Hub : Genes

MAP3K5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0460	0.0180	1.7e-03	0.027	0.028	0.022	0.027	0.028	2.8e-04	2.0e-04	9.9e-04	2.5e-04	2.1e-04
2	GTEx	Artery Tibial	0.0847	0.0293	1.0e-04	0.114	NA	0.096	NA	0.100	3.3e-09	NA	5.6e-08	NA	3.2e-08
3	NTR	Blood	0.0318	0.0103	1.0e-07	0.019	0.024	0.017	0.024	0.024	5.4e-07	2.4e-08	2.5e-06	3.2e-08	2.6e-08
4	YFS	Blood	0.0500	0.0108	0.0e+00	0.074	0.085	0.086	0.087	0.089	3.7e-23	1.6e-26	1.1e-26	3.9e-27	1.6e-27
5	TCGA	Brain Lower Grade Glioma	0.0785	0.0280	2.4e-09	0.060	0.068	0.063	NA	0.067	2.4e-07	3.4e-08	1.2e-07	NA	4.9e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.2	-0.2	0.2	0.2	0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	2.4	-1.2	-0.8	0.8	1.0	1.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.3	-1.1	0.0	0.8	0.8	1.2
Depression (Nagel 2018)	0.8	1.2	2.1	-1.2	0.2	0.9	1.4	1.2
Intelligence (Savage-Jansen 2018)	1.1	3.2	9.5	-0.3	3.1	1.7	1.4	1.4
Neuroticism (Nagel 2018)	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.4	-0.1
Schizophrenia (2018)	0.8	1.7	3.6	-1.5	-0.9	0.8	1.1	1.9
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	-0.2	0.2	0.7	0.6	0.0
Worry (Nagel 2018)	0.4	0.9	1.5	0.8	-0.9	-0.6	-1.2	-1.0
Alzheimer’s Disease (in mother)	1.0	1.2	2.1	-1.2	0.1	0.8	1.3	1.4
Alzheimer’s Disease (in father)	0.9	1.0	1.7	0.3	-1.2	-0.9	-1.1	-1.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	-0.7	-0.2	0.3	0.7	0.4
Crohns Disease (2017)	2.4	5.4	9.6	1.9	0.3	-2.7	-3.1	-2.6
Irritable Bowel Disease (IBD)	3.0	7.1	11.4	1.8	0.3	-3.4	-3.2	-3.2
Ulcerative Colitis (UC)	1.2	2.2	4.5	0.8	0.1	-2.1	-1.5	-1.9
Major Depression (MDD)	3.6	4.3	7.8	-2.8	-0.0	1.8	2.5	2.1
Reaction Time	0.8	1.5	3.2	-1.8	0.1	0.9	1.5	1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	5.4	0.6	2.3	0.8	0.7	0.6
Breast Cancer	0.6	1.4	5.2	0.8	-2.3	-0.5	-0.8	-0.7
Ovarian Cancer	1.1	1.5	2.1	-0.5	-1.2	1.3	1.4	1.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.8	2.2	0.5	-0.2	-1.1	-1.5	-0.7
Bipolar Disorder (2011)	0.8	0.7	1.4	-0.9	0.2	0.8	1.2	0.9
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.6	-0.2	0.1	0.2	0.1
Coronary Artery Disease (CAD)	1.3	1.6	3.6	-1.3	0.0	1.6	1.9	-0.1
Crohns Disease (2012)	2.4	3.8	6.9	1.6	0.1	-2.2	-2.6	-2.3
Mean Putamen Volume	1.1	1.3	3.1	1.1	-0.2	-1.0	-1.1	-1.8
Fasting Glucose	0.1	0.1	0.3	-0.1	-0.2	0.5	0.4	0.3
HbA1C	0.4	0.5	1.2	0.4	-0.5	-0.8	-1.1	0.2
HDL Cholesterol	2.5	4.1	7.2	-1.0	0.3	2.5	2.7	2.4
LDL Cholesterol	0.4	0.6	1.3	0.8	0.3	-0.7	-0.8	-1.1
Lupus	0.5	0.8	1.1	0.6	0.8	-1.0	-0.9	-1.0
Neuroticism (2016)	0.4	0.6	1.6	1.2	0.6	-0.3	-1.1	-0.3
Primary Biliary Cirrhosis	0.2	0.3	1.0	-0.2	-0.4	-1.0	-0.4	-0.6
Rheumatoid Arthritis	0.3	0.4	1.0	-1.0	-0.7	-0.2	0.4	-0.2
Schizophrenia (2014)	0.5	1.0	3.0	-0.9	-1.7	0.4	0.4	0.9
Triglycerides	1.6	2.6	4.8	1.3	-1.1	-2.2	-2.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.1	-0.0	-0.3	-0.2	-0.4	-1.1
Ulcerative Colitis	0.7	1.0	2.0	0.5	-0.4	-1.3	-1.0	-1.4
Blood Eosinophil Count	3.9	29.8	47.3	6.9	1.5	-4.9	-6.8	-5.3
Blood Platelet Count	1.7	19.4	37.9	-3.4	1.6	5.3	6.2	4.0
Blood Red Count	0.3	2.5	6.8	0.3	1.4	-2.6	-1.9	-0.3
Blood White Count	2.5	18.4	28.8	4.3	1.8	-5.2	-5.4	-3.7
Heel T-Score	0.1	0.6	2.5	-0.1	1.6	-0.0	0.2	-0.6
BMI	1.4	8.3	9.7	-3.1	-2.7	2.5	3.1	2.9
Height	0.0	0.8	1.4	-0.5	-0.5	0.8	1.2	1.2
Waist Hip Ratio (WHR)	0.1	0.6	1.7	-1.3	0.7	-0.4	0.7	0.6
Systolic Blood Pressure	0.0	0.2	0.7	-0.1	-0.8	0.1	0.2	0.2
Smoking Status	0.4	0.9	1.5	-0.6	0.8	0.7	1.2	1.2
Allergy or Eczema	4.3	11.3	18.5	3.2	-0.2	-3.6	-4.3	-3.8
Cardiovascular Disease	0.1	0.2	0.5	-0.1	0.7	0.1	0.7	0.2
Hypothyroidism (self reported)	2.3	5.3	10.0	-3.1	0.8	2.0	3.2	1.4
Respiratory disease	0.8	1.7	4.7	2.2	-1.4	-0.6	-0.9	-0.8
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.7	0.3	-1.3	-1.6	-1.0	-1.4
Lung FEV1/FVC ratio	0.1	0.7	2.4	-1.6	-1.0	-0.5	-0.1	0.1
Lung FVC	0.6	3.2	12.1	-0.1	3.5	1.2	1.4	0.7
Neuroticism	0.2	0.4	0.8	0.4	0.4	-0.5	-0.9	-0.8
Chronotype (morning person)	0.2	0.4	1.3	-1.1	0.1	-0.3	0.5	0.6
Hair Pigment	0.0	1.2	4.1	-0.1	2.0	1.0	0.8	0.1
Tanning	0.1	1.4	2.3	1.5	1.2	-1.3	-0.8	-0.9
Hand grip strength (left)	0.2	0.5	1.2	-1.1	-0.8	0.1	0.6	0.2
Number of treatments/medications taken	0.1	0.2	0.9	-0.4	-0.9	-0.2	-0.1	-0.2
Average weekly spirits intake	0.1	0.2	0.6	-0.3	0.2	0.1	0.4	0.8
Sensitivity / hurt feelings	0.4	0.7	0.9	1.0	0.5	-0.9	-0.9	-0.9
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.0	0.2	0.3	0.3	0.3
Hearing difficulty/problems: Yes	0.6	0.9	3.6	0.2	1.9	-0.8	0.3	0.1
Relative age of first facial hair	0.3	0.7	2.0	-0.3	-1.4	-0.7	-0.9	-0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	0.5	1.0	-0.7	-0.3	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	0.3	0.1	0.8	0.1	0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.2	-0.8	0.4	-0.3	-0.4
Systolic blood pressure, automated reading	0.3	0.9	3.7	-0.4	-1.9	-0.3	-0.3	0.7
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.7	0.5	-1.4	-1.6	-1.5	-0.6
Angina	0.4	0.6	1.8	0.4	1.3	-0.5	-0.5	0.6
Medication for hormone replacement therapy	0.3	0.4	0.9	-0.0	0.3	0.9	0.5	0.9
Vitamin and mineral supplements	0.3	0.4	0.9	-0.9	0.1	0.6	0.7	0.7
Supplements: Zinc	1.8	2.0	4.4	0.5	-2.1	-0.8	-0.6	-2.1
Medication: Co-codamol	0.4	0.4	1.1	-0.2	-0.4	0.8	0.4	1.0
Medication: Metformin	0.0	0.1	0.2	-0.3	-0.2	-0.4	-0.2	-0.1
Diabetes (father)	1.0	1.3	4.3	-1.2	-2.1	-0.1	0.0	-0.8
Diabetes (mother)	1.4	1.8	2.9	1.1	-1.6	-1.7	-1.4	-0.7
Severe depression (siblings)	0.3	0.4	1.3	-0.1	-0.5	0.6	0.2	1.1
Pack years adult smoking proportion	2.6	4.0	7.0	-1.6	-0.3	2.5	2.1	2.7
Impedance of leg (right)	0.1	0.4	0.6	0.5	0.7	-0.4	-0.6	-0.8
Leg fat-free mass (left)	0.5	2.9	3.6	-1.8	-1.2	1.6	1.9	1.9
Trunk fat percentage	2.0	8.0	12.0	-3.5	-2.5	2.5	2.6	3.0
Hand grip strength (right)	0.2	0.6	1.4	-0.7	-0.4	1.2	1.1	0.2
Townsend deprivation index at recruitment	0.3	0.5	1.4	-0.3	0.6	1.2	0.6	0.2
Current tobacco smoking	3.0	5.0	8.7	-2.0	-0.2	2.3	3.0	2.6
Average weekly fortified wine intake	0.5	0.6	1.3	0.9	0.8	-0.5	-0.5	-1.1
Maternal smoking around birth	1.9	2.7	5.5	-1.6	1.1	1.0	1.8	2.3
Fed-up feelings	0.0	0.1	0.2	0.2	0.3	-0.1	-0.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.2	-0.1	0.5	0.8	0.9
Relative age voice broke	0.8	1.2	2.2	0.9	0.0	-1.2	-1.3	-1.5
Taking other prescription medications	0.7	1.1	4.3	-0.8	-2.1	0.1	0.7	0.0
Age when periods started (menarche)	0.2	0.5	0.9	0.7	0.1	-0.7	-0.6	-1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-0.5	-1.0	1.3	0.9	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.0	-1.7	-0.2	0.9	0.9	1.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.4	-0.4	0.5	-0.1	0.5
Qualifications: CSEs or equivalent	0.2	0.2	0.7	-0.4	0.9	0.2	0.1	0.4
Serious illness, injury or assault to yourself	1.6	1.9	3.9	-1.0	-0.6	1.8	2.0	1.1
High blood pressure	0.4	1.0	2.8	-1.1	-0.9	0.3	0.7	1.7
Hayfever, allergic rhinitis or eczema	1.6	3.5	6.6	1.8	-0.4	-2.2	-2.6	-1.6
Multivitamins +/- minerals	0.1	0.2	0.5	0.7	-0.5	0.1	-0.1	-0.4
Stomach or abdominal pain in last month	0.5	0.6	1.0	0.6	-0.9	-0.6	-1.0	-0.8
Supplements: Glucosamine	1.6	2.0	3.6	1.4	0.5	-1.2	-1.7	-1.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.5	-0.1	0.6	1.9	1.2	0.9
Medication: Atenolol	0.4	0.5	1.7	0.8	-1.3	0.4	-0.1	0.1
Medication: Levothyroxine sodium	2.5	4.3	7.4	-2.7	-1.8	2.1	2.1	1.4
Sitting height	0.1	0.6	1.9	-0.4	1.4	0.2	0.7	-0.5
Chronic bronchitis/emphysema (father)	1.2	1.4	1.8	-1.1	-1.0	1.2	1.4	1.2
High blood pressure (mother)	1.0	1.3	2.4	-1.4	-0.6	1.4	1.5	-0.2
Body mass index (BMI)	1.5	6.6	9.3	-3.0	-2.1	2.3	2.5	2.8
Impedance of leg (left)	0.3	1.3	2.1	1.0	0.7	-1.1	-1.3	-1.5
Leg predicted mass (left)	0.5	2.8	3.5	-1.8	-1.2	1.6	1.8	1.9
Trunk fat mass	1.9	8.0	10.6	-3.3	-2.5	2.5	2.7	3.1
Waist circumference	2.5	9.2	13.8	-3.7	-1.5	2.6	3.3	3.5
Number of incorrect matches in round	2.2	3.6	5.3	-1.9	-2.3	1.7	1.9	1.7
Past tobacco smoking	0.2	0.4	0.9	-0.7	-1.0	0.4	0.3	-0.4
Alcohol usually taken with meals	0.4	0.6	2.2	1.5	0.6	0.2	0.4	-0.5
Nervous feelings	2.3	4.4	7.2	2.1	0.5	-2.2	-2.7	-2.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.0	-2.0	0.6	0.8	1.2	1.0
Hearing difficulty/problems with background noise	1.4	2.3	3.5	1.8	0.0	-1.9	-1.5	-1.6
Hair/balding pattern: Pattern 2	1.5	1.9	4.4	-0.6	-0.3	2.0	2.1	0.6
Had menopause	0.1	0.1	0.2	0.5	-0.1	0.4	-0.1	0.2
Had other major operations	0.4	0.5	1.0	0.5	0.2	1.0	0.9	0.6
Forced vital capacity (FVC)	0.6	2.3	10.6	-0.2	3.2	0.1	1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.0	-1.4	0.2	0.4	0.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.4	-1.1	-1.0	0.4	0.5	1.2
Qualifications: None of the above	1.2	2.5	9.2	-1.5	-3.0	-0.7	0.1	0.8
Financial difficulties in last 2 years	0.7	1.0	2.5	-0.4	-1.1	0.7	0.8	1.6
Mouth/teeth dental problems	0.1	0.2	0.3	0.0	0.3	-0.4	-0.5	-0.6
Heart attack	0.1	0.2	0.5	0.1	0.2	-0.7	-0.5	0.4
Allergy	1.4	3.2	4.9	-2.2	0.2	1.9	2.2	1.6
Pain all over the body in last month	0.6	0.7	1.7	0.3	-1.1	0.4	-0.3	1.3
Diabetes (self-reported)	0.5	0.8	1.3	0.2	-1.1	-1.1	-0.8	-1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.1	-0.6	-0.3	-0.3	-0.7
Medication: Ramipril	0.3	0.3	1.1	-1.0	0.3	0.5	0.5	-0.1
Medication: Simvastatin	2.0	3.0	4.7	2.2	0.9	-2.1	-1.8	-1.2
Fluid intelligence score	0.8	1.7	5.9	0.1	2.4	0.8	1.1	1.0
Illnesses of siblings	0.7	0.9	2.9	0.6	1.7	1.1	0.3	-0.2
Neuroticism score	0.6	1.2	1.7	1.2	0.3	-1.0	-1.3	-1.3
Weight	1.4	6.9	8.7	-2.9	-2.1	2.4	2.7	3.0
Impedance of arm (right)	0.3	1.4	2.6	1.6	0.7	-0.9	-1.4	-1.1
Arm fat percentage (right)	1.0	4.0	5.9	-2.2	-2.0	1.7	1.6	2.4
Trunk fat-free mass	0.1	0.6	0.9	-0.5	-0.6	0.8	0.9	0.9
Hip circumference	2.8	12.1	16.5	-4.1	-2.0	3.5	3.7	3.7
Time employed in main current job	1.1	1.3	3.0	0.4	0.9	-1.7	-1.1	-1.2
Alcohol intake versus 10 years previously	0.4	0.6	1.2	1.1	1.0	0.1	-0.5	-0.6
Father’s age at death	0.1	0.1	0.2	0.4	0.4	-0.2	-0.2	0.4
Worrier / anxious feelings	0.9	1.7	3.1	1.5	-0.4	-1.3	-1.8	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	4.0	-2.0	-1.7	0.6	1.0	1.0
Falls in the last year	1.6	2.2	4.0	-0.8	0.1	2.0	1.7	1.9
Hair/balding pattern: Pattern 3	0.6	0.8	1.9	0.5	0.8	-1.4	-1.1	-0.4
Number of live births	0.8	1.1	2.2	-1.5	-1.2	0.6	0.9	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	5.8	-0.5	2.4	-0.2	0.7	-0.5
Pulse rate	0.9	1.6	3.2	1.6	1.8	-0.9	-0.7	-0.8
Happiness	1.1	1.4	2.3	-1.5	-0.5	1.1	1.4	1.1
Noisy workplace	0.4	0.5	1.7	1.3	0.6	-0.1	0.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.0	0.3	1.7	0.5	0.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.8	0.3	0.4	-0.3	0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.2	-0.7	0.2	0.4	0.8
Asthma	1.0	2.0	5.3	2.3	-1.4	-0.9	-1.3	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	0.9	-0.2	-0.5	-1.1	-0.1
Medication: Cholesterol lowering	0.2	0.3	0.9	0.2	0.6	-1.0	-0.6	-0.0
Depression (self-reported)	0.7	0.9	2.1	-1.4	0.5	0.8	1.2	-0.1
Medication: Lansoprazole	0.9	1.1	2.2	-1.0	-0.8	-1.5	-0.8	-1.0
Prospective memory result	1.2	1.5	2.2	1.0	-0.5	-1.5	-1.3	-1.5
Lung cancer (father)	0.2	0.3	0.9	0.1	-1.0	0.5	0.3	0.3
Illnesses of mother	0.2	0.2	0.6	-0.5	0.8	0.2	0.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	6.0	-0.7	2.5	0.1	0.8	0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.4	-0.8	-0.4	-0.3	0.1
Impedance of arm (left)	0.0	0.2	0.5	0.7	0.2	0.0	-0.5	-0.3
Arm fat mass (right)	1.2	5.1	6.8	-2.6	-2.0	1.9	2.1	2.5
Trunk predicted mass	0.1	0.6	0.9	-0.5	-0.7	0.8	1.0	0.9
Standing height	0.0	0.3	0.5	-0.2	-0.3	0.5	0.7	0.6
Length of working week for main job	0.3	0.3	0.6	-0.5	0.3	-0.8	-0.1	-0.8
Exposure to tobacco smoke at home	0.7	0.8	2.4	-0.5	-1.6	-0.7	-0.4	-0.7
Breastfed as a baby	2.5	3.1	7.0	-1.8	-2.6	1.6	1.0	1.3
Tense / ‘highly strung’	1.4	2.2	5.0	1.2	-1.3	-1.6	-2.2	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	6.0	-2.0	-2.4	1.2	1.6	1.4
Hair/balding pattern: Pattern 4	0.4	0.9	1.3	-1.0	0.7	1.1	1.0	0.8
Birth weight of first child	0.7	1.2	2.8	-1.6	-1.7	0.3	0.7	0.4
Peak expiratory flow (PEF)	0.3	0.7	3.2	0.3	1.8	0.2	0.6	0.1
Pulse wave reflection index	0.3	0.4	1.1	0.1	-1.1	0.4	-0.1	0.8
Ever highly irritable/argumentative for 2 days	1.0	1.3	3.2	-0.2	-1.4	0.8	0.7	1.8
Loud music exposure frequency	0.3	0.3	1.1	-1.0	0.1	-0.6	-0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.6	-0.5	1.3	1.3	1.0	0.6
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	3.6	-1.3	-0.7	1.8	1.9	1.8
Blood clot in the leg (DVT)	1.3	1.7	2.1	-1.2	1.2	1.3	1.4	1.2
Medication: Paracetamol	0.1	0.1	0.2	-0.5	-0.3	0.4	0.0	0.2
Headache pain in last month	0.6	1.0	2.6	-0.9	-0.9	0.6	0.6	1.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	-0.0	-0.2	0.6	0.3	-0.4
Glaucoma (self-reported)	0.5	0.6	2.4	1.6	-0.0	-0.4	-0.6	-0.5
Gout (self-reported)	1.5	2.1	9.0	0.4	-3.0	-0.2	-0.8	-0.9
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	11.0	-3.3	-0.2	2.4	3.1	1.8
Medication: Amlodipine	0.0	0.0	0.1	-0.2	-0.0	0.1	0.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.2	0.6	0.5	0.8	0.1
Birth weight	0.3	0.7	2.1	1.4	0.2	-0.7	-0.8	-0.6
Chronic bronchitis/emphysema (mother)	2.4	2.7	3.9	-1.7	-1.0	1.6	2.0	1.8
High blood pressure (siblings)	0.8	1.2	4.6	-0.8	-2.1	-0.5	0.1	0.7
Forced vital capacity (FVC), Best measure	0.6	2.2	6.3	-1.0	2.5	0.8	1.6	0.8
Body fat percentage	2.1	8.1	11.4	-3.4	-2.4	2.5	2.6	3.2
Leg fat percentage (right)	2.0	7.2	9.7	-3.1	-2.4	2.3	2.3	3.1
Arm fat-free mass (right)	0.5	2.4	3.2	-1.6	-1.0	1.6	1.8	1.6
Exposure to tobacco smoke outside home	1.1	1.4	2.9	-0.2	1.1	1.1	1.4	1.7
Comparative body size at age 10	0.4	1.0	2.3	1.5	1.5	0.3	-0.2	-0.7
Number of full brothers	0.4	0.5	1.3	-1.2	-0.7	0.3	0.4	-0.4
Worry too long after embarrassment	3.4	5.7	8.2	2.9	1.4	-2.6	-2.5	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	5.9	7.6	12.5	-3.0	-0.2	3.0	3.5	2.7
Wheeze or whistling in the chest in last year	0.7	1.2	1.7	-1.3	-1.3	0.8	0.7	1.2
Number of children fathered	0.2	0.2	0.9	0.1	-0.4	-0.0	0.1	0.9
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	7.3	2.7	0.3	-1.4	-1.9	-2.2
Age at first live birth	0.8	1.5	3.0	1.7	1.1	-1.1	-1.0	-1.0
Pulse wave peak to peak time	0.3	0.3	0.6	-0.7	0.8	0.5	0.5	0.1
Health satisfaction	0.2	0.3	0.8	-0.9	0.5	0.0	0.5	0.5
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.3	0.7	-0.4	-0.1	-0.7
Qualifications: College or University degree	0.3	1.0	4.7	0.4	2.2	-0.0	0.4	-0.5
Eye problems/disorders: None of the above	1.0	1.2	2.0	-1.4	1.1	0.3	1.2	1.1
Mouth/teeth dental problems: Loose teeth	1.7	2.1	4.4	-0.8	0.9	2.1	1.6	1.3
Emphysema/chronic bronchitis	0.3	0.3	1.2	0.1	-0.1	1.1	0.6	0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.8	0.0	-0.5	-0.4	-0.8
Neck or shoulder pain in last month	0.4	0.5	2.0	0.1	-1.4	0.4	-0.4	-0.4
Medication: Blood pressure	0.1	0.2	0.9	-0.4	0.1	-0.2	-0.2	0.9
Angina (self-reported)	0.4	0.5	1.4	0.6	1.2	-0.6	-0.6	0.4
Migraine (self-reported)	3.7	4.6	7.9	-2.6	-0.1	1.8	2.2	2.8
Medication: Ibuprofen	0.1	0.1	0.3	0.0	0.1	-0.4	-0.4	0.6
Medication: Allopurinol	1.9	2.5	3.4	1.7	-1.8	-0.9	-1.5	-1.7
Medication: Omeprazole	0.1	0.2	0.5	-0.0	0.7	-0.6	0.2	-0.1
Medication: Seretide 50 evohaler	1.3	1.5	2.9	-1.7	-1.0	1.2	1.3	0.6
Mean time to correctly identify matches	0.6	1.1	2.1	-1.4	-0.4	0.9	1.1	1.2
Heart disease (mother)	0.8	0.9	1.5	0.7	-0.3	-1.2	-1.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.9	-1.3	-1.7	0.9	0.6	-0.3
Whole body fat mass	1.8	7.3	9.6	-3.0	-2.2	2.5	2.6	3.1
Leg fat mass (right)	1.9	7.5	10.0	-3.1	-2.3	2.5	2.6	3.2
Arm predicted mass (right)	0.5	2.6	3.6	-1.7	-1.1	1.6	1.9	1.7
Pulse rate, automated reading	0.4	1.3	3.1	-0.7	0.2	1.1	1.2	1.8
Alcohol intake frequency.	1.4	3.3	5.0	-2.0	-0.0	2.1	1.7	2.2
Comparative height size at age 10	0.4	2.0	3.0	-1.1	0.1	1.7	1.7	1.7
Number of full sisters	2.9	3.5	6.6	-1.8	1.0	1.4	2.1	2.6
Suffer from ‘nerves’	0.4	0.6	1.4	0.7	-0.6	-0.7	-1.2	-0.6
Overall health rating	0.1	0.1	0.3	0.2	-0.5	-0.0	-0.4	-0.4
Chest pain or discomfort	0.4	0.5	2.4	-0.5	-1.6	0.0	0.1	0.2
Had major operations	2.8	3.2	4.8	2.2	0.8	-2.2	-2.1	-1.2
Age at last live birth	1.0	1.4	2.3	1.5	1.4	-1.1	-0.8	-1.1
Family relationship satisfaction	1.4	1.8	4.1	-2.0	-0.4	1.3	1.5	0.9
Leg pain on walking	0.3	0.4	1.1	0.7	0.5	-0.3	-0.3	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	3.1	0.3	-0.2	1.8	0.7	0.9
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.3	-0.4	-0.1	-0.2	0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	0.3	0.7	-0.2	-0.2	-1.3
Medication: Aspirin	0.6	0.8	3.4	-0.8	1.9	0.0	0.3	0.1
Supplements: Vitamin C	0.2	0.2	0.4	0.6	0.1	-0.3	-0.3	-0.6
Knee pain experienced in last month	2.8	4.4	7.4	-1.2	-2.1	2.7	2.1	2.1
Hypertension (Self-reported)	0.3	0.8	2.2	-0.8	-0.8	0.2	0.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	-0.4	-0.7	-1.5	-0.9	-0.7
Illnesses of father: Heart disease	0.1	0.2	0.7	-0.2	-0.8	0.1	-0.3	0.2
Illnesses of siblings: Diabetes	1.2	1.4	4.4	-0.8	-0.7	-2.1	-0.7	-1.1
Smoking status: Previous	0.3	0.4	0.6	0.6	0.7	-0.6	-0.8	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.2	0.7	1.0	-1.1	-1.1	-1.0
Whole body fat-free mass	0.2	1.3	1.6	-1.1	-0.9	1.1	1.3	1.2
Leg fat-free mass (right)	0.3	1.8	2.1	-1.4	-1.1	1.2	1.4	1.4
Arm fat percentage (left)	1.6	6.4	8.8	-2.8	-2.2	2.4	2.2	3.0
Average weekly red wine intake	0.9	1.4	4.3	-0.4	2.1	0.2	1.2	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.7	2.3	-1.5	0.2	-0.1	0.8	0.5
Mood swings	0.3	0.5	1.3	-0.7	1.2	0.6	0.6	-0.2
Loneliness, isolation	0.3	0.4	1.2	-0.5	0.6	0.4	0.4	1.1
Long-standing illness, disability or infirmity	0.1	0.1	0.3	-0.2	-0.5	0.1	-0.1	-0.2
Ever had bowel cancer screening	2.3	2.7	4.8	2.2	-1.1	-1.3	-1.5	-1.9
Diabetes diagnosed by doctor	0.6	1.0	3.6	-0.6	-1.9	-0.9	-0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.6	-0.8	-0.3	0.9	1.3	1.3
Friendships satisfaction	0.4	0.5	1.7	-0.2	1.3	-0.9	0.1	-0.3
Qualifications: nursing, teaching	0.3	0.4	1.4	0.1	1.2	0.4	0.7	-0.3
Commuting to job workplace: Walk	1.4	1.5	2.8	0.9	0.2	-1.6	-1.1	-1.7
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.1	-0.6	0.1	-0.6	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.9	-0.2	-1.4	0.0	0.3	0.9
Medication for cholesterol	0.3	0.4	1.8	-0.1	1.3	-0.1	-0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	-1.2	-1.0	-0.0	-0.0	0.2
Back pain experienced in last month	0.4	0.6	1.8	1.4	0.5	0.1	-0.6	-0.5
Mineral and other dietary supplements	1.9	2.5	5.9	-1.3	-0.8	1.3	1.7	2.4
Breast cancer (self-reported)	0.8	0.9	3.8	0.3	2.0	0.5	0.6	0.2
Asthma (self-reported)	0.7	1.4	3.8	2.0	-1.4	-0.5	-0.9	-0.5
Osteoporosis (self-reported)	0.2	0.2	0.7	0.2	0.1	-0.5	-0.2	-0.8
Osteoarthritis (self-reported)	2.1	2.8	5.6	-1.4	-1.4	1.5	1.4	2.4
Medication: Aspirin	0.6	0.8	2.8	-1.0	1.7	-0.2	0.4	-0.0
Medication: Gliclazide	0.3	0.4	0.7	-0.6	-0.8	0.3	0.6	0.6
Illnesses of father: None of the above (group 1)	0.9	1.1	3.4	1.2	1.8	-0.3	-0.3	-0.6
Smoking status: Current	1.9	3.1	5.8	-1.6	-0.2	1.7	2.4	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.9	-1.4	0.5	0.5	0.8	0.1
Whole body water mass	0.2	1.1	1.6	-1.0	-0.7	1.0	1.3	1.2
Leg predicted mass (right)	0.3	1.8	2.1	-1.4	-1.1	1.2	1.4	1.4
Arm fat mass (left)	1.6	6.6	8.5	-2.8	-2.0	2.5	2.5	2.9
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	-0.7	-0.6	0.5	0.8	0.6
Average weekly champagne plus white wine intake	0.7	1.0	4.1	0.6	2.0	0.3	0.4	-0.6
Miserableness	0.8	1.5	2.5	-1.3	0.6	1.2	1.6	1.2
Guilty feelings	0.8	1.1	2.3	-0.1	0.4	1.5	1.1	1.4
Wears glasses or contact lenses	1.4	1.6	2.0	-1.4	-1.0	1.4	1.1	1.2
Ever taken oral contraceptive pill	0.8	0.9	1.7	1.3	-0.9	-0.7	-1.2	-0.5
Hearing aid user	0.8	0.9	1.9	-0.4	1.3	0.7	0.7	1.4
Mother’s age at death	0.3	0.4	0.8	0.3	0.4	-0.5	-0.6	-0.9
Financial situation satisfaction	1.5	1.9	3.1	-1.8	1.2	1.0	1.6	1.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.4	1.2	-0.7	-1.6	-0.9	-1.2
Commuting to job workplace: Public transport	0.8	0.9	2.0	1.0	1.4	0.6	0.1	1.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.5	1.2	-0.8	-0.1	-0.5	-0.7
Medication: Blood pressure	0.1	0.2	0.4	-0.3	-0.6	0.6	0.6	0.2
Pain type(s) experienced in last month: Hip pain	2.9	3.6	6.7	-1.5	0.1	2.6	2.4	1.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	-0.0	0.2	-0.7	-0.5	-1.0
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.0	-0.9	-0.8	0.1	-0.3
Medication: Bendroflumethiazide	0.1	0.1	0.4	-0.4	0.1	-0.0	-0.3	0.6
Medication: Paracetamol	0.0	0.1	0.2	-0.2	0.4	-0.0	-0.0	-0.3
Medication: Lisinopril	0.5	0.6	1.4	-0.8	-0.8	0.5	0.2	1.2
Medication: Atorvastatin	0.8	1.0	3.9	-2.0	-0.4	0.2	1.0	0.1
Illnesses of father: High blood pressure	0.5	0.6	2.8	-0.0	-1.7	0.2	-0.2	-0.1
Alcohol drinker status: Never	0.4	0.5	1.6	0.1	-1.3	0.4	0.5	0.6
Ever smoked	0.2	0.3	0.6	0.6	0.8	-0.2	-0.1	0.7
Basal metabolic rate	0.4	2.2	2.7	-1.6	-1.3	1.4	1.6	1.6
Leg fat percentage (left)	1.5	5.5	7.8	-2.8	-2.3	1.8	1.9	2.8
Arm fat-free mass (left)	0.2	1.2	2.0	-1.3	-0.7	1.0	1.4	1.0
Number of operations (self-reported)	0.3	0.5	1.6	1.3	-0.2	-0.3	-0.6	-0.4
Average weekly beer plus cider intake	1.3	2.0	4.0	0.9	1.0	-2.0	-1.5	-1.3
Irritability	0.2	0.3	1.0	1.0	0.1	0.3	-0.4	-0.5
Risk taking	1.8	2.6	4.7	-1.6	-0.0	1.8	2.2	1.6
Ever had prostate specific antigen (PSA) test	3.1	3.5	6.5	1.8	-0.2	-1.8	-2.5	-2.2
Fractured/broken bones in last 5 years	0.7	0.9	1.8	-0.7	0.6	1.4	0.8	1.0
Age started oral contraceptive pill	1.0	1.3	3.7	1.9	-0.9	-0.2	-1.3	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.6	0.6	-0.6	-0.8	-0.7	0.1
Ever depressed for a whole week	0.1	0.1	0.3	0.0	0.2	-0.6	-0.2	0.1
Unable to work because of sickness or disability	5.6	7.3	12.1	-3.5	-1.8	2.4	2.8	2.7
Commuting to job workplace: Cycle	0.3	0.4	0.8	-0.4	0.1	0.7	0.9	0.8
Myopia	0.8	1.1	3.8	-1.0	-0.9	-0.2	0.0	2.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.3	0.8	0.5	-0.2	-0.5	-1.5
Cholesterol lowering medication	0.3	0.5	1.2	0.6	-1.1	-0.8	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.7	0.1	0.5	0.9	0.5
Pain experienced in last month	0.6	1.0	2.2	0.1	1.5	-1.3	-0.2	-1.0
Supplements: Calcium	0.3	0.3	0.8	0.8	-0.9	0.3	-0.3	0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.4	-0.2	-0.3	0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.1	0.1	-0.6	-0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.5	-1.1	1.1	1.2	1.2	1.1
Heart disease (siblings)	1.4	1.8	3.7	0.9	0.2	-1.9	-1.7	-1.2
Alcohol drinker status: Previous	1.3	1.5	3.2	-1.5	-0.1	0.7	1.1	1.8
Pack years of smoking	2.0	2.9	6.6	-1.2	-0.4	1.9	1.5	2.6
Impedance of whole body	0.1	0.3	0.4	0.6	0.5	-0.4	-0.6	-0.6
Leg fat mass (left)	1.7	6.5	9.1	-2.9	-2.2	2.2	2.4	3.0
Arm predicted mass (left)	0.2	1.2	1.8	-1.3	-1.0	0.9	1.3	1.0