Best TWAS P=2.01e-82 · Best GWAS P=1.29e-78 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | NDFIP1 | 0.35 | -0.01 | enet | 38 | -0.01 | 7.8e-01 | -16.3 | -12.0 | 6.3e-33 | 0.48 | 0.04 | 0.59 | FALSE |
| 2 | GTEx | Muscle Skeletal | NDFIP1 | 0.20 | 0.10 | lasso | 9 | 0.12 | 3.8e-12 | -18.8 | 19.2 | 2.0e-82 | -0.93 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | GNPDA1 | 0.18 | 0.02 | lasso | 8 | 0.01 | 6.2e-02 | -11.4 | 9.2 | 4.3e-20 | -0.56 | 0.04 | 0.66 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | GNPDA1 | 0.11 | 0.00 | enet | 23 | 0.00 | 1.5e-01 | 15.4 | 12.6 | 4.0e-36 | -0.69 | 0.02 | 0.92 | TRUE |
| 5 | METSIM | Adipose | NDFIP1 | 0.23 | 0.15 | lasso | 8 | 0.16 | 7.1e-23 | -13.8 | -16.1 | 3.8e-58 | 0.73 | 1.00 | 0.00 | TRUE |
| 6 | NTR | Blood | NDFIP1 | 0.03 | 0.00 | blup | 610 | 0.01 | 2.9e-03 | -16.3 | -13.5 | 2.4e-41 | 0.63 | 0.03 | 0.96 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | SPRY4 | 0.10 | 0.07 | lasso | 4 | 0.07 | 2.1e-09 | 5.5 | 7.0 | 1.8e-12 | -0.16 | 1.00 | 0.00 | TRUE |
| 8 | YFS | Blood | NDFIP1 | 0.04 | 0.01 | enet | 14 | 0.03 | 2.3e-10 | 15.4 | -11.0 | 2.5e-28 | 0.45 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RNF14 | 0.11 | 0.01 | blup | 79 | 0.04 | 1.8e-04 | 1.4 | 6.6 | 3.4e-11 | -0.10 | 0.04 | 0.04 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NDFIP1 | 0.04 | 0.01 | lasso | 3 | 0.01 | 1.2e-03 | -9.1 | 13.5 | 1.7e-41 | -0.65 | 0.09 | 0.24 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | GNPDA1 | 0.11 | 0.00 | blup | 67 | 0.03 | 1.5e-03 | -10.9 | -6.8 | 8.8e-12 | 0.19 | 0.01 | 0.08 | TRUE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | NDFIP1 | 0.06 | 0.03 | enet | 3 | 0.04 | 3.3e-05 | -4.1 | -5.7 | 1.3e-08 | 0.20 | 0.84 | 0.00 | TRUE |