Best TWAS P=9.1e-14 · Best GWAS P=1.84e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | TTC12 | 0.48 | 0.39 | lasso | 5 | 0.43 | 3.2e-13 | 5.3 | 5.1 | 2.8e-07 | -0.10 | 0.75 | 0.22 | FALSE |
| 2 | GTEx | Brain Hypothalamus | RP11-159N11.4 | 0.44 | 0.06 | lasso | 19 | 0.03 | 7.5e-02 | 5.3 | 6.2 | 5.2e-10 | -0.08 | 0.13 | 0.06 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | TTC12 | 0.46 | 0.30 | lasso | 7 | 0.40 | 8.1e-22 | 5.3 | 5.4 | 8.5e-08 | -0.11 | 0.70 | 0.30 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | TTC12 | 0.67 | 0.39 | enet | 34 | 0.54 | 4.6e-23 | -4.4 | 5.2 | 1.9e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Heart Left Ventricle | TTC12 | 0.39 | 0.24 | enet | 36 | 0.38 | 2.5e-21 | 5.4 | 5.5 | 3.7e-08 | -0.16 | 0.97 | 0.03 | FALSE |
| 6 | GTEx | Spleen | RP11-159N11.4 | 0.30 | 0.06 | lasso | 6 | 0.06 | 1.4e-02 | 6.7 | 6.0 | 2.5e-09 | -0.14 | 0.13 | 0.13 | FALSE |
| 7 | GTEx | Testis | TTC12 | 0.42 | 0.16 | enet | 33 | 0.38 | 7.7e-18 | 6.7 | 6.6 | 5.4e-11 | -0.41 | 0.41 | 0.58 | FALSE |
| 8 | GTEx | Uterus | NCAM1 | 0.41 | -0.01 | lasso | 11 | -0.01 | 5.9e-01 | 5.3 | 6.5 | 6.4e-11 | -0.22 | 0.08 | 0.08 | FALSE |
| 9 | METSIM | Adipose | ANKK1 | 0.16 | 0.11 | enet | 13 | 0.16 | 9.8e-23 | -3.7 | -6.0 | 1.5e-09 | 0.28 | 1.00 | 0.00 | FALSE |
| 10 | YFS | Blood | ANKK1 | 0.04 | 0.03 | lasso | 3 | 0.03 | 2.9e-09 | -4.1 | -5.1 | 2.9e-07 | 0.24 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ANKK1 | 0.04 | 0.02 | blup | 66 | 0.03 | 5.0e-04 | 6.7 | 6.7 | 1.9e-11 | -0.32 | 0.02 | 0.92 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANKK1 | 0.04 | 0.03 | blup | 67 | 0.04 | 6.3e-05 | 6.1 | -6.6 | 3.7e-11 | 0.39 | 0.02 | 0.97 | FALSE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ANKK1 | 0.08 | 0.02 | blup | 66 | 0.04 | 5.6e-03 | 5.6 | -5.8 | 5.6e-09 | 0.16 | 0.04 | 0.79 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | DRD2 | 0.06 | 0.07 | lasso | 2 | 0.07 | 6.6e-09 | -7.3 | 7.5 | 9.1e-14 | -1.00 | 0.00 | 1.00 | TRUE |
| 15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TTC12 | 0.36 | 0.30 | lasso | 3 | 0.29 | 6.0e-12 | 5.4 | 5.4 | 6.9e-08 | -0.22 | 0.80 | 0.20 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TTC12 | 0.21 | 0.20 | lasso | 4 | 0.22 | 1.2e-22 | 5.4 | 5.2 | 2.6e-07 | -0.19 | 0.91 | 0.09 | FALSE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TTC12 | 0.07 | 0.06 | blup | 48 | 0.04 | 1.6e-02 | 4.4 | 5.9 | 4.2e-09 | -0.25 | 0.04 | 0.30 | FALSE |