TWAS hub - JAZF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1700	0.0660	0.00860	-0.003	NA	0.055	NA	0.012	5.0e-01	NA	5.8e-04	NA	7.1e-02
2	METSIM	Adipose	0.0397	0.0183	0.01900	0.018	0.003	0.012	0.010	0.017	9.6e-04	1.0e-01	5.6e-03	9.5e-03	1.2e-03
3	YFS	Blood	0.2416	0.0297	0.00000	0.117	0.151	0.167	0.153	0.161	2.3e-36	3.8e-47	3.0e-52	1.5e-47	2.7e-50
4	TCGA	Breast Invasive Carcinoma	0.0434	0.0165	0.00012	0.025	0.026	0.010	NA	0.019	5.6e-06	3.8e-06	3.6e-03	NA	6.0e-05
5	TCGA	Glioblastoma Multiforme	0.2390	0.0790	0.00150	0.076	0.072	0.066	NA	0.068	2.5e-03	3.3e-03	4.7e-03	NA	4.2e-03
6	TCGA	Thyroid Carcinoma	0.1210	0.0410	0.00003	0.091	0.071	0.089	NA	0.094	3.3e-09	2.1e-07	5.1e-09	NA	2.1e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood White Count	10.8	80.4	275.6	-4.5	-13.3	-16.6	2.5	0.9	1.5
Diabetes (self-reported)	10.7	16.5	53.6	-4.4	-2.2	0.2	2.4	4.0	7.3
Medication: Metformin	10.5	14.8	47.8	-5.0	-1.4	0.7	1.2	3.4	6.9
Type 2 Diabetes (T2D) (2012)	10.2	11.8	31.1	-3.0	-1.0	2.0	2.4	4.5	5.6
Type 2 Diabetes (T2D) (2018)	10.2	19.1	64.8	-4.2	-2.1	1.2	3.0	4.2	8.0
Diabetes diagnosed by doctor	10.2	16.7	58.6	-4.3	-1.3	1.4	1.7	4.1	7.7
Respiratory disease	8.7	19.4	45.8	-5.1	-2.1	1.2	4.8	6.8	3.9
Allergy or Eczema	8.6	22.7	52.0	-5.4	-2.3	0.9	5.2	7.2	4.6
Hayfever, allergic rhinitis or eczema	8.2	17.9	38.8	-4.5	-1.8	1.5	5.4	6.2	3.7
Asthma (self-reported)	7.8	15.6	29.4	-3.8	-3.5	0.1	4.8	5.4	3.8
Allergy	7.4	17.0	37.3	4.0	2.1	-2.0	-4.5	-6.1	-4.5
Asthma	7.4	14.6	26.5	-3.5	-3.4	-0.0	4.7	5.2	3.9
Height	5.8	111.8	605.2	-6.3	0.9	5.0	0.2	0.1	24.6
Impedance of leg (left)	5.6	27.4	90.4	-4.8	-1.9	2.1	6.2	2.0	9.5
Waist Hip Ratio (WHR)	5.5	24.7	95.6	-4.4	-2.1	1.1	3.6	3.8	9.8
Impedance of leg (right)	5.3	25.5	85.4	-4.5	-1.8	2.3	5.8	2.4	9.2
Standing height	5.2	51.6	295.8	-2.2	0.4	3.0	0.1	0.3	17.2
Impedance of whole body	4.5	22.9	73.3	-4.1	-1.5	2.0	6.2	1.8	8.6
Wheeze or whistling in the chest in last year	4.1	7.4	16.6	-4.0	-1.1	0.3	0.1	4.1	3.2
Comparative height size at age 10	4.1	22.5	127.7	-1.8	0.5	1.7	0.8	-0.5	11.3
Medication: Gliclazide	4.0	4.5	16.1	-2.7	0.1	1.0	0.3	1.6	4.0
Lung FVC	3.9	20.0	82.8	3.8	1.8	-2.9	-1.7	-3.0	-9.1
Crohns Disease (2017)	3.8	8.4	15.8	-3.9	-1.9	-0.9	2.8	2.8	4.0
Lupus	3.8	5.7	10.4	-2.3	0.5	2.9	1.6	2.8	3.2
Number of self-reported non-cancer illnesses	3.8	6.5	13.5	-3.2	-0.5	1.6	1.7	3.1	3.7
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.6	40.7	-0.8	-1.3	0.4	-0.4	1.6	6.4
Diabetes (father)	3.6	4.4	14.7	-2.0	-0.8	0.7	2.2	1.2	3.8
Medication: Cholesterol lowering	3.6	5.6	9.3	-3.1	-1.8	-0.5	2.5	2.6	2.8
Diabetes (mother)	3.4	4.4	9.7	-2.3	-1.3	0.1	1.4	2.8	3.1
Impedance of arm (left)	3.2	14.8	46.0	-2.7	-0.5	2.1	5.4	1.3	6.8
Basal cell carcinoma (self-reported)	3.1	3.6	9.5	3.1	0.8	0.5	-2.1	-0.9	-2.5
Prostate Cancer	3.0	4.3	14.2	1.9	-0.7	1.6	3.8	-2.2	0.5
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	10.4	3.0	1.0	0.2	-2.1	-2.4	-3.2
Mouth/teeth dental problems: Mouth ulcers	2.7	4.2	15.7	-0.7	2.9	4.0	0.9	0.3	0.4
Worrier / anxious feelings	2.6	5.0	15.6	1.3	3.2	4.0	-0.8	1.2	-0.2
Medication: Blood pressure	2.6	4.6	10.1	-3.0	-1.1	-0.5	2.2	1.6	3.2
Alzheimer’s Disease (including proxy)	2.5	3.7	6.7	2.0	-0.1	-1.4	-2.6	-2.0	-2.4
Angina	2.5	3.2	7.1	-2.7	-0.6	1.7	0.5	2.2	2.0
Rheumatoid Arthritis	2.4	3.3	9.4	1.1	1.0	0.4	-3.1	-2.5	1.2
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.6	18.6	-0.3	2.8	1.2	-4.3	1.1	-2.1
Impedance of arm (right)	2.4	11.3	35.8	-2.6	-0.4	2.0	4.5	1.1	6.0
Angina (self-reported)	2.4	3.2	7.6	-2.8	-0.7	1.6	0.3	2.2	1.8
Pulse rate, automated reading	2.4	7.6	17.4	-0.4	-1.5	1.9	3.3	3.4	4.2
Medication: Aspirin	2.4	3.2	8.5	-1.7	-1.7	-0.3	1.9	1.1	2.9
Breast Cancer	2.3	5.5	10.5	-3.2	-0.3	1.5	2.0	3.0	2.7
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	14.7	0.3	3.1	1.3	-3.8	0.4	-2.2
Pulse rate	2.3	3.9	8.1	-0.5	-2.2	0.6	2.1	2.3	2.9
Medication: Ventolin 100micrograms inhaler	2.3	3.0	10.2	-0.9	-3.2	-0.8	0.1	1.9	1.6
Medication: Atorvastatin	2.3	2.8	4.5	-2.0	-0.4	1.1	1.9	1.8	2.1
Medication: Ramipril	2.2	2.8	10.7	-1.9	-1.0	-0.6	0.3	0.8	3.3
Medication: Aspirin	2.2	2.9	6.7	-1.2	-2.0	-0.4	1.9	1.2	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	17.5	1.4	1.5	-0.9	-0.1	-2.4	-4.2
Alzheimer’s Disease (in mother)	2.0	2.4	4.1	2.0	1.4	0.3	-1.9	-1.2	-1.8
Irritable Bowel Disease (IBD)	2.0	4.7	8.1	-2.8	-1.3	-1.3	2.8	1.0	2.8
HbA1C	2.0	2.2	5.7	-1.6	-0.7	0.6	0.3	2.0	2.4
Sitting height	2.0	14.0	40.1	3.2	2.0	2.1	-4.7	-1.6	6.3
Health satisfaction	2.0	2.6	6.3	-0.1	-2.5	-1.0	0.9	2.0	1.9
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.5	5.4	-1.4	-1.7	-1.1	1.6	0.7	2.3
Knee pain experienced in last month	2.0	3.1	8.8	-1.9	0.7	1.4	0.5	1.9	3.0
Commuting to job workplace: Public transport	2.0	2.3	5.1	2.2	0.2	0.5	-1.7	-1.8	-1.6
Worry (Nagel 2018)	1.9	4.0	10.2	2.0	3.2	2.9	-0.8	0.6	0.4
Crohns Disease (2012)	1.9	3.0	10.4	-1.7	-1.5	-0.5	0.9	1.1	3.2
Hair Pigment	1.9	53.4	204.5	-5.3	-4.1	1.3	6.2	5.5	14.3
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	5.0	0.3	2.0	1.2	-2.2	-0.6	-1.4
Medication: Levothyroxine sodium	1.9	3.2	6.6	-0.8	2.5	1.9	-2.6	-0.2	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	6.0	0.6	2.2	2.5	0.4	-0.1	1.4
Age at last live birth	1.9	2.8	4.5	-2.1	-1.5	-2.1	1.3	1.9	0.6
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.2	-1.9	-1.1	-0.5	-0.5	2.3	1.5
Cardiovascular Disease	1.8	6.0	9.2	-3.0	-2.7	-0.3	2.6	2.0	3.0
Tanning	1.8	22.2	74.9	-4.9	-1.7	0.5	4.4	3.3	8.7
Multivitamins +/- minerals	1.8	2.3	5.1	-1.1	-1.7	-1.2	1.4	2.2	-1.0
Hair/balding pattern: Pattern 2	1.8	2.3	4.7	-1.0	1.5	1.4	-1.9	2.2	-0.4
Back pain experienced in last month	1.8	2.6	7.7	2.4	0.5	-0.7	0.1	-2.8	-1.2
Medication: Simvastatin	1.7	2.4	4.5	-2.1	-0.5	0.7	1.7	1.9	1.8
Neuroticism score	1.7	3.6	9.5	2.3	1.9	3.1	-1.1	0.4	1.2
Mean Putamen Volume	1.6	1.8	2.9	-0.9	-1.6	-1.5	1.7	1.5	0.3
Systolic Blood Pressure	1.6	8.2	17.2	-2.3	-3.4	-0.2	2.2	3.2	4.2
Relative age of first facial hair	1.6	3.3	9.4	-1.3	-1.1	1.4	1.5	1.8	3.1
Exposure to tobacco smoke outside home	1.6	2.1	5.5	-1.3	0.1	1.4	1.8	0.7	2.4
Hypertension (Self-reported)	1.6	4.5	8.7	-2.7	-1.8	-1.3	1.8	1.7	2.9
Illnesses of siblings: Diabetes	1.6	2.0	8.1	-0.1	0.7	1.8	0.4	-0.2	2.8
Vascular/heart problems diagnosed by doctor	1.6	4.4	7.7	2.8	2.0	1.0	-1.5	-1.9	-2.8
Heel T-Score	1.5	11.9	50.8	-0.8	2.3	-0.1	-7.1	1.5	-3.5
Sensitivity / hurt feelings	1.5	2.5	5.5	0.9	2.1	2.4	-0.3	-0.7	2.0
High blood pressure	1.5	4.1	7.8	-2.6	-1.7	-1.1	1.8	1.7	2.8
Hair/balding pattern: Pattern 4	1.5	3.6	7.1	2.5	-1.5	-1.2	-0.4	-2.2	-2.7
Medication: Seretide 50 evohaler	1.5	1.8	4.3	-1.4	-2.1	-1.6	0.8	1.1	0.2
Illnesses of father: Heart disease	1.5	2.1	6.4	-0.3	0.2	1.2	2.1	2.5	0.4
Handedness (chirality/laterality): Left-handed	1.5	1.8	7.1	0.7	1.0	0.3	-2.7	-1.4	0.4
Neuroticism (Nagel 2018)	1.4	3.2	9.7	0.6	1.9	3.1	-0.6	0.9	2.1
Blood Eosinophil Count	1.4	10.5	29.6	-3.4	0.3	3.8	0.6	2.7	5.4
Neuroticism	1.4	3.3	7.9	2.0	2.3	2.8	-1.2	0.6	1.0
Number of treatments/medications taken	1.4	2.4	6.7	-1.3	-0.8	0.2	0.5	2.3	2.6
Ever had hysterectomy (womb removed)	1.4	1.5	5.9	0.2	2.4	0.7	-1.1	-0.5	-1.2
Taking other prescription medications	1.4	2.1	5.9	-1.7	-0.2	0.8	-0.3	1.7	2.4
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.2	0.3	-0.4	-1.5	0.9	-1.7	-2.0
Body mass index (BMI)	1.4	6.1	19.8	0.4	0.7	-0.9	-3.9	-0.4	-4.5
Trunk fat-free mass	1.4	7.9	32.8	0.4	1.0	1.1	-3.5	-0.4	5.7
Trunk predicted mass	1.4	7.8	33.4	0.3	1.0	1.0	-3.3	-0.4	5.8
Average weekly red wine intake	1.4	2.1	3.7	1.6	1.9	0.6	-1.4	-1.9	0.7
BMI	1.3	7.4	27.0	0.9	-0.4	-1.3	-3.8	-0.3	-5.2
Qualifications: CSEs or equivalent	1.3	1.8	3.8	-1.4	-1.0	-0.5	-0.0	1.9	2.0
Number of incorrect matches in round	1.3	2.2	8.6	-1.6	-1.0	-0.5	2.9	1.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.9	0.1	1.9	2.0	-0.9	1.6	0.9
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	7.5	-0.0	2.3	1.5	-2.7	-0.2	0.0
Number of full brothers	1.3	1.6	3.0	-1.3	1.7	1.7	0.2	-0.5	1.4
Medication: Allopurinol	1.3	1.8	3.4	1.8	-1.8	0.2	-1.8	-0.2	0.7
Heart disease (mother)	1.3	1.5	4.2	-0.9	-0.5	-0.9	2.0	1.2	1.4
Medication for cholesterol	1.3	2.0	6.4	1.4	-0.3	-1.2	-0.5	-1.5	-2.5
Supplements: Fish oil (including cod liver oil)	1.3	1.7	5.1	-2.3	-0.5	-1.2	1.4	1.1	-0.2
High cholesterol (Self-reported)	1.3	2.3	5.5	-1.7	-0.5	0.1	2.3	1.7	1.6
Intelligence (Savage-Jansen 2018)	1.2	3.8	10.6	2.2	-0.2	-0.7	-3.2	-1.4	-2.3
Bipolar Disorder (2011)	1.2	1.2	5.4	0.2	0.2	1.0	0.6	2.3	0.6
Hearing difficulty/problems: Yes	1.2	1.9	7.4	2.7	-1.0	-0.2	0.2	-1.6	0.5
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.9	-0.5	2.2	1.6	-0.6	0.9	-0.5
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	7.2	-0.7	0.1	0.1	0.3	-0.5	2.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.4	-1.6	-0.5	-0.0	0.3	2.3	1.0
Time employed in main current job	1.2	1.4	5.5	-1.1	2.4	0.5	-0.3	-0.7	0.9
Comparative body size at age 10	1.2	3.3	8.9	0.9	2.1	1.4	-1.8	-0.5	-3.0
Smoking status: Previous	1.2	1.8	8.8	-0.9	-0.1	0.3	-3.0	0.8	0.6
Average weekly champagne plus white wine intake	1.2	1.6	4.7	0.9	1.2	0.2	-0.5	-2.2	-1.6
Verbal and Numeric Reasoning (VNR)	1.1	2.6	5.8	2.4	-1.0	-0.8	-2.4	-1.0	-1.2
Age at First Birth	1.1	1.6	5.7	-2.4	0.6	0.1	1.7	0.8	-0.5
Coronary Artery Disease (CAD)	1.1	1.3	3.1	0.8	-1.6	-0.2	0.7	1.8	1.0
Hypothyroidism (self reported)	1.1	2.4	9.9	0.2	1.5	1.3	-3.1	-0.7	-0.2
Hand grip strength (left)	1.1	2.9	8.1	1.0	1.2	-1.6	-2.9	-1.8	1.2
Supplements: Zinc	1.1	1.2	3.7	-0.2	-0.5	-1.1	1.3	-0.6	-1.9
Severe depression (siblings)	1.1	1.2	3.3	-1.6	-0.3	0.1	0.2	1.8	1.1
Serious illness, injury or assault to yourself	1.1	1.3	3.4	1.7	-1.1	-0.2	1.8	-0.5	-0.0
Past tobacco smoking	1.1	2.0	10.7	0.4	-0.2	-0.2	3.3	-0.7	-0.6
Illnesses of mother	1.1	1.4	3.6	-0.8	-0.2	-0.1	-1.0	-1.7	-1.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	7.8	2.8	-0.3	0.2	-0.7	-0.2	-0.6
Medication: Amlodipine	1.1	1.6	5.3	-1.3	-0.3	-0.5	0.7	1.3	2.3
Arm fat-free mass (right)	1.1	5.7	20.2	0.1	0.2	0.0	-3.7	-0.4	4.5
Arm predicted mass (right)	1.1	5.7	19.8	-0.1	0.5	0.3	-3.7	-0.5	4.5
Whole body fat-free mass	1.1	6.3	19.4	0.6	0.9	0.5	-4.1	-0.6	4.4
Commuting to job workplace: Walk	1.1	1.1	3.3	0.2	1.1	1.8	0.1	1.0	-1.1
Eye problems/disorders: Cataract	1.1	1.3	2.8	-1.2	-1.5	-1.7	0.6	0.7	0.8
Whole body water mass	1.1	6.1	17.9	0.7	0.9	0.4	-4.1	-0.6	4.2
Medication: Bendroflumethiazide	1.1	1.6	4.5	-1.5	-0.4	-0.1	0.2	2.1	1.7
Basal metabolic rate	1.1	6.1	18.4	0.3	0.7	0.3	-4.2	-0.4	4.3
Arm fat-free mass (left)	1.1	5.4	17.8	-0.2	0.3	-0.1	-3.8	-0.4	4.2
Risk taking	1.1	1.6	3.1	-1.0	-1.7	-1.8	0.5	1.1	-1.0
Age started oral contraceptive pill	1.1	1.4	6.1	0.2	0.7	-0.4	-0.8	-1.1	-2.5
Commuting to job workplace: Cycle	1.1	1.3	3.3	1.3	0.4	-0.7	-0.7	-1.8	-1.3
Body Mass Index (BMI) (2010)	1.0	1.3	2.5	1.4	1.0	0.6	-1.6	0.4	-1.4
Ulcerative Colitis	1.0	1.5	3.3	1.2	-0.6	-1.7	0.2	-1.8	-0.9
High blood pressure (mother)	1.0	1.5	3.1	0.9	-0.1	1.8	1.0	1.7	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.8	-0.2	-2.1	-0.7	-0.0	2.2	0.4
Glaucoma (self-reported)	1.0	1.2	3.4	0.1	-1.7	-1.8	-0.5	-0.6	-0.7
Gout (self-reported)	1.0	1.4	4.0	1.3	-1.3	-0.6	-2.0	0.7	0.3
Number of children fathered	1.0	1.1	3.0	-1.7	1.2	0.7	0.7	0.1	1.0
Age at first live birth	1.0	1.9	4.4	-2.1	-0.9	-1.7	1.1	1.3	-0.5
Neck or shoulder pain in last month	1.0	1.4	2.9	-0.8	1.7	1.2	-0.6	-0.3	1.6
Unable to work because of sickness or disability	1.0	1.3	4.3	-0.4	-1.7	0.0	-2.1	0.6	0.7
Supplements: Calcium	1.0	1.1	3.3	-1.2	-0.7	0.2	1.8	0.8	0.9
Alcohol drinker status: Previous	1.0	1.2	4.3	-0.8	-1.1	-0.5	-2.1	0.7	-0.6
Arm predicted mass (left)	1.0	5.2	16.6	-0.1	0.4	-0.1	-3.8	-0.5	4.1
Depressed Affect (Nagel 2018)	0.9	2.0	6.5	0.6	0.7	2.5	-1.7	1.0	0.9
Alzheimer’s Disease (in father)	0.9	1.0	3.4	-0.2	-1.4	-1.8	-0.8	-0.4	0.1
Triglycerides	0.9	1.5	4.1	-0.4	-2.0	-0.3	0.8	1.2	1.6
Systolic blood pressure, automated reading	0.9	2.6	5.7	-1.9	-2.4	-0.8	1.4	1.7	0.8
Leg fat-free mass (left)	0.9	4.8	21.3	0.9	1.0	-0.1	-4.6	-0.5	2.3
Townsend deprivation index at recruitment	0.9	1.3	6.0	0.8	0.3	0.7	-2.4	0.0	-0.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.5	1.3	-0.5	0.6	0.2	-0.2	1.9
Leg predicted mass (left)	0.9	4.7	20.9	1.0	1.0	-0.0	-4.6	-0.5	2.3
Trunk fat mass	0.9	4.0	12.3	-2.3	1.0	0.8	-2.1	0.4	3.5
Nervous feelings	0.9	1.7	3.5	1.9	1.8	1.8	-0.3	0.8	0.1
Mouth/teeth dental problems	0.9	1.4	2.5	0.1	-1.3	-1.2	1.6	0.6	-1.5
Weight	0.9	4.5	13.8	-0.5	0.8	0.5	-3.7	-0.2	3.4
Happiness	0.9	1.1	3.3	1.5	-1.8	-0.2	1.1	0.4	0.2
Medication: Lansoprazole	0.9	1.0	4.2	-0.4	0.8	0.1	-2.0	-0.8	-0.4
Pulse wave Arterial Stiffness index	0.9	1.1	2.7	0.5	-0.2	1.5	-0.0	1.1	1.6
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.8	0.2	1.7	1.4	0.9	-0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.7	-1.9	-0.3	0.2	-0.2	1.3	0.7
Eye problems/disorders: None of the above	0.9	1.0	4.1	-0.2	2.0	1.1	0.0	0.4	-0.8
Suffer from ‘nerves’	0.9	1.5	3.0	1.3	0.9	1.7	-1.0	0.7	1.4
Overall health rating	0.9	1.8	6.7	-0.2	-0.5	1.3	-0.9	1.3	2.6
Chest pain or discomfort	0.9	1.3	5.6	0.3	0.0	1.0	0.9	0.6	2.4
Had major operations	0.9	1.0	2.9	-1.1	-1.7	-0.4	0.8	1.1	0.4
Leg fat-free mass (right)	0.9	4.8	20.4	1.2	1.1	-0.1	-4.5	-0.9	2.3
Long-standing illness, disability or infirmity	0.9	1.4	5.7	-0.9	-1.2	-0.0	-0.8	-0.5	2.4
Leg predicted mass (right)	0.9	4.8	19.8	1.3	1.0	-0.3	-4.5	-0.9	2.3
Wears glasses or contact lenses	0.9	1.0	2.9	-0.7	1.7	1.4	-0.7	-0.3	0.6
Hearing aid user	0.9	1.0	3.5	-0.5	0.7	-0.0	0.7	-1.2	-1.9
Financial situation satisfaction	0.9	1.1	4.1	1.4	-2.0	0.3	-0.0	0.4	0.5
Cholesterol lowering medication	0.9	1.3	3.7	-0.3	0.8	1.9	1.0	1.1	1.3
Heart disease (siblings)	0.9	1.2	4.3	-0.2	0.4	2.1	-0.4	1.4	0.7
Ovarian Cancer	0.8	1.1	3.1	0.2	-0.8	-0.1	-1.8	-0.2	1.7
Medication: Co-codamol	0.8	0.9	2.8	-1.3	0.4	0.6	-0.5	-0.2	1.7
Hearing difficulty/problems with background noise	0.8	1.2	4.4	2.1	-0.0	0.3	0.1	-0.3	1.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.8	-0.2	-1.3	-1.4	1.0	-1.0	0.1
Pain all over the body in last month	0.8	0.8	1.7	0.9	-0.7	-0.7	-1.3	-0.7	-1.0
Noisy workplace	0.8	0.9	3.9	0.1	-2.0	-1.3	0.1	-0.1	-0.0
Lung cancer (father)	0.8	0.9	3.5	1.1	0.3	0.5	-0.1	-0.4	1.9
Pulse wave reflection index	0.8	1.0	2.9	0.7	1.1	0.5	-0.4	-0.8	-1.7
Leg pain on walking	0.8	0.9	3.5	-1.2	0.1	0.2	0.8	0.3	1.9
Loneliness, isolation	0.8	1.1	4.2	0.6	-0.2	1.3	-2.0	0.3	-0.4
Guilty feelings	0.8	1.2	2.9	1.7	-0.0	1.7	0.8	0.5	0.8
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.8	1.7	-1.4	-0.6	-0.3	-0.2	-0.2
Eye problems/disorders: Glaucoma	0.8	0.9	2.5	1.1	0.0	-0.2	-1.3	-1.6	-0.5
Medication: Blood pressure	0.8	1.6	6.0	-0.7	-0.7	0.4	1.1	1.2	2.4
Ever smoked	0.8	1.4	6.5	-0.2	0.3	0.2	-2.5	0.4	1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.5	-1.5	-1.9	-0.6	-0.0	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	-1.2	-0.5	-1.0	-0.0	-1.1	1.3
Medication for hormone replacement therapy	0.7	0.8	1.7	0.1	1.3	1.2	-0.9	0.6	0.4
Vitamin and mineral supplements	0.7	0.9	3.4	0.0	0.2	0.4	-0.2	-1.3	1.8
Average weekly fortified wine intake	0.7	0.8	2.4	1.6	-0.0	-0.2	0.5	-1.4	0.3
Maternal smoking around birth	0.7	0.9	3.8	-0.4	1.2	0.3	-0.4	-1.9	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	3.5	1.2	-0.4	-0.3	-1.9	0.7	-0.3
Alcohol usually taken with meals	0.7	1.1	3.0	0.9	1.1	-0.6	-0.5	-1.7	-0.9
Financial difficulties in last 2 years	0.7	1.0	2.1	1.3	-1.4	-1.1	0.2	0.7	-0.6
Heart attack	0.7	0.9	3.6	-1.3	-1.9	-0.5	-0.2	-0.2	-0.4
Hip circumference	0.7	3.0	15.2	0.9	0.8	0.3	-3.9	-1.0	0.2
Alcohol intake versus 10 years previously	0.7	1.0	3.1	-0.7	-1.2	0.3	0.3	1.8	0.7
Depression (self-reported)	0.7	0.9	2.3	1.5	1.1	0.4	-1.2	-0.2	-0.1
Exposure to tobacco smoke at home	0.7	0.8	2.9	1.7	0.2	0.9	-0.9	0.5	-0.3
Tense / ‘highly strung’	0.7	1.2	3.1	1.5	1.8	0.8	-0.3	0.9	-0.4
Blood clot in the leg (DVT)	0.7	0.8	2.7	0.7	0.3	0.8	-1.1	-1.6	0.3
Forced vital capacity (FVC), Best measure	0.7	2.6	14.2	-0.2	0.1	-0.3	0.3	-1.1	3.8
Medication for pain relief, constipation, heartburn	0.7	1.3	5.3	0.7	0.8	-0.2	-0.9	-0.7	-2.3
Mean time to correctly identify matches	0.7	1.3	3.3	0.3	0.5	-1.1	1.6	-0.5	-1.8
Whole body fat mass	0.7	3.0	6.2	-2.2	1.0	0.7	-2.4	0.4	2.5
Alcohol intake frequency.	0.7	1.7	4.7	-0.7	-1.6	0.3	1.4	2.2	-0.6
Number of full sisters	0.7	0.8	3.5	1.9	-0.6	-0.4	-0.8	0.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.4	-0.7	0.5	1.0	1.2	1.1	0.4
Qualifications: nursing, teaching	0.7	1.1	2.2	-0.6	0.5	1.5	-0.9	1.4	0.9
Mineral and other dietary supplements	0.7	0.9	1.6	1.2	0.4	0.6	-1.2	-1.2	0.7
Medication: Paracetamol	0.7	1.1	4.3	-0.4	-2.1	-1.0	0.4	0.6	0.8
Irritability	0.7	1.2	2.3	1.4	-0.4	1.5	0.6	-0.2	1.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.5	0.8	-0.8	-0.1	1.9	0.2	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.6	0.6	0.4	0.5	-1.1	-1.9	0.1
Depression (Nagel 2018)	0.6	0.9	2.0	1.1	0.2	0.8	-1.0	1.4	0.8
Schizophrenia vs Biploar Disorder	0.6	0.8	4.7	-0.4	-0.2	0.0	2.2	-0.5	0.0
Ulcerative Colitis (UC)	0.6	1.1	2.3	0.1	-0.6	-1.4	1.4	-1.5	0.2
Reaction Time	0.6	1.1	2.6	0.5	-0.1	-0.8	1.5	0.9	-1.6
Primary Biliary Cirrhosis	0.6	0.8	2.7	0.1	0.8	1.1	-0.7	0.2	1.6
Average weekly spirits intake	0.6	0.8	2.1	1.1	1.5	-0.2	-1.0	-0.6	-0.1
Hand grip strength (right)	0.6	1.7	6.3	0.7	1.4	-0.2	-2.5	-0.4	1.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	0.6	0.7	0.0	-0.3	-1.3	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.4	0.7	-1.6	-0.4	-0.7	1.6	0.1
Illnesses of siblings	0.6	0.8	1.7	0.8	-0.9	-1.3	-0.4	-0.0	-1.2
Falls in the last year	0.6	0.8	3.2	-1.8	-0.7	0.7	0.4	-0.5	0.6
Length of working week for main job	0.6	0.7	2.2	0.0	0.3	1.5	-0.9	0.9	-0.6
Birth weight of first child	0.6	1.0	1.4	1.2	-0.7	-0.9	1.0	1.1	1.1
Medication: Paracetamol	0.6	0.9	2.6	-0.8	-1.6	-0.5	1.1	0.8	0.5
Pulse wave peak to peak time	0.6	0.7	1.9	-0.8	0.2	-1.4	0.1	-1.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.8	1.7	-0.4	-0.8	0.1	-0.3	-0.8
Migraine (self-reported)	0.6	0.7	2.2	-0.2	-1.2	0.1	-0.3	0.7	-1.5
Leg fat mass (right)	0.6	2.3	7.7	-1.6	0.9	0.7	-2.8	0.7	1.3
Osteoarthritis (self-reported)	0.6	0.8	3.4	-0.5	-0.4	0.8	0.6	0.0	1.9
Miserableness	0.6	1.0	3.9	0.4	0.9	2.0	-0.5	0.8	0.6
Mother’s age at death	0.6	0.7	1.8	0.8	0.3	-0.9	-1.0	-1.3	-0.5
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.5	-0.6	0.8	1.6	0.5	0.4	1.0
Medication: Lisinopril	0.6	0.7	1.9	-1.3	0.1	0.8	-0.0	0.2	1.4
Leg fat mass (left)	0.6	2.5	7.3	-1.8	1.1	0.7	-2.7	0.7	1.4
Bipolar Disorder (2018)	0.5	0.8	2.6	-0.8	0.7	0.7	-0.4	1.6	0.7
Bipolar Disorder or Schizophrenia	0.5	1.3	3.3	-0.8	1.0	1.3	1.0	1.8	0.7
Major Depression (MDD)	0.5	0.6	1.7	-0.4	1.0	1.3	-0.8	0.2	0.2
Neuroticism (2016)	0.5	0.7	2.1	0.7	0.6	1.1	0.0	0.1	1.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	1.5	-0.8	-0.1	-0.5	1.0	-0.4
Trunk fat percentage	0.5	2.2	6.6	-2.6	0.6	0.3	-1.2	0.3	2.1
Stomach or abdominal pain in last month	0.5	0.7	3.1	0.0	-1.8	-0.2	-0.5	0.7	0.2
Supplements: Glucosamine	0.5	0.6	1.4	-0.5	0.2	-0.3	0.8	1.2	1.2
Waist circumference	0.5	1.9	6.9	-1.1	-0.0	0.0	-2.6	0.3	1.9
Had menopause	0.5	0.6	2.6	-0.4	1.6	0.5	-0.7	-0.2	-0.1
Had other major operations	0.5	0.6	2.8	0.8	0.4	0.1	0.1	0.4	1.7
Arm fat percentage (right)	0.5	1.8	4.5	-1.2	0.8	0.0	-2.1	0.0	-2.1
Mouth/teeth dental problems: Dentures	0.5	0.9	2.3	-0.6	1.4	0.5	-1.5	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	5.2	0.2	0.2	-0.4	1.2	-1.5	2.3
Arm fat mass (right)	0.5	1.9	10.2	-0.7	0.8	-0.0	-3.2	0.1	-0.3
Breastfed as a baby	0.5	0.6	2.2	0.8	0.5	-0.6	1.5	-0.4	0.1
High blood pressure (siblings)	0.5	0.7	2.3	-1.5	0.5	0.2	0.9	0.5	0.6
Leg fat percentage (right)	0.5	1.7	6.0	-2.4	0.5	0.7	-1.5	1.2	0.0
Worry too long after embarrassment	0.5	0.9	3.1	-0.2	0.9	1.0	0.6	-0.1	1.7
Family relationship satisfaction	0.5	0.6	1.9	0.7	-0.8	-0.7	-0.1	0.5	1.4
Supplements: Vitamin C	0.5	0.6	1.2	1.1	1.0	0.3	-0.6	0.0	-0.8
Mood swings	0.5	1.0	2.5	1.6	0.2	1.1	-1.3	-0.3	0.6
Ever had bowel cancer screening	0.5	0.5	1.3	-0.5	-0.3	-1.1	-0.5	-0.3	1.1
Leg fat percentage (left)	0.5	1.7	6.7	-2.6	0.7	0.7	-1.3	0.9	0.0
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.4	0.2	1.0	-0.9	1.3	0.6
Ever depressed for a whole week	0.5	0.7	1.2	0.8	-0.2	0.0	1.0	-1.1	-1.0
Schizophrenia (2018)	0.4	0.9	2.5	-0.3	0.7	1.0	1.6	1.0	0.3
Fasting Glucose	0.4	0.5	1.5	-0.3	-0.8	0.1	1.2	0.8	0.5
HDL Cholesterol	0.4	0.7	2.7	-0.4	-0.4	-0.7	0.7	-0.3	-1.7
LDL Cholesterol	0.4	0.6	2.7	0.1	0.1	-0.1	1.0	-0.1	-1.6
Schizophrenia (2014)	0.4	0.9	2.9	-0.7	-0.4	-0.1	1.7	1.3	0.2
Blood Platelet Count	0.4	4.1	10.4	-1.0	-1.3	1.1	2.0	3.2	2.4
Smoking Status	0.4	1.0	5.2	0.3	0.2	-0.5	-2.3	-0.5	-0.1
Age when periods started (menarche)	0.4	0.9	2.4	-0.9	-0.8	-1.6	-0.7	0.4	0.8
Forced vital capacity (FVC)	0.4	1.7	8.4	0.2	1.0	0.3	0.6	-0.3	2.9
Fluid intelligence score	0.4	0.8	1.6	0.1	-0.9	-0.9	-1.3	-0.2	-1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.9	1.3	0.0	0.8	0.6	-0.2
Number of live births	0.4	0.6	1.4	1.0	0.6	-0.3	0.3	-1.2	0.8
Loud music exposure frequency	0.4	0.5	1.9	-0.2	-1.4	0.0	0.3	0.7	0.6
Body fat percentage	0.4	1.5	5.5	-2.4	0.6	0.3	-1.4	0.3	1.1
Shortness of breath walking on level ground	0.4	0.5	1.7	0.5	-0.6	-0.0	-1.3	0.8	-0.4
Medication: Omeprazole	0.4	0.4	1.2	-1.1	0.6	0.4	-0.6	0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	2.1	0.5	-0.1	-0.2	-0.1	-0.4	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.9	-0.5	-0.1	-0.8	-1.0	-0.7	0.5
Friendships satisfaction	0.4	0.5	1.4	-0.1	0.4	1.1	0.2	1.2	-0.1
Smoking status: Current	0.4	0.6	1.3	0.3	0.7	-0.8	-0.7	-1.0	-1.2
Arm fat mass (left)	0.4	1.7	8.3	-0.9	1.0	0.2	-2.9	0.1	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.5	1.2	-0.6	-0.1	0.0	0.4	-1.0
Pack years of smoking	0.4	0.6	1.7	-0.8	0.4	0.8	-0.5	-1.3	0.2
Blood Red Count	0.3	3.1	8.7	-1.1	1.3	3.0	-0.7	0.8	2.4
Current tobacco smoking	0.3	0.4	0.7	0.1	0.7	-0.7	-0.6	-0.7	-0.8
Fed-up feelings	0.3	0.5	1.6	1.3	-0.0	0.7	-0.8	-0.3	0.0
Relative age voice broke	0.3	0.5	1.2	0.9	-0.1	1.1	0.8	-0.7	0.3
Father’s age at death	0.3	0.3	0.9	0.3	0.6	0.1	-0.1	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.6	0.2	0.9	0.1	1.2	-0.9	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.0	1.1	0.6	-0.5	-0.7	0.5
Peak expiratory flow (PEF)	0.3	0.7	1.3	0.2	1.2	-0.3	0.7	-1.0	-1.1
Headache pain in last month	0.3	0.5	1.0	-1.0	-0.7	0.4	-0.7	0.9	0.1
Qualifications: College or University degree	0.3	0.8	1.9	1.4	0.3	-0.3	-0.6	-1.0	-1.1
Medication: Ibuprofen	0.3	0.4	0.9	0.6	1.0	0.6	-0.3	-0.6	0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	-0.4	-0.0	-0.9	0.2	-0.1	-1.2
Arm fat percentage (left)	0.3	1.3	3.0	-1.2	0.8	0.2	-1.7	0.2	-1.6
Osteoporosis (self-reported)	0.3	0.3	0.7	0.3	-0.2	0.9	0.8	0.3	-0.7
Alcohol drinker status: Never	0.3	0.4	1.2	-0.4	0.6	-0.1	1.1	-0.2	-0.8
Number of operations (self-reported)	0.3	0.4	0.9	-0.6	0.3	0.7	-0.0	0.6	1.0
Fractured/broken bones in last 5 years	0.3	0.4	0.9	0.5	-1.0	-0.4	0.7	-0.9	-0.3
Diastolic blood pressure, automated reading	0.3	0.9	1.8	-0.5	-1.3	-0.1	0.6	1.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-1.1	0.4	0.3	-0.4	0.8	0.2
Lung FEV1/FVC ratio	0.2	1.2	4.7	-1.1	0.3	-0.0	1.0	-0.1	-2.2
Pack years adult smoking proportion	0.2	0.3	0.8	-0.5	-0.2	0.6	-0.0	-0.9	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	1.1	0.7	0.8	-0.3	-0.1	-0.8
Prospective memory result	0.2	0.2	0.5	0.7	-0.5	0.2	-0.1	0.2	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.9	0.2	-0.4	0.1	-0.3	0.9	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	-0.4	0.7	0.3	1.0	0.2	-0.1
Birth weight	0.2	0.5	0.8	0.9	-0.3	-0.9	0.8	0.7	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.8	0.1	0.3	-0.5	0.5	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.1	0.4	0.2	-0.7	0.5	-0.5
Breast cancer (self-reported)	0.2	0.3	0.9	0.0	-0.6	-0.4	1.0	-0.2	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.9	0.5	0.5	-0.5	-0.0	-0.4
Ever taken oral contraceptive pill	0.2	0.3	1.2	-0.6	0.2	-0.2	0.3	-1.1	0.1
Myopia	0.2	0.3	0.9	0.4	-0.6	-0.3	-0.3	0.6	-1.0
Pain experienced in last month	0.2	0.3	0.8	-0.0	-0.1	-0.5	-0.7	0.6	-0.9
Chronotype (morning person)	0.1	0.3	0.7	-0.8	0.8	0.2	-0.7	0.1	-0.5
Medication: Atenolol	0.1	0.1	0.2	-0.3	0.0	0.1	-0.4	0.1	0.5
Qualifications: None of the above	0.1	0.2	0.5	-0.6	0.0	0.2	-0.7	0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.0	-0.0	-0.1	0.7	-0.0	0.4

Hub : Genes

JAZF1

Models

Trait associations