[Hub]/) : Traits : Blood Eosinophil Count : ← →

chr6:108,612,536-110,843,638

Best TWAS P=1.53e-14 · Best GWAS P=4.07e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CD164	0.11	0.07	blup	376	0.10	1.6e-12	5.3	-7.4	1.9e-13	0.22	0.93	0.07	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MICAL1	0.17	0.12	lasso	9	0.14	4.0e-17	6.1	-5.2	2.3e-07	-0.02	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	SMPD2	0.14	0.10	lasso	10	0.12	2.3e-10	6.1	7.4	1.9e-13	0.02	0.98	0.02	FALSE
4	GTEx	Adipose Subcutaneous	AK9	0.12	0.09	lasso	7	0.10	2.1e-08	5.7	-5.7	1.0e-08	-0.04	0.94	0.01	FALSE
5	GTEx	Adipose Visceral Omentum	AK9	0.10	0.02	enet	27	0.04	2.7e-03	5.7	-5.2	2.5e-07	-0.15	0.75	0.02	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-425D10.10	0.16	0.10	lasso	6	0.06	7.2e-04	5.7	5.8	8.6e-09	0.12	0.63	0.03	FALSE
7	GTEx	Adrenal Gland	RP11-425D10.10	0.11	0.00	enet	11	0.02	4.9e-02	5.0	5.7	1.4e-08	0.11	0.21	0.06	FALSE
8	GTEx	Artery Aorta	SMPD2	0.10	0.04	enet	11	0.03	1.5e-02	6.6	6.4	1.3e-10	0.11	0.63	0.08	FALSE
9	GTEx	Artery Aorta	AK9	0.16	0.14	enet	32	0.14	3.7e-08	-3.2	-5.4	6.3e-08	0.02	1.00	0.00	FALSE
10	GTEx	Artery Coronary	SMPD2	0.11	0.09	lasso	4	0.07	1.9e-03	4.6	5.3	9.3e-08	0.07	0.36	0.04	FALSE
11	GTEx	Artery Coronary	RP11-425D10.10	0.31	0.00	enet	20	0.01	1.3e-01	-6.5	6.5	6.9e-11	-0.49	0.04	0.16	FALSE
12	GTEx	Artery Tibial	MICAL1	0.08	0.02	lasso	3	0.01	6.5e-02	6.1	6.1	1.1e-09	0.10	0.44	0.03	FALSE
13	GTEx	Artery Tibial	AK9	0.13	0.12	enet	18	0.13	3.5e-10	5.8	-5.8	5.2e-09	-0.08	1.00	0.00	FALSE
14	GTEx	Artery Tibial	RP11-425D10.10	0.10	0.10	lasso	4	0.10	3.9e-08	6.1	5.5	3.9e-08	0.12	0.96	0.04	FALSE
15	GTEx	Brain Caudate basal ganglia	AK9	0.20	0.16	enet	16	0.17	1.1e-05	5.8	-6.0	2.0e-09	-0.09	0.68	0.03	FALSE
16	GTEx	Brain Cerebellar Hemisphere	AK9	0.24	0.17	lasso	3	0.11	1.0e-03	5.7	-5.5	3.2e-08	-0.09	0.33	0.05	FALSE
17	GTEx	Brain Cortex	AK9	0.21	0.03	enet	29	0.16	3.2e-05	5.8	-6.2	6.3e-10	-0.03	0.59	0.04	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	AK9	0.28	0.02	enet	22	0.09	1.8e-03	5.8	-7.3	3.6e-13	0.14	0.18	0.29	FALSE
19	GTEx	Breast Mammary Tissue	SMPD2	0.14	0.09	lasso	5	0.05	2.2e-03	6.1	5.9	4.8e-09	0.08	0.49	0.03	FALSE
20	GTEx	Breast Mammary Tissue	RP11-425D10.10	0.12	0.12	lasso	1	0.08	5.1e-05	5.7	5.7	1.5e-08	0.10	0.92	0.02	FALSE
21	GTEx	Breast Mammary Tissue (Male)	AK9	0.10	0.03	lasso	3	-0.01	5.4e-01	6.6	-6.6	3.9e-11	-0.09	0.06	0.06	FALSE
22	GTEx	Breast Mammary Tissue (Female)	AK9	0.12	0.15	lasso	1	0.12	1.9e-04	5.7	-5.7	1.5e-08	-0.10	0.14	0.12	FALSE
23	GTEx	Breast Mammary Tissue (Female)	RP11-425D10.10	0.14	0.04	lasso	10	0.02	6.5e-02	6.2	6.3	3.3e-10	0.08	0.06	0.06	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	AK9	0.32	0.13	lasso	7	0.25	1.2e-08	5.8	-5.5	4.4e-08	-0.14	0.99	0.01	FALSE
25	GTEx	Cells Transformed fibroblasts	SMPD2	0.20	0.13	lasso	9	0.15	3.1e-11	6.1	6.1	8.1e-10	0.09	0.99	0.01	FALSE
26	GTEx	Colon Sigmoid	FIG4	0.17	0.11	lasso	9	0.03	3.7e-02	6.1	-6.6	3.1e-11	-0.09	0.20	0.23	FALSE
27	GTEx	Colon Transverse	SMPD2	0.19	0.25	lasso	5	0.24	1.1e-11	6.1	6.2	6.8e-10	0.05	0.96	0.04	FALSE
28	GTEx	Colon Transverse	RP11-425D10.10	0.12	0.13	enet	21	0.14	2.2e-07	6.1	6.5	1.0e-10	0.09	0.97	0.03	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	SMPD2	0.11	0.06	lasso	6	0.06	4.1e-03	4.6	5.2	2.4e-07	0.07	0.33	0.12	FALSE
30	GTEx	Esophagus Mucosa	SMPD2	0.17	0.20	lasso	10	0.22	2.2e-14	6.3	6.4	1.9e-10	0.08	0.96	0.04	FALSE
31	GTEx	Esophagus Mucosa	AK9	0.11	0.06	lasso	13	0.04	6.0e-04	5.8	-5.5	3.5e-08	-0.04	0.82	0.03	FALSE
32	GTEx	Esophagus Mucosa	RP11-425D10.10	0.09	0.13	lasso	5	0.12	1.1e-08	5.7	5.7	9.4e-09	0.10	0.99	0.01	FALSE
33	GTEx	Esophagus Muscularis	FIG4	0.14	0.02	enet	10	0.03	7.8e-03	5.8	-5.6	2.3e-08	-0.08	0.28	0.24	FALSE
34	GTEx	Esophagus Muscularis	CD164	0.04	0.02	enet	6	0.01	1.0e-01	6.0	6.3	2.4e-10	0.10	0.26	0.04	FALSE
35	GTEx	Heart Atrial Appendage	RP11-425D10.10	0.12	0.11	lasso	5	0.07	4.0e-04	5.7	5.6	2.3e-08	0.11	0.71	0.03	FALSE
36	GTEx	Lung	SMPD2	0.10	0.12	lasso	2	0.10	7.5e-08	6.1	6.1	8.4e-10	0.05	0.98	0.02	FALSE
37	GTEx	Lung	RP11-425D10.10	0.10	0.08	enet	24	0.07	6.4e-06	6.2	6.0	2.4e-09	0.12	0.96	0.03	FALSE
38	GTEx	Muscle Skeletal	CD164	0.07	0.07	enet	15	0.06	3.7e-06	-3.8	-6.1	1.2e-09	0.41	0.99	0.01	FALSE
39	GTEx	Nerve Tibial	SMPD2	0.12	0.08	lasso	4	0.08	3.6e-06	4.8	5.3	9.2e-08	0.07	0.95	0.01	FALSE
40	GTEx	Ovary	RP11-425D10.10	0.15	0.10	lasso	5	0.02	9.0e-02	5.7	5.9	4.2e-09	0.10	0.22	0.06	FALSE
41	GTEx	Pancreas	SMPD2	0.09	0.07	lasso	3	0.08	2.1e-04	6.1	5.4	6.4e-08	0.06	0.36	0.06	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	SMPD2	0.27	0.15	lasso	10	0.17	1.6e-09	5.7	6.3	2.8e-10	0.10	0.98	0.02	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	RP11-425D10.10	0.20	0.27	lasso	5	0.27	5.5e-15	5.8	5.9	3.6e-09	0.09	1.00	0.00	FALSE
44	GTEx	Skin Sun Exposed Lower leg	SMPD2	0.19	0.19	lasso	12	0.24	1.6e-19	5.8	6.2	4.5e-10	0.09	1.00	0.00	FALSE
45	GTEx	Skin Sun Exposed Lower leg	RP11-425D10.10	0.19	0.23	enet	18	0.23	3.4e-19	5.8	6.5	9.0e-11	0.07	1.00	0.00	FALSE
46	GTEx	Small Intestine Terminal Ileum	RP11-425D10.10	0.16	0.07	lasso	9	0.06	1.5e-02	6.3	6.2	6.2e-10	0.09	0.11	0.06	FALSE
47	GTEx	Stomach	SMPD2	0.14	-0.01	lasso	5	-0.01	8.6e-01	5.1	5.6	1.9e-08	-0.08	0.08	0.07	FALSE
48	GTEx	Stomach	RP11-425D10.10	0.25	0.10	lasso	6	0.09	3.0e-05	6.4	7.1	1.6e-12	0.00	0.84	0.08	FALSE
49	GTEx	Testis	ZBTB24	0.11	0.11	lasso	4	0.10	4.9e-05	5.7	-5.8	6.4e-09	-0.09	0.72	0.02	FALSE
50	GTEx	Testis	SMPD2	0.28	0.18	lasso	7	0.17	7.6e-08	6.1	6.2	6.8e-10	0.08	0.90	0.09	FALSE
51	GTEx	Thyroid	AK9	0.11	0.08	enet	22	0.13	1.9e-10	6.3	-5.4	5.5e-08	-0.14	0.97	0.03	FALSE
52	GTEx	Vagina	RP11-425D10.10	0.42	0.22	lasso	19	0.17	9.0e-05	5.7	5.8	5.6e-09	0.09	0.52	0.05	FALSE
53	GTEx	Whole Blood	SMPD2	0.15	0.16	lasso	8	0.15	1.0e-13	6.1	6.1	9.0e-10	0.08	0.98	0.02	FALSE
54	GTEx	Whole Blood	RP11-425D10.10	0.04	0.03	enet	16	0.03	6.2e-04	5.7	6.1	1.3e-09	0.11	0.76	0.03	FALSE
55	METSIM	Adipose	AK9	0.05	0.03	lasso	6	0.02	1.0e-04	6.6	-6.3	2.2e-10	-0.05	0.92	0.06	FALSE
56	METSIM	Adipose	SMPD2	0.06	0.08	enet	14	0.08	2.0e-12	6.1	5.9	3.7e-09	0.06	0.98	0.02	FALSE
57	NTR	Blood	SESN1	0.03	0.04	lasso	3	0.03	5.4e-11	-7.3	-7.3	2.0e-13	0.96	0.01	0.99	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	ZBTB24	0.03	0.00	blup	389	0.00	7.3e-02	6.6	-6.3	3.5e-10	-0.16	0.32	0.05	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	CD164	0.07	0.01	enet	16	0.05	1.6e-07	6.4	-7.0	2.0e-12	0.05	0.68	0.20	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	SMPD2	0.12	0.10	lasso	5	0.09	1.3e-11	6.1	5.7	1.2e-08	0.03	0.98	0.02	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	AK9	0.08	0.06	bslmm	456	0.06	5.3e-08	5.9	-6.9	3.9e-12	0.06	0.94	0.06	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	RP11-425D10.10	0.05	0.01	blup	367	0.02	5.0e-04	5.7	6.2	4.5e-10	0.08	0.97	0.01	FALSE
63	YFS	Blood	CD164	0.03	0.01	blup	382	0.02	1.9e-07	-3.8	5.7	1.4e-08	-0.32	0.98	0.02	FALSE
64	YFS	Blood	SESN1	0.10	0.12	lasso	15	0.12	1.4e-36	-7.2	-7.3	4.1e-13	0.95	0.02	0.98	FALSE
65	YFS	Blood	SMPD2	0.06	0.08	lasso	7	0.08	2.5e-24	6.1	6.3	3.8e-10	0.05	0.94	0.06	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ARMC2	0.04	0.05	lasso	1	0.04	3.4e-04	-6.6	6.6	5.1e-11	-0.88	0.02	0.89	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SMPD2	0.04	0.04	blup	43	0.05	3.9e-05	6.1	6.1	1.4e-09	0.11	0.03	0.95	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	AKD1	0.02	0.02	blup	122	0.03	1.0e-06	5.8	-5.3	1.2e-07	-0.15	0.05	0.95	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMPD2	0.04	0.07	lasso	4	0.07	8.8e-14	6.1	6.2	5.2e-10	0.05	0.01	0.99	FALSE
70	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMPD2	0.07	0.08	blup	45	0.07	2.3e-04	6.1	6.2	5.2e-10	0.04	0.03	0.93	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	SMPD2	0.17	0.14	lasso	4	0.14	2.3e-08	5.3	5.4	5.9e-08	0.04	0.04	0.96	FALSE
72	The Cancer Genome Atlas	Esophageal Carcinoma	C6orf182	0.10	-0.01	blup	40	0.03	4.2e-02	4.7	7.2	6.6e-13	-0.52	0.02	0.19	FALSE
73	The Cancer Genome Atlas	Esophageal Carcinoma	SMPD2	0.12	0.09	blup	41	0.07	2.6e-03	6.2	6.4	1.7e-10	0.07	0.02	0.81	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AKD1	0.07	0.06	blup	116	0.06	4.2e-07	6.2	-5.6	1.7e-08	-0.13	0.02	0.98	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMPD2	0.09	0.09	blup	42	0.10	2.1e-11	6.4	5.8	5.7e-09	0.01	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKD1	0.11	0.08	lasso	5	0.10	5.8e-11	6.1	-6.1	1.2e-09	-0.08	0.02	0.98	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMPD2	0.05	0.07	lasso	4	0.06	9.6e-08	5.3	6.0	1.6e-09	0.04	0.01	0.99	FALSE
78	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKD1	0.11	0.06	lasso	3	0.06	2.7e-04	5.8	-5.9	4.1e-09	-0.09	0.03	0.97	FALSE
79	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMPD2	0.12	0.15	enet	6	0.14	3.8e-08	6.1	6.1	1.0e-09	0.05	0.02	0.98	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKD1	0.12	0.11	lasso	6	0.12	9.8e-14	5.8	-5.7	1.5e-08	-0.08	0.09	0.91	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	MICAL1	0.08	0.11	lasso	4	0.12	1.8e-13	5.3	-5.7	1.0e-08	-0.04	0.05	0.95	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB24	0.04	0.05	lasso	4	0.04	7.8e-06	6.1	-6.2	5.8e-10	-0.10	0.04	0.96	FALSE
83	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIL6	0.07	0.03	blup	53	0.02	5.8e-02	6.1	-6.4	1.2e-10	-0.07	0.02	0.61	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	AKD1	0.05	0.03	blup	122	0.04	1.3e-05	6.2	-6.0	1.6e-09	-0.06	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	SMPD2	0.06	0.09	enet	11	0.08	4.7e-10	6.1	6.3	2.8e-10	0.08	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AKD1	0.06	0.07	lasso	4	0.05	2.8e-06	6.0	-5.3	1.1e-07	-0.13	0.05	0.95	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMPD2	0.04	0.06	blup	45	0.06	8.9e-08	6.5	6.7	2.7e-11	0.06	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AKD1	0.04	0.03	blup	114	0.03	4.7e-03	5.8	-6.0	1.9e-09	-0.12	0.05	0.69	FALSE
89	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SMPD2	0.06	0.05	lasso	3	0.06	9.2e-05	6.1	5.7	1.2e-08	0.03	0.02	0.97	FALSE
90	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SESN1	0.17	0.01	blup	45	0.02	5.5e-02	-7.3	6.2	5.9e-10	-0.77	0.01	0.52	FALSE
91	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMPD2	0.08	0.07	lasso	3	0.05	3.3e-03	6.1	6.1	8.7e-10	0.05	0.02	0.93	FALSE
92	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMPD2	0.10	0.04	lasso	2	0.07	1.2e-03	5.3	5.4	8.7e-08	0.04	0.01	0.72	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	SESN1	0.02	0.04	lasso	4	0.04	1.1e-04	-7.4	-7.4	1.7e-13	0.96	0.02	0.97	TRUE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMPD2	0.08	0.13	lasso	3	0.13	2.4e-13	6.1	6.1	1.1e-09	0.05	0.05	0.95	FALSE
95	The Cancer Genome Atlas	Rectum Adenocarcinoma	ARMC2	0.38	0.00	blup	88	0.08	7.2e-03	-2.5	6.5	6.4e-11	-0.63	0.01	0.21	FALSE
96	The Cancer Genome Atlas	Rectum Adenocarcinoma	SMPD2	0.13	0.08	lasso	2	0.06	1.5e-02	6.1	6.1	8.2e-10	0.05	0.01	0.47	FALSE
97	The Cancer Genome Atlas	Stomach Adenocarcinoma	AKD1	0.03	0.03	blup	121	0.02	6.3e-03	6.1	-5.6	2.6e-08	-0.14	0.03	0.81	FALSE
98	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMPD2	0.07	0.07	blup	44	0.08	3.4e-06	6.1	6.2	4.5e-10	0.09	0.04	0.96	FALSE
99	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SMPD2	0.23	0.13	lasso	5	0.17	1.4e-06	5.8	5.1	3.0e-07	0.11	0.04	0.95	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	CD164	0.03	0.01	blup	49	0.01	2.1e-02	6.1	7.7	1.5e-14	0.00	0.02	0.80	TRUE
101	The Cancer Genome Atlas	Thyroid Carcinoma	SMPD2	0.15	0.17	enet	14	0.18	9.4e-18	6.1	6.1	1.3e-09	0.00	0.02	0.98	FALSE