[Hub]/) : Traits : Crohns Disease (2017) : ← →

chr2:101,981,794-103,767,612

Best TWAS P=7.28e-13 · Best GWAS P=1.64e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Skin Sun Exposed Lower leg	IL18R1	0.05	0.02	lasso	6	0.02	7.4e-03	7.0	7.2	7.3e-13	0.98	0.02	0.96	TRUE
15	ROSMAP	Brain Pre-frontal Cortex	IL1RL1	0.45	0.51	enet	20	0.51	4.8e-77	-6.8	6.7	3.0e-11	0.46	0.20	0.80	TRUE
14	NTR	Blood	IL1RL1	0.04	0.04	lasso	6	0.04	7.7e-13	7.3	-7.0	2.3e-12	-0.99	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL1RL1	0.13	0.20	enet	8	0.20	4.5e-22	-6.8	6.8	1.3e-11	0.53	0.01	0.99	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	IL18R1	0.42	0.52	lasso	5	0.52	6.2e-78	-6.7	6.7	1.7e-11	0.53	0.20	0.80	FALSE
5	GTEx	Brain Cortex	IL18R1	0.21	0.12	lasso	9	0.13	1.7e-04	-6.7	6.7	2.2e-11	0.59	0.17	0.64	FALSE
2	GTEx	Brain Caudate basal ganglia	IL18R1	0.17	0.23	lasso	6	0.20	1.6e-06	-6.6	6.7	2.6e-11	0.53	0.22	0.73	FALSE
1	CommonMind	Brain Pre-frontal Cortex	IL18R1	0.31	0.38	bslmm	580	0.38	5.4e-49	-6.7	6.7	3.0e-11	0.61	0.26	0.74	FALSE
6	GTEx	Brain Hippocampus	IL18R1	0.25	0.06	lasso	11	0.07	1.0e-02	3.5	6.5	6.1e-11	0.82	0.05	0.80	FALSE
9	GTEx	Heart Atrial Appendage	IL1R1	0.13	0.04	enet	26	0.06	9.8e-04	4.3	6.5	8.6e-11	0.68	0.04	0.82	FALSE
13	GTEx	Whole Blood	IL18RAP	0.14	0.18	lasso	10	0.18	6.0e-16	6.7	-6.4	1.5e-10	-0.97	0.02	0.98	FALSE
8	GTEx	Brain Putamen basal ganglia	IL18R1	0.30	0.22	enet	21	0.24	1.8e-06	-6.7	6.3	2.5e-10	0.49	0.19	0.68	FALSE
4	GTEx	Brain Cerebellum	IL18R1	0.25	0.30	enet	26	0.26	3.4e-08	-6.6	6.2	5.6e-10	0.54	0.23	0.77	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL18RAP	0.03	0.03	lasso	3	0.01	7.7e-03	7.0	-6.0	2.2e-09	-0.95	0.01	0.94	FALSE
10	GTEx	Lung	IL1RL1	0.31	0.20	lasso	6	0.20	2.3e-15	-6.8	5.9	3.3e-09	0.43	0.25	0.75	FALSE
3	GTEx	Brain Cerebellar Hemisphere	IL18R1	0.25	0.25	enet	9	0.10	1.8e-03	-5.1	5.8	5.5e-09	0.50	0.16	0.60	FALSE
11	GTEx	Lung	IL18R1	0.06	0.01	lasso	4	0.02	1.2e-02	-6.7	5.8	6.6e-09	0.55	0.05	0.85	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL18R1	0.25	0.29	blup	108	0.31	1.6e-35	-6.7	5.6	1.8e-08	0.55	0.18	0.82	FALSE
7	GTEx	Brain Putamen basal ganglia	IL1RL1	0.24	0.12	lasso	8	0.21	8.7e-06	-6.6	5.2	1.7e-07	0.32	0.12	0.18	FALSE