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chr11:112,135,760-113,969,669

Best TWAS P=9.1e-14 · Best GWAS P=1.84e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	The Cancer Genome Atlas	Lung Adenocarcinoma	DRD2	0.06	0.07	lasso	2	0.07	6.6e-09	-7.3	7.5	9.1e-14	-1.00	0.00	1.00	TRUE
2	GTEx	Brain Hypothalamus	RP11-159N11.4	0.44	0.06	lasso	19	0.03	7.5e-02	5.3	6.2	5.2e-10	-0.08	0.13	0.06	TRUE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ANKK1	0.04	0.02	blup	66	0.03	5.0e-04	6.7	6.7	1.9e-11	-0.32	0.02	0.92	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANKK1	0.04	0.03	blup	67	0.04	6.3e-05	6.1	-6.6	3.7e-11	0.39	0.02	0.97	FALSE
7	GTEx	Testis	TTC12	0.42	0.16	enet	33	0.38	7.7e-18	6.7	6.6	5.4e-11	-0.41	0.41	0.58	FALSE
8	GTEx	Uterus	NCAM1	0.41	-0.01	lasso	11	-0.01	5.9e-01	5.3	6.5	6.4e-11	-0.22	0.08	0.08	FALSE
9	METSIM	Adipose	ANKK1	0.16	0.11	enet	13	0.16	9.8e-23	-3.7	-6.0	1.5e-09	0.28	1.00	0.00	FALSE
6	GTEx	Spleen	RP11-159N11.4	0.30	0.06	lasso	6	0.06	1.4e-02	6.7	6.0	2.5e-09	-0.14	0.13	0.13	FALSE
17	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TTC12	0.07	0.06	blup	48	0.04	1.6e-02	4.4	5.9	4.2e-09	-0.25	0.04	0.30	FALSE
13	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ANKK1	0.08	0.02	blup	66	0.04	5.6e-03	5.6	-5.8	5.6e-09	0.16	0.04	0.79	FALSE
5	GTEx	Heart Left Ventricle	TTC12	0.39	0.24	enet	36	0.38	2.5e-21	5.4	5.5	3.7e-08	-0.16	0.97	0.03	FALSE
15	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TTC12	0.36	0.30	lasso	3	0.29	6.0e-12	5.4	5.4	6.9e-08	-0.22	0.80	0.20	FALSE
3	GTEx	Breast Mammary Tissue	TTC12	0.46	0.30	lasso	7	0.40	8.1e-22	5.3	5.4	8.5e-08	-0.11	0.70	0.30	FALSE
4	GTEx	Esophagus Gastroesophageal Junction	TTC12	0.67	0.39	enet	34	0.54	4.6e-23	-4.4	5.2	1.9e-07	-0.10	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTC12	0.21	0.20	lasso	4	0.22	1.2e-22	5.4	5.2	2.6e-07	-0.19	0.91	0.09	FALSE
1	GTEx	Brain Cortex	TTC12	0.48	0.39	lasso	5	0.43	3.2e-13	5.3	5.1	2.8e-07	-0.10	0.75	0.22	FALSE
10	YFS	Blood	ANKK1	0.04	0.03	lasso	3	0.03	2.9e-09	-4.1	-5.1	2.9e-07	0.24	1.00	0.00	FALSE