[Hub]/) : Traits : Blood Eosinophil Count :

chr6:108,612,536-110,843,638

Best TWAS P=1.53e-14 · Best GWAS P=4.07e-14 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CD164 0.11 0.07 blup 376 0.10 1.6e-12 5.3 -7.4 1.9e-13 0.22 0.93 0.07 FALSE
2 CommonMind Brain Pre-frontal Cortex MICAL1 0.17 0.12 lasso 9 0.14 4.0e-17 6.1 -5.2 2.3e-07 -0.02 0.98 0.02 FALSE
3 GTEx Adipose Subcutaneous SMPD2 0.14 0.10 lasso 10 0.12 2.3e-10 6.1 7.4 1.9e-13 0.02 0.98 0.02 FALSE
4 GTEx Adipose Subcutaneous AK9 0.12 0.09 lasso 7 0.10 2.1e-08 5.7 -5.7 1.0e-08 -0.04 0.94 0.01 FALSE
5 GTEx Adipose Visceral Omentum AK9 0.10 0.02 enet 27 0.04 2.7e-03 5.7 -5.2 2.5e-07 -0.15 0.75 0.02 FALSE
6 GTEx Adipose Visceral Omentum RP11-425D10.10 0.16 0.10 lasso 6 0.06 7.2e-04 5.7 5.8 8.6e-09 0.12 0.63 0.03 FALSE
7 GTEx Adrenal Gland RP11-425D10.10 0.11 0.00 enet 11 0.02 4.9e-02 5.0 5.7 1.4e-08 0.11 0.21 0.06 FALSE
8 GTEx Artery Aorta SMPD2 0.10 0.04 enet 11 0.03 1.5e-02 6.6 6.4 1.3e-10 0.11 0.63 0.08 FALSE
9 GTEx Artery Aorta AK9 0.16 0.14 enet 32 0.14 3.7e-08 -3.2 -5.4 6.3e-08 0.02 1.00 0.00 FALSE
10 GTEx Artery Coronary SMPD2 0.11 0.09 lasso 4 0.07 1.9e-03 4.6 5.3 9.3e-08 0.07 0.36 0.04 FALSE
11 GTEx Artery Coronary RP11-425D10.10 0.31 0.00 enet 20 0.01 1.3e-01 -6.5 6.5 6.9e-11 -0.49 0.04 0.16 FALSE
12 GTEx Artery Tibial MICAL1 0.08 0.02 lasso 3 0.01 6.5e-02 6.1 6.1 1.1e-09 0.10 0.44 0.03 FALSE
13 GTEx Artery Tibial AK9 0.13 0.12 enet 18 0.13 3.5e-10 5.8 -5.8 5.2e-09 -0.08 1.00 0.00 FALSE
14 GTEx Artery Tibial RP11-425D10.10 0.10 0.10 lasso 4 0.10 3.9e-08 6.1 5.5 3.9e-08 0.12 0.96 0.04 FALSE
15 GTEx Brain Caudate basal ganglia AK9 0.20 0.16 enet 16 0.17 1.1e-05 5.8 -6.0 2.0e-09 -0.09 0.68 0.03 FALSE
16 GTEx Brain Cerebellar Hemisphere AK9 0.24 0.17 lasso 3 0.11 1.0e-03 5.7 -5.5 3.2e-08 -0.09 0.33 0.05 FALSE
17 GTEx Brain Cortex AK9 0.21 0.03 enet 29 0.16 3.2e-05 5.8 -6.2 6.3e-10 -0.03 0.59 0.04 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia AK9 0.28 0.02 enet 22 0.09 1.8e-03 5.8 -7.3 3.6e-13 0.14 0.18 0.29 FALSE
19 GTEx Breast Mammary Tissue SMPD2 0.14 0.09 lasso 5 0.05 2.2e-03 6.1 5.9 4.8e-09 0.08 0.49 0.03 FALSE
20 GTEx Breast Mammary Tissue RP11-425D10.10 0.12 0.12 lasso 1 0.08 5.1e-05 5.7 5.7 1.5e-08 0.10 0.92 0.02 FALSE
21 GTEx Breast Mammary Tissue (Male) AK9 0.10 0.03 lasso 3 -0.01 5.4e-01 6.6 -6.6 3.9e-11 -0.09 0.06 0.06 FALSE
22 GTEx Breast Mammary Tissue (Female) AK9 0.12 0.15 lasso 1 0.12 1.9e-04 5.7 -5.7 1.5e-08 -0.10 0.14 0.12 FALSE
23 GTEx Breast Mammary Tissue (Female) RP11-425D10.10 0.14 0.04 lasso 10 0.02 6.5e-02 6.2 6.3 3.3e-10 0.08 0.06 0.06 FALSE
24 GTEx Cells EBV-transformed lymphocytes AK9 0.32 0.13 lasso 7 0.25 1.2e-08 5.8 -5.5 4.4e-08 -0.14 0.99 0.01 FALSE
25 GTEx Cells Transformed fibroblasts SMPD2 0.20 0.13 lasso 9 0.15 3.1e-11 6.1 6.1 8.1e-10 0.09 0.99 0.01 FALSE
26 GTEx Colon Sigmoid FIG4 0.17 0.11 lasso 9 0.03 3.7e-02 6.1 -6.6 3.1e-11 -0.09 0.20 0.23 FALSE
27 GTEx Colon Transverse SMPD2 0.19 0.25 lasso 5 0.24 1.1e-11 6.1 6.2 6.8e-10 0.05 0.96 0.04 FALSE
28 GTEx Colon Transverse RP11-425D10.10 0.12 0.13 enet 21 0.14 2.2e-07 6.1 6.5 1.0e-10 0.09 0.97 0.03 FALSE
29 GTEx Esophagus Gastroesophageal Junction SMPD2 0.11 0.06 lasso 6 0.06 4.1e-03 4.6 5.2 2.4e-07 0.07 0.33 0.12 FALSE
30 GTEx Esophagus Mucosa SMPD2 0.17 0.20 lasso 10 0.22 2.2e-14 6.3 6.4 1.9e-10 0.08 0.96 0.04 FALSE
31 GTEx Esophagus Mucosa AK9 0.11 0.06 lasso 13 0.04 6.0e-04 5.8 -5.5 3.5e-08 -0.04 0.82 0.03 FALSE
32 GTEx Esophagus Mucosa RP11-425D10.10 0.09 0.13 lasso 5 0.12 1.1e-08 5.7 5.7 9.4e-09 0.10 0.99 0.01 FALSE
33 GTEx Esophagus Muscularis FIG4 0.14 0.02 enet 10 0.03 7.8e-03 5.8 -5.6 2.3e-08 -0.08 0.28 0.24 FALSE
34 GTEx Esophagus Muscularis CD164 0.04 0.02 enet 6 0.01 1.0e-01 6.0 6.3 2.4e-10 0.10 0.26 0.04 FALSE
35 GTEx Heart Atrial Appendage RP11-425D10.10 0.12 0.11 lasso 5 0.07 4.0e-04 5.7 5.6 2.3e-08 0.11 0.71 0.03 FALSE
36 GTEx Lung SMPD2 0.10 0.12 lasso 2 0.10 7.5e-08 6.1 6.1 8.4e-10 0.05 0.98 0.02 FALSE
37 GTEx Lung RP11-425D10.10 0.10 0.08 enet 24 0.07 6.4e-06 6.2 6.0 2.4e-09 0.12 0.96 0.03 FALSE
38 GTEx Muscle Skeletal CD164 0.07 0.07 enet 15 0.06 3.7e-06 -3.8 -6.1 1.2e-09 0.41 0.99 0.01 FALSE
39 GTEx Nerve Tibial SMPD2 0.12 0.08 lasso 4 0.08 3.6e-06 4.8 5.3 9.2e-08 0.07 0.95 0.01 FALSE
40 GTEx Ovary RP11-425D10.10 0.15 0.10 lasso 5 0.02 9.0e-02 5.7 5.9 4.2e-09 0.10 0.22 0.06 FALSE
41 GTEx Pancreas SMPD2 0.09 0.07 lasso 3 0.08 2.1e-04 6.1 5.4 6.4e-08 0.06 0.36 0.06 FALSE
42 GTEx Skin Not Sun Exposed Suprapubic SMPD2 0.27 0.15 lasso 10 0.17 1.6e-09 5.7 6.3 2.8e-10 0.10 0.98 0.02 FALSE
43 GTEx Skin Not Sun Exposed Suprapubic RP11-425D10.10 0.20 0.27 lasso 5 0.27 5.5e-15 5.8 5.9 3.6e-09 0.09 1.00 0.00 FALSE
44 GTEx Skin Sun Exposed Lower leg SMPD2 0.19 0.19 lasso 12 0.24 1.6e-19 5.8 6.2 4.5e-10 0.09 1.00 0.00 FALSE
45 GTEx Skin Sun Exposed Lower leg RP11-425D10.10 0.19 0.23 enet 18 0.23 3.4e-19 5.8 6.5 9.0e-11 0.07 1.00 0.00 FALSE
46 GTEx Small Intestine Terminal Ileum RP11-425D10.10 0.16 0.07 lasso 9 0.06 1.5e-02 6.3 6.2 6.2e-10 0.09 0.11 0.06 FALSE
47 GTEx Stomach SMPD2 0.14 -0.01 lasso 5 -0.01 8.6e-01 5.1 5.6 1.9e-08 -0.08 0.08 0.07 FALSE
48 GTEx Stomach RP11-425D10.10 0.25 0.10 lasso 6 0.09 3.0e-05 6.4 7.1 1.6e-12 0.00 0.84 0.08 FALSE
49 GTEx Testis ZBTB24 0.11 0.11 lasso 4 0.10 4.9e-05 5.7 -5.8 6.4e-09 -0.09 0.72 0.02 FALSE
50 GTEx Testis SMPD2 0.28 0.18 lasso 7 0.17 7.6e-08 6.1 6.2 6.8e-10 0.08 0.90 0.09 FALSE
51 GTEx Thyroid AK9 0.11 0.08 enet 22 0.13 1.9e-10 6.3 -5.4 5.5e-08 -0.14 0.97 0.03 FALSE
52 GTEx Vagina RP11-425D10.10 0.42 0.22 lasso 19 0.17 9.0e-05 5.7 5.8 5.6e-09 0.09 0.52 0.05 FALSE
53 GTEx Whole Blood SMPD2 0.15 0.16 lasso 8 0.15 1.0e-13 6.1 6.1 9.0e-10 0.08 0.98 0.02 FALSE
54 GTEx Whole Blood RP11-425D10.10 0.04 0.03 enet 16 0.03 6.2e-04 5.7 6.1 1.3e-09 0.11 0.76 0.03 FALSE
55 METSIM Adipose AK9 0.05 0.03 lasso 6 0.02 1.0e-04 6.6 -6.3 2.2e-10 -0.05 0.92 0.06 FALSE
56 METSIM Adipose SMPD2 0.06 0.08 enet 14 0.08 2.0e-12 6.1 5.9 3.7e-09 0.06 0.98 0.02 FALSE
57 NTR Blood SESN1 0.03 0.04 lasso 3 0.03 5.4e-11 -7.3 -7.3 2.0e-13 0.96 0.01 0.99 FALSE
58 ROSMAP Brain Pre-frontal Cortex ZBTB24 0.03 0.00 blup 389 0.00 7.3e-02 6.6 -6.3 3.5e-10 -0.16 0.32 0.05 FALSE
59 ROSMAP Brain Pre-frontal Cortex CD164 0.07 0.01 enet 16 0.05 1.6e-07 6.4 -7.0 2.0e-12 0.05 0.68 0.20 FALSE
60 ROSMAP Brain Pre-frontal Cortex SMPD2 0.12 0.10 lasso 5 0.09 1.3e-11 6.1 5.7 1.2e-08 0.03 0.98 0.02 FALSE
61 ROSMAP Brain Pre-frontal Cortex AK9 0.08 0.06 bslmm 456 0.06 5.3e-08 5.9 -6.9 3.9e-12 0.06 0.94 0.06 FALSE
62 ROSMAP Brain Pre-frontal Cortex RP11-425D10.10 0.05 0.01 blup 367 0.02 5.0e-04 5.7 6.2 4.5e-10 0.08 0.97 0.01 FALSE
63 YFS Blood CD164 0.03 0.01 blup 382 0.02 1.9e-07 -3.8 5.7 1.4e-08 -0.32 0.98 0.02 FALSE
64 YFS Blood SESN1 0.10 0.12 lasso 15 0.12 1.4e-36 -7.2 -7.3 4.1e-13 0.95 0.02 0.98 FALSE
65 YFS Blood SMPD2 0.06 0.08 lasso 7 0.08 2.5e-24 6.1 6.3 3.8e-10 0.05 0.94 0.06 FALSE
66 The Cancer Genome Atlas Bladder Urothelial Carcinoma ARMC2 0.04 0.05 lasso 1 0.04 3.4e-04 -6.6 6.6 5.1e-11 -0.88 0.02 0.89 FALSE
67 The Cancer Genome Atlas Bladder Urothelial Carcinoma SMPD2 0.04 0.04 blup 43 0.05 3.9e-05 6.1 6.1 1.4e-09 0.11 0.03 0.95 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma AKD1 0.02 0.02 blup 122 0.03 1.0e-06 5.8 -5.3 1.2e-07 -0.15 0.05 0.95 FALSE
69 The Cancer Genome Atlas Breast Invasive Carcinoma SMPD2 0.04 0.07 lasso 4 0.07 8.8e-14 6.1 6.2 5.2e-10 0.05 0.01 0.99 FALSE
70 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SMPD2 0.07 0.08 blup 45 0.07 2.3e-04 6.1 6.2 5.2e-10 0.04 0.03 0.93 FALSE
71 The Cancer Genome Atlas Colon Adenocarcinoma SMPD2 0.17 0.14 lasso 4 0.14 2.3e-08 5.3 5.4 5.9e-08 0.04 0.04 0.96 FALSE
72 The Cancer Genome Atlas Esophageal Carcinoma C6orf182 0.10 -0.01 blup 40 0.03 4.2e-02 4.7 7.2 6.6e-13 -0.52 0.02 0.19 FALSE
73 The Cancer Genome Atlas Esophageal Carcinoma SMPD2 0.12 0.09 blup 41 0.07 2.6e-03 6.2 6.4 1.7e-10 0.07 0.02 0.81 FALSE
74 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma AKD1 0.07 0.06 blup 116 0.06 4.2e-07 6.2 -5.6 1.7e-08 -0.13 0.02 0.98 FALSE
75 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SMPD2 0.09 0.09 blup 42 0.10 2.1e-11 6.4 5.8 5.7e-09 0.01 0.01 0.99 FALSE
76 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AKD1 0.11 0.08 lasso 5 0.10 5.8e-11 6.1 -6.1 1.2e-09 -0.08 0.02 0.98 FALSE
77 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SMPD2 0.05 0.07 lasso 4 0.06 9.6e-08 5.3 6.0 1.6e-09 0.04 0.01 0.99 FALSE
78 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma AKD1 0.11 0.06 lasso 3 0.06 2.7e-04 5.8 -5.9 4.1e-09 -0.09 0.03 0.97 FALSE
79 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SMPD2 0.12 0.15 enet 6 0.14 3.8e-08 6.1 6.1 1.0e-09 0.05 0.02 0.98 FALSE
80 The Cancer Genome Atlas Brain Lower Grade Glioma AKD1 0.12 0.11 lasso 6 0.12 9.8e-14 5.8 -5.7 1.5e-08 -0.08 0.09 0.91 FALSE
81 The Cancer Genome Atlas Brain Lower Grade Glioma MICAL1 0.08 0.11 lasso 4 0.12 1.8e-13 5.3 -5.7 1.0e-08 -0.04 0.05 0.95 FALSE
82 The Cancer Genome Atlas Brain Lower Grade Glioma ZBTB24 0.04 0.05 lasso 4 0.04 7.8e-06 6.1 -6.2 5.8e-10 -0.10 0.04 0.96 FALSE
83 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PPIL6 0.07 0.03 blup 53 0.02 5.8e-02 6.1 -6.4 1.2e-10 -0.07 0.02 0.61 FALSE
84 The Cancer Genome Atlas Lung Adenocarcinoma AKD1 0.05 0.03 blup 122 0.04 1.3e-05 6.2 -6.0 1.6e-09 -0.06 0.02 0.98 FALSE
85 The Cancer Genome Atlas Lung Adenocarcinoma SMPD2 0.06 0.09 enet 11 0.08 4.7e-10 6.1 6.3 2.8e-10 0.08 0.01 0.99 FALSE
86 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AKD1 0.06 0.07 lasso 4 0.05 2.8e-06 6.0 -5.3 1.1e-07 -0.13 0.05 0.95 FALSE
87 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SMPD2 0.04 0.06 blup 45 0.06 8.9e-08 6.5 6.7 2.7e-11 0.06 0.01 0.99 FALSE
88 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma AKD1 0.04 0.03 blup 114 0.03 4.7e-03 5.8 -6.0 1.9e-09 -0.12 0.05 0.69 FALSE
89 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SMPD2 0.06 0.05 lasso 3 0.06 9.2e-05 6.1 5.7 1.2e-08 0.03 0.02 0.97 FALSE
90 The Cancer Genome Atlas Pancreatic Adenocarcinoma SESN1 0.17 0.01 blup 45 0.02 5.5e-02 -7.3 6.2 5.9e-10 -0.77 0.01 0.52 FALSE
91 The Cancer Genome Atlas Pancreatic Adenocarcinoma SMPD2 0.08 0.07 lasso 3 0.05 3.3e-03 6.1 6.1 8.7e-10 0.05 0.02 0.93 FALSE
92 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SMPD2 0.10 0.04 lasso 2 0.07 1.2e-03 5.3 5.4 8.7e-08 0.04 0.01 0.72 FALSE
93 The Cancer Genome Atlas Prostate Adenocarcinoma SESN1 0.02 0.04 lasso 4 0.04 1.1e-04 -7.4 -7.4 1.7e-13 0.96 0.02 0.97 TRUE
94 The Cancer Genome Atlas Prostate Adenocarcinoma SMPD2 0.08 0.13 lasso 3 0.13 2.4e-13 6.1 6.1 1.1e-09 0.05 0.05 0.95 FALSE
95 The Cancer Genome Atlas Rectum Adenocarcinoma ARMC2 0.38 0.00 blup 88 0.08 7.2e-03 -2.5 6.5 6.4e-11 -0.63 0.01 0.21 FALSE
96 The Cancer Genome Atlas Rectum Adenocarcinoma SMPD2 0.13 0.08 lasso 2 0.06 1.5e-02 6.1 6.1 8.2e-10 0.05 0.01 0.47 FALSE
97 The Cancer Genome Atlas Stomach Adenocarcinoma AKD1 0.03 0.03 blup 121 0.02 6.3e-03 6.1 -5.6 2.6e-08 -0.14 0.03 0.81 FALSE
98 The Cancer Genome Atlas Stomach Adenocarcinoma SMPD2 0.07 0.07 blup 44 0.08 3.4e-06 6.1 6.2 4.5e-10 0.09 0.04 0.96 FALSE
99 The Cancer Genome Atlas Testicular Germ Cell Tumors SMPD2 0.23 0.13 lasso 5 0.17 1.4e-06 5.8 5.1 3.0e-07 0.11 0.04 0.95 FALSE
100 The Cancer Genome Atlas Thyroid Carcinoma CD164 0.03 0.01 blup 49 0.01 2.1e-02 6.1 7.7 1.5e-14 0.00 0.02 0.80 TRUE
101 The Cancer Genome Atlas Thyroid Carcinoma SMPD2 0.15 0.17 enet 14 0.18 9.4e-18 6.1 6.1 1.3e-09 0.00 0.02 0.98 FALSE