4
Multivitamins +/- minerals	0.0	0.0	0.0	0.1	-0.2	0.1
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	-0.0	-0.2
Pain all over the body in last month	0.0	0.0	0.1	0.0	0.1	-0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.2	-0.4	0.4
Blood clot in the leg (DVT)	0.0	0.1	0.1	-0.0	-0.3	0.3
Medication: Amlodipine	0.0	0.1	0.1	-0.2	0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.1	-0.0	-0.4	-0.2
Pulse wave peak to peak time	0.0	0.1	0.1	0.2	-0.3	0.1
Arm fat percentage (left)	0.0	0.1	0.4	0.2	0.1	-0.6
Irritability	0.0	0.0	0.0	0.1	0.1	-0.2
Commuting to job workplace: Cycle	0.0	0.1	0.1	0.2	-0.1	-0.3

Hub : Genes

IL23R

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Trait associations