[Hub]/) : Traits : Depressed Affect (Nagel 2018) : ← →

chr2:23,453,834-25,141,538

Best TWAS P=1.34e-11 · Best GWAS P=5.42e-11 conditioned to 0.00901

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex UBXN2A 0.22 0.18 enet 28 0.24 3.0e-28 4.3 -5.6 2.7e-08 -0.93 0.01 0.99 FALSE
2 GTEx Heart Atrial Appendage UBXN2A 0.08 0.02 lasso 3 0.02 5.2e-02 6.0 6.2 6.9e-10 0.93 0.03 0.89 FALSE
3 GTEx Testis AC009228.1 0.27 0.34 lasso 5 0.38 5.4e-18 5.5 5.2 2.3e-07 0.54 0.77 0.23 FALSE
4 METSIM Adipose UBXN2A 0.07 0.03 bslmm 403 0.06 5.3e-10 4.3 5.7 9.6e-09 0.78 0.15 0.85 FALSE
5 ROSMAP Brain Pre-frontal Cortex UBXN2A 0.03 0.01 lasso 4 0.02 2.2e-03 6.1 -5.7 1.2e-08 -0.80 0.03 0.92 FALSE
6 The Cancer Genome Atlas Esophageal Carcinoma C2orf84 0.13 0.04 lasso 3 0.06 4.8e-03 4.3 5.3 1.4e-07 0.49 0.02 0.92 FALSE
7 The Cancer Genome Atlas Glioblastoma Multiforme C2orf84 0.13 0.07 blup 56 0.05 1.5e-02 2.8 5.2 2.6e-07 0.51 0.01 0.33 FALSE
8 The Cancer Genome Atlas Brain Lower Grade Glioma UBXN2A 0.04 0.04 lasso 1 0.03 1.4e-04 6.0 -6.0 1.5e-09 -0.96 0.02 0.95 FALSE
9 The Cancer Genome Atlas Lung Adenocarcinoma UBXN2A 0.05 0.00 blup 46 0.01 1.3e-02 -2.2 6.8 1.3e-11 0.69 0.01 0.37 TRUE
10 The Cancer Genome Atlas Prostate Adenocarcinoma ATAD2B 0.15 0.02 enet 33 0.03 1.4e-04 -2.4 5.6 2.5e-08 0.42 0.02 0.07 FALSE