[Hub]/) : Traits : Depressed Affect (Nagel 2018) :

chr11:112,135,760-113,969,669

Best TWAS P=9.1e-14 · Best GWAS P=1.84e-13 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cortex TTC12 0.48 0.39 lasso 5 0.43 3.2e-13 5.3 5.1 2.8e-07 -0.10 0.75 0.22 FALSE
2 GTEx Brain Hypothalamus RP11-159N11.4 0.44 0.06 lasso 19 0.03 7.5e-02 5.3 6.2 5.2e-10 -0.08 0.13 0.06 TRUE
3 GTEx Breast Mammary Tissue TTC12 0.46 0.30 lasso 7 0.40 8.1e-22 5.3 5.4 8.5e-08 -0.11 0.70 0.30 FALSE
4 GTEx Esophagus Gastroesophageal Junction TTC12 0.67 0.39 enet 34 0.54 4.6e-23 -4.4 5.2 1.9e-07 -0.10 1.00 0.00 FALSE
5 GTEx Heart Left Ventricle TTC12 0.39 0.24 enet 36 0.38 2.5e-21 5.4 5.5 3.7e-08 -0.16 0.97 0.03 FALSE
6 GTEx Spleen RP11-159N11.4 0.30 0.06 lasso 6 0.06 1.4e-02 6.7 6.0 2.5e-09 -0.14 0.13 0.13 FALSE
7 GTEx Testis TTC12 0.42 0.16 enet 33 0.38 7.7e-18 6.7 6.6 5.4e-11 -0.41 0.41 0.58 FALSE
8 GTEx Uterus NCAM1 0.41 -0.01 lasso 11 -0.01 5.9e-01 5.3 6.5 6.4e-11 -0.22 0.08 0.08 FALSE
9 METSIM Adipose ANKK1 0.16 0.11 enet 13 0.16 9.8e-23 -3.7 -6.0 1.5e-09 0.28 1.00 0.00 FALSE
10 YFS Blood ANKK1 0.04 0.03 lasso 3 0.03 2.9e-09 -4.1 -5.1 2.9e-07 0.24 1.00 0.00 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ANKK1 0.04 0.02 blup 66 0.03 5.0e-04 6.7 6.7 1.9e-11 -0.32 0.02 0.92 FALSE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ANKK1 0.04 0.03 blup 67 0.04 6.3e-05 6.1 -6.6 3.7e-11 0.39 0.02 0.97 FALSE
13 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ANKK1 0.08 0.02 blup 66 0.04 5.6e-03 5.6 -5.8 5.6e-09 0.16 0.04 0.79 FALSE
14 The Cancer Genome Atlas Lung Adenocarcinoma DRD2 0.06 0.07 lasso 2 0.07 6.6e-09 -7.3 7.5 9.1e-14 -1.00 0.00 1.00 TRUE
15 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TTC12 0.36 0.30 lasso 3 0.29 6.0e-12 5.4 5.4 6.9e-08 -0.22 0.80 0.20 FALSE
16 The Cancer Genome Atlas Prostate Adenocarcinoma TTC12 0.21 0.20 lasso 4 0.22 1.2e-22 5.4 5.2 2.6e-07 -0.19 0.91 0.09 FALSE
17 The Cancer Genome Atlas Testicular Germ Cell Tumors TTC12 0.07 0.06 blup 48 0.04 1.6e-02 4.4 5.9 4.2e-09 -0.25 0.04 0.30 FALSE