Best TWAS P=7.23e-13 · Best GWAS P=5.87e-14 conditioned to 0.0151
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | AHSA2 | 0.25 | 0.13 | enet | 13 | 0.23 | 5.8e-07 | 4.6 | -5.2 | 2.4e-07 | -0.50 | 0.75 | 0.03 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | KIAA1841 | 0.17 | 0.16 | lasso | 3 | 0.18 | 1.7e-05 | -5.3 | -5.2 | 2.1e-07 | -0.59 | 0.28 | 0.33 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | AHSA2 | 0.27 | 0.12 | lasso | 6 | 0.08 | 6.3e-03 | -5.3 | -6.2 | 4.4e-10 | -0.76 | 0.02 | 0.86 | FALSE |
| 4 | GTEx | Colon Transverse | AC010733.5 | 0.12 | 0.00 | lasso | 6 | 0.00 | 4.5e-01 | 4.3 | -7.0 | 3.5e-12 | -0.77 | 0.02 | 0.76 | FALSE |
| 5 | GTEx | Uterus | PUS10 | 0.34 | 0.21 | lasso | 8 | 0.14 | 7.4e-04 | -4.1 | -5.8 | 5.5e-09 | -0.53 | 0.04 | 0.54 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PEX13 | 0.10 | 0.06 | blup | 330 | 0.10 | 1.7e-12 | 5.6 | 6.0 | 1.9e-09 | 0.52 | 0.91 | 0.09 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PUS10 | 0.04 | 0.00 | blup | 64 | 0.03 | 3.8e-04 | 5.6 | -5.3 | 9.5e-08 | -0.34 | 0.03 | 0.04 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PEX13 | 0.06 | 0.03 | lasso | 3 | 0.04 | 1.3e-02 | 6.5 | 7.2 | 7.2e-13 | 0.90 | 0.00 | 0.91 | TRUE |
| 9 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | PEX13 | 0.11 | 0.00 | blup | 40 | 0.03 | 6.6e-02 | -3.9 | 6.1 | 1.0e-09 | 0.51 | 0.02 | 0.21 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | PEX13 | 0.03 | 0.03 | enet | 6 | 0.04 | 1.9e-04 | 4.5 | 5.7 | 1.3e-08 | 0.43 | 0.14 | 0.24 | FALSE |