Hub : Genes

JAZF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1700 0.0660 0.00860 -0.003 NA 0.055 NA 0.012 5.0e-01 NA 5.8e-04 NA 7.1e-02
2 METSIM Adipose 0.0397 0.0183 0.01900 0.018 0.003 0.012 0.010 0.017 9.6e-04 1.0e-01 5.6e-03 9.5e-03 1.2e-03
3 YFS Blood 0.2416 0.0297 0.00000 0.117 0.151 0.167 0.153 0.161 2.3e-36 3.8e-47 3.0e-52 1.5e-47 2.7e-50
4 TCGA Breast Invasive Carcinoma 0.0434 0.0165 0.00012 0.025 0.026 0.010 NA 0.019 5.6e-06 3.8e-06 3.6e-03 NA 6.0e-05
5 TCGA Glioblastoma Multiforme 0.2390 0.0790 0.00150 0.076 0.072 0.066 NA 0.068 2.5e-03 3.3e-03 4.7e-03 NA 4.2e-03
6 TCGA Thyroid Carcinoma 0.1210 0.0410 0.00003 0.091 0.071 0.089 NA 0.094 3.3e-09 2.1e-07 5.1e-09 NA 2.1e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 2.6 -0.8 0.7 0.7 -0.4 1.6 0.7
Bipolar Disorder or Schizophrenia 0.5 1.3 3.3 -0.8 1.0 1.3 1.0 1.8 0.7
Depressed Affect (Nagel 2018) 0.9 2.0 6.5 0.6 0.7 2.5 -1.7 1.0 0.9
Depression (Nagel 2018) 0.6 0.9 2.0 1.1 0.2 0.8 -1.0 1.4 0.8
Intelligence (Savage-Jansen 2018) 1.2 3.8 10.6 2.2 -0.2 -0.7 -3.2 -1.4 -2.3
Neuroticism (Nagel 2018) 1.4 3.2 9.7 0.6 1.9 3.1 -0.6 0.9 2.1
Schizophrenia (2018) 0.4 0.9 2.5 -0.3 0.7 1.0 1.6 1.0 0.3
Schizophrenia vs Biploar Disorder 0.6 0.8 4.7 -0.4 -0.2 0.0 2.2 -0.5 0.0
Worry (Nagel 2018) 1.9 4.0 10.2 2.0 3.2 2.9 -0.8 0.6 0.4
Alzheimer’s Disease (in mother) 2.0 2.4 4.1 2.0 1.4 0.3 -1.9 -1.2 -1.8
Alzheimer’s Disease (in father) 0.9 1.0 3.4 -0.2 -1.4 -1.8 -0.8 -0.4 0.1
Alzheimer’s Disease (including proxy) 2.5 3.7 6.7 2.0 -0.1 -1.4 -2.6 -2.0 -2.4
Crohns Disease (2017) 3.8 8.4 15.8 -3.9 -1.9 -0.9 2.8 2.8 4.0
Irritable Bowel Disease (IBD) 2.0 4.7 8.1 -2.8 -1.3 -1.3 2.8 1.0 2.8
Ulcerative Colitis (UC) 0.6 1.1 2.3 0.1 -0.6 -1.4 1.4 -1.5 0.2
Major Depression (MDD) 0.5 0.6 1.7 -0.4 1.0 1.3 -0.8 0.2 0.2
Reaction Time 0.6 1.1 2.6 0.5 -0.1 -0.8 1.5 0.9 -1.6
Verbal and Numeric Reasoning (VNR) 1.1 2.6 5.8 2.4 -1.0 -0.8 -2.4 -1.0 -1.2
Breast Cancer 2.3 5.5 10.5 -3.2 -0.3 1.5 2.0 3.0 2.7
Ovarian Cancer 0.8 1.1 3.1 0.2 -0.8 -0.1 -1.8 -0.2 1.7
Prostate Cancer 3.0 4.3 14.2 1.9 -0.7 1.6 3.8 -2.2 0.5
Age at First Birth 1.1 1.6 5.7 -2.4 0.6 0.1 1.7 0.8 -0.5
Bipolar Disorder (2011) 1.2 1.2 5.4 0.2 0.2 1.0 0.6 2.3 0.6
Body Mass Index (BMI) (2010) 1.0 1.3 2.5 1.4 1.0 0.6 -1.6 0.4 -1.4
Coronary Artery Disease (CAD) 1.1 1.3 3.1 0.8 -1.6 -0.2 0.7 1.8 1.0
Crohns Disease (2012) 1.9 3.0 10.4 -1.7 -1.5 -0.5 0.9 1.1 3.2
Mean Putamen Volume 1.6 1.8 2.9 -0.9 -1.6 -1.5 1.7 1.5 0.3
Fasting Glucose 0.4 0.5 1.5 -0.3 -0.8 0.1 1.2 0.8 0.5
HbA1C 2.0 2.2 5.7 -1.6 -0.7 0.6 0.3 2.0 2.4
HDL Cholesterol 0.4 0.7 2.7 -0.4 -0.4 -0.7 0.7 -0.3 -1.7
LDL Cholesterol 0.4 0.6 2.7 0.1 0.1 -0.1 1.0 -0.1 -1.6
Lupus 3.8 5.7 10.4 -2.3 0.5 2.9 1.6 2.8 3.2
Neuroticism (2016) 0.5 0.7 2.1 0.7 0.6 1.1 0.0 0.1 1.5
Primary Biliary Cirrhosis 0.6 0.8 2.7 0.1 0.8 1.1 -0.7 0.2 1.6
Rheumatoid Arthritis 2.4 3.3 9.4 1.1 1.0 0.4 -3.1 -2.5 1.2
Schizophrenia (2014) 0.4 0.9 2.9 -0.7 -0.4 -0.1 1.7 1.3 0.2
Triglycerides 0.9 1.5 4.1 -0.4 -2.0 -0.3 0.8 1.2 1.6
Type 2 Diabetes (T2D) (2012) 10.2 11.8 31.1 -3.0 -1.0 2.0 2.4 4.5 5.6
Ulcerative Colitis 1.0 1.5 3.3 1.2 -0.6 -1.7 0.2 -1.8 -0.9
Blood Eosinophil Count 1.4 10.5 29.6 -3.4 0.3 3.8 0.6 2.7 5.4
Blood Platelet Count 0.4 4.1 10.4 -1.0 -1.3 1.1 2.0 3.2 2.4
Blood Red Count 0.3 3.1 8.7 -1.1 1.3 3.0 -0.7 0.8 2.4
Blood White Count 10.8 80.4 275.6 -4.5 -13.3 -16.6 2.5 0.9 1.5
Heel T-Score 1.5 11.9 50.8 -0.8 2.3 -0.1 -7.1 1.5 -3.5
BMI 1.3 7.4 27.0 0.9 -0.4 -1.3 -3.8 -0.3 -5.2
Height 5.8 111.8 605.2 -6.3 0.9 5.0 0.2 0.1 24.6
Waist Hip Ratio (WHR) 5.5 24.7 95.6 -4.4 -2.1 1.1 3.6 3.8 9.8
Systolic Blood Pressure 1.6 8.2 17.2 -2.3 -3.4 -0.2 2.2 3.2 4.2
Smoking Status 0.4 1.0 5.2 0.3 0.2 -0.5 -2.3 -0.5 -0.1
Allergy or Eczema 8.6 22.7 52.0 -5.4 -2.3 0.9 5.2 7.2 4.6
Cardiovascular Disease 1.8 6.0 9.2 -3.0 -2.7 -0.3 2.6 2.0 3.0
Hypothyroidism (self reported) 1.1 2.4 9.9 0.2 1.5 1.3 -3.1 -0.7 -0.2
Respiratory disease 8.7 19.4 45.8 -5.1 -2.1 1.2 4.8 6.8 3.9
Type 2 Diabetes (T2D) (2018) 10.2 19.1 64.8 -4.2 -2.1 1.2 3.0 4.2 8.0
Lung FEV1/FVC ratio 0.2 1.2 4.7 -1.1 0.3 -0.0 1.0 -0.1 -2.2
Lung FVC 3.9 20.0 82.8 3.8 1.8 -2.9 -1.7 -3.0 -9.1
Neuroticism 1.4 3.3 7.9 2.0 2.3 2.8 -1.2 0.6 1.0
Chronotype (morning person) 0.1 0.3 0.7 -0.8 0.8 0.2 -0.7 0.1 -0.5
Hair Pigment 1.9 53.4 204.5 -5.3 -4.1 1.3 6.2 5.5 14.3
Tanning 1.8 22.2 74.9 -4.9 -1.7 0.5 4.4 3.3 8.7
Hand grip strength (left) 1.1 2.9 8.1 1.0 1.2 -1.6 -2.9 -1.8 1.2
Number of treatments/medications taken 1.4 2.4 6.7 -1.3 -0.8 0.2 0.5 2.3 2.6
Average weekly spirits intake 0.6 0.8 2.1 1.1 1.5 -0.2 -1.0 -0.6 -0.1
Sensitivity / hurt feelings 1.5 2.5 5.5 0.9 2.1 2.4 -0.3 -0.7 2.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.2 1.5 -0.8 -0.1 -0.5 1.0 -0.4
Hearing difficulty/problems: Yes 1.2 1.9 7.4 2.7 -1.0 -0.2 0.2 -1.6 0.5
Relative age of first facial hair 1.6 3.3 9.4 -1.3 -1.1 1.4 1.5 1.8 3.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.6 -1.2 -0.5 -1.0 -0.0 -1.1 1.3
Ever used hormone-replacement therapy (HRT) 1.2 1.5 4.9 -0.5 2.2 1.6 -0.6 0.9 -0.5
Ever had hysterectomy (womb removed) 1.4 1.5 5.9 0.2 2.4 0.7 -1.1 -0.5 -1.2
Systolic blood pressure, automated reading 0.9 2.6 5.7 -1.9 -2.4 -0.8 1.4 1.7 0.8
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 7.2 -0.7 0.1 0.1 0.3 -0.5 2.7
Angina 2.5 3.2 7.1 -2.7 -0.6 1.7 0.5 2.2 2.0
Medication for hormone replacement therapy 0.7 0.8 1.7 0.1 1.3 1.2 -0.9 0.6 0.4
Vitamin and mineral supplements 0.7 0.9 3.4 0.0 0.2 0.4 -0.2 -1.3 1.8
Supplements: Zinc 1.1 1.2 3.7 -0.2 -0.5 -1.1 1.3 -0.6 -1.9
Medication: Co-codamol 0.8 0.9 2.8 -1.3 0.4 0.6 -0.5 -0.2 1.7
Medication: Metformin 10.5 14.8 47.8 -5.0 -1.4 0.7 1.2 3.4 6.9
Diabetes (father) 3.6 4.4 14.7 -2.0 -0.8 0.7 2.2 1.2 3.8
Diabetes (mother) 3.4 4.4 9.7 -2.3 -1.3 0.1 1.4 2.8 3.1
Severe depression (siblings) 1.1 1.2 3.3 -1.6 -0.3 0.1 0.2 1.8 1.1
Pack years adult smoking proportion 0.2 0.3 0.8 -0.5 -0.2 0.6 -0.0 -0.9 0.5
Impedance of leg (right) 5.3 25.5 85.4 -4.5 -1.8 2.3 5.8 2.4 9.2
Leg fat-free mass (left) 0.9 4.8 21.3 0.9 1.0 -0.1 -4.6 -0.5 2.3
Trunk fat percentage 0.5 2.2 6.6 -2.6 0.6 0.3 -1.2 0.3 2.1
Hand grip strength (right) 0.6 1.7 6.3 0.7 1.4 -0.2 -2.5 -0.4 1.3
Townsend deprivation index at recruitment 0.9 1.3 6.0 0.8 0.3 0.7 -2.4 0.0 -0.5
Current tobacco smoking 0.3 0.4 0.7 0.1 0.7 -0.7 -0.6 -0.7 -0.8
Average weekly fortified wine intake 0.7 0.8 2.4 1.6 -0.0 -0.2 0.5 -1.4 0.3
Maternal smoking around birth 0.7 0.9 3.8 -0.4 1.2 0.3 -0.4 -1.9 0.3
Fed-up feelings 0.3 0.5 1.6 1.3 -0.0 0.7 -0.8 -0.3 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 3.5 1.2 -0.4 -0.3 -1.9 0.7 -0.3
Relative age voice broke 0.3 0.5 1.2 0.9 -0.1 1.1 0.8 -0.7 0.3
Taking other prescription medications 1.4 2.1 5.9 -1.7 -0.2 0.8 -0.3 1.7 2.4
Age when periods started (menarche) 0.4 0.9 2.4 -0.9 -0.8 -1.6 -0.7 0.4 0.8
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 5.0 0.3 2.0 1.2 -2.2 -0.6 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.2 14.7 0.3 3.1 1.3 -3.8 0.4 -2.2
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 3.5 1.3 -0.5 0.6 0.2 -0.2 1.9
Qualifications: CSEs or equivalent 1.3 1.8 3.8 -1.4 -1.0 -0.5 -0.0 1.9 2.0
Serious illness, injury or assault to yourself 1.1 1.3 3.4 1.7 -1.1 -0.2 1.8 -0.5 -0.0
High blood pressure 1.5 4.1 7.8 -2.6 -1.7 -1.1 1.8 1.7 2.8
Hayfever, allergic rhinitis or eczema 8.2 17.9 38.8 -4.5 -1.8 1.5 5.4 6.2 3.7
Multivitamins +/- minerals 1.8 2.3 5.1 -1.1 -1.7 -1.2 1.4 2.2 -1.0
Stomach or abdominal pain in last month 0.5 0.7 3.1 0.0 -1.8 -0.2 -0.5 0.7 0.2
Supplements: Glucosamine 0.5 0.6 1.4 -0.5 0.2 -0.3 0.8 1.2 1.2
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 4.2 0.3 -0.4 -1.5 0.9 -1.7 -2.0
Medication: Atenolol 0.1 0.1 0.2 -0.3 0.0 0.1 -0.4 0.1 0.5
Medication: Levothyroxine sodium 1.9 3.2 6.6 -0.8 2.5 1.9 -2.6 -0.2 1.3
Sitting height 2.0 14.0 40.1 3.2 2.0 2.1 -4.7 -1.6 6.3
Chronic bronchitis/emphysema (father) 0.6 0.7 1.8 0.6 0.7 0.0 -0.3 -1.3 -1.3
High blood pressure (mother) 1.0 1.5 3.1 0.9 -0.1 1.8 1.0 1.7 1.0
Body mass index (BMI) 1.4 6.1 19.8 0.4 0.7 -0.9 -3.9 -0.4 -4.5
Impedance of leg (left) 5.6 27.4 90.4 -4.8 -1.9 2.1 6.2 2.0 9.5
Leg predicted mass (left) 0.9 4.7 20.9 1.0 1.0 -0.0 -4.6 -0.5 2.3
Trunk fat mass 0.9 4.0 12.3 -2.3 1.0 0.8 -2.1 0.4 3.5
Waist circumference 0.5 1.9 6.9 -1.1 -0.0 0.0 -2.6 0.3 1.9
Number of incorrect matches in round 1.3 2.2 8.6 -1.6 -1.0 -0.5 2.9 1.0 0.2
Past tobacco smoking 1.1 2.0 10.7 0.4 -0.2 -0.2 3.3 -0.7 -0.6
Alcohol usually taken with meals 0.7 1.1 3.0 0.9 1.1 -0.6 -0.5 -1.7 -0.9
Nervous feelings 0.9 1.7 3.5 1.9 1.8 1.8 -0.3 0.8 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.4 0.7 -1.6 -0.4 -0.7 1.6 0.1
Hearing difficulty/problems with background noise 0.8 1.2 4.4 2.1 -0.0 0.3 0.1 -0.3 1.7
Hair/balding pattern: Pattern 2 1.8 2.3 4.7 -1.0 1.5 1.4 -1.9 2.2 -0.4
Had menopause 0.5 0.6 2.6 -0.4 1.6 0.5 -0.7 -0.2 -0.1
Had other major operations 0.5 0.6 2.8 0.8 0.4 0.1 0.1 0.4 1.7
Forced vital capacity (FVC) 0.4 1.7 8.4 0.2 1.0 0.3 0.6 -0.3 2.9
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.6 18.6 -0.3 2.8 1.2 -4.3 1.1 -2.1
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.8 -0.2 -1.3 -1.4 1.0 -1.0 0.1
Qualifications: None of the above 0.1 0.2 0.5 -0.6 0.0 0.2 -0.7 0.3 -0.1
Financial difficulties in last 2 years 0.7 1.0 2.1 1.3 -1.4 -1.1 0.2 0.7 -0.6
Mouth/teeth dental problems 0.9 1.4 2.5 0.1 -1.3 -1.2 1.6 0.6 -1.5
Heart attack 0.7 0.9 3.6 -1.3 -1.9 -0.5 -0.2 -0.2 -0.4
Allergy 7.4 17.0 37.3 4.0 2.1 -2.0 -4.5 -6.1 -4.5
Pain all over the body in last month 0.8 0.8 1.7 0.9 -0.7 -0.7 -1.3 -0.7 -1.0
Diabetes (self-reported) 10.7 16.5 53.6 -4.4 -2.2 0.2 2.4 4.0 7.3
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 5.4 -1.6 -0.5 -0.0 0.3 2.3 1.0
Medication: Ramipril 2.2 2.8 10.7 -1.9 -1.0 -0.6 0.3 0.8 3.3
Medication: Simvastatin 1.7 2.4 4.5 -2.1 -0.5 0.7 1.7 1.9 1.8
Fluid intelligence score 0.4 0.8 1.6 0.1 -0.9 -0.9 -1.3 -0.2 -1.2
Illnesses of siblings 0.6 0.8 1.7 0.8 -0.9 -1.3 -0.4 -0.0 -1.2
Neuroticism score 1.7 3.6 9.5 2.3 1.9 3.1 -1.1 0.4 1.2
Weight 0.9 4.5 13.8 -0.5 0.8 0.5 -3.7 -0.2 3.4
Impedance of arm (right) 2.4 11.3 35.8 -2.6 -0.4 2.0 4.5 1.1 6.0
Arm fat percentage (right) 0.5 1.8 4.5 -1.2 0.8 0.0 -2.1 0.0 -2.1
Trunk fat-free mass 1.4 7.9 32.8 0.4 1.0 1.1 -3.5 -0.4 5.7
Hip circumference 0.7 3.0 15.2 0.9 0.8 0.3 -3.9 -1.0 0.2
Time employed in main current job 1.2 1.4 5.5 -1.1 2.4 0.5 -0.3 -0.7 0.9
Alcohol intake versus 10 years previously 0.7 1.0 3.1 -0.7 -1.2 0.3 0.3 1.8 0.7
Father’s age at death 0.3 0.3 0.9 0.3 0.6 0.1 -0.1 -0.9 -0.8
Worrier / anxious feelings 2.6 5.0 15.6 1.3 3.2 4.0 -0.8 1.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 4.8 -0.2 -2.1 -0.7 -0.0 2.2 0.4
Falls in the last year 0.6 0.8 3.2 -1.8 -0.7 0.7 0.4 -0.5 0.6
Hair/balding pattern: Pattern 3 0.4 0.6 1.6 -0.9 1.3 0.0 0.8 0.6 -0.2
Number of live births 0.4 0.6 1.4 1.0 0.6 -0.3 0.3 -1.2 0.8
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.6 0.2 0.9 0.1 1.2 -0.9 1.6
Pulse rate 2.3 3.9 8.1 -0.5 -2.2 0.6 2.1 2.3 2.9
Happiness 0.9 1.1 3.3 1.5 -1.8 -0.2 1.1 0.4 0.2
Noisy workplace 0.8 0.9 3.9 0.1 -2.0 -1.3 0.1 -0.1 -0.0
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.3 1.1 0.7 0.8 -0.3 -0.1 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 6.0 0.6 2.2 2.5 0.4 -0.1 1.4
Mouth/teeth dental problems: Dentures 0.5 0.9 2.3 -0.6 1.4 0.5 -1.5 -0.5 -0.6
Asthma 7.4 14.6 26.5 -3.5 -3.4 -0.0 4.7 5.2 3.9
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.1 0.0 1.1 0.6 -0.5 -0.7 0.5
Medication: Cholesterol lowering 3.6 5.6 9.3 -3.1 -1.8 -0.5 2.5 2.6 2.8
Depression (self-reported) 0.7 0.9 2.3 1.5 1.1 0.4 -1.2 -0.2 -0.1
Medication: Lansoprazole 0.9 1.0 4.2 -0.4 0.8 0.1 -2.0 -0.8 -0.4
Prospective memory result 0.2 0.2 0.5 0.7 -0.5 0.2 -0.1 0.2 0.6
Lung cancer (father) 0.8 0.9 3.5 1.1 0.3 0.5 -0.1 -0.4 1.9
Illnesses of mother 1.1 1.4 3.6 -0.8 -0.2 -0.1 -1.0 -1.7 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 5.2 0.2 0.2 -0.4 1.2 -1.5 2.3
Pulse wave Arterial Stiffness index 0.9 1.1 2.7 0.5 -0.2 1.5 -0.0 1.1 1.6
Impedance of arm (left) 3.2 14.8 46.0 -2.7 -0.5 2.1 5.4 1.3 6.8
Arm fat mass (right) 0.5 1.9 10.2 -0.7 0.8 -0.0 -3.2 0.1 -0.3
Trunk predicted mass 1.4 7.8 33.4 0.3 1.0 1.0 -3.3 -0.4 5.8
Standing height 5.2 51.6 295.8 -2.2 0.4 3.0 0.1 0.3 17.2
Length of working week for main job 0.6 0.7 2.2 0.0 0.3 1.5 -0.9 0.9 -0.6
Exposure to tobacco smoke at home 0.7 0.8 2.9 1.7 0.2 0.9 -0.9 0.5 -0.3
Breastfed as a baby 0.5 0.6 2.2 0.8 0.5 -0.6 1.5 -0.4 0.1
Tense / ‘highly strung’ 0.7 1.2 3.1 1.5 1.8 0.8 -0.3 0.9 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 3.9 0.1 1.9 2.0 -0.9 1.6 0.9
Hair/balding pattern: Pattern 4 1.5 3.6 7.1 2.5 -1.5 -1.2 -0.4 -2.2 -2.7
Birth weight of first child 0.6 1.0 1.4 1.2 -0.7 -0.9 1.0 1.1 1.1
Peak expiratory flow (PEF) 0.3 0.7 1.3 0.2 1.2 -0.3 0.7 -1.0 -1.1
Pulse wave reflection index 0.8 1.0 2.9 0.7 1.1 0.5 -0.4 -0.8 -1.7
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.9 0.2 -0.4 0.1 -0.3 0.9 -0.0
Loud music exposure frequency 0.4 0.5 1.9 -0.2 -1.4 0.0 0.3 0.7 0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 -0.4 0.7 0.3 1.0 0.2 -0.1
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 7.8 2.8 -0.3 0.2 -0.7 -0.2 -0.6
Blood clot in the leg (DVT) 0.7 0.8 2.7 0.7 0.3 0.8 -1.1 -1.6 0.3
Medication: Paracetamol 0.6 0.9 2.6 -0.8 -1.6 -0.5 1.1 0.8 0.5
Headache pain in last month 0.3 0.5 1.0 -1.0 -0.7 0.4 -0.7 0.9 0.1
Medication for cholesterol, blood pressure or diabetes 3.0 5.0 10.4 3.0 1.0 0.2 -2.1 -2.4 -3.2
Glaucoma (self-reported) 1.0 1.2 3.4 0.1 -1.7 -1.8 -0.5 -0.6 -0.7
Gout (self-reported) 1.0 1.4 4.0 1.3 -1.3 -0.6 -2.0 0.7 0.3
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 7.5 -0.0 2.3 1.5 -2.7 -0.2 0.0
Medication: Amlodipine 1.1 1.6 5.3 -1.3 -0.3 -0.5 0.7 1.3 2.3
Medication: Ventolin 100micrograms inhaler 2.3 3.0 10.2 -0.9 -3.2 -0.8 0.1 1.9 1.6
Birth weight 0.2 0.5 0.8 0.9 -0.3 -0.9 0.8 0.7 0.4
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.8 0.2 1.7 1.4 0.9 -0.5 0.6
High blood pressure (siblings) 0.5 0.7 2.3 -1.5 0.5 0.2 0.9 0.5 0.6
Forced vital capacity (FVC), Best measure 0.7 2.6 14.2 -0.2 0.1 -0.3 0.3 -1.1 3.8
Body fat percentage 0.4 1.5 5.5 -2.4 0.6 0.3 -1.4 0.3 1.1
Leg fat percentage (right) 0.5 1.7 6.0 -2.4 0.5 0.7 -1.5 1.2 0.0
Arm fat-free mass (right) 1.1 5.7 20.2 0.1 0.2 0.0 -3.7 -0.4 4.5
Exposure to tobacco smoke outside home 1.6 2.1 5.5 -1.3 0.1 1.4 1.8 0.7 2.4
Comparative body size at age 10 1.2 3.3 8.9 0.9 2.1 1.4 -1.8 -0.5 -3.0
Number of full brothers 1.3 1.6 3.0 -1.3 1.7 1.7 0.2 -0.5 1.4
Worry too long after embarrassment 0.5 0.9 3.1 -0.2 0.9 1.0 0.6 -0.1 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.5 0.0 -0.0 -0.1 0.7 -0.0 0.4
Wheeze or whistling in the chest in last year 4.1 7.4 16.6 -4.0 -1.1 0.3 0.1 4.1 3.2
Number of children fathered 1.0 1.1 3.0 -1.7 1.2 0.7 0.7 0.1 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 3.7 -1.9 -0.3 0.2 -0.2 1.3 0.7
Age at first live birth 1.0 1.9 4.4 -2.1 -0.9 -1.7 1.1 1.3 -0.5
Pulse wave peak to peak time 0.6 0.7 1.9 -0.8 0.2 -1.4 0.1 -1.1 -0.5
Health satisfaction 2.0 2.6 6.3 -0.1 -2.5 -1.0 0.9 2.0 1.9
Shortness of breath walking on level ground 0.4 0.5 1.7 0.5 -0.6 -0.0 -1.3 0.8 -0.4
Qualifications: College or University degree 0.3 0.8 1.9 1.4 0.3 -0.3 -0.6 -1.0 -1.1
Eye problems/disorders: None of the above 0.9 1.0 4.1 -0.2 2.0 1.1 0.0 0.4 -0.8
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.8 1.7 -0.4 -0.8 0.1 -0.3 -0.8
Emphysema/chronic bronchitis 0.2 0.2 0.7 -0.8 0.1 0.3 -0.5 0.5 0.0
Medication for pain relief, constipation, heartburn 0.7 1.3 5.3 0.7 0.8 -0.2 -0.9 -0.7 -2.3
Neck or shoulder pain in last month 1.0 1.4 2.9 -0.8 1.7 1.2 -0.6 -0.3 1.6
Medication: Blood pressure 2.6 4.6 10.1 -3.0 -1.1 -0.5 2.2 1.6 3.2
Angina (self-reported) 2.4 3.2 7.6 -2.8 -0.7 1.6 0.3 2.2 1.8
Migraine (self-reported) 0.6 0.7 2.2 -0.2 -1.2 0.1 -0.3 0.7 -1.5
Medication: Ibuprofen 0.3 0.4 0.9 0.6 1.0 0.6 -0.3 -0.6 0.3
Medication: Allopurinol 1.3 1.8 3.4 1.8 -1.8 0.2 -1.8 -0.2 0.7
Medication: Omeprazole 0.4 0.4 1.2 -1.1 0.6 0.4 -0.6 0.7 0.4
Medication: Seretide 50 evohaler 1.5 1.8 4.3 -1.4 -2.1 -1.6 0.8 1.1 0.2
Mean time to correctly identify matches 0.7 1.3 3.3 0.3 0.5 -1.1 1.6 -0.5 -1.8
Heart disease (mother) 1.3 1.5 4.2 -0.9 -0.5 -0.9 2.0 1.2 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 2.1 0.5 -0.1 -0.2 -0.1 -0.4 1.4
Whole body fat mass 0.7 3.0 6.2 -2.2 1.0 0.7 -2.4 0.4 2.5
Leg fat mass (right) 0.6 2.3 7.7 -1.6 0.9 0.7 -2.8 0.7 1.3
Arm predicted mass (right) 1.1 5.7 19.8 -0.1 0.5 0.3 -3.7 -0.5 4.5
Pulse rate, automated reading 2.4 7.6 17.4 -0.4 -1.5 1.9 3.3 3.4 4.2
Alcohol intake frequency. 0.7 1.7 4.7 -0.7 -1.6 0.3 1.4 2.2 -0.6
Comparative height size at age 10 4.1 22.5 127.7 -1.8 0.5 1.7 0.8 -0.5 11.3
Number of full sisters 0.7 0.8 3.5 1.9 -0.6 -0.4 -0.8 0.2 0.0
Suffer from ‘nerves’ 0.9 1.5 3.0 1.3 0.9 1.7 -1.0 0.7 1.4
Overall health rating 0.9 1.8 6.7 -0.2 -0.5 1.3 -0.9 1.3 2.6
Chest pain or discomfort 0.9 1.3 5.6 0.3 0.0 1.0 0.9 0.6 2.4
Had major operations 0.9 1.0 2.9 -1.1 -1.7 -0.4 0.8 1.1 0.4
Age at last live birth 1.9 2.8 4.5 -2.1 -1.5 -2.1 1.3 1.9 0.6
Family relationship satisfaction 0.5 0.6 1.9 0.7 -0.8 -0.7 -0.1 0.5 1.4
Leg pain on walking 0.8 0.9 3.5 -1.2 0.1 0.2 0.8 0.3 1.9
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.5 5.4 -1.4 -1.7 -1.1 1.6 0.7 2.3
Commuting to job workplace: Car/motor vehicle 1.9 2.2 5.2 -1.9 -1.1 -0.5 -0.5 2.3 1.5
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.4 -0.4 -0.0 -0.9 0.2 -0.1 -1.2
Medication: Aspirin 2.2 2.9 6.7 -1.2 -2.0 -0.4 1.9 1.2 2.6
Supplements: Vitamin C 0.5 0.6 1.2 1.1 1.0 0.3 -0.6 0.0 -0.8
Knee pain experienced in last month 2.0 3.1 8.8 -1.9 0.7 1.4 0.5 1.9 3.0
Hypertension (Self-reported) 1.6 4.5 8.7 -2.7 -1.8 -1.3 1.8 1.7 2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.9 -0.5 -0.1 -0.8 -1.0 -0.7 0.5
Illnesses of father: Heart disease 1.5 2.1 6.4 -0.3 0.2 1.2 2.1 2.5 0.4
Illnesses of siblings: Diabetes 1.6 2.0 8.1 -0.1 0.7 1.8 0.4 -0.2 2.8
Smoking status: Previous 1.2 1.8 8.8 -0.9 -0.1 0.3 -3.0 0.8 0.6
Forced expiratory volume in 1-second (FEV1), predicted 3.7 7.6 40.7 -0.8 -1.3 0.4 -0.4 1.6 6.4
Whole body fat-free mass 1.1 6.3 19.4 0.6 0.9 0.5 -4.1 -0.6 4.4
Leg fat-free mass (right) 0.9 4.8 20.4 1.2 1.1 -0.1 -4.5 -0.9 2.3
Arm fat percentage (left) 0.3 1.3 3.0 -1.2 0.8 0.2 -1.7 0.2 -1.6
Average weekly red wine intake 1.4 2.1 3.7 1.6 1.9 0.6 -1.4 -1.9 0.7
Handedness (chirality/laterality): Left-handed 1.5 1.8 7.1 0.7 1.0 0.3 -2.7 -1.4 0.4
Mood swings 0.5 1.0 2.5 1.6 0.2 1.1 -1.3 -0.3 0.6
Loneliness, isolation 0.8 1.1 4.2 0.6 -0.2 1.3 -2.0 0.3 -0.4
Long-standing illness, disability or infirmity 0.9 1.4 5.7 -0.9 -1.2 -0.0 -0.8 -0.5 2.4
Ever had bowel cancer screening 0.5 0.5 1.3 -0.5 -0.3 -1.1 -0.5 -0.3 1.1
Diabetes diagnosed by doctor 10.2 16.7 58.6 -4.3 -1.3 1.4 1.7 4.1 7.7
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.4 -0.7 0.5 1.0 1.2 1.1 0.4
Friendships satisfaction 0.4 0.5 1.4 -0.1 0.4 1.1 0.2 1.2 -0.1
Qualifications: nursing, teaching 0.7 1.1 2.2 -0.6 0.5 1.5 -0.9 1.4 0.9
Commuting to job workplace: Walk 1.1 1.1 3.3 0.2 1.1 1.8 0.1 1.0 -1.1
Eye problems/disorders: Cataract 1.1 1.3 2.8 -1.2 -1.5 -1.7 0.6 0.7 0.8
Mouth/teeth dental problems: Mouth ulcers 2.7 4.2 15.7 -0.7 2.9 4.0 0.9 0.3 0.4
Medication for cholesterol 1.3 2.0 6.4 1.4 -0.3 -1.2 -0.5 -1.5 -2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 -0.1 0.4 0.2 -0.7 0.5 -0.5
Back pain experienced in last month 1.8 2.6 7.7 2.4 0.5 -0.7 0.1 -2.8 -1.2
Mineral and other dietary supplements 0.7 0.9 1.6 1.2 0.4 0.6 -1.2 -1.2 0.7
Breast cancer (self-reported) 0.2 0.3 0.9 0.0 -0.6 -0.4 1.0 -0.2 0.2
Asthma (self-reported) 7.8 15.6 29.4 -3.8 -3.5 0.1 4.8 5.4 3.8
Osteoporosis (self-reported) 0.3 0.3 0.7 0.3 -0.2 0.9 0.8 0.3 -0.7
Osteoarthritis (self-reported) 0.6 0.8 3.4 -0.5 -0.4 0.8 0.6 0.0 1.9
Medication: Aspirin 2.4 3.2 8.5 -1.7 -1.7 -0.3 1.9 1.1 2.9
Medication: Gliclazide 4.0 4.5 16.1 -2.7 0.1 1.0 0.3 1.6 4.0
Illnesses of father: None of the above (group 1) 0.2 0.3 0.7 -0.9 0.5 0.5 -0.5 -0.0 -0.4
Smoking status: Current 0.4 0.6 1.3 0.3 0.7 -0.8 -0.7 -1.0 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.7 17.5 1.4 1.5 -0.9 -0.1 -2.4 -4.2
Whole body water mass 1.1 6.1 17.9 0.7 0.9 0.4 -4.1 -0.6 4.2
Leg predicted mass (right) 0.9 4.8 19.8 1.3 1.0 -0.3 -4.5 -0.9 2.3
Arm fat mass (left) 0.4 1.7 8.3 -0.9 1.0 0.2 -2.9 0.1 0.3
Number of self-reported non-cancer illnesses 3.8 6.5 13.5 -3.2 -0.5 1.6 1.7 3.1 3.7
Average weekly champagne plus white wine intake 1.2 1.6 4.7 0.9 1.2 0.2 -0.5 -2.2 -1.6
Miserableness 0.6 1.0 3.9 0.4 0.9 2.0 -0.5 0.8 0.6
Guilty feelings 0.8 1.2 2.9 1.7 -0.0 1.7 0.8 0.5 0.8
Wears glasses or contact lenses 0.9 1.0 2.9 -0.7 1.7 1.4 -0.7 -0.3 0.6
Ever taken oral contraceptive pill 0.2 0.3 1.2 -0.6 0.2 -0.2 0.3 -1.1 0.1
Hearing aid user 0.9 1.0 3.5 -0.5 0.7 -0.0 0.7 -1.2 -1.9
Mother’s age at death 0.6 0.7 1.8 0.8 0.3 -0.9 -1.0 -1.3 -0.5
Financial situation satisfaction 0.9 1.1 4.1 1.4 -2.0 0.3 -0.0 0.4 0.5
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.8 1.7 -1.4 -0.6 -0.3 -0.2 -0.2
Commuting to job workplace: Public transport 2.0 2.3 5.1 2.2 0.2 0.5 -1.7 -1.8 -1.6
Eye problems/disorders: Glaucoma 0.8 0.9 2.5 1.1 0.0 -0.2 -1.3 -1.6 -0.5
Medication: Blood pressure 0.8 1.6 6.0 -0.7 -0.7 0.4 1.1 1.2 2.4
Pain type(s) experienced in last month: Hip pain 0.6 0.8 2.5 -0.6 0.8 1.6 0.5 0.4 1.0
Supplements: Fish oil (including cod liver oil) 1.3 1.7 5.1 -2.3 -0.5 -1.2 1.4 1.1 -0.2
High cholesterol (Self-reported) 1.3 2.3 5.5 -1.7 -0.5 0.1 2.3 1.7 1.6
Medication: Bendroflumethiazide 1.1 1.6 4.5 -1.5 -0.4 -0.1 0.2 2.1 1.7
Medication: Paracetamol 0.7 1.1 4.3 -0.4 -2.1 -1.0 0.4 0.6 0.8
Medication: Lisinopril 0.6 0.7 1.9 -1.3 0.1 0.8 -0.0 0.2 1.4
Medication: Atorvastatin 2.3 2.8 4.5 -2.0 -0.4 1.1 1.9 1.8 2.1
Illnesses of father: High blood pressure 0.4 0.5 1.5 1.2 -0.6 -0.1 0.0 0.4 -1.0
Alcohol drinker status: Never 0.3 0.4 1.2 -0.4 0.6 -0.1 1.1 -0.2 -0.8
Ever smoked 0.8 1.4 6.5 -0.2 0.3 0.2 -2.5 0.4 1.2
Basal metabolic rate 1.1 6.1 18.4 0.3 0.7 0.3 -4.2 -0.4 4.3
Leg fat percentage (left) 0.5 1.7 6.7 -2.6 0.7 0.7 -1.3 0.9 0.0
Arm fat-free mass (left) 1.1 5.4 17.8 -0.2 0.3 -0.1 -3.8 -0.4 4.2
Number of operations (self-reported) 0.3 0.4 0.9 -0.6 0.3 0.7 -0.0 0.6 1.0
Average weekly beer plus cider intake 0.5 0.7 1.7 -0.4 0.2 1.0 -0.9 1.3 0.6
Irritability 0.7 1.2 2.3 1.4 -0.4 1.5 0.6 -0.2 1.5
Risk taking 1.1 1.6 3.1 -1.0 -1.7 -1.8 0.5 1.1 -1.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 3.5 0.8 -0.8 -0.1 1.9 0.2 -0.0
Fractured/broken bones in last 5 years 0.3 0.4 0.9 0.5 -1.0 -0.4 0.7 -0.9 -0.3
Age started oral contraceptive pill 1.1 1.4 6.1 0.2 0.7 -0.4 -0.8 -1.1 -2.5
Diastolic blood pressure, automated reading 0.3 0.9 1.8 -0.5 -1.3 -0.1 0.6 1.3 -1.2
Ever depressed for a whole week 0.5 0.7 1.2 0.8 -0.2 0.0 1.0 -1.1 -1.0
Unable to work because of sickness or disability 1.0 1.3 4.3 -0.4 -1.7 0.0 -2.1 0.6 0.7
Commuting to job workplace: Cycle 1.1 1.3 3.3 1.3 0.4 -0.7 -0.7 -1.8 -1.3
Myopia 0.2 0.3 0.9 0.4 -0.6 -0.3 -0.3 0.6 -1.0
Vascular/heart problems diagnosed by doctor 1.6 4.4 7.7 2.8 2.0 1.0 -1.5 -1.9 -2.8
Cholesterol lowering medication 0.9 1.3 3.7 -0.3 0.8 1.9 1.0 1.1 1.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.1 -1.1 0.4 0.3 -0.4 0.8 0.2
Pain experienced in last month 0.2 0.3 0.8 -0.0 -0.1 -0.5 -0.7 0.6 -0.9
Supplements: Calcium 1.0 1.1 3.3 -1.2 -0.7 0.2 1.8 0.8 0.9
Basal cell carcinoma (self-reported) 3.1 3.6 9.5 3.1 0.8 0.5 -2.1 -0.9 -2.5
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.5 -1.5 -1.9 -0.6 -0.0 0.1 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.6 0.6 0.4 0.5 -1.1 -1.9 0.1
Heart disease (siblings) 0.9 1.2 4.3 -0.2 0.4 2.1 -0.4 1.4 0.7
Alcohol drinker status: Previous 1.0 1.2 4.3 -0.8 -1.1 -0.5 -2.1 0.7 -0.6
Pack years of smoking 0.4 0.6 1.7 -0.8 0.4 0.8 -0.5 -1.3 0.2
Impedance of whole body 4.5 22.9 73.3 -4.1 -1.5 2.0 6.2 1.8 8.6
Leg fat mass (left) 0.6 2.5 7.3 -1.8 1.1 0.7 -2.7 0.7 1.4
Arm predicted mass (left) 1.0 5.2 16.6 -0.1 0.4 -0.1 -3.8 -0.5 4.1