[Hub]/) : Traits : Crohns Disease (2017) :

chr22:21,075,537-22,685,340

Best TWAS P=3.43e-16 · Best GWAS P=6.27e-16 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex UBE2L3 0.10 0.12 enet 16 0.11 9.7e-14 8.00 8.0 1.2e-15 0.93 0.03 0.97 FALSE
2 GTEx Adipose Subcutaneous CCDC116 0.15 0.12 lasso 7 0.13 1.7e-10 7.96 -7.5 4.7e-14 -0.95 0.03 0.97 FALSE
3 GTEx Adipose Visceral Omentum CCDC116 0.09 0.05 lasso 3 0.03 1.4e-02 7.77 -7.9 2.7e-15 -0.96 0.03 0.95 FALSE
4 GTEx Artery Aorta CCDC116 0.18 0.18 lasso 10 0.18 5.5e-10 7.71 -7.7 1.1e-14 -0.96 0.03 0.97 FALSE
5 GTEx Artery Coronary CCDC116 0.16 0.06 lasso 4 0.09 5.6e-04 7.85 -7.7 1.6e-14 -0.94 0.02 0.95 FALSE
6 GTEx Artery Tibial CCDC116 0.14 0.15 lasso 5 0.14 2.7e-11 7.96 -7.8 5.3e-15 -0.96 0.02 0.98 FALSE
7 GTEx Brain Cerebellum CCDC116 0.25 0.16 lasso 4 0.10 6.5e-04 7.77 -7.8 7.6e-15 -0.95 0.03 0.95 FALSE
8 GTEx Brain Cortex CCDC116 0.17 0.17 lasso 2 0.15 7.3e-05 7.88 -7.9 3.2e-15 -0.95 0.03 0.92 FALSE
9 GTEx Breast Mammary Tissue CCDC116 0.15 0.12 enet 20 0.13 5.1e-07 7.75 -7.1 1.7e-12 -0.82 0.03 0.96 FALSE
10 GTEx Breast Mammary Tissue (Female) CCDC116 0.11 -0.01 enet 15 -0.01 5.7e-01 7.96 -7.2 8.2e-13 -0.82 0.03 0.70 FALSE
11 GTEx Colon Sigmoid CCDC116 0.30 0.14 lasso 5 0.24 6.0e-09 4.44 -7.4 1.5e-13 -0.84 0.03 0.97 FALSE
12 GTEx Colon Transverse CCDC116 0.15 0.03 enet 16 0.04 6.3e-03 7.74 -5.7 9.2e-09 -0.79 0.03 0.83 FALSE
13 GTEx Esophagus Gastroesophageal Junction CCDC116 0.20 0.08 lasso 8 0.12 6.0e-05 7.79 -8.0 1.5e-15 -0.96 0.03 0.95 FALSE
14 GTEx Esophagus Mucosa CCDC116 0.10 0.06 lasso 4 0.06 8.7e-05 7.75 -7.8 6.1e-15 -0.97 0.03 0.97 FALSE
15 GTEx Esophagus Muscularis CCDC116 0.15 0.20 lasso 1 0.19 6.5e-12 7.71 -7.7 1.3e-14 -0.96 0.05 0.95 FALSE
16 GTEx Heart Atrial Appendage CCDC116 0.11 0.03 lasso 3 0.05 1.8e-03 7.96 -8.0 1.0e-15 -0.98 0.02 0.96 FALSE
17 GTEx Lung CCDC116 0.12 0.15 lasso 2 0.14 5.3e-11 7.79 -7.8 4.4e-15 -0.95 0.03 0.97 FALSE
18 GTEx Nerve Tibial CCDC116 0.22 0.25 enet 9 0.29 1.8e-20 7.99 -8.0 9.6e-16 -0.97 0.02 0.98 FALSE
19 GTEx Ovary CCDC116 0.54 0.15 lasso 10 0.20 1.5e-05 7.97 -7.6 3.2e-14 -0.82 0.02 0.82 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic CCDC116 0.12 0.05 lasso 5 0.02 2.1e-02 7.71 -7.7 1.8e-14 -0.92 0.03 0.92 FALSE
21 GTEx Skin Sun Exposed Lower leg CCDC116 0.07 0.08 enet 8 0.08 6.6e-07 7.96 -7.2 4.4e-13 -0.87 0.03 0.97 FALSE
22 GTEx Spleen CCDC116 0.20 0.07 enet 15 0.14 1.8e-04 7.96 -6.7 1.6e-11 -0.88 0.03 0.87 FALSE
23 GTEx Thyroid CCDC116 0.10 0.07 lasso 4 0.07 3.7e-06 7.99 -7.9 1.9e-15 -0.96 0.02 0.97 FALSE
24 GTEx Thyroid HIC2 0.07 0.00 lasso 4 0.00 5.9e-01 7.86 8.0 1.5e-15 0.97 0.02 0.67 FALSE
25 GTEx Whole Blood UBE2L3 0.06 0.00 enet 22 0.01 4.0e-02 7.91 6.2 4.3e-10 0.73 0.03 0.88 FALSE
26 METSIM Adipose CCDC116 0.06 0.07 enet 22 0.08 4.6e-12 7.98 -7.8 8.2e-15 -0.94 0.02 0.98 FALSE
27 METSIM Adipose UBE2L3 0.04 0.01 enet 18 0.02 1.2e-04 7.79 5.4 7.0e-08 0.57 0.04 0.94 FALSE
28 METSIM Adipose YDJC 0.05 0.04 enet 11 0.04 7.7e-07 7.98 6.6 3.2e-11 0.82 0.01 0.99 FALSE
29 YFS Blood UBE2L3 0.13 0.25 bslmm 330 0.25 1.3e-82 7.77 8.0 1.3e-15 0.96 0.03 0.97 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma CCDC116 0.03 0.02 enet 12 0.02 5.1e-03 7.81 -6.6 4.7e-11 -0.82 0.01 0.74 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma CCDC116 0.04 0.04 blup 40 0.05 1.1e-09 7.99 -6.6 5.7e-11 -0.88 0.02 0.98 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma YDJC 0.02 0.00 blup 34 0.01 1.6e-03 -0.84 5.6 2.7e-08 0.75 0.01 0.19 FALSE
33 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCDC116 0.05 0.06 lasso 1 0.05 1.3e-03 7.81 -7.8 5.6e-15 -0.92 0.02 0.85 FALSE
34 The Cancer Genome Atlas Colon Adenocarcinoma CCDC116 0.05 0.00 blup 40 0.02 1.8e-02 6.68 -7.5 6.9e-14 -0.87 0.01 0.54 FALSE
35 The Cancer Genome Atlas Glioblastoma Multiforme CCDC116 0.10 0.06 blup 39 0.07 4.4e-03 7.81 -7.9 2.1e-15 -0.93 0.02 0.81 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC116 0.02 0.02 lasso 2 0.02 1.4e-03 7.96 -7.9 2.1e-15 -0.99 0.01 0.86 FALSE
37 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma YDJC 0.04 0.00 blup 34 0.02 4.0e-02 8.08 7.2 5.9e-13 0.93 0.01 0.69 FALSE
38 The Cancer Genome Atlas Brain Lower Grade Glioma CCDC116 0.07 0.12 blup 40 0.11 1.2e-12 8.08 -7.6 2.2e-14 -0.95 0.01 0.99 FALSE
39 The Cancer Genome Atlas Brain Lower Grade Glioma YDJC 0.08 0.14 blup 34 0.15 2.9e-16 7.79 7.9 2.5e-15 0.94 0.02 0.98 FALSE
40 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PPIL2 0.03 0.00 blup 61 0.02 4.4e-03 6.68 5.6 1.6e-08 0.54 0.02 0.34 FALSE
41 The Cancer Genome Atlas Pancreatic Adenocarcinoma CCDC116 0.07 0.02 blup 40 0.03 1.5e-02 7.96 -7.5 9.0e-14 -0.94 0.01 0.79 FALSE
42 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CCDC116 0.11 0.14 enet 14 0.12 2.3e-05 7.96 -8.2 3.4e-16 -0.97 0.02 0.98 TRUE
43 The Cancer Genome Atlas Prostate Adenocarcinoma CCDC116 0.06 0.05 blup 40 0.06 4.3e-07 7.99 -6.8 1.2e-11 -0.85 0.02 0.98 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma CCDC116 0.05 0.07 blup 40 0.07 4.6e-07 7.91 -7.7 1.1e-14 -0.95 0.02 0.98 FALSE