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chr6:134,582,344-137,931,117

Best TWAS P=1.01e-19 · Best GWAS P=4.25e-85 conditioned to 1.76e-52

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAP3K5	0.05	0.03	blup	408	0.03	2.0e-04	5.6	6.9	6.1e-12	-0.07	0.06	0.91	FALSE
2	GTEx	Adipose Subcutaneous	PEX7	0.13	0.08	lasso	6	0.06	5.3e-06	7.6	7.2	4.4e-13	-0.02	0.01	0.99	FALSE
3	GTEx	Adrenal Gland	PEX7	0.25	0.04	lasso	6	0.04	2.0e-02	6.4	6.6	5.6e-11	0.03	0.05	0.46	FALSE
4	GTEx	Artery Aorta	HBS1L	0.11	0.07	enet	10	0.08	2.7e-05	-4.9	6.6	3.7e-11	-0.40	0.26	0.66	FALSE
5	GTEx	Artery Coronary	HBS1L	0.30	0.14	enet	22	0.13	4.1e-05	-5.6	6.6	4.3e-11	-0.40	0.45	0.12	FALSE
6	GTEx	Artery Tibial	HBS1L	0.07	0.07	lasso	4	0.05	1.3e-04	-5.6	7.6	4.0e-14	-0.52	0.34	0.65	FALSE
7	GTEx	Brain Caudate basal ganglia	PEX7	0.25	0.04	enet	9	0.08	2.2e-03	6.4	6.4	1.7e-10	-0.01	0.16	0.49	FALSE
8	GTEx	Brain Frontal Cortex BA9	AHI1	0.19	0.00	enet	14	0.05	1.5e-02	1.4	-9.1	1.0e-19	-0.10	0.08	0.05	TRUE
9	GTEx	Brain Nucleus accumbens basal ganglia	PEX7	0.20	0.09	lasso	3	0.02	8.5e-02	5.8	6.1	8.3e-10	0.03	0.05	0.88	FALSE
10	GTEx	Breast Mammary Tissue	PEX7	0.18	0.16	enet	12	0.14	6.8e-08	7.4	7.4	1.4e-13	-0.02	0.04	0.96	FALSE
11	GTEx	Breast Mammary Tissue (Male)	PEX7	0.11	0.00	lasso	3	0.00	3.7e-01	5.1	6.4	1.4e-10	0.01	0.03	0.47	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	PEX7	0.27	0.18	lasso	4	0.27	1.7e-09	5.1	7.1	8.9e-13	0.03	0.01	0.99	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	AHI1	0.38	0.24	enet	19	0.23	5.4e-08	4.1	-5.2	2.1e-07	0.06	0.94	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	PEX7	0.24	0.24	lasso	4	0.32	1.3e-24	-4.0	6.3	2.5e-10	0.02	0.98	0.02	FALSE
15	GTEx	Esophagus Muscularis	HBS1L	0.18	0.10	lasso	7	0.05	4.7e-04	-5.6	5.7	1.4e-08	-0.44	0.81	0.18	FALSE
16	GTEx	Heart Left Ventricle	HBS1L	0.22	0.11	lasso	5	0.07	1.2e-04	-5.7	5.6	2.5e-08	-0.45	0.79	0.02	FALSE
17	GTEx	Nerve Tibial	HBS1L	0.10	0.09	lasso	3	0.08	1.5e-06	-3.5	6.7	1.6e-11	-0.55	0.39	0.61	FALSE
18	GTEx	Nerve Tibial	PEX7	0.31	0.20	enet	26	0.22	1.8e-15	7.8	7.4	9.7e-14	0.01	0.01	0.99	TRUE
19	GTEx	Pancreas	PEX7	0.43	0.27	enet	36	0.26	1.9e-11	7.8	6.6	4.9e-11	0.00	0.01	0.99	FALSE
20	GTEx	Pituitary	PEX7	0.26	0.05	lasso	6	0.20	9.8e-06	5.1	6.5	6.9e-11	0.01	0.02	0.93	FALSE
21	GTEx	Prostate	PEX7	0.45	0.17	lasso	8	0.08	5.4e-03	7.5	7.4	1.2e-13	0.01	0.03	0.87	FALSE
22	GTEx	Spleen	HBS1L	0.28	0.09	lasso	6	0.13	3.4e-04	-5.6	6.2	6.7e-10	-0.45	0.14	0.34	FALSE
23	GTEx	Testis	PEX7	0.24	0.06	enet	33	0.05	2.4e-03	5.8	5.7	9.0e-09	0.02	0.04	0.94	FALSE
24	GTEx	Thyroid	PEX7	0.16	0.09	enet	11	0.10	3.6e-08	7.6	7.2	7.6e-13	-0.01	0.02	0.98	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	PEX7	0.18	0.10	bslmm	396	0.13	1.4e-16	6.4	6.4	1.1e-10	-0.03	0.04	0.96	FALSE
26	YFS	Blood	MAP3K5	0.05	0.07	lasso	14	0.09	1.6e-27	5.7	-6.8	7.4e-12	0.04	0.07	0.93	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PEX7	0.05	0.02	lasso	2	0.03	1.4e-03	-4.0	6.1	1.1e-09	0.03	0.02	0.64	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	PEX7	0.12	0.05	lasso	6	0.10	1.2e-19	-4.0	6.7	2.5e-11	0.00	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	PEX7	0.42	0.11	lasso	5	0.18	7.9e-11	5.1	5.9	3.8e-09	0.02	0.34	0.65	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	PEX7	0.20	0.04	enet	7	0.08	1.6e-03	6.4	7.1	1.1e-12	0.02	0.02	0.53	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PEX7	0.28	0.16	lasso	6	0.20	1.8e-22	-4.0	5.8	7.0e-09	0.02	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PEX7	0.18	0.16	blup	56	0.16	1.6e-09	5.1	6.0	2.7e-09	-0.04	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAP3K5	0.08	0.06	blup	112	0.07	3.4e-08	5.7	-5.3	1.1e-07	0.06	0.85	0.15	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	PEX7	0.28	0.24	enet	14	0.31	1.8e-35	6.4	6.8	1.1e-11	0.02	0.11	0.89	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	PEX7	0.13	0.08	lasso	3	0.09	1.8e-10	-4.0	6.0	2.2e-09	0.02	0.80	0.20	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYB	0.04	0.01	blup	52	0.02	1.8e-03	8.1	-8.5	1.5e-17	0.20	0.04	0.03	TRUE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	PEX7	0.22	0.06	lasso	8	0.16	6.6e-16	7.7	6.7	1.6e-11	0.02	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Soft Tissue Sarcoma	PEX7	0.10	0.07	enet	7	0.09	7.8e-06	7.7	7.1	1.5e-12	0.01	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	PEX7	0.16	0.05	enet	10	0.08	4.1e-06	6.7	6.1	1.3e-09	0.01	0.01	0.94	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	HBS1L	0.03	0.02	lasso	2	0.04	1.6e-04	-9.8	6.8	9.9e-12	-0.52	0.37	0.32	TRUE
41	The Cancer Genome Atlas	Thyroid Carcinoma	PEX7	0.20	0.05	enet	13	0.09	2.8e-09	-4.0	5.9	3.7e-09	0.01	0.38	0.55	FALSE