TWAS hub - MMP9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0630	0.0181	9.9e-08	0.039	0.023	0.041	0.039	0.036	7.3e-13	4.6e-08	2.7e-13	8.5e-13	6.8e-12
2	TCGA	Bladder Urothelial Carcinoma	0.0650	0.0290	1.1e-04	0.030	0.031	0.014	NA	0.037	1.4e-03	1.1e-03	2.2e-02	NA	3.9e-04
3	TCGA	Glioblastoma Multiforme	0.2460	0.1020	4.5e-03	0.160	0.102	0.162	NA	0.156	1.4e-05	5.4e-04	1.2e-05	NA	1.8e-05
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0235	0.0124	3.8e-03	0.017	0.018	0.005	NA	0.011	4.9e-03	3.5e-03	7.4e-02	NA	1.9e-02
5	TCGA	Lung Adenocarcinoma	0.0338	0.0211	9.1e-03	0.014	0.005	0.000	NA	0.002	8.3e-03	6.7e-02	3.7e-01	NA	1.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
HDL Cholesterol	10.8	18.0	35.5	-4.0	-4.4	6.0	1.5	4.1
Triglycerides	9.5	15.5	28.4	3.2	2.9	-5.3	-2.6	-4.9
Crohns Disease (2017)	8.4	18.5	34.8	-3.4	2.4	3.5	5.3	5.9
Reaction Time	6.0	11.4	24.1	-3.6	1.7	4.9	2.1	3.6
Mean time to correctly identify matches	5.5	10.5	20.2	-3.5	1.3	4.5	2.2	3.6
Loud music exposure frequency	5.0	5.4	11.5	-3.4	-2.1	2.6	-1.4	1.6
Qualifications: nursing, teaching	5.0	7.8	16.8	-4.1	-0.2	3.4	0.7	3.2
Guilty feelings	4.9	7.4	13.0	3.0	3.6	-2.6	2.8	0.8
Bipolar Disorder (2011)	4.6	4.5	14.0	0.9	1.0	0.2	3.7	2.6
Smoking status: Previous	4.2	6.2	19.4	2.8	0.2	-4.4	-1.2	-1.5
Father’s age at death	4.0	5.4	15.4	-0.2	-2.1	-1.2	-3.9	-2.4
Qualifications: A levels/AS levels or equivalent	3.9	8.7	15.6	-3.1	1.3	4.0	2.1	3.5
Irritable Bowel Disease (IBD)	3.8	9.1	23.0	-1.8	1.7	1.9	3.6	4.8
Chronotype (morning person)	3.3	7.5	17.8	1.1	-1.7	-1.0	-3.8	-4.2
Crohns Disease (2012)	3.2	5.1	9.3	-1.8	1.2	2.0	3.1	2.7
Neuroticism (2016)	3.2	4.6	9.1	2.9	1.8	-3.0	0.7	-1.3
Forced vital capacity (FVC)	3.2	12.3	20.4	-3.2	1.8	3.7	3.7	4.5
Depressed Affect (Nagel 2018)	3.1	6.4	14.9	3.9	0.6	-3.8	1.4	-0.9
Forced vital capacity (FVC), Best measure	3.0	10.9	16.7	-2.9	1.9	3.5	3.6	4.1
Neuroticism score	2.9	6.0	12.4	3.5	1.9	-3.1	2.1	0.2
Leg pain on walking	2.9	3.7	9.9	3.1	-0.2	-2.9	0.3	0.0
Neuroticism (Nagel 2018)	2.7	6.4	13.5	3.7	1.6	-3.4	2.2	-0.2
Major Depression (MDD)	2.7	3.3	7.5	2.7	1.1	-2.3	1.6	-0.2
Past tobacco smoking	2.7	4.9	16.3	-2.6	-1.2	4.0	0.1	0.2
Commuting to job workplace: Public transport	2.7	3.3	5.5	-2.1	0.2	1.8	1.7	2.3
Sensitivity / hurt feelings	2.6	4.5	9.7	2.9	1.4	-3.1	1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	11.4	-0.9	3.4	1.4	2.9	2.3
Neuroticism	2.5	6.0	12.5	3.5	1.3	-3.1	2.4	0.5
Financial difficulties in last 2 years	2.4	3.2	7.7	1.7	1.7	-1.6	2.8	0.4
Diabetes (self-reported)	2.4	3.7	9.2	-0.6	1.9	1.0	3.0	2.0
Qualifications: College or University degree	2.4	7.7	12.4	-3.5	2.2	3.2	1.6	2.9
Commuting to job workplace: Car/motor vehicle	2.4	2.8	5.4	1.5	-0.4	-1.5	-1.9	-2.3
Mood swings	2.4	4.3	9.9	2.8	0.1	-3.1	1.2	-1.5
Irritability	2.4	4.0	11.2	1.1	2.4	-0.3	3.4	1.3
Basal cell carcinoma (self-reported)	2.4	2.9	6.5	2.5	0.4	-2.6	-0.8	-0.8
Heel T-Score	2.3	17.9	27.9	2.7	-2.1	-4.9	-5.3	-5.1
Friendships satisfaction	2.3	2.8	4.0	1.7	-1.3	-1.7	-2.0	-1.6
Supplements: Fish oil (including cod liver oil)	2.3	3.0	9.0	-1.2	-3.0	0.4	-2.1	-0.1
High cholesterol (Self-reported)	2.3	4.2	9.2	1.8	0.8	-2.2	-1.7	-3.0
Medication: Ramipril	2.2	2.8	5.2	-2.3	1.1	1.5	0.9	2.1
Noisy workplace	2.2	2.7	10.5	-1.2	-3.2	0.5	-1.0	0.7
Loneliness, isolation	2.2	3.0	8.7	2.9	0.8	-2.2	0.8	-0.2
Mineral and other dietary supplements	2.2	3.0	7.5	1.5	2.7	-0.8	2.0	-0.5
Ever taken oral contraceptive pill	2.2	2.4	5.0	1.4	1.0	-0.3	2.2	2.0
Financial situation satisfaction	2.2	2.8	5.2	1.0	2.0	-1.6	2.3	0.8
Commuting to job workplace: Cycle	2.2	2.7	5.0	-2.2	0.3	2.1	0.9	1.8
Supplements: Calcium	2.2	2.4	4.0	-1.8	-1.3	2.0	-1.7	0.4
Mouth/teeth dental problems	2.1	3.3	5.0	-1.9	-2.0	2.2	-1.9	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	8.9	-2.6	1.7	2.7	2.7	3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	5.0	2.2	0.4	-0.9	1.7	2.1
Breast cancer (self-reported)	2.1	2.6	7.1	1.3	-0.3	-2.7	-1.1	-1.6
Age at First Birth	2.0	2.9	4.7	2.2	1.5	-1.9	0.4	-1.9
Hearing difficulty/problems: Yes	2.0	3.0	5.2	-0.6	2.2	1.0	1.9	2.3
Hair/balding pattern: Pattern 3	2.0	2.9	5.5	1.2	-0.7	-2.2	-1.5	-2.3
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.8	-0.3	-2.2	-0.2	-1.9	-1.7
Chest pain or discomfort	2.0	2.9	5.9	1.6	2.2	-0.8	2.4	0.5
Miserableness	2.0	3.5	7.5	2.3	1.7	-1.3	2.7	0.4
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.3	2.1	1.3	-2.0	-0.9	-1.3
Ever smoked	2.0	3.6	9.5	1.7	2.2	-3.1	0.5	0.7
HbA1C	1.9	2.1	4.1	-2.0	0.3	1.3	0.9	1.9
Smoking Status	1.9	4.5	9.3	2.2	1.9	-3.0	2.1	0.6
Forced expiratory volume in 1-second (FEV1)	1.9	6.3	10.5	-2.5	1.6	2.5	2.5	3.2
Prospective memory result	1.9	2.3	4.8	0.9	-2.2	-1.7	-1.7	-0.5
Blood Red Count	1.8	16.9	41.7	-4.9	-1.1	6.5	0.8	4.1
Type 2 Diabetes (T2D) (2018)	1.8	3.4	7.6	-0.7	1.5	1.7	2.8	2.0
Lung FVC	1.8	9.3	13.0	-3.1	2.1	2.9	3.5	3.6
Age when periods started (menarche)	1.8	4.4	12.7	-3.6	-1.1	2.8	-0.0	0.4
Multivitamins +/- minerals	1.8	2.3	5.8	0.0	-2.4	-1.4	-1.7	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.7	4.8	1.4	2.2	-1.4	2.2	0.6
Birth weight of first child	1.8	3.3	8.5	-0.8	2.9	0.9	2.0	1.6
Worry too long after embarrassment	1.8	3.0	9.5	1.7	3.1	-1.2	1.0	-0.5
Number of self-reported non-cancer illnesses	1.8	3.2	7.4	2.0	0.0	-2.7	-0.9	-1.8
Ever had prostate specific antigen (PSA) test	1.8	2.0	4.3	1.6	-1.1	-2.1	-0.6	-1.3
Ever depressed for a whole week	1.8	2.2	5.1	2.3	0.3	-2.3	0.8	-0.6
Depression (Nagel 2018)	1.7	2.6	5.3	2.0	1.0	-2.3	1.5	-0.3
Vitamin and mineral supplements	1.7	2.3	8.5	0.6	2.9	0.5	1.6	-0.1
Fed-up feelings	1.7	3.0	8.2	2.3	0.6	-2.9	1.2	-0.1
Medication: Cholesterol lowering	1.7	2.7	4.5	2.1	2.1	-1.6	0.6	-1.4
Bipolar Disorder (2018)	1.6	2.6	4.8	1.8	0.8	-1.1	2.2	1.8
Chronic bronchitis/emphysema (mother)	1.6	1.9	6.0	-2.4	1.4	1.2	0.6	0.1
Rheumatoid Arthritis	1.5	2.1	5.8	0.7	0.4	0.4	-2.0	-2.4
Hearing difficulty/problems with background noise	1.5	2.4	5.2	-0.3	2.1	0.2	2.3	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.6	1.9	-0.2	-2.6	0.9	-1.1
Hearing aid user	1.5	1.7	3.7	0.7	1.0	0.3	1.9	1.8
Respiratory disease	1.4	3.1	8.4	-1.6	-0.0	2.9	0.7	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	5.7	-2.4	0.5	2.3	0.5	1.6
Back pain experienced in last month	1.4	2.0	8.5	0.0	-2.9	-1.0	-0.7	0.2
Lupus	1.3	1.9	3.7	-1.9	-1.5	1.3	0.3	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	4.2	1.4	-0.5	-2.1	-0.7	-1.4
Serious illness, injury or assault to yourself	1.3	1.6	2.7	-1.6	-0.8	1.5	-0.2	1.6
Nervous feelings	1.3	2.4	4.3	2.1	1.6	-2.1	0.9	-0.2
Qualifications: None of the above	1.3	2.8	5.7	2.2	-1.3	-2.4	-0.5	-1.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	5.0	2.2	0.4	-1.7	-0.2	-0.2
Diabetes diagnosed by doctor	1.3	2.2	4.5	-0.8	1.2	1.3	2.1	1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.0	2.0	1.4	-1.0	1.9	0.2
Average weekly champagne plus white wine intake	1.3	1.8	4.7	-1.2	0.2	1.6	0.5	2.2
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.6	-0.5	1.5	0.9	1.0	1.9
Heart disease (siblings)	1.3	1.6	3.5	1.9	1.2	-1.1	1.1	-0.5
Bipolar Disorder or Schizophrenia	1.2	2.8	8.1	1.6	0.2	-1.0	2.8	1.5
Severe depression (siblings)	1.2	1.3	2.3	1.2	-1.5	-0.9	1.2	0.6
Current tobacco smoking	1.2	2.0	3.8	1.2	1.6	-1.3	1.9	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	8.1	0.1	0.0	-1.2	-2.0	-2.8
Hayfever, allergic rhinitis or eczema	1.2	2.6	7.4	-0.6	2.7	1.7	0.9	1.4
Supplements: Glucosamine	1.2	1.5	5.0	-0.4	-2.2	-0.2	-1.5	0.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.9	0.3	2.2	1.4	0.6	-0.9
Fluid intelligence score	1.2	2.5	4.2	-1.4	1.4	2.0	1.9	0.9
Mouth/teeth dental problems: Dentures	1.2	2.0	4.3	1.5	2.1	-1.6	0.7	0.0
Depression (self-reported)	1.2	1.4	4.3	2.1	0.0	-1.6	0.3	0.5
Smoking status: Current	1.2	1.9	4.5	0.9	1.4	-0.9	2.1	1.2
Body Mass Index (BMI) (2010)	1.1	1.5	3.5	-0.1	1.9	0.5	1.8	0.7
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.8	0.9	0.6	-1.2	2.2	0.7
Maternal smoking around birth	1.1	1.5	4.8	1.1	0.3	-2.2	1.2	-0.4
Hair/balding pattern: Pattern 2	1.1	1.3	2.2	-1.0	1.0	1.2	1.0	1.5
Pulse rate	1.1	1.8	6.5	0.8	1.3	-0.3	-0.3	-2.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.0	-1.7	-1.4	1.6	-0.9	0.9
Exposure to tobacco smoke outside home	1.1	1.5	4.1	-0.5	-0.6	0.5	1.6	2.0
Shortness of breath walking on level ground	1.1	1.3	3.2	1.8	0.8	-1.3	0.3	1.0
Neck or shoulder pain in last month	1.1	1.5	3.5	1.9	0.3	-1.6	1.2	0.3
Leg fat-free mass (right)	1.1	5.8	13.1	-0.4	2.1	1.1	3.6	3.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.2	0.1	-0.8	-1.3	-1.2	-1.8
Arm predicted mass (left)	1.1	5.6	12.7	0.4	3.0	-0.0	3.6	2.5
Coronary Artery Disease (CAD)	1.0	1.2	2.5	-0.5	-0.7	1.4	1.6	0.9
BMI	1.0	5.6	12.7	0.4	2.2	1.8	3.6	2.7
Average weekly spirits intake	1.0	1.3	2.6	1.3	0.1	-1.4	1.6	0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.8	0.2	-0.9	-1.4	-1.9	-2.2
Trunk fat-free mass	1.0	5.6	13.1	0.6	2.7	-0.1	3.6	2.8
Lung cancer (father)	1.0	1.1	3.0	0.6	-0.3	-1.3	-1.7	-0.7
Trunk predicted mass	1.0	5.6	13.2	0.7	2.6	-0.1	3.6	2.8
Comparative body size at age 10	1.0	2.6	4.8	0.8	-1.7	-0.8	-2.2	-2.1
Number of children fathered	1.0	1.2	3.3	1.0	-0.1	-1.8	-0.5	-1.1
Emphysema/chronic bronchitis	1.0	1.1	2.6	1.6	-0.2	-1.1	0.7	1.1
Suffer from ‘nerves’	1.0	1.6	3.0	0.9	1.0	-0.8	1.6	1.7
Family relationship satisfaction	1.0	1.2	3.2	1.5	-0.3	-1.8	-0.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	3.7	0.2	-1.9	-1.1	-0.2	-0.2
Leg predicted mass (right)	1.0	5.6	12.7	-0.3	2.1	1.0	3.6	3.1
Basal metabolic rate	1.0	5.3	12.2	0.3	2.4	0.4	3.5	2.8
Arm fat-free mass (left)	1.0	5.3	12.0	0.3	2.8	0.3	3.5	2.5
Age started oral contraceptive pill	1.0	1.3	4.3	-0.3	-2.1	0.6	-1.2	0.1
Unable to work because of sickness or disability	1.0	1.3	4.5	0.0	0.4	0.5	2.1	1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	2.9	-1.4	-0.8	0.2	-0.7	-1.7
Alzheimer’s Disease (in father)	0.9	1.0	2.1	1.2	0.6	-0.9	1.5	0.6
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.9	-0.5	2.2	1.6	1.2	1.2
Leg fat-free mass (left)	0.9	4.7	10.6	-0.4	2.0	0.9	3.3	2.8
Medication: Atenolol	0.9	1.1	2.9	0.3	-0.6	-1.7	-1.1	-1.0
Leg predicted mass (left)	0.9	4.6	10.2	-0.4	2.0	0.9	3.2	2.8
Heart attack	0.9	1.1	3.7	0.4	1.2	-0.4	1.9	0.5
Allergy	0.9	2.1	4.3	0.8	-1.8	-2.1	-0.4	-1.5
Medication: Simvastatin	0.9	1.3	4.0	0.8	2.0	-0.7	0.8	-0.8
Worrier / anxious feelings	0.9	1.7	4.0	1.8	-0.9	-2.0	0.1	-0.4
Gout (self-reported)	0.9	1.2	2.8	-1.5	0.8	1.7	0.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.3	1.5	1.1	-1.2	0.8	-0.2
Medication: Blood pressure	0.9	1.6	4.4	0.2	1.4	-0.7	2.1	1.1
Arm predicted mass (right)	0.9	4.5	10.9	0.4	2.6	-0.2	3.3	2.2
Pulse rate, automated reading	0.9	2.9	4.8	1.7	2.2	-1.7	-0.5	-2.0
Overall health rating	0.9	1.9	5.9	1.7	0.6	-2.4	0.7	-0.2
Whole body fat-free mass	0.9	5.4	12.9	0.3	2.5	0.3	3.6	2.8
Whole body water mass	0.9	5.4	12.7	0.3	2.6	0.3	3.6	2.7
Medication: Lisinopril	0.9	1.1	4.4	0.6	0.9	-0.3	2.1	0.1
Number of operations (self-reported)	0.9	1.4	4.9	1.2	0.4	-2.2	-0.5	-0.4
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.8	0.3	1.1	-0.3	2.0	0.6
Alcohol drinker status: Previous	0.9	1.0	2.0	0.7	-1.4	-0.7	-0.8	-1.1
Mean Putamen Volume	0.8	0.9	2.3	1.0	0.1	-1.5	1.0	0.4
Cardiovascular Disease	0.8	2.8	6.3	1.6	0.9	-2.5	-0.6	-2.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.9	0.5	-1.3	-0.7	1.4	0.0
Qualifications: CSEs or equivalent	0.8	1.1	2.4	1.1	-0.6	-1.6	-0.7	-0.9
High blood pressure (mother)	0.8	1.1	3.9	-0.3	-2.0	-0.1	-1.1	0.2
Alcohol usually taken with meals	0.8	1.2	3.3	-0.3	-1.6	0.5	-1.8	0.3
Had other major operations	0.8	1.0	1.9	-0.3	-1.4	-1.0	-1.3	-0.5
Impedance of arm (right)	0.8	3.8	6.2	-1.9	-2.3	1.9	-2.5	0.1
Happiness	0.8	1.0	1.8	1.3	-1.0	-1.3	-0.8	-0.3
Impedance of arm (left)	0.8	3.7	7.3	-1.5	-2.6	1.4	-2.7	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.2	1.8	-0.5	-1.2	0.7	0.7
Arm fat-free mass (right)	0.8	4.2	10.6	0.4	2.3	-0.2	3.2	2.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.3	0.7	-0.1	-1.8	0.1	-1.0
Medication: Seretide 50 evohaler	0.8	0.9	2.2	0.1	-1.5	0.2	-1.4	0.2
Number of full sisters	0.8	1.0	3.5	0.9	1.9	-0.1	0.7	-0.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.2	1.5	0.9	-1.2	-0.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.4	-0.8	-0.3	0.2	-0.8	-1.8
Osteoarthritis (self-reported)	0.8	1.0	1.7	1.3	0.4	-1.2	-1.3	-0.4
Medication: Blood pressure	0.8	1.5	2.4	0.5	-1.0	-1.5	-1.4	-1.3
Risk taking	0.8	1.2	3.7	0.0	1.1	-0.3	1.9	0.9
Myopia	0.8	1.1	2.3	-1.5	0.7	1.5	-0.4	-0.7
Pain experienced in last month	0.8	1.4	3.7	-0.5	1.1	1.9	1.1	0.6
Fasting Glucose	0.7	0.8	1.7	-1.3	-0.9	0.4	-1.1	0.2
Relative age of first facial hair	0.7	1.5	2.9	-1.1	0.2	1.7	1.2	1.4
Birth weight	0.7	1.5	3.9	1.3	2.0	-1.0	0.3	0.9
Had major operations	0.7	0.8	3.8	0.2	-0.4	-0.2	0.4	2.0
Average weekly red wine intake	0.7	1.1	1.8	1.0	1.2	-1.3	0.9	-0.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.8	-0.5	-1.7	0.1	-1.0	-0.1
Long-standing illness, disability or infirmity	0.7	1.1	3.4	0.9	0.5	-1.8	0.7	0.8
Medication: Aspirin	0.7	1.0	2.2	0.4	0.7	-0.7	1.5	1.2
Medication: Bendroflumethiazide	0.7	1.1	2.9	0.1	-1.3	-0.8	-1.7	-0.4
Alcohol drinker status: Never	0.7	0.9	1.7	0.6	1.3	-0.3	1.3	0.8
Pack years of smoking	0.7	1.1	3.0	1.1	-0.3	-1.7	-0.1	-1.0
Impedance of whole body	0.7	3.6	8.5	-1.3	-2.5	0.8	-2.9	-1.1
Ulcerative Colitis (UC)	0.6	1.2	4.2	0.3	0.7	-0.5	0.9	2.0
Breast Cancer	0.6	1.3	3.7	1.3	0.2	-1.9	0.8	-0.8
Waist Hip Ratio (WHR)	0.6	2.5	6.3	2.2	1.1	-2.5	-0.1	-0.5
Allergy or Eczema	0.6	1.5	4.1	0.1	2.0	1.6	0.5	0.7
Systolic blood pressure, automated reading	0.6	1.8	3.4	0.4	-1.6	-0.5	-1.8	-1.7
Medication: Metformin	0.6	0.8	1.8	0.5	0.6	0.2	1.4	1.3
Pack years adult smoking proportion	0.6	0.9	2.7	1.1	-0.1	-1.6	0.4	-0.6
Impedance of leg (right)	0.6	2.7	7.0	-0.9	-1.6	-0.1	-2.6	-1.7
Townsend deprivation index at recruitment	0.6	0.9	1.2	1.0	1.1	-0.8	1.1	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	0.3	-0.6	-1.0	-0.7	-1.3
Number of incorrect matches in round	0.6	1.0	3.9	0.5	-2.0	-0.7	-0.5	-0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.8	1.3	-0.3	-0.8	1.2	-0.2
Illnesses of siblings	0.6	0.8	2.5	-1.1	0.3	1.6	-0.2	0.7
Falls in the last year	0.6	0.9	1.4	-1.1	1.0	0.0	1.2	0.8
Asthma	0.6	1.2	4.1	-0.9	0.5	2.0	0.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	0.6	-1.2	-1.3	-0.1	-0.8
Arm fat mass (right)	0.6	2.5	4.5	0.9	1.7	0.4	2.1	2.0
Length of working week for main job	0.6	0.7	1.6	-1.2	-1.0	-0.4	-0.8	-0.1
Peak expiratory flow (PEF)	0.6	1.3	2.4	-1.6	-1.1	0.8	-1.4	0.5
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	-1.0	1.4	1.2	0.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.2	-0.6	0.3	-0.3	1.5	1.0
Blood clot in the leg (DVT)	0.6	0.8	2.1	-1.4	-0.5	0.8	-0.9	-0.0
Glaucoma (self-reported)	0.6	0.7	2.1	0.5	1.5	-0.2	0.4	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.2	-1.8	0.3	1.4	0.4	0.6
Medication: Omeprazole	0.6	0.7	2.1	0.1	-0.3	-0.9	-0.8	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.4	0.8	-0.3	-0.7	-1.1	-1.2
Supplements: Vitamin C	0.6	0.7	1.0	-0.8	-0.8	0.8	0.8	1.0
Osteoporosis (self-reported)	0.6	0.8	2.0	-0.5	-1.4	0.4	-1.1	0.5
Wears glasses or contact lenses	0.6	0.7	1.8	1.4	-0.6	-0.8	-0.6	-0.2
Fractured/broken bones in last 5 years	0.6	0.8	2.7	0.4	-1.1	-0.4	-1.6	0.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.9	-0.4	2.0	1.9	0.7	0.1
Schizophrenia (2018)	0.5	1.0	3.7	0.6	-0.4	-0.5	1.9	0.5
Alzheimer’s Disease (including proxy)	0.5	0.8	2.0	0.9	-0.8	-1.4	0.2	-0.6
Schizophrenia (2014)	0.5	1.1	3.8	0.7	-0.6	-0.7	2.0	0.7
Systolic Blood Pressure	0.5	2.3	4.6	0.7	-1.8	-1.1	-1.4	-2.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.3	-1.2	-0.7	-0.7	-0.7	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	2.0	0.6	-0.4	-1.4	0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	0.9	1.0	-0.5	0.6	-0.2
Medication for hormone replacement therapy	0.5	0.6	2.2	0.2	-1.5	-0.4	-0.6	0.3
Diabetes (father)	0.5	0.6	1.9	0.6	1.4	-0.1	0.8	-0.2
Average weekly fortified wine intake	0.5	0.6	1.8	0.3	-1.3	-0.8	-0.7	0.4
Sitting height	0.5	3.9	6.9	-2.6	0.7	2.2	1.6	2.1
Waist circumference	0.5	2.0	3.1	1.6	1.8	-0.7	1.5	1.1
Weight	0.5	2.5	5.5	0.5	1.5	0.5	2.3	2.1
Time employed in main current job	0.5	0.6	1.2	-0.6	-1.1	0.5	0.9	0.7
Pulse wave reflection index	0.5	0.6	1.3	0.6	0.2	0.9	0.7	1.1
Number of full brothers	0.5	0.6	1.1	0.7	0.9	-0.7	-0.6	-1.0
Health satisfaction	0.5	0.6	1.3	1.1	0.2	-0.8	0.7	0.8
Eye problems/disorders: None of the above	0.5	0.6	1.0	-0.8	-1.0	0.9	0.2	-0.4
Medication: Allopurinol	0.5	0.7	2.2	-0.8	1.5	0.8	-0.2	-0.3
Heart disease (mother)	0.5	0.6	2.2	-0.5	-1.5	0.8	-0.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	1.1	-0.5	-0.9	-0.8	0.0
Medication: Aspirin	0.5	0.6	1.6	0.3	0.0	-0.6	1.2	1.1
Medication for cholesterol	0.5	0.8	1.6	-0.2	1.3	0.9	1.1	0.3
Arm fat mass (left)	0.5	2.1	3.9	0.6	1.5	0.5	1.9	2.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.6	-1.3	-0.4	1.0	-0.8	0.1
Worry (Nagel 2018)	0.4	0.9	2.6	1.3	-0.2	-1.6	0.3	-0.1
Alzheimer’s Disease (in mother)	0.4	0.4	1.1	0.6	-0.6	-1.1	0.1	-0.6
LDL Cholesterol	0.4	0.6	1.3	-0.9	1.2	0.2	-0.8	-0.4
Primary Biliary Cirrhosis	0.4	0.5	1.5	-0.5	-1.2	0.4	-0.8	0.3
Ulcerative Colitis	0.4	0.6	2.1	0.6	-0.4	-0.2	0.5	1.5
Blood Platelet Count	0.4	4.5	11.7	1.7	-3.4	-0.6	-1.9	-2.1
Lung FEV1/FVC ratio	0.4	1.8	3.0	1.2	0.9	-1.5	-1.7	-1.3
Number of treatments/medications taken	0.4	0.7	2.0	0.4	0.4	-1.4	0.3	1.0
Angina	0.4	0.5	1.4	-0.6	-1.2	0.1	-0.9	-0.3
Supplements: Zinc	0.4	0.4	0.9	-0.0	-0.2	-0.7	0.8	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	-0.1	0.2	0.2	0.8	1.2
Impedance of leg (left)	0.4	1.9	4.6	-0.7	-1.5	-0.0	-2.1	-1.3
Hip circumference	0.4	1.5	3.2	0.4	1.3	0.6	1.5	1.8
Number of live births	0.4	0.5	1.3	0.9	0.1	-1.1	0.4	-0.6
Illnesses of mother	0.4	0.4	0.6	0.7	0.8	-0.4	-0.7	-0.7
Standing height	0.4	3.9	9.7	-1.7	0.6	1.6	2.0	3.1
Exposure to tobacco smoke at home	0.4	0.5	1.5	-1.2	-0.6	0.2	-0.6	0.2
Breastfed as a baby	0.4	0.5	0.8	-0.9	0.6	0.7	0.5	0.8
High blood pressure (siblings)	0.4	0.6	1.0	-0.2	-0.9	-1.0	-1.0	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	2.7	-0.4	0.3	1.6	-0.5	0.6
Knee pain experienced in last month	0.4	0.6	2.1	0.2	-0.7	-1.5	0.3	-0.4
Hypertension (Self-reported)	0.4	1.1	4.4	0.6	0.4	-2.1	-0.1	-0.7
Illnesses of father: Heart disease	0.4	0.5	1.4	0.6	-0.5	-0.5	1.2	-0.2
Ever had bowel cancer screening	0.4	0.4	1.1	0.0	-1.1	-0.4	-0.7	-0.6
Commuting to job workplace: Walk	0.4	0.4	0.9	-0.7	-0.7	-0.1	-0.9	-0.5
Eye problems/disorders: Cataract	0.4	0.4	1.0	1.0	-0.3	-0.7	-0.8	0.0
Asthma (self-reported)	0.4	0.8	3.0	-0.4	0.6	1.7	0.5	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.3	-0.1	-0.5	-1.1	-0.8
Mother’s age at death	0.4	0.5	1.1	-0.5	-0.9	0.5	-1.1	0.3
Cholesterol lowering medication	0.4	0.5	1.0	0.5	0.7	-0.9	-0.2	-1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	0.0	-0.7	-0.8	0.1	0.9
Medication: Co-codamol	0.3	0.3	0.7	-0.2	0.6	-0.2	0.9	0.8
Diabetes (mother)	0.3	0.4	1.3	-1.1	-0.2	0.6	-0.2	0.3
High blood pressure	0.3	0.9	3.2	0.2	0.1	-1.8	-0.5	-0.9
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.8	0.3	-0.2	0.8	0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	0.5	0.4	-0.2	-1.0	0.4
Body mass index (BMI)	0.3	1.3	2.4	1.2	1.4	-0.3	1.5	0.8
Trunk fat mass	0.3	1.1	2.9	0.0	0.7	0.8	1.2	1.7
Had menopause	0.3	0.4	1.1	-0.7	-1.0	0.2	-0.7	0.2
Pain all over the body in last month	0.3	0.3	0.5	0.3	0.7	-0.7	-0.1	-0.6
Arm fat percentage (right)	0.3	1.0	2.3	0.3	0.9	1.0	1.0	1.5
Medication: Lansoprazole	0.3	0.3	0.5	0.2	0.1	-0.7	-0.7	-0.7
Angina (self-reported)	0.3	0.4	1.3	-0.4	-1.1	-0.0	-0.8	-0.0
Whole body fat mass	0.3	1.4	2.8	0.3	1.1	0.7	1.6	1.7
Leg fat mass (right)	0.3	1.3	2.8	0.4	1.1	0.4	1.7	1.5
Comparative height size at age 10	0.3	1.5	3.4	-1.1	0.2	1.6	0.7	1.9
Medication: Paracetamol	0.3	0.4	0.9	-1.0	0.3	0.5	0.4	0.8
Leg fat mass (left)	0.3	1.3	2.8	0.6	0.9	0.3	1.7	1.5
Ovarian Cancer	0.2	0.2	0.6	0.2	-0.1	-0.6	0.4	-0.8
Tanning	0.2	1.9	4.5	-1.4	-2.1	-0.2	-1.4	1.0
Hand grip strength (right)	0.2	0.6	2.1	-1.5	-0.7	0.4	0.4	-0.0
Relative age voice broke	0.2	0.3	0.7	-0.4	0.5	0.4	-0.8	0.4
Medication: Levothyroxine sodium	0.2	0.4	1.4	-1.2	0.4	0.4	0.4	-0.4
Alcohol intake versus 10 years previously	0.2	0.4	0.7	-0.4	0.4	0.5	0.9	-0.7
Pulse wave Arterial Stiffness index	0.2	0.3	1.0	1.0	-0.1	0.2	0.6	0.3
Tense / ‘highly strung’	0.2	0.3	0.5	-0.1	0.3	-0.5	0.7	-0.7
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	-0.1	-0.9	-0.1	-1.0	-0.3
Medication: Amlodipine	0.2	0.3	0.8	-0.8	-0.9	0.0	0.2	0.1
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.5	0.2	-0.2	0.9	0.9
Age at first live birth	0.2	0.4	1.2	-0.4	0.1	1.1	0.3	0.6
Pulse wave peak to peak time	0.2	0.3	1.2	-1.1	0.3	-0.1	-0.2	-0.0
Migraine (self-reported)	0.2	0.2	0.4	-0.6	-0.1	0.7	0.4	-0.0
Medication: Ibuprofen	0.2	0.2	0.7	0.0	-0.6	-0.4	0.8	0.1
Alcohol intake frequency.	0.2	0.5	1.8	0.7	-1.4	-0.0	0.3	-0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.5	-0.7	-0.0	-0.2	0.6	0.6
Arm fat percentage (left)	0.2	0.7	1.7	0.4	0.5	0.8	0.8	1.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	-0.4	0.9	-0.4	-0.1	-0.5
Medication: Atorvastatin	0.2	0.3	0.8	0.9	0.6	0.0	0.3	0.5
Average weekly beer plus cider intake	0.2	0.3	1.2	0.0	0.1	0.4	-0.5	-1.1
Diastolic blood pressure, automated reading	0.2	0.7	1.2	-0.2	-1.0	-0.4	-1.0	-1.1
Prostate Cancer	0.1	0.1	0.3	0.2	-0.6	0.2	-0.6	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.5	-0.1	-0.1	0.5	0.5
Blood Eosinophil Count	0.1	1.1	3.0	0.7	-1.7	-0.6	0.7	1.1
Blood White Count	0.1	0.6	1.8	-0.1	0.5	-1.4	0.4	-0.7
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.8	0.1	0.5	-0.3	0.1
Hair Pigment	0.1	3.2	7.0	1.4	2.6	-1.9	1.9	-0.0
Hand grip strength (left)	0.1	0.3	1.2	-0.4	-0.2	0.1	-0.3	-1.1
Trunk fat percentage	0.1	0.4	1.0	-0.1	0.1	0.9	0.3	1.0
Taking other prescription medications	0.1	0.1	0.4	-0.5	0.0	-0.1	-0.2	0.7
Medication: Paracetamol	0.1	0.2	0.3	-0.5	0.5	-0.2	0.5	0.0
Headache pain in last month	0.1	0.2	0.5	0.1	-0.7	-0.6	-0.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.3	0.3	-0.1	0.4	-0.2
Body fat percentage	0.1	0.3	0.9	0.1	0.3	0.7	0.5	1.0
Age at last live birth	0.1	0.2	0.3	-0.4	0.4	0.4	0.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.7	0.1	-0.1	-0.0	-0.8	-0.3
Medication: Gliclazide	0.1	0.1	0.2	-0.1	0.2	-0.5	-0.0	-0.3
Illnesses of father: High blood pressure	0.1	0.2	0.7	-0.2	-0.4	-0.1	-0.1	-0.8
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.5	0.2	-0.3	1.2	0.1	0.6
Height	0.0	0.4	1.2	-0.1	-0.3	0.3	0.7	1.1
Leg fat percentage (right)	0.0	0.1	0.3	0.5	-0.1	-0.1	-0.1	0.0
Leg fat percentage (left)	0.0	0.1	0.6	0.8	-0.3	-0.2	0.0	-0.0

Hub : Genes

MMP9

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Trait associations