[Hub]/) : Traits : Crohns Disease (2017) :

chr9:138,525,778-140,321,666

Best TWAS P=1.23e-28 · Best GWAS P=3.14e-30 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex INPP5E 0.18 0.14 enet 21 0.21 1.6e-24 8.13 -8.9 5.8e-19 -0.66 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex SNAPC4 0.06 0.04 lasso 2 0.05 9.0e-07 10.32 -9.2 2.5e-20 -0.86 0.81 0.16 FALSE
3 GTEx Adipose Subcutaneous SDCCAG3 0.13 0.00 enet 21 0.04 4.8e-04 6.56 -6.3 2.5e-10 -0.38 0.20 0.07 FALSE
4 GTEx Adrenal Gland INPP5E 0.18 0.02 enet 23 0.10 2.2e-04 7.69 -8.0 1.1e-15 -0.63 0.16 0.33 FALSE
5 GTEx Artery Tibial SDCCAG3 0.05 0.00 lasso 4 0.00 2.2e-01 -8.32 -9.2 4.8e-20 -0.75 0.02 0.93 FALSE
6 GTEx Brain Caudate basal ganglia INPP5E 0.23 0.20 enet 8 0.22 7.2e-07 8.35 -8.9 3.8e-19 -0.73 0.41 0.34 FALSE
7 GTEx Brain Caudate basal ganglia SNHG7 0.37 0.10 lasso 6 0.27 2.5e-08 -0.23 6.0 2.5e-09 0.34 0.10 0.43 FALSE
8 GTEx Brain Cerebellar Hemisphere INPP5E 0.25 0.23 enet 6 0.17 3.4e-05 8.40 -9.2 4.2e-20 -0.76 0.30 0.56 FALSE
9 GTEx Brain Cerebellar Hemisphere GPSM1 0.26 0.07 lasso 4 0.11 9.6e-04 2.82 -6.3 3.5e-10 -0.53 0.08 0.45 FALSE
10 GTEx Brain Cerebellum INPP5E 0.40 0.30 enet 20 0.29 3.6e-09 8.35 -9.0 2.0e-19 -0.72 0.88 0.12 FALSE
11 GTEx Brain Putamen basal ganglia INPP5E 0.28 0.20 enet 6 0.01 2.2e-01 8.51 -9.5 2.2e-21 -0.80 0.12 0.64 FALSE
12 GTEx Cells EBV-transformed lymphocytes INPP5E 0.27 0.05 enet 21 0.14 2.0e-05 8.40 -7.4 9.8e-14 -0.50 0.09 0.42 FALSE
13 GTEx Cells Transformed fibroblasts SDCCAG3 0.12 0.03 enet 21 0.06 5.4e-05 6.56 -7.2 4.8e-13 -0.71 0.79 0.20 FALSE
14 GTEx Cells Transformed fibroblasts CARD9 0.10 0.01 enet 15 0.02 8.0e-03 -5.73 -9.2 5.3e-20 -0.56 0.06 0.84 FALSE
15 GTEx Colon Sigmoid INPP5E 0.22 0.10 lasso 3 0.01 1.6e-01 10.22 -10.5 8.7e-26 -0.94 0.02 0.96 FALSE
16 GTEx Colon Transverse SEC16A 0.13 0.04 lasso 4 0.05 2.5e-03 7.86 -6.5 5.9e-11 -0.49 0.14 0.17 FALSE
17 GTEx Colon Transverse SDCCAG3 0.11 0.01 lasso 8 0.02 5.5e-02 6.56 -6.7 1.7e-11 -0.58 0.18 0.27 FALSE
18 GTEx Esophagus Gastroesophageal Junction SEC16A 0.14 0.00 enet 12 0.02 5.1e-02 2.85 -6.1 9.6e-10 -0.37 0.14 0.07 FALSE
19 GTEx Esophagus Mucosa INPP5E 0.11 0.12 lasso 3 0.12 1.0e-08 8.40 -8.5 1.6e-17 -0.65 0.97 0.03 FALSE
20 GTEx Esophagus Muscularis SDCCAG3 0.10 0.02 enet 5 0.02 3.6e-02 4.58 -7.0 3.4e-12 -0.46 0.22 0.19 FALSE
21 GTEx Heart Atrial Appendage INPP5E 0.13 0.12 lasso 2 0.10 3.5e-05 7.94 -8.0 1.9e-15 -0.61 0.24 0.26 FALSE
22 GTEx Lung INPP5E 0.10 0.05 enet 13 0.04 6.1e-04 8.35 -8.8 1.9e-18 -0.72 0.61 0.21 FALSE
23 GTEx Lung SEC16A 0.14 0.11 enet 23 0.10 2.5e-08 2.86 -5.8 8.1e-09 -0.42 1.00 0.00 FALSE
24 GTEx Lung CARD9 0.08 0.04 enet 6 0.04 2.5e-04 6.83 8.8 9.3e-19 0.88 0.01 0.99 FALSE
25 GTEx Muscle Skeletal CARD9 0.16 0.12 enet 28 0.11 9.0e-11 -5.73 -7.2 7.7e-13 -0.27 1.00 0.00 TRUE
26 GTEx Nerve Tibial INPP5E 0.13 0.17 enet 10 0.14 3.7e-10 8.70 -8.8 2.0e-18 -0.65 1.00 0.00 FALSE
27 GTEx Ovary INPP5E 0.24 0.13 enet 11 0.15 1.9e-04 9.40 -9.8 1.2e-22 -0.80 0.09 0.49 FALSE
28 GTEx Ovary SEC16A 0.33 0.06 enet 10 0.14 3.4e-04 8.51 -6.7 2.7e-11 -0.64 0.04 0.44 FALSE
29 GTEx Pancreas SEC16A 0.28 0.10 enet 16 0.16 4.1e-07 7.86 -8.8 1.3e-18 -0.50 0.50 0.44 FALSE
30 GTEx Pancreas SDCCAG3 0.21 0.03 lasso 4 0.01 9.5e-02 5.45 -5.2 1.6e-07 -0.55 0.10 0.05 FALSE
31 GTEx Pituitary INPP5E 0.21 0.24 lasso 3 0.14 1.8e-04 8.35 8.0 1.0e-15 0.60 0.14 0.51 FALSE
32 GTEx Pituitary SEC16A 0.37 0.07 lasso 8 0.11 9.1e-04 1.55 -5.3 9.8e-08 -0.38 0.13 0.08 FALSE
33 GTEx Skin Sun Exposed Lower leg INPP5E 0.10 0.10 lasso 2 0.09 5.2e-08 8.40 -8.7 2.3e-18 -0.72 0.95 0.05 FALSE
34 GTEx Skin Sun Exposed Lower leg RP11-611D20.2 0.21 0.16 enet 16 0.17 3.3e-14 2.23 5.3 1.3e-07 0.18 1.00 0.00 TRUE
35 GTEx Spleen PMPCA 0.24 0.15 lasso 2 0.10 1.7e-03 7.30 7.0 3.4e-12 0.65 0.03 0.61 FALSE
36 GTEx Stomach INPP5E 0.13 0.00 enet 27 0.00 2.0e-01 8.55 -7.0 3.3e-12 -0.43 0.05 0.23 FALSE
37 GTEx Stomach SEC16A 0.15 0.09 lasso 4 0.10 1.8e-05 7.95 -8.1 5.2e-16 -0.60 0.62 0.28 FALSE
38 GTEx Testis INPP5E 0.24 0.32 enet 10 0.30 5.4e-14 8.70 -8.7 2.6e-18 -0.69 1.00 0.00 FALSE
39 GTEx Testis SDCCAG3 0.15 0.09 lasso 4 0.13 3.3e-06 6.56 -8.4 3.8e-17 -0.65 0.51 0.34 FALSE
40 GTEx Thyroid INPP5E 0.23 0.35 enet 16 0.37 8.2e-30 8.55 -9.5 2.4e-21 -0.81 0.94 0.06 FALSE
41 GTEx Thyroid PMPCA 0.10 0.05 enet 11 0.10 8.7e-08 7.81 -9.0 2.8e-19 -0.57 0.33 0.65 FALSE
42 GTEx Thyroid SDCCAG3 0.16 0.11 lasso 3 0.12 9.4e-10 6.56 -6.4 1.9e-10 -0.61 1.00 0.00 FALSE
43 GTEx Uterus INPP5E 0.60 0.04 enet 10 0.22 3.4e-05 9.53 -9.7 2.5e-22 -0.73 0.06 0.43 FALSE
44 GTEx Whole Blood SEC16A 0.07 0.05 lasso 5 0.04 1.3e-04 7.86 -8.1 4.3e-16 -0.62 0.69 0.27 FALSE
45 GTEx Whole Blood SDCCAG3 0.07 0.03 enet 6 0.02 3.4e-03 7.77 -9.6 8.5e-22 -0.83 0.02 0.98 FALSE
46 GTEx Whole Blood CARD9 0.08 0.07 lasso 1 0.05 4.2e-05 11.10 11.1 1.2e-28 0.98 0.02 0.98 TRUE
47 METSIM Adipose CARD9 0.04 0.05 enet 6 0.06 5.9e-09 -8.32 9.9 3.0e-23 0.78 0.16 0.84 FALSE
48 NTR Blood SNAPC4 0.02 0.01 lasso 5 0.02 6.3e-07 8.55 -7.1 9.2e-13 -0.67 0.21 0.77 FALSE
49 YFS Blood CARD9 0.22 0.37 lasso 5 0.39 1.3e-137 11.33 11.0 2.2e-28 0.97 0.00 1.00 FALSE
50 YFS Blood INPP5E 0.33 0.55 lasso 6 0.57 2.9e-235 9.53 -9.2 3.5e-20 -0.71 1.00 0.00 FALSE
51 YFS Blood PMPCA 0.03 0.01 lasso 5 0.02 2.7e-07 8.55 8.6 1.2e-17 0.79 0.08 0.92 FALSE
52 YFS Blood SDCCAG3 0.14 0.11 bslmm 310 0.14 1.6e-44 6.62 -5.1 3.1e-07 -0.54 1.00 0.00 FALSE
53 The Cancer Genome Atlas Bladder Urothelial Carcinoma SEC16A 0.12 0.02 enet 10 0.03 2.2e-03 -0.13 -5.4 7.7e-08 -0.30 0.06 0.07 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma SDCCAG3 0.05 0.01 blup 61 0.01 7.9e-04 7.95 -6.5 8.8e-11 -0.47 0.07 0.14 FALSE
55 The Cancer Genome Atlas Breast Invasive Carcinoma SEC16A 0.02 0.00 blup 69 0.01 1.0e-03 8.35 -10.2 1.7e-24 -0.66 0.11 0.40 FALSE
56 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma INPP5E 0.25 0.10 lasso 3 0.09 4.9e-05 9.53 -9.6 8.2e-22 -0.70 0.26 0.31 FALSE
57 The Cancer Genome Atlas Colon Adenocarcinoma INPP5E 0.11 0.08 lasso 2 0.08 3.4e-05 9.53 -9.5 1.6e-21 -0.71 0.14 0.16 FALSE
58 The Cancer Genome Atlas Colon Adenocarcinoma SDCCAG3 0.08 0.01 lasso 4 0.02 3.1e-02 5.45 -7.9 3.7e-15 -0.69 0.04 0.19 FALSE
59 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma INPP5E 0.03 0.01 blup 54 0.01 1.1e-02 9.45 -9.2 4.8e-20 -0.81 0.01 0.73 FALSE
60 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SDCCAG3 0.04 0.05 enet 6 0.04 5.1e-05 5.45 -7.6 3.3e-14 -0.73 0.54 0.41 FALSE
61 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma INPP5E 0.07 0.04 blup 54 0.07 6.0e-05 7.52 -10.3 7.7e-25 -0.82 0.04 0.87 FALSE
62 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SDCCAG3 0.05 0.01 blup 61 0.01 5.9e-02 8.13 -9.8 1.7e-22 -0.85 0.03 0.56 FALSE
63 The Cancer Genome Atlas Brain Lower Grade Glioma GPSM1 0.06 0.01 enet 11 0.02 1.0e-03 8.62 -5.3 1.2e-07 -0.67 0.01 0.90 FALSE
64 The Cancer Genome Atlas Brain Lower Grade Glioma INPP5E 0.04 0.02 blup 54 0.03 4.4e-04 8.35 -8.3 8.6e-17 -0.67 0.22 0.36 FALSE
65 The Cancer Genome Atlas Brain Lower Grade Glioma SNAPC4 0.13 0.05 enet 7 0.06 1.7e-07 6.45 -6.1 1.0e-09 -0.66 0.77 0.09 FALSE
66 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SNAPC4 0.40 0.12 lasso 2 0.11 4.0e-05 3.95 -5.5 4.7e-08 -0.52 0.08 0.05 FALSE
67 The Cancer Genome Atlas Prostate Adenocarcinoma SDCCAG3 0.08 0.05 lasso 2 0.05 3.3e-06 5.45 -7.7 1.1e-14 -0.75 0.60 0.32 FALSE
68 The Cancer Genome Atlas Prostate Adenocarcinoma SEC16A 0.08 0.10 lasso 4 0.08 1.9e-08 7.48 -7.7 1.2e-14 -0.58 1.00 0.00 FALSE
69 The Cancer Genome Atlas Rectum Adenocarcinoma DNLZ 0.75 0.03 enet 20 0.22 7.0e-06 0.56 -6.9 7.0e-12 -0.42 0.00 0.11 FALSE
70 The Cancer Genome Atlas Testicular Germ Cell Tumors INPP5E 0.10 0.06 blup 54 0.08 8.1e-04 8.40 -9.9 4.0e-23 -0.83 0.03 0.73 FALSE
71 The Cancer Genome Atlas Thyroid Carcinoma INPP5E 0.11 0.16 lasso 3 0.16 2.4e-15 9.45 -9.5 1.7e-21 -0.82 0.87 0.13 FALSE
72 The Cancer Genome Atlas Thyroid Carcinoma SDCCAG3 0.16 0.14 lasso 4 0.12 8.2e-12 5.45 -5.6 2.6e-08 -0.57 1.00 0.00 FALSE