Hub : Genes

GNPDA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.1770	0.0540	1.1e-03	0.023	NA	-0.003	NA	0.013	2.0e-02	NA	5.1e-01	NA	6.2e-02
2	GTEx	Skin Sun Exposed Lower leg	0.1060	0.0340	7.8e-04	0.000	NA	0.004	NA	0.002	2.9e-01	NA	1.5e-01	NA	2.3e-01
3	METSIM	Adipose	0.0970	0.0300	2.2e-05	0.029	0.019	0.021	0.020	0.036	2.6e-05	5.4e-04	3.6e-04	5.1e-04	3.5e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.1039	0.0303	5.3e-06	0.016	0.032	0.057	0.047	0.057	3.0e-03	5.2e-05	8.3e-08	1.1e-06	6.8e-08
5	YFS	Blood	0.0599	0.0141	1.4e-11	0.027	0.042	0.037	0.042	0.036	3.1e-09	1.2e-13	2.7e-12	1.4e-13	8.9e-12
6	TCGA	Thyroid Carcinoma	0.1110	0.0570	8.2e-03	0.004	0.025	0.010	NA	0.005	1.2e-01	1.5e-03	3.1e-02	NA	1.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.4	0.9	-0.3	-0.5	0.5	-0.8	1.0	-0.2
Bipolar Disorder or Schizophrenia	0.6	1.3	2.6	-1.6	-0.6	0.4	-1.6	1.5	0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	0.4	-0.1	0.0	-0.1	-0.7	-0.8
Depression (Nagel 2018)	1.8	2.7	8.0	1.9	0.8	0.8	-1.5	1.0	-2.8
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.9	-2.0	-1.3	-0.6	1.6	-0.7	1.1
Neuroticism (Nagel 2018)	0.2	0.5	0.9	0.4	-0.4	-0.7	-0.9	-0.6	-0.9
Schizophrenia (2018)	0.6	1.2	3.3	-1.8	-0.3	0.1	-1.4	1.2	0.6
Schizophrenia vs Biploar Disorder	0.7	1.0	3.3	-0.1	1.8	0.5	0.8	-1.0	-0.7
Worry (Nagel 2018)	0.2	0.4	1.1	0.5	0.5	-0.3	-0.9	0.3	-1.0
Alzheimer’s Disease (in mother)	1.3	1.5	4.0	1.1	-0.4	1.3	-2.0	1.3	0.6
Alzheimer’s Disease (in father)	0.9	1.0	2.7	0.1	-1.6	-0.9	-1.0	0.9	0.7
Alzheimer’s Disease (including proxy)	2.2	3.1	8.8	0.7	-3.0	0.0	-2.5	1.8	0.5
Crohns Disease (2017)	3.7	8.1	18.6	2.6	3.9	1.9	-0.7	4.3	-2.1
Irritable Bowel Disease (IBD)	3.4	8.0	20.2	3.1	4.5	1.9	-0.0	2.9	-2.5
Ulcerative Colitis (UC)	2.2	4.2	12.4	2.3	3.5	1.5	0.4	0.9	-2.1
Major Depression (MDD)	0.3	0.4	1.2	0.1	-0.7	-0.7	0.2	-1.1	-0.4
Reaction Time	0.3	0.5	2.4	-0.5	-0.1	-1.5	0.2	-0.1	-0.4
Verbal and Numeric Reasoning (VNR)	1.4	3.3	12.6	-1.0	-0.8	0.6	3.5	-1.6	1.6
Breast Cancer	0.8	1.9	4.8	1.2	2.2	1.2	-0.6	1.8	-0.2
Ovarian Cancer	0.3	0.4	1.5	-0.2	-0.5	-0.7	0.0	-0.0	1.2
Prostate Cancer	1.5	2.1	3.7	-1.7	-1.1	-1.7	-1.9	-1.1	0.9
Age at First Birth	0.6	0.9	2.2	-1.2	-0.6	-0.9	0.2	-1.5	0.5
Bipolar Disorder (2011)	0.9	0.9	2.7	0.6	-0.6	0.5	-1.3	1.6	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	2.2	-0.5	-0.4	0.6	-1.3	1.5	-1.0
Coronary Artery Disease (CAD)	2.9	3.5	6.8	-2.1	-0.9	-2.6	0.8	-1.3	2.5
Crohns Disease (2012)	2.5	4.0	8.7	1.6	2.5	1.8	-0.6	3.0	-1.6
Mean Putamen Volume	0.7	0.8	2.8	0.1	0.6	1.7	0.5	1.1	-0.1
Fasting Glucose	0.2	0.2	0.4	-0.2	-0.1	-0.6	0.6	-0.4	0.7
HbA1C	1.5	1.7	4.2	1.1	1.2	-0.9	-2.0	1.2	1.0
HDL Cholesterol	0.6	1.0	1.9	-0.7	-1.4	0.6	1.0	1.1	-0.8
LDL Cholesterol	0.4	0.7	1.9	0.3	-0.3	-1.4	-0.9	-0.5	1.1
Lupus	0.7	1.0	4.1	-0.2	-0.7	-1.1	-2.0	0.1	-0.7
Neuroticism (2016)	0.0	0.1	0.1	-0.2	-0.2	0.3	-0.3	-0.2	-0.3
Primary Biliary Cirrhosis	0.6	0.8	1.9	0.8	1.4	1.3	0.0	-0.1	-0.9
Rheumatoid Arthritis	1.5	2.0	5.5	0.9	0.6	-2.2	0.1	-2.3	1.0
Schizophrenia (2014)	0.5	1.2	4.6	-2.1	-0.7	-0.4	-1.2	0.3	0.6
Triglycerides	0.5	0.8	1.9	0.9	0.5	0.0	-1.4	-1.3	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.1	-0.6	-0.8	-0.9	0.8	0.3
Ulcerative Colitis	0.8	1.2	2.7	0.9	1.2	1.6	0.3	0.2	-1.3
Blood Eosinophil Count	7.1	54.8	158.8	9.2	12.6	4.5	2.9	3.2	-6.8
Blood Platelet Count	2.9	34.0	59.1	7.1	5.8	5.6	0.1	7.7	-5.5
Blood Red Count	0.6	5.9	21.6	2.4	2.1	-1.2	-1.4	4.7	0.2
Blood White Count	2.5	18.7	50.4	5.6	7.1	3.6	1.8	3.3	-1.7
Heel T-Score	0.2	1.4	3.6	0.6	0.9	-0.3	1.6	1.9	-0.8
BMI	0.2	1.0	4.9	-2.2	0.3	0.1	0.4	0.7	0.1
Height	0.4	7.3	21.5	-0.2	0.2	-4.6	-2.9	-3.5	1.2
Waist Hip Ratio (WHR)	0.3	1.4	7.8	2.8	-0.5	0.5	0.3	-0.2	0.1
Systolic Blood Pressure	0.9	4.7	9.7	-0.8	1.5	-0.7	-2.9	3.1	2.7
Smoking Status	0.6	1.5	2.4	-1.5	-0.7	-1.4	1.5	-1.4	-0.1
Allergy or Eczema	3.3	8.7	27.4	3.0	5.2	1.0	1.1	1.9	-3.1
Cardiovascular Disease	0.9	3.0	7.1	0.7	2.7	-0.4	-1.8	1.2	2.3
Hypothyroidism (self reported)	0.4	0.8	3.6	0.2	0.6	0.2	-1.9	0.9	0.2
Respiratory disease	2.7	6.1	23.0	2.9	4.8	0.2	1.9	-0.5	-0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.2	1.8	1.6	0.2	-0.3	-0.7	-0.4
Lung FEV1/FVC ratio	1.3	6.6	23.0	-1.0	-4.8	-0.9	0.7	-1.0	3.6
Lung FVC	0.6	2.8	8.0	2.8	0.0	1.6	-0.2	0.9	-2.4
Neuroticism	0.1	0.4	1.0	0.1	-0.2	0.0	-1.0	-0.3	-1.0
Chronotype (morning person)	2.3	5.4	10.5	1.9	1.1	2.5	-1.7	3.2	-2.9
Hair Pigment	0.1	2.2	5.9	-2.0	-1.5	-2.4	-0.1	-0.6	0.8
Tanning	0.1	0.9	2.0	-0.0	1.3	-1.4	-0.7	0.8	0.4
Hand grip strength (left)	0.8	2.1	7.6	-1.1	-0.5	-1.3	-2.8	1.1	0.7
Number of treatments/medications taken	1.3	2.4	7.1	1.9	2.7	0.8	1.0	0.8	-1.1
Average weekly spirits intake	0.7	0.9	1.9	0.9	1.1	1.4	-0.4	-0.8	-0.7
Sensitivity / hurt feelings	0.4	0.7	2.0	0.8	0.3	-0.1	-1.2	1.4	-0.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.6	1.1	1.2	1.2	0.0	0.5	-1.9
Hearing difficulty/problems: Yes	1.9	2.9	8.1	-0.4	-1.8	-0.7	2.2	-2.9	0.5
Relative age of first facial hair	0.4	0.8	2.6	1.0	1.6	1.0	-0.1	0.2	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.4	0.1	0.6	-0.5	0.8	-1.6	0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	1.1	0.9	0.5	0.3	0.0	-0.7
Ever had hysterectomy (womb removed)	1.8	2.0	6.0	-2.4	-0.6	-2.1	-0.5	-0.2	1.0
Systolic blood pressure, automated reading	0.8	2.3	4.3	-1.3	1.0	-1.4	-0.9	2.1	2.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	0.0	0.7	1.0	-0.5	-0.8	-0.1
Angina	0.5	0.7	1.7	-1.3	1.0	-0.0	-0.4	-0.7	-1.0
Medication for hormone replacement therapy	0.9	1.0	3.0	1.4	0.3	0.4	1.7	0.1	0.9
Vitamin and mineral supplements	1.5	2.0	5.0	2.2	1.2	1.5	1.2	0.2	-1.4
Supplements: Zinc	2.0	2.2	4.1	-1.9	-0.7	1.0	-2.0	2.0	0.2
Medication: Co-codamol	1.7	2.0	4.8	2.2	2.0	1.4	0.6	0.3	-0.9
Medication: Metformin	0.2	0.3	0.8	0.2	0.3	-0.9	0.6	-0.6	-0.6
Diabetes (father)	0.2	0.2	0.7	-0.3	0.1	-0.8	-0.1	0.4	-0.5
Diabetes (mother)	0.6	0.8	1.8	1.1	0.3	-0.5	-1.2	-0.3	1.3
Severe depression (siblings)	0.5	0.6	1.7	0.5	0.8	-0.3	-0.7	-0.5	1.3
Pack years adult smoking proportion	0.8	1.2	5.8	-0.5	1.0	0.3	-0.4	-0.0	-2.4
Impedance of leg (right)	1.2	5.8	24.0	4.9	1.1	1.7	-0.7	2.1	-1.2
Leg fat-free mass (left)	0.8	4.2	8.0	-2.8	-0.3	-2.5	-1.7	-2.1	1.8
Trunk fat percentage	0.9	3.7	12.2	1.4	3.5	1.3	0.1	1.6	-2.0
Hand grip strength (right)	0.7	2.0	6.0	-1.4	-0.5	-1.7	-2.4	0.2	0.9
Townsend deprivation index at recruitment	0.3	0.4	1.6	0.4	0.6	1.3	0.3	0.3	0.3
Current tobacco smoking	0.5	0.9	2.1	0.0	1.1	0.5	1.5	-1.2	-0.4
Average weekly fortified wine intake	1.1	1.2	3.8	1.3	1.9	0.6	0.5	0.2	-1.1
Maternal smoking around birth	0.6	0.8	2.4	1.5	1.4	0.5	0.3	-0.5	0.1
Fed-up feelings	0.2	0.3	0.8	0.5	-0.8	-0.0	-0.9	-0.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.8	1.8	0.5	2.2	0.6	0.8	-2.2
Relative age voice broke	1.2	1.8	3.6	1.9	1.8	0.9	0.5	0.7	-1.6
Taking other prescription medications	3.2	4.9	11.6	2.5	3.4	0.7	2.7	0.3	-1.9
Age when periods started (menarche)	0.9	2.1	6.5	0.7	2.5	-0.1	1.5	-1.8	-0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.6	-0.2	-0.8	0.7	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.9	-0.9	-0.3	-0.1	-1.4	1.7	0.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.5	1.9	0.7	0.9	1.0	0.7	-0.5
Qualifications: CSEs or equivalent	0.7	0.9	2.6	0.7	-1.6	0.7	-0.8	1.0	-0.3
Serious illness, injury or assault to yourself	0.7	0.9	3.8	-0.1	-0.0	2.0	-0.3	-0.5	1.1
High blood pressure	0.2	0.5	0.9	-0.9	0.4	-0.4	-0.6	0.9	0.9
Hayfever, allergic rhinitis or eczema	2.7	5.9	14.7	2.4	3.8	1.3	0.4	1.7	-3.2
Multivitamins +/- minerals	2.0	2.6	6.3	-1.8	-1.4	-1.5	-2.5	0.1	1.3
Stomach or abdominal pain in last month	0.3	0.4	1.1	0.2	0.1	0.4	0.2	-1.1	0.9
Supplements: Glucosamine	0.4	0.5	1.9	0.1	0.6	-0.4	-0.6	-0.2	-1.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.9	0.6	1.5	1.7	1.0	0.1	0.6
Medication: Atenolol	0.4	0.5	0.9	-0.5	-0.9	-0.2	0.5	-0.6	1.0
Medication: Levothyroxine sodium	0.6	1.0	2.1	-1.4	-1.0	0.4	-1.4	-0.0	0.7
Sitting height	0.8	5.4	13.9	-1.9	-1.8	-3.7	-1.7	-2.5	1.6
Chronic bronchitis/emphysema (father)	0.8	1.0	4.1	-1.2	0.1	-2.0	-0.4	-0.1	0.2
High blood pressure (mother)	0.7	1.0	3.7	-0.5	1.0	-0.8	-0.6	-0.4	1.9
Body mass index (BMI)	0.3	1.2	4.4	-2.1	0.7	0.5	-0.4	1.3	-0.7
Impedance of leg (left)	1.4	6.6	25.7	5.1	1.4	2.0	0.0	2.2	-1.8
Leg predicted mass (left)	0.8	4.0	7.6	-2.8	-0.2	-2.4	-1.8	-2.1	1.8
Trunk fat mass	0.3	1.4	6.2	0.3	2.5	0.2	-0.4	0.7	-1.2
Waist circumference	0.1	0.3	0.5	-0.5	0.7	0.1	-0.6	0.6	-0.5
Number of incorrect matches in round	0.3	0.6	1.9	0.4	-0.3	-1.0	-1.4	0.1	-0.4
Past tobacco smoking	1.1	2.1	5.3	1.7	1.8	2.3	-0.4	0.6	-0.6
Alcohol usually taken with meals	1.5	2.5	9.1	-0.7	-3.0	-1.6	-1.0	1.2	-0.3
Nervous feelings	0.2	0.4	1.1	0.2	1.0	-0.1	-0.1	-0.5	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.4	-0.8	-0.1	-0.2	-0.0	-0.9
Hearing difficulty/problems with background noise	1.5	2.5	4.9	-1.1	-2.1	-1.3	1.6	-2.2	-0.3
Hair/balding pattern: Pattern 2	1.6	2.1	8.5	-2.0	-2.9	-0.2	-0.0	0.0	0.2
Had menopause	0.2	0.2	0.9	0.3	0.3	-1.0	0.3	0.4	-0.0
Had other major operations	1.0	1.2	3.3	-1.2	-0.4	-1.8	-0.8	-0.8	1.0
Forced vital capacity (FVC)	0.4	1.4	5.7	1.6	-0.6	-0.3	-2.4	-0.2	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.1	0.3	1.3	0.4	-1.1	1.5	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	1.1	0.5	0.1	-0.4	0.1	0.9
Qualifications: None of the above	0.9	1.9	4.3	1.4	2.1	0.2	1.0	1.1	-1.7
Financial difficulties in last 2 years	0.4	0.6	1.8	1.0	0.3	0.7	0.4	1.4	0.0
Mouth/teeth dental problems	0.6	1.0	3.0	0.3	0.5	1.4	1.7	-0.1	-0.6
Heart attack	0.8	1.0	1.5	-1.0	-0.9	-1.0	1.2	-0.3	-1.2
Allergy	2.7	6.3	22.4	-2.0	-4.7	-0.8	-0.6	-1.1	3.1
Pain all over the body in last month	0.4	0.5	1.8	1.3	0.9	0.1	0.2	-0.4	-0.1
Diabetes (self-reported)	0.3	0.5	1.3	1.2	1.0	-0.2	-0.1	-0.1	-0.7
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	3.4	1.8	1.6	1.3	1.0	1.4	-1.7
Medication: Ramipril	1.0	1.3	2.6	-0.6	-1.3	-0.8	-1.4	-0.2	1.6
Medication: Simvastatin	0.3	0.5	1.8	0.9	1.4	-0.0	-0.4	0.1	0.2
Fluid intelligence score	0.7	1.4	4.3	-0.5	-0.6	0.8	1.4	-0.7	2.1
Illnesses of siblings	1.1	1.5	6.6	2.6	1.0	0.1	-0.7	0.9	0.4
Neuroticism score	0.3	0.6	1.3	0.4	-0.4	0.7	-1.1	0.5	-1.0
Weight	0.3	1.4	4.0	-2.0	0.4	-1.2	-1.6	-0.3	0.4
Impedance of arm (right)	0.9	4.2	15.5	3.9	2.7	0.6	0.6	-0.1	-1.2
Arm fat percentage (right)	0.5	2.0	6.2	-0.1	2.5	1.1	0.1	1.2	-1.7
Trunk fat-free mass	1.3	7.2	11.9	-3.1	-1.9	-3.5	-2.1	-2.6	2.7
Hip circumference	0.2	1.0	2.4	-1.6	1.3	-0.5	-0.9	0.1	-0.8
Time employed in main current job	1.2	1.4	4.2	0.6	0.4	1.1	-1.4	2.0	-1.0
Alcohol intake versus 10 years previously	1.2	1.9	5.5	0.3	1.7	1.3	-0.1	1.1	-2.3
Father’s age at death	0.7	0.9	3.8	0.1	-1.9	1.3	0.2	0.3	-0.3
Worrier / anxious feelings	0.3	0.6	2.7	0.5	0.2	-0.5	-1.7	-0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.5	0.2	0.7	0.0	-0.8	-0.4
Falls in the last year	0.8	1.1	4.9	2.2	0.5	0.7	0.7	0.4	-0.6
Hair/balding pattern: Pattern 3	0.5	0.7	2.6	0.4	1.6	0.8	0.9	0.0	-0.4
Number of live births	1.1	1.5	3.3	0.9	-0.7	0.8	1.8	-1.8	0.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.8	1.4	-1.9	-0.1	-2.2	-0.2	0.8
Pulse rate	0.4	0.6	1.8	-0.3	1.4	0.8	-0.8	0.7	0.1
Happiness	1.6	1.9	5.4	0.5	0.0	2.3	-1.0	2.0	-1.0
Noisy workplace	0.2	0.2	0.6	0.1	0.6	-0.6	0.1	-0.0	-0.8
Qualifications: A levels/AS levels or equivalent	1.6	3.5	6.9	-1.4	-2.2	-2.0	-1.7	-0.9	2.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.8	-1.1	-0.2	-1.0	1.2	-1.3	1.3
Mouth/teeth dental problems: Dentures	0.5	0.9	3.9	-0.2	0.7	-2.0	0.2	-0.7	0.8
Asthma	1.9	3.8	16.6	1.6	4.1	0.3	0.9	0.3	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.7	-1.6	-0.5	0.9	-1.6	0.2	-0.4
Medication: Cholesterol lowering	0.3	0.4	1.1	0.1	1.0	-0.9	0.7	0.2	0.1
Depression (self-reported)	0.7	0.9	1.6	1.2	1.2	0.2	-0.9	-0.3	-1.3
Medication: Lansoprazole	0.4	0.4	1.1	0.5	0.1	-0.1	1.1	-0.5	1.0
Prospective memory result	0.3	0.4	1.3	-0.4	-0.6	-0.6	-0.3	-1.1	-0.4
Lung cancer (father)	1.8	2.1	10.2	-1.4	-0.4	-0.7	-0.4	-0.2	3.2
Illnesses of mother	0.4	0.5	1.2	-0.4	-0.8	-0.1	-0.1	1.1	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.8	1.9	-1.3	0.3	-2.2	0.1	0.4
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	1.0	0.8	-1.5	-0.8	0.3	-1.1
Impedance of arm (left)	0.8	3.7	12.2	3.5	2.8	0.6	0.9	-0.2	-0.9
Arm fat mass (right)	0.2	0.8	3.0	-1.1	1.7	0.2	-0.4	0.4	-0.7
Trunk predicted mass	1.2	7.0	11.4	-3.1	-1.8	-3.4	-2.0	-2.5	2.6
Standing height	0.6	6.0	12.3	0.4	-0.3	-3.5	-2.4	-3.5	2.4
Length of working week for main job	0.7	0.7	1.6	0.1	-1.1	-0.2	1.0	-0.7	1.2
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.1	-0.1	0.8	0.4	0.3	-0.4
Breastfed as a baby	1.8	2.2	6.1	-2.5	-2.3	-1.3	-0.1	-0.3	-0.2
Tense / ‘highly strung’	0.5	0.8	4.7	0.4	-0.1	-0.1	0.4	0.1	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.6	-0.6	0.6	-0.7	0.0	-1.6	1.1
Hair/balding pattern: Pattern 4	1.4	3.4	6.0	-2.2	-1.9	-1.6	0.1	-1.9	2.4
Birth weight of first child	0.3	0.5	1.0	-0.9	-0.2	-0.8	1.0	-0.5	0.7
Peak expiratory flow (PEF)	1.1	2.5	12.7	-0.0	-3.6	0.4	-1.4	0.0	0.7
Pulse wave reflection index	0.8	1.0	3.9	1.0	0.6	-0.1	0.0	0.8	-2.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	1.1	1.0	0.3	0.5	-0.9	0.1
Loud music exposure frequency	0.4	0.5	1.3	0.0	1.1	-0.2	-0.8	-0.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.1	-0.5	-0.6	-0.7	-0.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.6	0.9	0.1	1.6	-0.8	0.5	-0.8
Blood clot in the leg (DVT)	0.5	0.7	1.5	-0.9	-0.3	-0.4	-0.5	1.1	-1.2
Medication: Paracetamol	0.4	0.6	1.7	1.3	1.2	-0.7	-0.0	-0.3	0.4
Headache pain in last month	0.8	1.4	2.8	1.6	1.3	0.9	-1.7	-0.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	-0.3	-1.2	1.3	-0.1	-0.2	-0.9
Glaucoma (self-reported)	1.1	1.3	3.1	0.6	-0.5	-0.2	1.8	-1.1	1.6
Gout (self-reported)	0.1	0.1	0.5	0.1	-0.2	-0.1	0.7	-0.4	0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.3	-0.4	-0.3	0.6	-1.5	0.2	0.3
Medication: Amlodipine	1.2	1.7	4.0	-1.2	0.4	-1.9	-0.4	-0.7	2.0
Medication: Ventolin 100micrograms inhaler	1.3	1.7	6.2	1.1	2.5	-0.3	1.0	0.4	-1.1
Birth weight	0.3	0.7	1.7	0.4	0.9	-0.2	-1.1	0.0	1.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.5	0.4	0.7	0.9	0.0	-0.3	-1.6
High blood pressure (siblings)	1.0	1.4	4.4	-2.1	-1.6	-0.7	0.6	-0.3	0.7
Forced vital capacity (FVC), Best measure	0.5	1.8	6.2	2.1	0.1	0.3	-2.5	0.1	-0.2
Body fat percentage	0.8	3.2	8.7	0.9	3.0	1.4	0.0	1.8	-2.1
Leg fat percentage (right)	0.7	2.6	7.7	0.3	1.6	1.0	-0.5	2.8	-2.0
Arm fat-free mass (right)	0.6	2.8	4.9	-2.2	-0.9	-2.0	-2.2	-0.9	1.3
Exposure to tobacco smoke outside home	1.0	1.4	3.8	-1.9	-2.0	-0.6	0.6	-0.4	0.5
Comparative body size at age 10	1.0	2.6	7.9	-0.7	-0.1	0.3	-2.6	0.8	-2.8
Number of full brothers	0.9	1.1	4.0	0.7	-1.1	1.0	-0.2	0.0	-2.0
Worry too long after embarrassment	0.4	0.6	1.6	-0.1	-0.7	0.0	-1.0	-0.8	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.6	1.9	1.6	0.9	-0.4	0.8	-0.6
Wheeze or whistling in the chest in last year	1.4	2.4	6.7	0.9	2.3	0.6	0.5	0.9	-2.6
Number of children fathered	0.7	0.8	2.8	0.1	-0.9	0.3	1.7	-0.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.6	5.4	-1.5	-1.8	-2.1	-2.3	-0.9	-0.4
Age at first live birth	0.7	1.2	4.7	-0.5	-0.9	-0.2	-2.2	0.8	0.8
Pulse wave peak to peak time	0.9	1.0	2.1	-1.0	-0.9	1.2	0.5	-0.8	1.4
Health satisfaction	0.4	0.5	1.5	-0.2	-1.2	0.5	-0.5	0.1	0.9
Shortness of breath walking on level ground	0.6	0.7	2.2	1.0	1.5	-0.6	-0.7	0.1	0.2
Qualifications: College or University degree	1.7	5.5	10.3	-2.2	-1.8	-2.9	-1.6	-1.9	3.2
Eye problems/disorders: None of the above	0.8	0.9	2.6	1.0	-0.2	0.7	-1.6	0.5	-1.0
Mouth/teeth dental problems: Loose teeth	1.3	1.6	4.4	0.6	1.9	0.6	2.1	-0.4	-0.8
Emphysema/chronic bronchitis	0.6	0.7	1.5	1.0	0.2	0.4	1.0	-0.7	-1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	-0.9	-0.9	0.1	0.2	-1.2	1.1
Neck or shoulder pain in last month	1.2	1.7	4.5	1.3	0.4	1.3	-0.8	2.1	-1.2
Medication: Blood pressure	0.6	1.1	2.3	-0.7	1.0	-1.2	-1.2	0.2	1.5
Angina (self-reported)	0.4	0.6	1.3	-1.1	0.8	-0.1	-0.5	-0.7	-0.9
Migraine (self-reported)	1.3	1.6	6.0	0.7	0.7	1.1	0.4	1.0	-2.4
Medication: Ibuprofen	1.0	1.2	3.3	-1.4	-0.5	1.0	-1.8	-0.0	-0.7
Medication: Allopurinol	0.1	0.2	0.6	0.2	-0.8	-0.1	0.4	-0.1	-0.5
Medication: Omeprazole	3.7	4.4	6.0	2.4	2.2	2.4	2.4	0.7	-1.9
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.6	0.4	0.2	0.6	-0.6	-0.7
Mean time to correctly identify matches	0.5	1.0	4.2	-0.3	0.0	-2.1	1.0	-0.4	-0.9
Heart disease (mother)	1.3	1.6	7.3	0.2	-0.7	0.0	1.3	-2.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.4	-0.0	-0.4	1.0	-0.7	1.1	-2.1
Whole body fat mass	0.3	1.1	4.1	-0.4	2.0	0.4	-0.5	0.7	-1.1
Leg fat mass (right)	0.2	0.9	2.1	-0.5	1.2	0.5	-0.8	1.4	-0.9
Arm predicted mass (right)	0.7	3.4	6.1	-2.5	-1.0	-2.2	-2.1	-1.3	1.6
Pulse rate, automated reading	0.7	2.1	9.5	0.9	3.1	0.8	1.0	0.4	0.8
Alcohol intake frequency.	0.6	1.5	3.5	0.7	-0.0	1.6	1.1	1.1	-1.9
Comparative height size at age 10	0.6	3.5	6.6	1.2	1.3	-2.6	-1.4	-2.5	1.8
Number of full sisters	1.3	1.5	4.2	-1.8	-1.2	0.1	-0.5	-0.1	2.1
Suffer from ‘nerves’	0.2	0.4	1.0	-0.3	-0.8	-0.3	1.0	0.3	-0.6
Overall health rating	0.4	0.9	2.8	0.6	1.7	1.0	0.1	-0.2	-1.1
Chest pain or discomfort	0.5	0.7	1.8	-1.0	-0.4	-0.3	1.3	-1.1	0.0
Had major operations	0.8	0.9	3.8	-0.3	0.6	0.5	-0.2	0.9	-1.9
Age at last live birth	0.4	0.5	1.6	-0.0	-0.6	-0.2	-0.6	-0.9	1.3
Family relationship satisfaction	1.6	1.9	9.9	0.2	0.1	3.2	0.4	0.9	-0.7
Leg pain on walking	0.5	0.6	2.0	-0.1	-0.1	-1.2	-1.4	-0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.4	0.4	0.7	2.1	1.1	1.2	-1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.2	-0.3	-0.1	-0.2	0.9	-0.4	1.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.5	-0.9	-1.3	-1.6	-1.6	0.2	-1.0
Medication: Aspirin	0.2	0.3	0.8	-0.9	-0.0	-0.1	0.2	0.7	-0.6
Supplements: Vitamin C	0.5	0.6	2.0	-1.4	-0.7	-0.8	0.3	0.8	-0.2
Knee pain experienced in last month	0.4	0.7	2.4	0.1	0.4	1.6	0.5	-0.8	-0.8
Hypertension (Self-reported)	0.3	1.0	2.7	-0.6	0.9	-0.0	-1.2	1.6	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	7.3	1.8	0.6	1.1	2.7	-1.1	-0.2
Illnesses of father: Heart disease	0.7	0.9	2.1	-0.3	0.9	-1.4	0.4	-1.2	0.9
Illnesses of siblings: Diabetes	1.7	2.1	5.1	-1.9	-1.0	-1.7	0.4	-2.3	0.1
Smoking status: Previous	1.5	2.3	6.0	-1.6	-2.2	-2.5	-0.1	0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.2	-1.0	-1.5	-1.4	-0.4	-1.4	0.1
Whole body fat-free mass	1.0	5.5	9.1	-3.0	-1.2	-2.8	-1.9	-2.3	2.3
Leg fat-free mass (right)	0.8	4.0	8.4	-2.9	-0.2	-2.3	-1.4	-2.3	1.8
Arm fat percentage (left)	0.5	2.1	6.9	-0.2	2.6	1.1	0.2	1.3	-1.7
Average weekly red wine intake	0.2	0.3	0.7	-0.7	-0.6	-0.2	-0.8	-0.5	-0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	0.8	1.0	-0.0	0.6	-0.9	0.5
Mood swings	0.1	0.2	0.7	-0.2	-0.3	-0.1	0.4	-0.6	-0.9
Loneliness, isolation	0.7	0.9	1.9	1.1	1.4	0.8	-0.6	0.6	-1.1
Long-standing illness, disability or infirmity	1.1	1.6	4.2	-0.7	1.1	-1.4	1.2	-2.0	-0.8
Ever had bowel cancer screening	1.1	1.3	3.1	1.1	1.8	0.9	1.2	-0.8	0.5
Diabetes diagnosed by doctor	0.3	0.4	1.0	1.0	0.9	-0.3	-0.2	-0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.9	-0.5	0.9	-2.0	-0.8	-0.5	1.6
Friendships satisfaction	0.9	1.1	3.5	-0.1	-0.5	1.9	-0.2	0.4	1.6
Qualifications: nursing, teaching	3.0	4.7	13.7	-1.8	-2.3	-1.2	-0.8	-2.0	3.7
Commuting to job workplace: Walk	1.7	1.8	3.7	1.4	-0.9	1.9	-1.0	0.6	-1.8
Eye problems/disorders: Cataract	0.5	0.5	1.6	-0.0	1.0	-1.2	0.0	-0.7	0.5
Mouth/teeth dental problems: Mouth ulcers	2.8	4.5	10.3	-2.3	-1.9	-3.2	-2.1	-0.5	1.6
Medication for cholesterol	0.5	0.7	1.7	-0.7	-0.7	-1.3	-1.2	-0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	5.8	-1.3	-2.0	-1.8	-2.4	-0.3	-0.0
Back pain experienced in last month	0.5	0.8	2.7	-1.0	0.5	0.4	-0.6	-0.6	-1.6
Mineral and other dietary supplements	0.2	0.2	0.5	0.0	-0.1	0.5	0.7	-0.7	-0.1
Breast cancer (self-reported)	0.6	0.7	1.7	0.2	1.2	-0.6	0.9	-1.3	-0.1
Asthma (self-reported)	1.9	3.8	16.2	1.7	4.0	0.3	0.8	0.3	-1.8
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.3	0.4	-0.2	0.7	0.6	-0.3
Osteoarthritis (self-reported)	1.4	1.8	6.5	1.4	1.2	0.2	0.9	0.7	-2.5
Medication: Aspirin	0.2	0.2	0.8	-0.9	-0.0	-0.2	0.3	0.6	-0.4
Medication: Gliclazide	0.3	0.4	1.0	-0.2	-0.2	-1.0	0.7	-0.8	-0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	3.3	-0.6	-1.8	1.2	-0.7	0.2	-1.0
Smoking status: Current	0.8	1.2	4.0	-0.2	1.0	0.3	2.0	-1.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.8	2.6	-0.9	1.1	-1.4	1.9	0.8
Whole body water mass	0.9	5.2	8.5	-2.9	-1.2	-2.8	-1.9	-2.2	2.2
Leg predicted mass (right)	0.7	3.9	8.0	-2.8	-0.2	-2.3	-1.3	-2.3	1.7
Arm fat mass (left)	0.2	0.9	3.6	-1.0	1.9	0.2	-0.5	0.5	-0.5
Number of self-reported non-cancer illnesses	2.0	3.4	10.3	1.9	3.2	0.5	1.4	0.1	-2.1
Average weekly champagne plus white wine intake	0.3	0.4	1.4	0.2	-1.2	-0.3	0.7	-0.1	0.6
Miserableness	0.4	0.6	2.5	-0.7	-0.7	-0.4	0.6	-1.6	0.0
Guilty feelings	0.7	1.1	2.8	-0.3	-1.2	-0.0	-1.5	1.7	-0.4
Wears glasses or contact lenses	1.2	1.3	3.9	-0.7	-0.3	0.2	1.8	0.2	-2.0
Ever taken oral contraceptive pill	0.8	0.9	2.2	-0.6	-0.5	-0.0	-1.4	-0.9	1.5
Hearing aid user	2.4	2.8	8.4	-2.3	0.1	-1.4	0.3	-2.9	0.8
Mother’s age at death	2.6	3.2	7.0	-2.2	-2.7	-0.5	0.5	-2.3	1.2
Financial situation satisfaction	0.7	0.8	1.7	-1.0	-1.3	0.6	-0.9	1.1	0.0
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.1	-0.3	0.6	0.7	0.3	0.5
Commuting to job workplace: Public transport	0.8	1.0	2.8	0.8	-0.3	1.7	1.2	0.4	-0.8
Eye problems/disorders: Glaucoma	0.6	0.7	1.9	0.9	0.1	1.4	1.0	-0.3	0.3
Medication: Blood pressure	0.4	0.8	1.9	-0.3	0.1	1.4	-0.6	1.2	-0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.8	-0.9	0.2	-0.2	-1.9	0.4	-1.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.9	0.5	-0.1	-0.9	-0.5	0.3	0.3
High cholesterol (Self-reported)	0.8	1.5	4.7	0.6	2.2	-0.1	1.9	-0.2	0.6
Medication: Bendroflumethiazide	0.7	1.1	4.5	-2.1	0.4	-0.2	-1.0	1.1	0.1
Medication: Paracetamol	0.3	0.5	1.6	1.3	0.9	-0.4	-0.4	-0.3	-0.2
Medication: Lisinopril	0.6	0.8	1.9	-0.4	-0.1	-1.1	-0.7	1.1	1.4
Medication: Atorvastatin	1.2	1.5	6.8	0.0	0.3	-0.0	2.6	0.7	-1.2
Illnesses of father: High blood pressure	0.7	0.8	4.5	0.7	0.1	-0.0	-0.2	0.2	2.1
Alcohol drinker status: Never	0.1	0.2	0.3	0.3	0.5	0.5	0.5	-0.4	-0.2
Ever smoked	1.3	2.4	4.1	-1.6	-2.0	-2.0	-0.0	-1.4	1.3
Basal metabolic rate	0.8	4.2	7.7	-2.8	-0.8	-2.4	-2.0	-1.8	1.9
Leg fat percentage (left)	0.8	3.0	7.7	0.3	1.8	1.2	-0.2	2.8	-2.3
Arm fat-free mass (left)	0.6	3.2	6.6	-2.6	-1.1	-1.9	-1.9	-1.3	1.7
Number of operations (self-reported)	0.4	0.7	1.4	-1.0	-0.3	-0.7	1.0	-1.2	-0.3
Average weekly beer plus cider intake	0.4	0.5	2.0	-0.0	0.5	-0.3	1.4	-0.8	0.2
Irritability	1.1	1.9	3.7	-1.1	-1.9	1.0	0.4	-1.8	1.5
Risk taking	1.5	2.3	8.8	-1.7	-3.0	-0.5	1.0	-0.1	0.7
Ever had prostate specific antigen (PSA) test	1.6	1.8	5.8	-1.1	-1.6	-0.4	0.9	-2.4	0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.3	0.2	0.3	-0.3	0.6	-1.1	-0.6
Age started oral contraceptive pill	0.6	0.8	1.5	-1.2	-0.4	-1.0	-1.1	0.5	-0.9
Diastolic blood pressure, automated reading	0.8	2.4	6.3	0.3	2.2	-0.5	-0.9	2.5	1.3
Ever depressed for a whole week	1.5	1.8	6.4	-0.2	-2.0	0.0	0.2	0.4	2.5
Unable to work because of sickness or disability	1.0	1.3	5.2	2.3	0.9	1.1	0.2	-0.3	-0.7
Commuting to job workplace: Cycle	1.0	1.2	2.3	0.6	1.3	-1.2	-1.5	0.1	-1.2
Myopia	1.2	1.7	5.7	-1.0	-2.4	-1.4	-0.3	0.6	1.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.9	0.9	-0.3	0.3	0.5	-0.7	-0.5
Cholesterol lowering medication	0.8	1.2	2.3	0.6	1.5	1.5	1.3	0.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	4.7	2.2	1.6	1.1	1.9	0.7	-1.3
Pain experienced in last month	0.5	0.8	2.3	-0.4	-1.0	-1.5	0.5	-0.0	1.1
Supplements: Calcium	0.5	0.5	2.3	-0.1	-1.5	0.8	0.2	-0.3	0.5
Basal cell carcinoma (self-reported)	0.9	1.1	3.0	-1.7	-0.7	0.0	-0.6	0.7	1.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.8	-0.9	-0.7	-1.0	1.3	-0.2	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.1	-0.7	-0.1	-0.3	-0.5	1.3	-1.4
Heart disease (siblings)	0.5	0.6	1.6	-0.7	0.7	0.8	0.1	-1.3	-0.4
Alcohol drinker status: Previous	2.9	3.3	9.8	1.4	-0.8	1.3	-0.1	3.1	-2.4
Pack years of smoking	0.8	1.1	5.4	-0.5	0.9	0.1	-0.7	-0.1	-2.3
Impedance of whole body	1.3	6.7	23.9	4.9	2.6	1.8	0.6	1.6	-1.8
Leg fat mass (left)	0.2	0.9	1.9	-0.6	1.2	0.4	-0.6	1.4	-1.0
Arm predicted mass (left)	0.5	2.6	5.4	-2.3	-0.8	-1.8	-1.8	-1.1	1.4