Hub : Genes

PMPCA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.3130	0.1030	8.8e-04	0.002	NA	0.021	NA	0.061	2.9e-01	NA	8.3e-02	NA	8.9e-03
2	GTEx	Spleen	0.2440	0.1060	7.7e-03	0.147	NA	0.011	NA	0.098	1.4e-04	NA	1.6e-01	NA	1.7e-03
3	GTEx	Thyroid	0.0980	0.0320	4.6e-05	0.051	NA	0.096	NA	0.094	8.4e-05	NA	8.7e-08	NA	1.1e-07
4	YFS	Blood	0.0273	0.0097	8.5e-06	0.015	0.017	0.020	0.018	0.020	1.0e-05	1.7e-06	2.9e-07	9.7e-07	2.7e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.5	3.3	-0.2	-1.8	0.0	-1.6
Bipolar Disorder or Schizophrenia	0.1	0.1	0.2	0.5	0.4	0.0	-0.4
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	0.3	1.2	-0.6	-0.3
Depression (Nagel 2018)	0.2	0.2	0.5	0.5	0.7	-0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.4	1.0	1.4	-1.8	-0.2
Neuroticism (Nagel 2018)	0.3	0.7	1.5	0.1	1.2	-1.2	-0.0
Schizophrenia (2018)	1.1	2.3	4.2	0.8	1.9	-2.1	0.8
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.4	0.9	2.0	0.4	0.6	-1.4	1.0
Alzheimer’s Disease (in mother)	3.1	3.7	4.4	2.0	2.0	-1.6	2.1
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.4	0.6	-0.1	0.4
Alzheimer’s Disease (including proxy)	0.9	1.4	1.7	1.3	1.3	-0.8	1.3
Crohns Disease (2017)	25.2	55.4	80.5	4.4	7.0	-9.0	8.6
Irritable Bowel Disease (IBD)	29.7	70.6	88.9	6.4	8.0	-9.4	9.4
Ulcerative Colitis (UC)	15.9	29.9	34.0	5.0	5.2	-5.7	5.8
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.9	1.7	2.9	-1.3	-1.3	0.5	-1.7
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.8	1.4	1.3	-1.7	-0.1
Breast Cancer	0.3	0.7	1.4	-1.2	-0.4	0.8	-0.9
Ovarian Cancer	0.1	0.1	0.3	0.5	-0.0	-0.3	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.4	1.7	-1.3	-1.3	1.1	-1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	0.5	-0.5	0.1	-0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	9.8	15.8	63.0	0.0	0.0	0.0	7.9
Mean Putamen Volume	2.4	2.8	5.6	-0.9	-1.8	2.4	-1.2
Fasting Glucose	1.5	1.8	3.1	-0.0	-1.8	1.4	-1.6
HbA1C	1.6	1.7	2.4	-1.5	-1.4	1.2	-1.0
HDL Cholesterol	0.4	0.7	1.3	-0.1	-0.7	0.9	-1.2
LDL Cholesterol	0.8	1.2	1.9	0.7	-1.0	1.2	-1.4
Lupus	0.2	0.4	0.9	0.3	-0.5	0.4	-0.9
Neuroticism (2016)	2.0	2.8	5.3	0.0	2.1	-2.3	1.2
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.7	0.1	0.4	0.1
Rheumatoid Arthritis	2.0	2.7	3.4	-1.6	-1.9	1.5	-1.6
Schizophrenia (2014)	0.2	0.4	1.4	0.1	0.4	-1.2	-0.1
Triglycerides	3.4	5.6	8.2	2.4	2.9	-2.4	1.6
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	18.5	26.8	35.0	4.5	4.8	-5.9	5.4
Blood Eosinophil Count	3.7	28.5	49.7	5.4	7.0	-4.3	4.0
Blood Platelet Count	0.3	3.6	8.8	3.0	1.5	-1.0	1.5
Blood Red Count	0.6	6.1	12.0	2.2	3.5	-2.1	1.7
Blood White Count	9.5	70.0	96.0	7.4	9.8	-8.1	8.0
Heel T-Score	0.1	0.4	1.7	-1.3	-0.2	0.2	-0.1
BMI	0.3	1.7	2.5	1.4	-1.6	1.4	0.2
Height	2.9	55.8	77.1	5.5	8.8	-8.0	7.2
Waist Hip Ratio (WHR)	0.7	2.9	5.4	-1.8	-2.3	0.6	-1.7
Systolic Blood Pressure	0.1	0.5	0.8	-0.9	-0.6	-0.5	0.9
Smoking Status	2.2	5.2	7.6	-2.6	-2.8	1.8	-1.7
Allergy or Eczema	0.2	0.5	0.9	0.9	0.2	-0.5	0.8
Cardiovascular Disease	1.0	3.2	7.8	1.7	-0.4	-2.8	1.4
Hypothyroidism (self reported)	0.4	1.0	1.5	-1.0	-0.8	0.8	-1.2
Respiratory disease	1.4	3.1	6.8	1.0	2.6	-1.6	1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	0.2	-1.4	0.0	-0.3
Lung FEV1/FVC ratio	0.4	2.1	3.0	1.2	-1.5	1.7	-1.3
Lung FVC	6.1	31.2	37.6	-6.1	-5.8	4.9	-5.4
Neuroticism	0.5	1.2	2.4	1.0	1.2	-1.5	0.1
Chronotype (morning person)	7.9	18.4	22.3	3.7	4.0	-4.7	4.7
Hair Pigment	0.2	5.7	9.7	1.2	2.5	-2.3	3.1
Tanning	0.2	2.8	4.3	-1.7	-1.4	2.1	-1.5
Hand grip strength (left)	0.1	0.2	0.8	-0.9	-0.2	0.0	0.0
Number of treatments/medications taken	0.4	0.8	2.8	0.5	-0.1	-1.7	-0.5
Average weekly spirits intake	0.9	1.1	3.1	-0.7	-1.8	-0.6	0.6
Sensitivity / hurt feelings	1.1	1.9	4.5	1.0	2.1	-1.4	0.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.9	1.1	1.4	-1.2	0.7
Hearing difficulty/problems: Yes	1.3	2.0	3.3	1.5	1.1	-1.1	1.8
Relative age of first facial hair	0.5	1.0	2.0	0.1	0.3	-1.4	1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.5	-1.2	-0.2	-0.1	-0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.2	-0.7	-0.4	-1.5	0.7
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.7	-0.4	-1.0	-0.5
Systolic blood pressure, automated reading	0.3	0.9	3.0	0.3	-1.7	0.5	0.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.7	0.8	-1.6	0.6	0.6
Angina	0.4	0.5	1.2	0.5	-0.8	-0.3	-1.1
Medication for hormone replacement therapy	0.6	0.7	1.3	-1.2	-0.8	-1.0	0.1
Vitamin and mineral supplements	1.2	1.7	3.2	-0.1	-1.7	1.8	-0.8
Supplements: Zinc	0.5	0.5	1.6	-1.3	-0.6	0.3	0.1
Medication: Co-codamol	0.3	0.3	0.8	-0.4	-0.6	0.3	-0.9
Medication: Metformin	0.4	0.6	2.0	1.4	-0.4	0.2	0.4
Diabetes (father)	6.6	8.2	12.7	-1.8	-2.8	3.6	-3.0
Diabetes (mother)	2.3	2.9	7.0	-0.3	-0.3	2.1	-2.6
Severe depression (siblings)	0.4	0.5	1.1	-1.1	-0.5	0.6	0.1
Pack years adult smoking proportion	0.3	0.5	1.7	0.4	-0.5	1.3	0.0
Impedance of leg (right)	0.3	1.5	2.7	-1.4	1.1	-1.6	0.3
Leg fat-free mass (left)	1.3	6.8	8.1	2.8	2.6	-2.3	2.7
Trunk fat percentage	0.2	0.9	1.8	1.4	0.3	-1.2	0.7
Hand grip strength (right)	0.2	0.7	0.9	-0.9	-0.5	1.0	-0.8
Townsend deprivation index at recruitment	2.5	3.5	6.9	-1.7	-2.6	1.7	-1.1
Current tobacco smoking	0.7	1.1	2.4	-1.6	-0.8	1.0	-0.5
Average weekly fortified wine intake	0.4	0.5	1.3	-1.1	-0.7	0.5	-0.1
Maternal smoking around birth	0.5	0.7	1.6	0.2	0.8	-0.8	1.2
Fed-up feelings	0.2	0.3	1.1	-0.2	0.2	-0.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.2	-0.2	0.7	0.3	-1.5
Relative age voice broke	0.5	0.7	2.1	0.3	0.6	-1.4	0.6
Taking other prescription medications	0.5	0.8	2.0	1.4	0.5	-1.0	-0.2
Age when periods started (menarche)	0.3	0.8	2.6	-0.3	0.1	0.8	-1.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.2	-0.8	-0.0	-0.0	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	0.6	1.3	-0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.7	-0.1	-1.5	1.7	-1.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.2	-0.2	0.2	0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.7	-0.5	0.2	-0.1
High blood pressure	1.2	3.3	6.8	2.2	0.3	-2.6	1.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.3	0.4	0.6	-0.4
Multivitamins +/- minerals	0.5	0.6	1.3	-0.4	1.1	-1.0	-0.2
Stomach or abdominal pain in last month	0.5	0.7	1.8	0.5	0.8	-0.1	1.4
Supplements: Glucosamine	0.8	1.1	4.1	-0.3	0.3	-2.0	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.2	0.3	-0.2	0.1
Medication: Atenolol	0.1	0.2	0.3	-0.4	0.0	-0.5	-0.6
Medication: Levothyroxine sodium	2.0	3.4	5.3	-2.3	-1.8	1.5	-1.6
Sitting height	3.6	25.4	29.9	4.8	5.5	-5.2	4.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.5	0.5	-0.6	0.3
High blood pressure (mother)	1.2	1.7	4.5	-0.9	-2.1	0.0	-1.2
Body mass index (BMI)	0.2	0.8	1.7	1.0	-1.3	0.8	-0.2
Impedance of leg (left)	0.4	1.8	4.2	-0.5	1.6	-2.0	0.6
Leg predicted mass (left)	1.3	6.7	8.2	2.9	2.6	-2.3	2.6
Trunk fat mass	0.7	3.2	5.0	2.2	1.2	-1.9	1.6
Waist circumference	0.2	0.9	2.2	1.5	-0.4	-0.6	0.8
Number of incorrect matches in round	0.1	0.2	0.2	-0.4	-0.3	0.5	0.3
Past tobacco smoking	2.8	5.1	8.7	2.3	3.0	-2.1	1.5
Alcohol usually taken with meals	0.9	1.5	4.4	2.1	0.4	1.1	-0.4
Nervous feelings	0.5	1.0	3.2	-0.2	-0.0	-1.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.7	0.3	0.8	-0.1	-0.8
Hearing difficulty/problems with background noise	2.6	4.1	6.2	2.1	0.8	-2.5	2.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	1.3	-0.3	-0.4	0.8
Had menopause	0.2	0.3	0.5	0.6	-0.1	-0.7	0.6
Had other major operations	0.4	0.5	2.0	-0.3	-1.4	0.1	0.2
Forced vital capacity (FVC)	0.2	0.8	2.4	-1.6	-0.3	-0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.3	0.9	2.1	-0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.4	0.7	0.1	1.1
Qualifications: None of the above	0.0	0.1	0.1	-0.3	0.1	0.1	-0.3
Financial difficulties in last 2 years	0.6	0.8	1.8	-0.3	0.2	1.1	-1.3
Mouth/teeth dental problems	1.7	2.6	3.2	1.3	1.8	-1.6	1.7
Heart attack	1.8	2.4	3.4	-1.6	-1.8	0.3	-1.9
Allergy	0.1	0.3	1.1	0.1	-1.0	-0.1	-0.3
Pain all over the body in last month	1.0	1.1	2.6	1.6	1.1	-0.6	0.3
Diabetes (self-reported)	1.4	2.2	3.4	-0.5	-1.4	1.8	-1.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.1	1.0	-0.5	0.1
Medication: Ramipril	1.4	1.8	4.2	0.6	1.6	-2.0	-0.4
Medication: Simvastatin	0.5	0.7	1.1	1.0	-0.6	-1.0	0.6
Fluid intelligence score	1.5	3.2	4.7	2.1	1.8	-2.2	0.5
Illnesses of siblings	0.9	1.3	3.0	-0.7	0.8	-1.1	1.7
Neuroticism score	0.5	1.1	2.1	0.6	1.4	-1.5	-0.1
Weight	1.7	8.3	11.4	3.4	2.4	-2.7	2.9
Impedance of arm (right)	0.2	1.1	1.4	-1.2	0.9	-1.1	-0.9
Arm fat percentage (right)	0.2	0.7	1.3	1.1	-1.1	0.5	-0.5
Trunk fat-free mass	2.8	16.0	18.2	4.0	4.0	-3.7	4.3
Hip circumference	1.0	4.4	8.4	2.9	1.3	-1.7	2.2
Time employed in main current job	1.4	1.6	3.8	0.6	-0.8	-1.3	1.9
Alcohol intake versus 10 years previously	0.4	0.7	1.4	-0.9	-0.5	-0.5	-1.2
Father’s age at death	1.4	1.9	3.0	-1.2	-1.2	1.7	-1.4
Worrier / anxious feelings	0.7	1.4	2.6	-1.1	-1.6	-0.2	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.1	-0.5	0.1	1.0	-1.1
Falls in the last year	0.9	1.2	3.2	1.0	-0.2	-0.8	1.8
Hair/balding pattern: Pattern 3	1.2	1.7	2.7	-1.6	-0.9	1.2	-1.3
Number of live births	0.2	0.2	0.6	0.2	0.2	0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	-1.2	-0.4	0.2	-1.1
Pulse rate	0.6	1.0	3.2	0.6	0.5	-0.6	1.8
Happiness	1.2	1.5	4.1	-2.0	-0.9	0.4	-0.9
Noisy workplace	0.9	1.1	2.6	-1.6	0.4	-1.0	-0.9
Qualifications: A levels/AS levels or equivalent	1.5	3.4	3.9	-2.0	-2.0	1.5	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.5	-0.4	1.2	-0.2	-0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	1.8	-0.1	-1.3	1.0	-0.9
Asthma	1.1	2.2	5.6	0.8	2.4	-1.6	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	-0.3	0.7	0.1	-0.2
Medication: Cholesterol lowering	0.8	1.2	2.9	1.1	0.8	-1.7	0.1
Depression (self-reported)	0.4	0.5	0.8	-0.7	-0.9	0.7	-0.5
Medication: Lansoprazole	0.7	0.8	2.4	1.5	0.2	-0.9	0.3
Prospective memory result	3.5	4.3	9.8	-3.1	-2.2	1.0	-1.2
Lung cancer (father)	0.3	0.4	1.2	-1.1	0.3	-0.0	-0.6
Illnesses of mother	1.7	2.1	4.2	-2.1	-0.8	1.2	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.1	-1.5	-0.9	0.3	-1.3
Pulse wave Arterial Stiffness index	1.0	1.1	4.2	2.1	0.2	0.4	0.3
Impedance of arm (left)	0.3	1.2	1.5	-1.2	1.2	-1.2	-0.7
Arm fat mass (right)	0.4	1.4	4.4	2.1	0.3	-0.8	0.8
Trunk predicted mass	2.7	15.5	17.7	3.9	4.0	-3.6	4.2
Standing height	5.0	50.0	64.6	5.2	8.0	-7.8	6.8
Length of working week for main job	0.1	0.1	0.3	-0.1	-0.5	-0.5	0.0
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.2	0.5	0.7	-0.1
Breastfed as a baby	0.7	0.9	2.0	-0.3	-1.4	0.8	-0.9
Tense / ‘highly strung’	1.2	2.0	2.7	1.3	1.6	-1.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	-0.0	0.8	-1.2	-0.1
Hair/balding pattern: Pattern 4	0.4	1.0	3.5	1.9	0.6	-0.2	0.4
Birth weight of first child	0.3	0.5	1.2	0.4	1.1	-0.8	0.1
Peak expiratory flow (PEF)	0.6	1.4	2.3	-1.3	-1.1	0.6	-1.5
Pulse wave reflection index	1.0	1.2	4.0	0.9	0.1	0.2	-2.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.2	0.1	-0.9	0.5
Loud music exposure frequency	0.4	0.4	0.6	-0.8	-0.2	0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	2.9	4.7	6.7	-2.6	-1.8	2.3	-1.9
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.5	-1.2	-0.6	1.1	-1.2
Blood clot in the leg (DVT)	0.4	0.5	1.2	1.1	-0.2	0.8	0.3
Medication: Paracetamol	0.4	0.7	1.4	-0.9	1.2	-0.5	-0.4
Headache pain in last month	1.1	1.8	5.4	-2.3	-0.6	0.8	-1.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	3.6	-1.4	-0.8	1.9	-0.1
Glaucoma (self-reported)	2.1	2.5	3.4	1.8	1.8	-1.3	1.2
Gout (self-reported)	0.5	0.6	1.2	1.1	0.8	-0.7	0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	-1.6	-0.9	0.3	-1.0
Medication: Amlodipine	0.7	1.0	2.3	1.2	-1.5	0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.2	0.4	-0.0	-0.8
Birth weight	2.0	4.3	10.8	1.6	3.3	-1.4	1.3
Chronic bronchitis/emphysema (mother)	1.9	2.2	2.8	1.5	1.4	-1.3	1.7
High blood pressure (siblings)	0.4	0.5	1.1	0.5	-1.1	0.6	-0.5
Forced vital capacity (FVC), Best measure	0.4	1.3	3.7	-1.9	-0.8	-0.3	-0.9
Body fat percentage	0.2	0.8	2.2	1.5	-0.1	-0.7	0.6
Leg fat percentage (right)	0.2	0.6	1.6	1.3	-0.7	-0.1	0.5
Arm fat-free mass (right)	2.2	11.3	15.8	3.3	3.1	-3.1	4.0
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.5	0.1	-0.5	-0.5
Comparative body size at age 10	0.9	2.4	5.2	-0.9	-2.3	1.5	-1.2
Number of full brothers	0.9	1.1	2.6	1.6	0.6	-1.2	-0.2
Worry too long after embarrassment	0.3	0.5	1.6	-0.3	0.1	0.5	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.9	0.9	1.0	-1.4	1.7
Wheeze or whistling in the chest in last year	0.6	1.2	2.1	0.8	1.4	-1.4	0.1
Number of children fathered	1.7	1.9	3.8	-0.3	-1.9	1.7	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	-0.5	0.3	-0.5	-0.7
Age at first live birth	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.2
Pulse wave peak to peak time	0.7	0.8	2.0	-1.4	0.5	-1.0	0.2
Health satisfaction	0.1	0.1	0.3	0.3	-0.5	0.4	0.0
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.4	-0.5	-0.1	-0.7
Qualifications: College or University degree	0.1	0.2	0.5	0.3	-0.7	0.3	-0.3
Eye problems/disorders: None of the above	0.4	0.4	0.9	-1.0	-0.0	-0.3	-0.8
Mouth/teeth dental problems: Loose teeth	2.5	3.0	4.6	-2.1	-1.5	1.6	-1.7
Emphysema/chronic bronchitis	0.9	1.0	3.4	-0.3	-0.7	1.8	-0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	0.0	-0.3	1.0	-0.5
Neck or shoulder pain in last month	0.6	0.8	1.8	-0.2	-0.7	0.9	-1.3
Medication: Blood pressure	0.5	0.8	1.9	1.2	0.0	-1.4	-0.2
Angina (self-reported)	0.5	0.6	1.5	0.4	-0.8	-0.4	-1.2
Migraine (self-reported)	0.6	0.8	2.0	-0.6	-0.6	0.5	-1.4
Medication: Ibuprofen	0.1	0.1	0.3	-0.3	0.4	0.6	-0.2
Medication: Allopurinol	1.1	1.5	3.1	1.8	1.3	-0.7	0.7
Medication: Omeprazole	2.2	2.6	5.2	1.1	1.6	-2.3	1.2
Medication: Seretide 50 evohaler	0.7	0.8	1.8	0.4	0.9	-1.4	0.6
Mean time to correctly identify matches	0.8	1.6	3.2	-0.8	-1.5	0.4	-1.8
Heart disease (mother)	2.6	3.1	5.9	2.2	2.4	-0.3	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.9	0.5	0.7	1.7	-1.5
Whole body fat mass	0.7	3.1	5.7	2.4	0.9	-1.7	1.7
Leg fat mass (right)	0.5	2.0	3.7	1.9	0.3	-1.2	1.6
Arm predicted mass (right)	2.3	11.7	15.0	3.4	3.1	-3.3	3.9
Pulse rate, automated reading	1.8	5.9	8.3	2.5	2.9	-1.4	2.6
Alcohol intake frequency.	0.5	1.1	2.6	1.6	1.0	-0.7	-0.4
Comparative height size at age 10	3.8	21.2	29.0	3.1	4.5	-5.0	5.4
Number of full sisters	0.8	1.0	1.6	1.3	1.2	-0.5	0.8
Suffer from ‘nerves’	0.2	0.4	1.1	-0.1	0.5	-1.1	0.2
Overall health rating	1.3	2.7	4.3	2.1	1.1	-2.1	1.1
Chest pain or discomfort	1.3	1.9	3.3	-0.7	-1.8	0.8	-1.8
Had major operations	0.2	0.2	0.6	0.8	0.3	-0.3	0.4
Age at last live birth	0.3	0.4	0.5	-0.7	-0.7	0.7	-0.0
Family relationship satisfaction	0.4	0.5	1.3	-0.6	-0.2	0.4	-1.1
Leg pain on walking	0.7	0.9	1.7	-1.3	-0.7	0.1	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	2.6	0.8	1.6	-1.4	1.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.2	-0.3	-0.4	0.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.2	-2.1	-1.0	0.2	-1.0
Medication: Aspirin	0.5	0.7	2.0	-0.9	-1.4	-0.2	-0.0
Supplements: Vitamin C	1.0	1.2	4.2	0.3	0.2	-0.8	2.1
Knee pain experienced in last month	0.5	0.8	1.7	-1.3	0.5	-1.1	-0.3
Hypertension (Self-reported)	0.9	2.5	5.0	1.9	0.3	-2.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.8	1.9	1.2	-0.9	0.4
Illnesses of father: Heart disease	1.2	1.7	3.5	1.9	1.6	0.0	0.8
Illnesses of siblings: Diabetes	0.6	0.8	2.5	0.3	-0.4	0.6	-1.6
Smoking status: Previous	3.8	5.7	10.3	-2.1	-3.2	2.2	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	4.7	9.8	17.4	1.9	4.2	-2.7	3.4
Whole body fat-free mass	2.2	12.4	14.5	3.6	3.4	-3.2	3.8
Leg fat-free mass (right)	1.6	8.5	10.9	3.3	2.9	-2.5	2.9
Arm fat percentage (left)	0.2	0.7	1.3	1.0	-1.2	0.6	-0.5
Average weekly red wine intake	2.2	3.2	6.6	-1.1	-2.6	1.1	-2.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.6	0.5	1.6	-0.7	0.7
Mood swings	0.9	1.7	4.2	-0.2	2.0	-1.5	0.0
Loneliness, isolation	1.7	2.4	4.0	1.7	2.0	-1.1	1.2
Long-standing illness, disability or infirmity	0.8	1.2	2.4	1.5	0.3	-1.4	0.6
Ever had bowel cancer screening	1.2	1.4	2.3	0.6	0.9	-1.5	1.5
Diabetes diagnosed by doctor	0.5	0.8	1.2	0.4	-1.1	1.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	4.0	1.2	1.0	-1.2	2.0
Friendships satisfaction	1.2	1.5	2.2	-1.3	-0.7	1.5	-1.4
Qualifications: nursing, teaching	0.6	0.9	2.2	-1.1	-1.5	0.1	-0.5
Commuting to job workplace: Walk	1.3	1.4	2.4	-1.6	-0.9	1.1	-1.2
Eye problems/disorders: Cataract	0.1	0.1	0.4	0.0	-0.3	-0.6	0.0
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	3.8	-2.0	-1.4	1.4	-1.8
Medication for cholesterol	1.2	1.8	3.8	-0.6	1.4	1.9	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.5	-0.0	1.6	-0.0	-0.7
Back pain experienced in last month	0.7	1.0	2.5	0.5	1.0	-0.5	1.6
Mineral and other dietary supplements	0.6	0.8	1.4	1.2	-0.6	1.0	0.5
Breast cancer (self-reported)	0.4	0.5	0.8	-0.8	-0.9	-0.5	-0.7
Asthma (self-reported)	0.9	1.8	4.3	0.5	2.1	-1.6	0.5
Osteoporosis (self-reported)	0.3	0.4	0.9	1.0	0.1	-0.2	0.8
Osteoarthritis (self-reported)	0.4	0.5	1.7	0.2	1.3	-0.5	-0.3
Medication: Aspirin	0.4	0.5	1.5	-0.6	-1.2	0.1	-0.5
Medication: Gliclazide	0.3	0.3	0.6	-0.8	-0.6	0.5	-0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.4	-1.1	-1.2	-0.3	-0.5
Smoking status: Current	0.5	0.7	1.9	-1.4	-0.5	0.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	6.4	-2.5	-2.0	1.8	-2.3
Whole body water mass	2.3	12.9	15.0	3.8	3.5	-3.2	3.9
Leg predicted mass (right)	1.6	8.3	10.8	3.3	2.8	-2.5	2.9
Arm fat mass (left)	0.3	1.4	4.1	2.0	0.2	-0.8	0.8
Number of self-reported non-cancer illnesses	0.6	1.0	2.3	1.1	0.7	-1.5	0.1
Average weekly champagne plus white wine intake	0.6	0.9	2.7	1.7	0.3	0.1	0.8
Miserableness	0.1	0.2	0.8	0.2	0.9	-0.0	-0.2
Guilty feelings	0.2	0.3	0.7	-0.6	0.2	-0.2	-0.8
Wears glasses or contact lenses	0.2	0.2	0.5	0.7	0.4	0.5	0.1
Ever taken oral contraceptive pill	0.5	0.6	1.6	-0.0	0.8	0.1	-1.3
Hearing aid user	3.6	4.1	7.5	1.0	2.1	-2.7	1.9
Mother’s age at death	0.4	0.5	1.0	0.1	-0.9	1.0	-0.5
Financial situation satisfaction	1.0	1.2	2.2	-1.1	-1.2	1.5	0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.1	-0.6	0.2	1.4	-0.5
Commuting to job workplace: Public transport	0.3	0.4	0.9	0.9	-0.4	0.8	0.0
Eye problems/disorders: Glaucoma	1.1	1.3	3.2	1.8	1.3	-0.2	0.7
Medication: Blood pressure	0.8	1.4	2.1	0.9	-1.3	-1.0	1.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	0.0	-0.4	-0.5	-1.1
Supplements: Fish oil (including cod liver oil)	3.0	3.9	10.2	-3.2	-1.1	0.5	-2.0
High cholesterol (Self-reported)	1.2	2.2	5.2	1.7	-0.5	-2.3	0.6
Medication: Bendroflumethiazide	1.2	1.9	4.3	1.2	1.0	-2.1	0.9
Medication: Paracetamol	0.2	0.3	0.8	-0.4	0.9	-0.1	-0.3
Medication: Lisinopril	0.6	0.8	1.5	1.2	-0.3	-0.3	1.2
Medication: Atorvastatin	1.4	1.7	5.9	0.7	0.6	-2.4	0.4
Illnesses of father: High blood pressure	1.1	1.3	3.7	-1.9	-0.6	0.4	-1.0
Alcohol drinker status: Never	0.3	0.4	0.5	0.5	0.6	-0.7	-0.7
Ever smoked	2.5	4.4	6.5	-2.1	-2.5	2.1	-1.4
Basal metabolic rate	2.2	12.0	13.4	3.7	3.4	-3.2	3.6
Leg fat percentage (left)	0.2	0.9	2.9	1.7	-0.4	-0.3	0.5
Arm fat-free mass (left)	2.9	14.6	17.5	3.9	3.6	-3.6	4.2
Number of operations (self-reported)	0.4	0.6	2.3	1.5	-0.3	0.3	-0.2
Average weekly beer plus cider intake	0.8	1.2	3.7	-1.9	-0.7	-0.2	-0.8
Irritability	1.4	2.4	5.7	-1.6	0.3	1.1	-2.4
Risk taking	0.4	0.5	0.7	-0.5	-0.7	0.8	0.8
Ever had prostate specific antigen (PSA) test	2.5	2.9	5.2	1.5	2.3	-1.8	0.9
Fractured/broken bones in last 5 years	0.6	0.8	1.6	0.8	-0.8	0.6	-1.3
Age started oral contraceptive pill	1.4	1.7	4.3	0.5	0.8	-2.1	1.3
Diastolic blood pressure, automated reading	2.2	6.8	8.2	2.2	2.6	-2.9	2.7
Ever depressed for a whole week	1.7	2.1	3.1	-1.3	-1.6	1.0	-1.8
Unable to work because of sickness or disability	0.3	0.4	1.2	-0.1	-0.5	0.4	-1.1
Commuting to job workplace: Cycle	2.7	3.3	4.2	-2.0	-1.4	1.8	-2.1
Myopia	0.1	0.2	0.6	-0.8	-0.4	-0.2	0.2
Vascular/heart problems diagnosed by doctor	1.1	3.0	6.9	-2.0	0.2	2.6	-1.0
Cholesterol lowering medication	1.5	2.2	3.3	1.8	-1.3	-1.7	0.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.3	0.4	1.1	-1.8	0.9
Pain experienced in last month	0.3	0.5	1.7	1.3	0.0	0.3	0.6
Supplements: Calcium	0.8	0.9	2.4	0.5	1.5	-0.8	0.3
Basal cell carcinoma (self-reported)	1.3	1.5	4.6	1.0	2.1	-0.6	-0.2
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.3	-1.5	-1.6	0.3	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	1.2	0.3	0.6	0.4
Heart disease (siblings)	0.6	0.7	1.7	0.2	-0.1	1.3	-1.1
Alcohol drinker status: Previous	0.5	0.5	1.1	0.5	1.1	-0.0	0.8
Pack years of smoking	0.3	0.5	1.6	0.5	-0.5	1.3	-0.0
Impedance of whole body	0.3	1.5	2.3	-1.4	1.2	-1.5	-0.4
Leg fat mass (left)	0.6	2.3	4.8	2.2	0.4	-1.3	1.6
Arm predicted mass (left)	2.6	13.0	16.2	3.7	3.2	-3.4	4.0