TWAS
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Models
Genes
Traits
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Traits
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Depressed Affect (Nagel 2018)
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chr12:109,295,508-110,704,487
Best TWAS P=4.29e-08 · Best GWAS P=5.1e-09 conditioned to 0.0391
109.4M
109.6M
109.8M
110M
110.2M
110.4M
110.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
MMAB
0.07
0.06
enet
9
0.05
7.3e-05
5.2
-5.5
4.3e-08
-0.91
0.01
0.98
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
KCTD10
0.15
0.08
lasso
6
0.08
2.1e-08
5.0
-5.4
5.9e-08
-0.90
0.04
0.96
FALSE
2
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
MMAB
0.03
0.02
blup
57
0.02
2.2e-03
5.0
-5.1
3.0e-07
-0.74
0.01
0.80
FALSE