TWAS
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Usage
Models
Genes
Traits
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Traits
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Crohns Disease (2017)
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chr20:43,825,556-45,456,440
Best TWAS P=3.69e-09 · Best GWAS P=1.33e-09 conditioned to 0.0303
43.8M
44M
44.2M
44.4M
44.6M
44.8M
45M
45.2M
45.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Lung Adenocarcinoma
MMP9
0.03
0.01
blup
46
0.01
6.7e-02
-5.7
5.9
3.7e-09
-0.72
0.01
0.72
TRUE
2
METSIM
Adipose
CD40
0.07
0.04
lasso
4
0.05
3.5e-08
5.0
-5.7
1.2e-08
0.36
0.26
0.74
TRUE
1
GTEx
Skin Not Sun Exposed Suprapubic
NEURL2
0.17
0.09
lasso
4
0.03
8.7e-03
-5.7
5.8
6.1e-09
-0.98
0.01
0.95
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
MMP9
0.02
0.02
blup
46
0.02
3.5e-03
-5.2
5.3
1.1e-07
-0.88
0.02
0.78
FALSE