[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr19:388,413-1,802,433

Best TWAS P=5.1e-16 · Best GWAS P=9.1e-21 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex POLR2E 0.23 0.14 bslmm 451 0.17 5.2e-20 -5.1 -5.2 1.9e-07 -0.12 1.00 0.00 TRUE
2 GTEx Breast Mammary Tissue POLR2E 0.39 0.06 lasso 8 0.16 2.1e-08 5.6 -8.1 5.1e-16 -0.47 0.41 0.17 TRUE
3 GTEx Cells Transformed fibroblasts GPX4 0.37 0.20 lasso 9 0.23 4.3e-17 5.4 5.6 2.3e-08 0.63 1.00 0.00 TRUE
4 GTEx Prostate GPX4 0.41 0.23 lasso 3 0.22 4.1e-06 5.4 6.9 7.2e-12 0.65 0.02 0.80 FALSE
5 The Cancer Genome Atlas Bladder Urothelial Carcinoma GPX4 0.08 0.01 lasso 7 0.02 4.7e-03 9.3 8.1 5.3e-16 0.87 0.00 0.97 FALSE
6 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GPX4 0.06 0.02 enet 8 0.06 5.8e-07 8.9 5.8 8.6e-09 0.63 0.01 0.98 TRUE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ABCA7 0.05 0.02 blup 71 0.04 4.7e-05 -5.1 -5.5 5.0e-08 -0.29 0.44 0.04 FALSE
8 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GPX4 0.12 0.11 lasso 4 0.12 3.9e-13 5.4 5.7 1.1e-08 0.63 1.00 0.00 TRUE
9 The Cancer Genome Atlas Liver Hepatocellular Carcinoma GPX4 0.17 0.03 blup 45 0.10 1.2e-05 5.4 6.4 1.5e-10 0.67 0.01 0.92 TRUE
10 The Cancer Genome Atlas Prostate Adenocarcinoma GPX4 0.21 0.15 lasso 4 0.14 6.9e-15 5.4 5.4 5.8e-08 0.66 1.00 0.00 FALSE
11 The Cancer Genome Atlas Prostate Adenocarcinoma POLR2E 0.06 0.00 blup 53 0.03 2.3e-04 -1.3 -5.2 1.5e-07 -0.37 0.05 0.26 TRUE
12 The Cancer Genome Atlas Testicular Germ Cell Tumors GPX4 0.27 0.03 lasso 5 0.15 4.5e-06 1.9 5.6 2.5e-08 0.47 0.01 0.35 TRUE