TWAS hub - TNFSF15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0479	0.0189	0.0026	0.056	0.017	0.053	0.046	0.057	7.1e-09	0.0010	2.1e-08	2e-07	5.4e-09
2	TCGA	Breast Invasive Carcinoma	0.0195	0.0111	0.0088	0.007	0.008	-0.001	NA	0.001	1.2e-02	0.0077	4.9e-01	NA	2.1e-01
3	TCGA	Colon Adenocarcinoma	0.0510	0.0270	0.0052	-0.002	0.041	0.011	NA	0.015	4.2e-01	0.0021	7.5e-02	NA	4.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Irritable Bowel Disease (IBD)	29.8	70.9	104.0	-10.2	-10.2	2.1
Crohns Disease (2017)	26.5	58.1	88.9	-9.4	-9.2	0.8
Crohns Disease (2012)	23.8	38.3	60.4	-7.8	-7.4	0.3
Ulcerative Colitis (UC)	17.7	33.3	46.5	-6.8	-6.8	2.7
Ulcerative Colitis	9.8	14.2	23.8	-4.3	-4.9	0.7
Mouth/teeth dental problems: Mouth ulcers	9.1	14.4	18.8	4.3	3.8	-3.1
Number of treatments/medications taken	6.1	10.9	16.9	-3.9	-4.1	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.1	7.2	12.6	3.0	3.5	-0.2
Heart attack	5.4	6.9	10.9	-3.1	-3.3	0.3
Long-standing illness, disability or infirmity	5.4	8.3	13.3	-3.6	-2.9	1.8
Heart attack/myocardial infarction (self-reported)	5.3	6.9	11.0	-3.1	-3.3	0.2
Primary Biliary Cirrhosis	4.9	7.0	13.4	-2.7	-3.7	-0.5
Pulse wave reflection index	4.6	5.7	11.0	-2.5	-3.3	0.1
Taking other prescription medications	4.4	6.8	11.8	-3.4	-2.9	0.6
Medication: Lansoprazole	4.4	5.0	10.0	-1.7	-3.2	-1.4
Asthma	3.8	7.5	12.6	-3.6	-1.1	2.9
Asthma (self-reported)	3.7	7.4	12.0	-3.5	-0.8	3.1
Pulse wave Arterial Stiffness index	3.5	4.1	7.9	-2.0	-2.8	0.5
Respiratory disease	3.4	7.7	14.9	-3.9	-1.8	2.2
Mood swings	3.3	5.9	8.1	-2.9	-1.9	2.5
Medication: Ramipril	3.2	4.1	5.3	-2.1	-2.3	1.5
Pulse wave peak to peak time	3.2	3.8	7.5	2.0	2.7	-0.3
Number of self-reported non-cancer illnesses	3.2	5.5	6.9	-2.6	-2.6	1.7
Diabetes (father)	3.1	3.8	8.4	-1.7	-0.0	2.9
Smoking status: Previous	3.1	4.6	9.5	-2.1	-3.1	-0.2
Pack years adult smoking proportion	2.7	4.1	9.2	-1.7	-0.4	3.0
Pack years of smoking	2.7	4.0	6.6	-2.1	-1.0	2.6
Allergy or Eczema	2.6	6.9	12.5	-2.8	-0.3	3.5
Hayfever, allergic rhinitis or eczema	2.6	5.6	12.5	-2.0	0.6	3.5
Worrier / anxious feelings	2.6	4.9	7.7	-2.1	-1.6	2.8
Medication: Ventolin 100micrograms inhaler	2.6	3.4	6.8	-2.6	-0.8	1.7
Number of full brothers	2.6	3.3	4.4	1.8	1.5	-2.1
Back pain experienced in last month	2.6	3.8	5.7	-2.1	-1.1	2.4
Blood Eosinophil Count	2.5	19.3	29.3	5.4	5.1	-1.6
Fed-up feelings	2.5	4.6	5.4	-2.3	-2.0	2.1
Average weekly champagne plus white wine intake	2.5	3.4	6.6	2.6	1.8	-0.7
Multivitamins +/- minerals	2.4	3.1	8.1	0.6	-0.9	-2.8
Chest pain or discomfort	2.3	3.4	7.2	-1.5	-0.7	2.7
Commuting to job workplace: Public transport	2.3	2.8	4.8	-1.8	-0.6	2.2
Neuroticism (2016)	2.2	3.1	6.2	-1.7	-0.5	2.5
Past tobacco smoking	2.2	4.0	8.4	1.9	2.9	0.5
Hearing difficulty/problems: Yes	2.1	3.2	5.5	-2.3	-0.1	2.0
Overall health rating	2.1	4.6	7.2	-2.7	-2.5	0.6
Number of incorrect matches in round	2.0	3.3	6.8	-1.7	-2.6	-0.2
Allergy	2.0	4.6	10.4	1.8	-0.3	-3.2
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	5.4	-2.3	-2.1	0.3
Ever smoked	2.0	3.5	7.2	-1.8	-2.7	-0.5
Irritability	2.0	3.3	7.9	-1.5	-0.0	2.8
Age at First Birth	1.9	2.8	5.2	1.8	2.3	0.2
Bipolar Disorder (2011)	1.9	1.9	4.2	-1.0	0.7	2.0
Vitamin and mineral supplements	1.9	2.6	5.6	-1.4	-0.3	2.4
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	6.5	2.5	2.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	5.8	2.4	2.1	-1.4
Depression (Nagel 2018)	1.8	2.8	6.2	-1.4	-0.4	2.5
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	4.0	2.0	1.6	-1.6
Alzheimer’s Disease (including proxy)	1.7	2.5	3.0	1.7	1.6	-1.4
Wheeze or whistling in the chest in last year	1.7	3.0	5.7	-2.4	-0.5	1.8
Eye problems/disorders: None of the above	1.7	2.0	2.2	-1.2	-1.5	-1.5
Medication: Aspirin	1.7	2.2	4.1	-1.6	-2.0	-0.3
Frequency of depressed mood in last 2 weeks	1.6	2.3	3.6	-1.6	-0.8	1.9
Medication: Cholesterol lowering	1.6	2.5	3.9	-1.7	-2.0	0.8
Angina (self-reported)	1.6	2.1	3.8	-1.6	-1.9	0.0
Average weekly red wine intake	1.6	2.4	4.2	2.0	1.4	-1.0
Medication: Co-codamol	1.5	1.8	3.6	-1.9	-1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.5	-1.3	0.7	1.9
Illnesses of father: Heart disease	1.5	2.1	4.2	-1.4	-0.4	2.1
Medication: Aspirin	1.5	2.0	3.8	-1.4	-1.9	-0.1
Alzheimer’s Disease (in mother)	1.4	1.6	3.2	1.1	0.7	-1.8
Body Mass Index (BMI) (2010)	1.4	1.9	2.5	1.6	0.9	-1.5
Age when periods started (menarche)	1.4	3.3	4.4	-2.0	-2.1	-1.2
Exposure to tobacco smoke at home	1.4	1.5	3.2	-1.2	0.0	1.8
Illnesses of father: None of the above (group 1)	1.4	1.8	3.7	0.8	-1.0	-1.9
Ever taken oral contraceptive pill	1.4	1.6	2.6	1.6	-0.2	-1.5
Basal cell carcinoma (self-reported)	1.4	1.6	2.3	-1.5	-1.3	1.0
Schizophrenia (2018)	1.3	2.7	3.8	-2.0	-0.8	1.9
Schizophrenia (2014)	1.3	2.8	4.1	-1.9	-0.9	2.0
Smoking Status	1.3	3.2	7.2	-1.3	-2.7	0.7
Ever used hormone-replacement therapy (HRT)	1.3	1.7	4.2	-0.7	-2.0	-0.5
Angina	1.3	1.8	3.0	-1.5	-1.7	0.0
Hand grip strength (right)	1.3	3.7	6.4	2.5	2.1	-0.3
Length of working week for main job	1.3	1.4	1.8	1.3	1.1	1.1
Medication: Blood pressure	1.3	2.3	3.4	-1.8	-1.4	1.2
Medication: Omeprazole	1.3	1.5	2.5	-0.9	-1.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.3	-1.2	-1.5	-0.8
Average weekly beer plus cider intake	1.3	1.8	3.4	-0.5	-1.4	-1.8
Rheumatoid Arthritis	1.2	1.7	3.3	0.3	1.8	1.3
Triglycerides	1.2	2.0	3.3	1.8	1.6	0.2
Health satisfaction	1.2	1.6	2.4	-0.8	-1.3	1.6
Had major operations	1.2	1.4	3.2	-0.2	-1.0	-1.8
Age at last live birth	1.2	1.8	3.6	1.2	1.9	-0.5
Leg pain on walking	1.2	1.5	3.6	-0.8	0.5	1.9
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.0	1.4	1.2	-1.0
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.0	-1.7	-1.2	-0.0
Unable to work because of sickness or disability	1.2	1.6	3.3	-1.8	-1.2	0.1
Fasting Glucose	1.1	1.3	3.8	-0.2	-0.3	-2.0
Serious illness, injury or assault to yourself	1.1	1.4	2.4	-1.3	-1.6	0.1
Illnesses of mother	1.1	1.4	2.0	-0.6	-1.4	1.4
Qualifications: College or University degree	1.1	3.4	6.5	2.5	1.7	-0.9
Neck or shoulder pain in last month	1.1	1.5	2.8	-1.7	-0.4	1.3
Wears glasses or contact lenses	1.1	1.2	1.4	-1.0	-1.1	1.2
Hearing aid user	1.1	1.2	1.4	-1.2	-0.9	1.2
Medication: Lisinopril	1.1	1.4	3.1	1.0	1.8	0.5
Depressed Affect (Nagel 2018)	1.0	2.1	3.1	-1.8	-1.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.3	-1.2	-0.5	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.3	-1.5	-1.2	0.9
Mouth/teeth dental problems: Dentures	1.0	1.6	2.5	-1.1	-1.1	1.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.2	1.5	1.3	-0.9
Medication for pain relief, constipation, heartburn	1.0	1.7	2.9	1.7	1.5	-0.3
Knee pain experienced in last month	1.0	1.5	3.2	-0.6	-0.9	-1.8
Medication: Gliclazide	1.0	1.1	2.2	-1.5	-0.6	0.9
Bipolar Disorder or Schizophrenia	0.9	2.1	3.0	-1.7	-0.7	1.7
Neuroticism (Nagel 2018)	0.9	2.2	5.1	-1.3	-0.2	2.3
Worry (Nagel 2018)	0.9	1.9	4.2	-1.1	-0.3	2.0
Alzheimer’s Disease (in father)	0.9	1.0	1.3	1.1	1.1	-0.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.0	-1.7	-0.6	0.0
Number of live births	0.9	1.3	2.3	1.5	1.3	-0.2
Loud music exposure frequency	0.9	0.9	2.6	0.1	0.5	1.6
Migraine (self-reported)	0.9	1.2	3.2	0.0	0.6	1.8
Osteoporosis (self-reported)	0.9	1.1	1.5	-0.9	-1.2	-0.9
Medication: Bendroflumethiazide	0.9	1.3	1.8	-0.9	-1.1	1.3
Myopia	0.9	1.4	1.9	-1.4	-1.2	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.6	1.9	1.5	-0.3
HDL Cholesterol	0.8	1.3	2.2	-1.5	-0.5	1.3
Medication: Paracetamol	0.8	1.4	2.0	-1.3	-1.4	-0.7
Birth weight	0.8	1.7	3.9	1.0	2.0	-0.3
Eye problems/disorders: Cataract	0.8	1.0	2.0	-0.9	-1.4	0.4
Medication: Paracetamol	0.8	1.2	2.1	-1.4	-1.2	-0.0
Medication: Atorvastatin	0.8	1.0	1.7	-1.3	-1.1	0.3
Illnesses of father: High blood pressure	0.8	1.0	2.4	0.8	1.6	0.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	2.8	1.7	1.5	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.1	-0.5	-1.5	0.6
Major Depression (MDD)	0.7	0.8	2.0	0.1	0.7	1.4
Hand grip strength (left)	0.7	1.8	3.1	1.8	1.5	-0.4
Relative age voice broke	0.7	1.1	3.0	0.5	0.4	1.7
Hair/balding pattern: Pattern 2	0.7	0.8	1.8	0.8	1.3	-0.1
Neuroticism score	0.7	1.4	2.6	-1.2	-0.5	1.6
Falls in the last year	0.7	1.0	1.8	-1.4	-0.9	0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.0	2.2	1.0	-1.0
Pulse rate	0.7	1.2	2.6	-0.9	-0.4	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.1	-0.7	-0.9	1.1
Prospective memory result	0.7	0.8	1.3	0.7	0.8	-1.1
Shortness of breath walking on level ground	0.7	0.8	1.6	-0.9	0.3	1.3
Mean time to correctly identify matches	0.7	1.3	2.5	-1.6	-1.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.6	-1.3	-0.9	0.3
Loneliness, isolation	0.7	0.9	2.0	-1.4	-0.7	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.2	1.1	0.8	-0.5
Mineral and other dietary supplements	0.7	1.0	2.3	-0.7	0.4	1.5
Eye problems/disorders: Glaucoma	0.7	0.9	2.3	0.4	1.5	0.5
Arm fat-free mass (left)	0.7	3.5	4.8	2.2	2.2	1.0
Pain experienced in last month	0.7	1.2	2.8	0.8	0.4	-1.7
Coronary Artery Disease (CAD)	0.6	0.7	1.4	-0.9	-0.1	1.2
Mean Putamen Volume	0.6	0.6	1.9	-0.1	0.1	-1.4
Lung FEV1/FVC ratio	0.6	3.2	5.3	2.3	0.3	-2.0
Townsend deprivation index at recruitment	0.6	0.8	1.8	-1.4	-0.8	0.3
Stomach or abdominal pain in last month	0.6	0.7	2.1	-0.1	-0.2	1.5
Diabetes (self-reported)	0.6	1.0	1.5	-1.2	-0.4	1.1
Fluid intelligence score	0.6	1.2	2.1	1.4	1.2	-0.3
Hair/balding pattern: Pattern 3	0.6	0.8	1.4	0.1	-1.0	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.8	1.9	1.1	-1.0
Peak expiratory flow (PEF)	0.6	1.4	2.3	1.5	1.3	-0.6
Medication: Amlodipine	0.6	0.9	1.4	-1.0	-1.2	-0.6
Commuting to job workplace: Walk	0.6	0.6	0.9	0.8	0.6	-1.0
Ever depressed for a whole week	0.6	0.7	1.2	0.9	1.1	0.5
Heart disease (siblings)	0.6	0.8	1.5	0.8	0.4	-1.2
Arm predicted mass (left)	0.6	3.2	5.2	2.3	2.0	0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.3	1.5	0.6	-1.5
LDL Cholesterol	0.5	0.9	1.3	-1.1	-1.1	0.2
Cardiovascular Disease	0.5	1.8	4.2	-1.1	-0.1	2.1
Neuroticism	0.5	1.1	2.0	-1.0	-0.5	1.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	0.3	0.7	1.0
Supplements: Zinc	0.5	0.6	1.0	0.4	0.7	1.0
Medication: Metformin	0.5	0.7	1.8	-0.4	0.1	1.4
Current tobacco smoking	0.5	0.9	2.0	0.1	-0.7	1.4
Qualifications: CSEs or equivalent	0.5	0.6	0.9	0.9	0.8	-0.6
High blood pressure	0.5	1.3	2.3	-1.1	-0.7	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.5	-0.1	-0.2	-1.9
Pain all over the body in last month	0.5	0.5	1.4	-0.2	-1.2	-0.2
Father’s age at death	0.5	0.7	1.7	0.6	0.3	-1.3
Tense / ‘highly strung’	0.5	0.9	2.0	-0.7	-0.2	1.4
Arm fat-free mass (right)	0.5	2.8	4.7	2.2	1.8	0.8
Exposure to tobacco smoke outside home	0.5	0.7	1.0	-1.0	-0.6	-0.7
Number of children fathered	0.5	0.5	1.2	0.5	-0.3	-1.1
Medication: Allopurinol	0.5	0.6	1.6	0.3	0.4	-1.3
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-1.1	-0.1	0.8
Arm predicted mass (right)	0.5	2.5	4.2	2.0	1.7	0.7
Alcohol intake frequency.	0.5	1.1	1.6	0.2	1.3	1.3
Hypertension (Self-reported)	0.5	1.4	2.7	-1.1	-0.6	1.6
Guilty feelings	0.5	0.8	1.5	0.4	1.2	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.2	0.0	-1.0	-1.1
Number of operations (self-reported)	0.5	0.7	1.8	-0.1	-1.3	-0.5
Fractured/broken bones in last 5 years	0.5	0.6	0.7	-0.7	-0.9	0.8
Heel T-Score	0.4	3.4	6.9	1.3	1.3	-2.6
Waist Hip Ratio (WHR)	0.4	1.8	5.2	-0.4	-0.1	2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.6	-0.8	-0.2	1.3
Average weekly spirits intake	0.4	0.5	0.8	-0.5	-0.6	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	-0.7	-0.5	0.9
Impedance of leg (right)	0.4	1.7	3.0	-1.7	-0.5	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.5	0.0	0.1	-1.6
Supplements: Glucosamine	0.4	0.5	0.8	0.4	-0.7	-0.9
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	1.0	-0.1	-0.7
Impedance of leg (left)	0.4	1.9	2.8	-1.7	0.2	1.6
Qualifications: None of the above	0.4	0.8	1.3	-1.0	-1.2	0.2
Mouth/teeth dental problems	0.4	0.7	1.3	-0.3	-1.1	-0.8
Time employed in main current job	0.4	0.5	0.9	0.9	-0.4	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.3	0.9	0.5	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	0.9	0.5	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	0.6	0.5	-0.9
Diabetes diagnosed by doctor	0.4	0.7	1.0	-0.9	-0.3	1.0
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.3	-0.4	1.2
Whole body water mass	0.4	2.1	3.6	1.9	1.5	0.6
High cholesterol (Self-reported)	0.4	0.8	1.2	-0.5	-1.0	1.1
Diastolic blood pressure, automated reading	0.4	1.1	2.2	-1.5	-0.8	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.8	-0.1	-0.4
Blood Red Count	0.3	3.0	6.4	2.5	1.6	-0.4
Blood White Count	0.3	2.1	2.2	-1.5	-1.4	1.4
Chronotype (morning person)	0.3	0.8	2.2	-0.3	0.2	1.5
Sensitivity / hurt feelings	0.3	0.6	1.5	-0.1	-0.4	1.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.8	0.1	-0.6
Severe depression (siblings)	0.3	0.3	0.6	-0.5	-0.4	-0.8
Leg fat-free mass (left)	0.3	1.4	3.1	1.7	1.0	-0.2
Leg predicted mass (left)	0.3	1.4	3.1	1.8	1.0	-0.2
Alcohol usually taken with meals	0.3	0.5	0.7	0.7	0.8	0.5
Nervous feelings	0.3	0.6	1.4	0.1	0.6	1.2
Had menopause	0.3	0.4	1.1	-0.1	-1.1	-0.2
Had other major operations	0.3	0.3	0.8	-0.4	-0.9	0.2
Forced vital capacity (FVC)	0.3	1.1	2.8	1.7	0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.7	-0.8	0.4	0.4
Trunk fat-free mass	0.3	2.0	3.0	1.7	1.4	0.9
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.9	-0.1	0.7
Noisy workplace	0.3	0.4	1.1	-0.2	-1.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.8	0.9	0.8	-0.8
Depression (self-reported)	0.3	0.4	0.7	-0.6	-0.8	-0.1
Trunk predicted mass	0.3	1.9	2.7	1.6	1.4	1.0
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.1	-0.8	0.7
Glaucoma (self-reported)	0.3	0.4	0.6	-0.1	0.7	0.7
High blood pressure (siblings)	0.3	0.5	0.6	-0.8	-0.7	0.6
Forced vital capacity (FVC), Best measure	0.3	0.9	2.0	1.4	0.9	0.1
Heart disease (mother)	0.3	0.3	0.8	0.5	0.1	-0.9
Number of full sisters	0.3	0.4	0.6	0.5	-0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.4	-0.5	-0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	0.8	0.6	-0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.4	0.9	-0.3
Whole body fat-free mass	0.3	1.9	3.5	1.9	1.4	0.5
Leg fat-free mass (right)	0.3	1.7	3.2	1.8	1.3	-0.2
Smoking status: Current	0.3	0.4	0.9	0.3	-0.6	0.9
Leg predicted mass (right)	0.3	1.7	3.3	1.8	1.3	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.3	0.8	0.4
Alcohol drinker status: Never	0.3	0.3	0.4	-0.4	0.5	0.6
Basal metabolic rate	0.3	1.6	2.9	1.7	1.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.2	-0.7	0.8
Alcohol drinker status: Previous	0.3	0.4	0.9	1.0	0.5	-0.0
Blood Platelet Count	0.2	2.3	5.8	-2.4	-1.1	0.1
Height	0.2	2.9	8.1	-0.6	-0.5	2.8
Systolic Blood Pressure	0.2	1.2	3.0	-1.7	-0.7	0.4
Relative age of first facial hair	0.2	0.4	0.6	0.8	0.5	0.5
Systolic blood pressure, automated reading	0.2	0.6	0.8	-0.9	-0.7	-0.6
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.2	0.2	-0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.8	-0.0	0.4
Financial difficulties in last 2 years	0.2	0.3	0.4	0.5	0.7	0.4
Medication: Simvastatin	0.2	0.2	0.6	-0.3	-0.2	0.8
Impedance of arm (right)	0.2	0.7	1.9	-1.4	-0.5	-0.1
Impedance of arm (left)	0.2	0.9	2.2	-1.5	-0.7	-0.0
Standing height	0.2	1.9	4.4	0.3	1.1	2.1
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.1	1.0	0.6
Headache pain in last month	0.2	0.3	0.6	0.4	0.4	0.8
Gout (self-reported)	0.2	0.3	0.7	0.0	0.8	-0.5
Worry too long after embarrassment	0.2	0.3	0.6	0.5	0.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.8	-0.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.7	0.2	-0.8	-0.3
Comparative height size at age 10	0.2	1.4	3.6	-0.6	-0.3	1.9
Suffer from ‘nerves’	0.2	0.4	0.9	0.5	0.9	0.1
Family relationship satisfaction	0.2	0.2	0.4	0.4	0.6	0.3
Supplements: Vitamin C	0.2	0.2	0.3	0.5	-0.4	-0.4
Friendships satisfaction	0.2	0.3	0.6	-0.2	0.8	0.4
Medication for cholesterol	0.2	0.3	0.5	-0.2	0.4	0.7
Mother’s age at death	0.2	0.3	0.7	0.9	0.3	-0.3
Age started oral contraceptive pill	0.2	0.2	0.5	-0.2	-0.1	0.7
Cholesterol lowering medication	0.2	0.3	0.7	-0.5	-0.8	0.2
Supplements: Calcium	0.2	0.3	0.5	0.7	0.3	-0.4
Impedance of whole body	0.2	1.2	2.9	-1.7	-0.3	0.8
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.2	-0.1	0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.3	0.2	0.6
Reaction Time	0.1	0.2	0.4	-0.7	-0.1	0.3
Breast Cancer	0.1	0.3	0.5	-0.4	0.7	0.4
HbA1C	0.1	0.1	0.1	0.4	0.1	-0.4
BMI	0.1	0.3	0.4	0.7	-0.6	-0.5
Lung FVC	0.1	0.5	1.1	0.4	-1.0	-0.4
Tanning	0.1	1.6	3.6	-1.1	-0.1	1.9
Average weekly fortified wine intake	0.1	0.1	0.2	0.5	0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.2	-0.6	-0.2
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.4	-0.1	-0.3
Sitting height	0.1	0.7	1.2	1.1	0.9	0.2
High blood pressure (mother)	0.1	0.2	0.3	-0.4	0.5	-0.4
Body mass index (BMI)	0.1	0.5	0.9	0.7	-0.3	-1.0
Waist circumference	0.1	0.4	1.1	0.1	-0.0	1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	0.4	0.2	-0.6
Illnesses of siblings	0.1	0.2	0.4	-0.0	-0.3	0.7
Arm fat percentage (right)	0.1	0.3	0.9	0.2	-0.3	-1.0
Hip circumference	0.1	0.5	0.7	0.8	0.8	-0.3
Happiness	0.1	0.1	0.2	-0.4	-0.3	0.3
Arm fat mass (right)	0.1	0.2	0.5	0.7	0.0	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.2	0.4	0.1
Body fat percentage	0.1	0.2	0.5	-0.1	-0.4	-0.7
Leg fat percentage (right)	0.1	0.3	0.6	-0.2	-0.8	-0.5
Comparative body size at age 10	0.1	0.3	0.5	0.3	-0.5	-0.7
Age at first live birth	0.1	0.3	0.5	-0.1	0.5	-0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.2	0.3	0.4
Pulse rate, automated reading	0.1	0.3	0.6	-0.8	-0.1	0.6
Arm fat percentage (left)	0.1	0.5	1.2	0.2	-0.4	-1.1
Ever had bowel cancer screening	0.1	0.1	0.3	0.2	0.5	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.4	0.6	0.2
Arm fat mass (left)	0.1	0.4	0.7	0.8	0.0	-0.7
Miserableness	0.1	0.2	0.4	-0.4	0.3	0.6
Risk taking	0.1	0.2	0.2	-0.4	-0.5	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.3	-0.4	0.4
Ovarian Cancer	0.0	0.1	0.1	-0.2	0.1	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.1	-0.3	-0.2	-0.1
Hypothyroidism (self reported)	0.0	0.1	0.2	0.2	-0.0	-0.5
Hair Pigment	0.0	0.8	1.7	-0.9	-0.2	-1.3
Diabetes (mother)	0.0	0.1	0.1	-0.2	-0.4	0.0
Trunk fat percentage	0.0	0.1	0.3	0.1	-0.2	-0.6
Maternal smoking around birth	0.0	0.0	0.1	0.1	0.3	0.0
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.1	0.2	0.3	0.1
Medication: Atenolol	0.0	0.0	0.1	-0.1	0.0	0.3
Trunk fat mass	0.0	0.1	0.1	0.3	0.0	-0.3
Weight	0.0	0.2	0.6	0.8	0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.0	-0.0	0.2
Lung cancer (father)	0.0	0.1	0.1	0.4	0.1	0.2
Breastfed as a baby	0.0	0.0	0.0	0.0	0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	-0.1	0.4
Birth weight of first child	0.0	0.0	0.1	-0.1	-0.3	-0.0
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.1	-0.1	-0.0
Medication: Ibuprofen	0.0	0.0	0.1	0.2	0.1	-0.0
Whole body fat mass	0.0	0.0	0.1	0.3	-0.1	-0.1
Leg fat mass (right)	0.0	0.1	0.1	0.3	-0.3	-0.2
Breast cancer (self-reported)	0.0	0.0	0.1	0.1	0.3	0.1
Financial situation satisfaction	0.0	0.0	0.1	-0.2	0.3	0.2
Medication: Blood pressure	0.0	0.1	0.2	0.4	-0.2	-0.2
Leg fat percentage (left)	0.0	0.1	0.1	-0.0	-0.2	-0.4
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.1	-0.2	-0.1
Leg fat mass (left)	0.0	0.1	0.2	0.5	0.0	-0.2

Hub : Genes

TNFSF15

Models

Trait associations