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chr22:21,075,537-22,685,340

Best TWAS P=3.43e-16 · Best GWAS P=6.27e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC116	0.11	0.14	enet	14	0.12	2.3e-05	7.96	-8.2	3.4e-16	-0.97	0.02	0.98	TRUE
18	GTEx	Nerve Tibial	CCDC116	0.22	0.25	enet	9	0.29	1.8e-20	7.99	-8.0	9.6e-16	-0.97	0.02	0.98	FALSE
16	GTEx	Heart Atrial Appendage	CCDC116	0.11	0.03	lasso	3	0.05	1.8e-03	7.96	-8.0	1.0e-15	-0.98	0.02	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	UBE2L3	0.10	0.12	enet	16	0.11	9.7e-14	8.00	8.0	1.2e-15	0.93	0.03	0.97	FALSE
29	YFS	Blood	UBE2L3	0.13	0.25	bslmm	330	0.25	1.3e-82	7.77	8.0	1.3e-15	0.96	0.03	0.97	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	CCDC116	0.20	0.08	lasso	8	0.12	6.0e-05	7.79	-8.0	1.5e-15	-0.96	0.03	0.95	FALSE
24	GTEx	Thyroid	HIC2	0.07	0.00	lasso	4	0.00	5.9e-01	7.86	8.0	1.5e-15	0.97	0.02	0.67	FALSE
23	GTEx	Thyroid	CCDC116	0.10	0.07	lasso	4	0.07	3.7e-06	7.99	-7.9	1.9e-15	-0.96	0.02	0.97	FALSE
35	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC116	0.10	0.06	blup	39	0.07	4.4e-03	7.81	-7.9	2.1e-15	-0.93	0.02	0.81	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC116	0.02	0.02	lasso	2	0.02	1.4e-03	7.96	-7.9	2.1e-15	-0.99	0.01	0.86	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	YDJC	0.08	0.14	blup	34	0.15	2.9e-16	7.79	7.9	2.5e-15	0.94	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	CCDC116	0.09	0.05	lasso	3	0.03	1.4e-02	7.77	-7.9	2.7e-15	-0.96	0.03	0.95	FALSE
8	GTEx	Brain Cortex	CCDC116	0.17	0.17	lasso	2	0.15	7.3e-05	7.88	-7.9	3.2e-15	-0.95	0.03	0.92	FALSE
17	GTEx	Lung	CCDC116	0.12	0.15	lasso	2	0.14	5.3e-11	7.79	-7.8	4.4e-15	-0.95	0.03	0.97	FALSE
6	GTEx	Artery Tibial	CCDC116	0.14	0.15	lasso	5	0.14	2.7e-11	7.96	-7.8	5.3e-15	-0.96	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCDC116	0.05	0.06	lasso	1	0.05	1.3e-03	7.81	-7.8	5.6e-15	-0.92	0.02	0.85	FALSE
14	GTEx	Esophagus Mucosa	CCDC116	0.10	0.06	lasso	4	0.06	8.7e-05	7.75	-7.8	6.1e-15	-0.97	0.03	0.97	FALSE
7	GTEx	Brain Cerebellum	CCDC116	0.25	0.16	lasso	4	0.10	6.5e-04	7.77	-7.8	7.6e-15	-0.95	0.03	0.95	FALSE
26	METSIM	Adipose	CCDC116	0.06	0.07	enet	22	0.08	4.6e-12	7.98	-7.8	8.2e-15	-0.94	0.02	0.98	FALSE
4	GTEx	Artery Aorta	CCDC116	0.18	0.18	lasso	10	0.18	5.5e-10	7.71	-7.7	1.1e-14	-0.96	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC116	0.05	0.07	blup	40	0.07	4.6e-07	7.91	-7.7	1.1e-14	-0.95	0.02	0.98	FALSE
15	GTEx	Esophagus Muscularis	CCDC116	0.15	0.20	lasso	1	0.19	6.5e-12	7.71	-7.7	1.3e-14	-0.96	0.05	0.95	FALSE
5	GTEx	Artery Coronary	CCDC116	0.16	0.06	lasso	4	0.09	5.6e-04	7.85	-7.7	1.6e-14	-0.94	0.02	0.95	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	CCDC116	0.12	0.05	lasso	5	0.02	2.1e-02	7.71	-7.7	1.8e-14	-0.92	0.03	0.92	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC116	0.07	0.12	blup	40	0.11	1.2e-12	8.08	-7.6	2.2e-14	-0.95	0.01	0.99	FALSE
19	GTEx	Ovary	CCDC116	0.54	0.15	lasso	10	0.20	1.5e-05	7.97	-7.6	3.2e-14	-0.82	0.02	0.82	FALSE
2	GTEx	Adipose Subcutaneous	CCDC116	0.15	0.12	lasso	7	0.13	1.7e-10	7.96	-7.5	4.7e-14	-0.95	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC116	0.05	0.00	blup	40	0.02	1.8e-02	6.68	-7.5	6.9e-14	-0.87	0.01	0.54	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCDC116	0.07	0.02	blup	40	0.03	1.5e-02	7.96	-7.5	9.0e-14	-0.94	0.01	0.79	FALSE
11	GTEx	Colon Sigmoid	CCDC116	0.30	0.14	lasso	5	0.24	6.0e-09	4.44	-7.4	1.5e-13	-0.84	0.03	0.97	FALSE
21	GTEx	Skin Sun Exposed Lower leg	CCDC116	0.07	0.08	enet	8	0.08	6.6e-07	7.96	-7.2	4.4e-13	-0.87	0.03	0.97	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	YDJC	0.04	0.00	blup	34	0.02	4.0e-02	8.08	7.2	5.9e-13	0.93	0.01	0.69	FALSE
10	GTEx	Breast Mammary Tissue (Female)	CCDC116	0.11	-0.01	enet	15	-0.01	5.7e-01	7.96	-7.2	8.2e-13	-0.82	0.03	0.70	FALSE
9	GTEx	Breast Mammary Tissue	CCDC116	0.15	0.12	enet	20	0.13	5.1e-07	7.75	-7.1	1.7e-12	-0.82	0.03	0.96	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC116	0.06	0.05	blup	40	0.06	4.3e-07	7.99	-6.8	1.2e-11	-0.85	0.02	0.98	FALSE
22	GTEx	Spleen	CCDC116	0.20	0.07	enet	15	0.14	1.8e-04	7.96	-6.7	1.6e-11	-0.88	0.03	0.87	FALSE
28	METSIM	Adipose	YDJC	0.05	0.04	enet	11	0.04	7.7e-07	7.98	6.6	3.2e-11	0.82	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CCDC116	0.03	0.02	enet	12	0.02	5.1e-03	7.81	-6.6	4.7e-11	-0.82	0.01	0.74	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC116	0.04	0.04	blup	40	0.05	1.1e-09	7.99	-6.6	5.7e-11	-0.88	0.02	0.98	FALSE
25	GTEx	Whole Blood	UBE2L3	0.06	0.00	enet	22	0.01	4.0e-02	7.91	6.2	4.3e-10	0.73	0.03	0.88	FALSE
12	GTEx	Colon Transverse	CCDC116	0.15	0.03	enet	16	0.04	6.3e-03	7.74	-5.7	9.2e-09	-0.79	0.03	0.83	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PPIL2	0.03	0.00	blup	61	0.02	4.4e-03	6.68	5.6	1.6e-08	0.54	0.02	0.34	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	YDJC	0.02	0.00	blup	34	0.01	1.6e-03	-0.84	5.6	2.7e-08	0.75	0.01	0.19	FALSE
27	METSIM	Adipose	UBE2L3	0.04	0.01	enet	18	0.02	1.2e-04	7.79	5.4	7.0e-08	0.57	0.04	0.94	FALSE