Best TWAS P=9.29e-13 · Best GWAS P=3.62e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SKAP2 | 0.12 | 0.08 | lasso | 1 | 0.08 | 1.7e-09 | -7.1 | 7.1 | 9.3e-13 | -0.99 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Brain Cortex | SKAP2 | 0.27 | -0.01 | lasso | 11 | 0.00 | 4.5e-01 | -6.5 | 6.6 | 3.2e-11 | -0.83 | 0.03 | 0.77 | FALSE |
| 3 | METSIM | Adipose | HOXA2 | 0.06 | 0.02 | enet | 26 | 0.04 | 9.9e-07 | 3.3 | -5.2 | 2.2e-07 | 0.50 | 0.47 | 0.52 | FALSE |
| 4 | METSIM | Adipose | HOXA4 | 0.04 | 0.02 | blup | 391 | 0.02 | 8.3e-04 | -7.3 | -6.2 | 4.4e-10 | 0.79 | 0.02 | 0.98 | FALSE |
| 5 | NTR | Blood | C7orf71 | 0.02 | 0.01 | blup | 441 | 0.01 | 5.6e-03 | -6.5 | -6.7 | 2.1e-11 | 0.76 | 0.02 | 0.97 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | SKAP2 | 0.15 | 0.14 | bslmm | 626 | 0.14 | 4.0e-17 | -7.1 | 7.0 | 3.2e-12 | -0.95 | 0.01 | 0.99 | FALSE |
| 7 | YFS | Blood | HOXA5 | 0.07 | 0.09 | lasso | 8 | 0.10 | 3.4e-32 | 3.4 | -5.2 | 1.7e-07 | 0.59 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | JAZF1 | 0.12 | 0.09 | lasso | 4 | 0.09 | 2.1e-09 | 5.3 | 5.4 | 5.4e-08 | -0.01 | 0.00 | 1.00 | TRUE |