Hub : Genes

SKAP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0330	2.6e-06	0.083	0.054	0.062	0.070	0.076	2.6e-10	3.9e-07	4.6e-08	6.0e-09	1.7e-09
2	GTEx	Adrenal Gland	0.3039	0.1061	7.2e-03	0.058	NA	0.015	NA	0.058	4.1e-03	NA	9.1e-02	NA	4.0e-03
3	GTEx	Brain Cortex	0.2730	0.0960	5.9e-03	-0.010	NA	-0.006	NA	-0.005	7.8e-01	NA	5.0e-01	NA	4.5e-01
4	GTEx	Colon Transverse	0.1480	0.0540	6.1e-03	0.042	NA	0.029	NA	0.044	4.6e-03	NA	1.6e-02	NA	3.8e-03
5	GTEx	Skin Sun Exposed Lower leg	0.1660	0.0480	1.3e-04	0.015	NA	0.048	NA	0.026	1.8e-02	NA	8.0e-05	NA	3.1e-03
6	GTEx	Whole Blood	0.2140	0.0440	1.3e-11	0.194	NA	0.183	NA	0.193	1.3e-17	NA	1.3e-16	NA	1.6e-17
7	METSIM	Adipose	0.0770	0.0257	8.9e-06	0.019	0.049	0.051	0.049	0.043	5.7e-04	7.6e-08	3.2e-08	7.3e-08	3.6e-07
8	NTR	Blood	0.0759	0.0144	0.0e+00	0.119	0.099	0.123	0.116	0.121	3.1e-36	3.4e-30	2.0e-37	2.6e-35	6.9e-37
9	ROSMAP	Brain Pre-frontal Cortex	0.1504	0.0336	8.4e-14	0.136	0.124	0.128	0.136	0.135	3.9e-17	1.1e-15	4.0e-16	4.0e-17	5.9e-17
10	YFS	Blood	0.5739	0.0333	0.0e+00	0.624	0.604	0.639	0.644	0.643	2.5e-270	7.7e-256	9.7e-282	4.0e-285	1.7e-284

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	3.6	5.7	11.4	2.6	-1.4	1.3	1.1	-1.8	-3.4	-1.2	-3.3	2.9	-3.2
Bipolar Disorder or Schizophrenia	0.7	1.6	3.4	1.7	-0.6	1.0	1.0	0.3	-1.6	-0.6	-1.3	1.8	-1.5
Depressed Affect (Nagel 2018)	0.5	1.0	2.4	1.6	0.7	1.5	0.6	-0.3	-0.9	-0.1	-0.4	1.4	-1.0
Depression (Nagel 2018)	2.3	3.5	7.3	2.7	-0.3	2.0	2.3	0.1	-1.5	-1.5	-1.6	2.7	-1.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	-0.3	0.9	0.2	-1.1	-0.6	0.6	1.2	0.7	-0.0	0.6
Neuroticism (Nagel 2018)	0.5	1.3	3.3	1.3	-0.5	1.1	-0.0	-0.5	-1.8	0.3	-1.4	1.2	-1.7
Schizophrenia (2018)	0.3	0.5	3.2	0.1	0.3	0.3	0.3	1.8	0.6	0.2	0.9	-0.0	0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	0.0	0.8	-0.0	1.2	0.7	0.7	0.5	0.9	0.1	0.8
Worry (Nagel 2018)	1.6	3.3	9.4	1.3	-1.0	1.2	0.2	-1.2	-3.1	0.1	-2.8	1.6	-2.8
Alzheimer’s Disease (in mother)	0.7	0.8	2.5	-0.2	-1.1	-0.2	-1.6	-1.0	-0.8	1.1	-0.8	0.4	-0.7
Alzheimer’s Disease (in father)	0.3	0.4	1.1	-0.5	-0.3	-0.3	1.1	0.4	0.1	1.1	0.2	0.3	0.7
Alzheimer’s Disease (including proxy)	1.0	1.5	4.2	0.1	-1.1	0.5	-0.5	-0.1	-2.1	1.4	-1.8	1.3	-1.4
Crohns Disease (2017)	2.6	5.7	21.9	-3.2	-1.2	-4.7	-1.5	0.9	0.6	2.3	0.7	-3.5	1.4
Irritable Bowel Disease (IBD)	0.8	1.8	5.3	-1.8	-1.2	-2.3	-0.1	1.7	0.8	0.8	0.5	-1.7	0.9
Ulcerative Colitis (UC)	0.3	0.5	1.7	-0.4	-1.1	-0.3	1.3	1.1	-0.1	-0.4	-0.4	0.2	-0.3
Major Depression (MDD)	0.6	0.8	1.5	0.2	-1.1	-0.4	-0.8	-1.2	-1.2	1.1	-0.8	0.7	-0.6
Reaction Time	0.4	0.8	2.8	-1.7	-0.9	-0.9	0.9	-0.7	0.2	0.4	0.3	-1.1	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.9	0.2	0.1	-0.0	-0.1	-1.4	-0.0	0.2	-0.2	0.6	-0.5
Breast Cancer	0.3	0.8	4.6	0.2	0.6	1.4	2.1	0.1	0.1	0.6	0.7	0.3	0.3
Ovarian Cancer	0.2	0.3	1.8	0.7	0.4	0.0	-0.5	0.4	-0.3	-1.3	-0.3	0.2	0.0
Prostate Cancer	3.2	4.5	28.2	1.3	1.0	0.2	3.1	-5.3	-0.7	0.2	-1.0	1.1	-1.2
Age at First Birth	0.6	0.8	3.6	-0.7	0.7	-1.2	-0.4	-1.9	0.0	-0.3	0.4	-1.3	0.2
Bipolar Disorder (2011)	0.9	0.9	2.2	-0.6	-1.5	-1.2	-0.6	0.2	-1.3	-0.1	-1.3	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	0.2	1.1	-0.1	0.6	0.8	0.4	-1.0	0.3	-0.2	-0.2
Coronary Artery Disease (CAD)	1.1	1.3	4.2	-0.0	-2.1	0.3	0.5	-0.5	-1.5	0.6	-1.6	0.8	-1.6
Crohns Disease (2012)	3.2	5.1	13.0	-3.3	-1.0	-3.6	-1.1	-0.4	1.4	1.9	1.6	-3.4	2.2
Mean Putamen Volume	0.2	0.2	0.6	-0.3	0.4	-0.1	0.0	0.5	0.7	-0.3	0.7	-0.4	0.8
Fasting Glucose	0.4	0.5	1.1	0.1	0.3	0.2	-1.0	0.7	1.0	0.7	1.0	0.1	0.7
HbA1C	0.7	0.7	2.8	0.1	0.0	-0.1	-1.7	1.0	1.1	0.6	0.9	0.1	1.0
HDL Cholesterol	1.5	2.5	7.2	-2.1	0.2	-2.4	-2.7	0.9	0.3	-0.5	0.5	-2.2	0.9
LDL Cholesterol	0.7	1.1	2.5	1.5	-0.4	1.3	-0.1	1.3	-0.3	-1.0	-0.5	1.6	-1.0
Lupus	5.3	8.0	17.4	2.9	-0.7	2.6	1.5	1.5	-3.3	-1.7	-3.8	3.7	-4.2
Neuroticism (2016)	0.4	0.6	2.4	0.4	-0.3	-0.2	1.3	0.1	-0.4	1.6	-0.7	-0.2	-1.0
Primary Biliary Cirrhosis	1.4	2.0	6.3	1.8	1.9	2.5	-1.2	1.1	0.8	-1.5	0.6	1.2	-0.1
Rheumatoid Arthritis	2.3	3.1	10.0	0.8	-1.3	1.0	-0.2	1.2	-3.2	-0.5	-2.7	1.2	-2.7
Schizophrenia (2014)	0.5	1.1	3.2	1.4	0.3	1.5	0.0	1.8	-0.6	-0.2	-0.4	1.7	-0.8
Triglycerides	0.4	0.7	1.7	-0.5	0.2	-0.9	-0.2	0.2	1.1	1.3	1.1	-0.6	1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.5	-0.6	0.0	-0.4	1.6	-0.7	-0.7	0.2	-0.5	-0.6	-0.7
Ulcerative Colitis	0.9	1.3	3.9	-1.1	-0.3	-0.3	1.0	0.4	2.0	0.6	1.7	-1.1	1.6
Blood Eosinophil Count	3.0	23.1	51.0	7.1	4.1	6.6	2.3	-0.7	-3.7	-4.0	-3.6	7.0	-4.7
Blood Platelet Count	0.3	4.0	18.8	2.9	1.7	4.3	1.2	-0.9	0.0	0.1	0.2	2.6	-0.4
Blood Red Count	0.5	4.6	11.4	1.5	-0.6	1.6	1.8	3.4	-2.6	-0.3	-2.7	1.9	-3.0
Blood White Count	0.7	5.1	11.9	-0.4	2.8	-0.4	-0.1	-2.8	3.0	1.5	3.5	-0.8	3.3
Heel T-Score	1.9	14.9	75.0	4.1	-0.1	1.6	-1.6	3.6	-1.3	-8.7	-2.5	4.8	-2.8
BMI	0.8	4.6	20.3	1.9	4.5	1.8	0.1	-0.5	2.5	-2.6	1.8	0.7	1.3
Height	0.2	3.1	14.9	-0.9	2.7	-1.2	-1.7	-3.9	1.0	0.2	1.2	-0.5	1.0
Waist Hip Ratio (WHR)	1.2	5.5	18.8	1.7	-0.2	2.2	0.6	-4.3	-2.7	-0.8	-2.1	3.2	-2.4
Systolic Blood Pressure	1.8	9.2	42.4	-1.9	-0.0	-1.8	5.9	-6.5	0.3	2.2	-0.3	-1.7	0.1
Smoking Status	0.4	1.0	5.1	-0.4	-1.2	-0.9	-2.2	0.9	-0.3	1.1	-0.0	-0.4	0.1
Allergy or Eczema	0.1	0.3	1.0	0.1	1.0	0.4	0.6	1.0	-0.1	0.4	-0.4	0.1	-0.6
Cardiovascular Disease	0.7	2.2	12.9	-0.5	-0.2	-0.2	2.7	-3.6	-0.7	0.9	-0.5	-0.5	-0.4
Hypothyroidism (self reported)	3.1	7.2	18.8	4.0	0.7	4.3	1.4	0.6	-2.3	-1.3	-2.1	3.9	-2.8
Respiratory disease	0.5	1.0	3.3	0.1	0.7	0.6	-0.2	1.1	-1.6	-0.1	-1.8	0.2	-1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.9	1.0	-0.4	1.7	0.2	-0.1	-0.8	-0.4	-0.7	1.3	-0.7
Lung FEV1/FVC ratio	1.6	8.3	21.6	1.9	4.7	2.0	-0.7	1.2	4.5	-0.5	4.5	0.7	3.2
Lung FVC	4.3	22.1	45.6	-5.4	0.6	-4.8	4.3	2.5	5.0	4.4	4.9	-6.8	5.4
Neuroticism	0.9	2.2	7.3	1.2	-0.7	0.8	0.4	-1.1	-2.7	0.3	-2.1	1.0	-2.4
Chronotype (morning person)	1.9	4.4	6.1	-2.5	-0.2	-1.9	-2.4	2.3	2.2	1.6	2.2	-2.4	2.2
Hair Pigment	0.1	2.8	6.5	1.3	-0.7	2.5	1.8	0.1	-2.0	-0.4	-2.0	1.6	-2.3
Tanning	0.4	4.8	12.2	-3.3	-1.8	-3.5	-1.6	1.1	0.5	2.2	0.6	-3.3	1.3
Hand grip strength (left)	1.7	4.4	11.4	-0.7	2.2	-0.1	-2.0	1.9	3.1	0.7	3.4	-1.4	2.8
Number of treatments/medications taken	1.5	2.7	5.4	1.9	0.4	2.1	2.3	-1.1	-1.3	-0.6	-1.5	2.2	-1.7
Average weekly spirits intake	0.3	0.4	1.6	0.4	1.0	0.3	0.0	-1.2	0.5	-0.8	0.6	0.2	0.3
Sensitivity / hurt feelings	0.2	0.3	0.8	0.7	0.5	0.5	-0.9	0.7	-0.6	0.3	-0.5	0.1	-0.5
Frequency of depressed mood in last 2 weeks	2.5	3.4	6.0	2.3	-1.3	1.3	1.5	-0.7	-2.2	-0.5	-2.4	2.5	-2.4
Hearing difficulty/problems: Yes	0.6	0.9	2.5	0.7	-0.9	0.8	-0.4	1.6	-1.1	0.9	-0.9	0.8	-1.1
Relative age of first facial hair	0.2	0.4	1.4	0.7	0.1	0.6	-0.1	1.2	-0.5	-0.7	-0.6	0.6	-0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.6	0.6	-0.5	1.6	0.3	-1.2	-0.5	-1.5	-0.5	0.8	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	0.9	0.9	0.6	-0.4	0.2	0.0	-0.2	0.1	0.6	0.0
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	0.1	1.1	-0.7	0.5	-0.2	1.6	0.3	1.6	-0.5	1.7
Systolic blood pressure, automated reading	1.5	4.5	22.9	-0.4	-0.5	-1.2	4.8	-3.9	-0.9	1.3	-1.3	-0.1	-1.0
Eye problems/disorders: Diabetes related eye disease	3.8	4.2	8.1	1.5	-0.3	2.4	0.9	1.6	-2.5	-2.2	-2.8	1.9	-2.9
Angina	0.1	0.1	0.7	0.1	-0.5	0.1	-0.3	-0.2	0.0	0.9	-0.0	-0.3	-0.1
Medication for hormone replacement therapy	0.3	0.4	1.5	-0.4	-0.3	-0.9	-0.8	0.4	-0.1	1.2	0.2	-0.3	0.4
Vitamin and mineral supplements	0.8	1.0	2.9	-1.7	-0.3	-1.5	-0.1	-0.4	0.8	0.6	0.7	-1.7	0.7
Supplements: Zinc	0.4	0.5	2.2	0.6	1.5	0.8	0.1	-0.6	0.6	-0.6	0.6	0.3	0.2
Medication: Co-codamol	1.0	1.2	4.2	1.1	-0.6	1.2	2.0	0.8	-0.4	-1.1	-0.6	1.2	-0.7
Medication: Metformin	0.8	1.1	4.0	1.6	0.3	1.6	0.3	-0.7	-0.4	-0.5	-0.4	2.0	-1.0
Diabetes (father)	0.5	0.6	2.0	0.4	-1.2	0.5	-1.4	0.4	-0.9	-0.0	-0.7	0.6	-0.5
Diabetes (mother)	0.9	1.2	4.1	1.6	0.6	2.0	0.2	-0.1	-0.5	-0.8	-0.9	1.5	-0.9
Severe depression (siblings)	0.6	0.7	1.8	1.4	0.8	1.0	-0.4	0.1	0.4	-1.2	-0.3	1.1	-0.8
Pack years adult smoking proportion	0.7	1.0	1.7	1.2	0.4	0.5	0.0	-1.2	-1.3	-1.3	-1.1	1.1	-1.2
Impedance of leg (right)	0.1	0.7	4.7	-0.4	-2.2	-0.7	0.9	0.9	0.2	-0.2	0.3	0.1	0.2
Leg fat-free mass (left)	0.3	1.5	5.7	0.7	2.4	0.6	-1.9	-1.9	0.2	-1.0	-0.1	0.6	-0.0
Trunk fat percentage	1.6	6.3	25.5	3.8	2.2	2.6	-0.4	0.1	1.3	-5.0	0.4	3.1	-0.3
Hand grip strength (right)	1.1	2.9	7.0	-0.2	2.5	0.0	-0.6	1.8	2.6	-0.4	2.6	-0.7	2.2
Townsend deprivation index at recruitment	2.9	4.0	10.4	0.2	-2.3	1.2	3.2	-2.0	-2.6	0.8	-2.6	0.7	-2.1
Current tobacco smoking	1.3	2.2	6.3	-1.1	-2.1	-2.5	-2.5	-0.3	-0.6	1.0	0.0	-1.3	0.8
Average weekly fortified wine intake	0.2	0.3	1.5	0.3	0.9	0.4	0.2	-1.2	0.1	0.0	0.3	0.2	0.2
Maternal smoking around birth	0.4	0.6	2.2	0.6	1.1	0.9	-1.5	0.2	0.5	0.4	0.8	-0.5	0.7
Fed-up feelings	0.2	0.4	1.7	0.4	0.5	0.3	0.7	-1.3	-0.7	1.0	-0.1	0.4	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	7.2	1.3	-0.6	1.1	2.7	-0.3	-0.7	-0.6	-1.0	1.3	-1.2
Relative age voice broke	0.2	0.4	1.2	0.7	0.6	0.7	0.1	1.1	0.1	-0.9	0.2	0.3	-0.1
Taking other prescription medications	1.7	2.6	4.9	1.9	-0.6	2.2	0.7	-1.1	-1.9	-0.7	-1.9	2.1	-1.9
Age when periods started (menarche)	0.9	2.1	7.1	-2.3	-1.4	-1.3	-0.3	-0.1	-0.6	2.7	-0.3	-2.2	0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.5	0.5	0.8	0.1	0.7	0.5	-0.2	0.5	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.6	23.0	3.8	0.3	1.8	-1.6	1.6	-0.7	-4.8	-1.2	3.7	-2.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.3	0.7	1.8	0.8	-1.1	1.8	0.4	1.4	0.3	0.6	0.4
Qualifications: CSEs or equivalent	1.4	1.8	6.3	1.4	2.2	0.5	-2.5	1.4	-0.2	-1.7	-0.1	0.4	-0.3
Serious illness, injury or assault to yourself	0.5	0.7	2.1	-0.3	-0.7	-0.9	0.7	-1.4	-0.9	0.7	-0.8	0.2	-0.7
High blood pressure	1.3	3.7	21.1	-1.5	-1.0	-1.0	2.4	-4.6	-0.5	2.0	-0.2	-1.5	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.5	0.6	1.2	0.7	1.2	0.7	-0.1	0.2	-0.4	0.5	-0.6
Multivitamins +/- minerals	1.0	1.3	3.2	1.6	0.5	1.5	0.2	-0.5	-1.1	-0.8	-1.0	1.8	-1.3
Stomach or abdominal pain in last month	2.2	2.8	7.1	2.5	0.9	1.4	0.4	0.3	-2.0	-0.9	-1.7	2.7	-1.9
Supplements: Glucosamine	0.5	0.6	1.6	-0.2	0.6	0.3	1.2	0.1	1.0	0.0	1.3	-0.8	1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.2	1.1	0.1	1.8	-0.5	0.1	-0.9	-0.3	-1.1	1.5	-1.5
Medication: Atenolol	0.8	1.1	2.5	0.7	0.1	1.0	1.6	0.3	-1.2	-0.3	-1.4	0.8	-1.5
Medication: Levothyroxine sodium	1.1	1.8	8.8	1.9	1.1	3.0	1.5	0.4	-0.1	-0.2	0.2	1.6	-0.2
Sitting height	0.2	1.1	3.0	-1.1	0.4	-0.8	0.7	-1.7	-1.7	0.7	-1.3	-0.5	-0.6
Chronic bronchitis/emphysema (father)	1.1	1.3	5.4	-1.0	-2.3	-1.2	0.7	-0.7	-0.6	1.5	-0.9	-0.6	-0.4
High blood pressure (mother)	0.8	1.1	8.1	0.9	0.7	0.8	2.8	0.2	0.9	-0.4	0.3	0.3	0.0
Body mass index (BMI)	0.6	2.5	6.0	2.1	2.5	2.0	-0.8	0.1	1.4	-2.3	0.9	1.3	0.5
Impedance of leg (left)	0.1	0.6	2.9	-0.0	-1.7	-0.4	1.5	0.7	0.3	-0.4	0.4	0.3	0.2
Leg predicted mass (left)	0.3	1.5	5.7	0.6	2.4	0.4	-2.0	-1.9	0.2	-0.9	-0.1	0.5	-0.0
Trunk fat mass	1.0	4.4	16.6	2.9	2.4	2.1	-1.0	-0.4	1.2	-4.1	0.5	2.4	-0.1
Waist circumference	0.8	3.1	7.2	2.7	1.2	2.4	-0.7	-1.0	-0.6	-2.1	-1.0	2.7	-1.3
Number of incorrect matches in round	0.1	0.1	0.6	-0.2	-0.2	-0.3	-0.8	0.1	-0.1	0.2	0.0	-0.0	0.0
Past tobacco smoking	0.1	0.3	1.1	0.2	-0.6	-0.2	-0.1	-0.7	-1.0	0.0	-0.6	0.2	-0.4
Alcohol usually taken with meals	0.4	0.7	2.0	0.2	0.7	-0.3	-1.4	0.7	1.1	-1.4	0.7	-0.2	0.4
Nervous feelings	0.8	1.5	5.5	-0.0	-1.1	-0.3	-1.4	-0.2	-2.3	0.3	-1.9	0.0	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.6	2.1	0.5	1.5	1.5	0.4	-1.4	0.6	-1.4	1.8	-1.7
Hearing difficulty/problems with background noise	0.7	1.1	3.5	0.6	0.0	1.8	1.0	1.9	-0.7	0.6	-0.6	0.8	-1.1
Hair/balding pattern: Pattern 2	1.1	1.5	4.8	0.7	-0.7	1.3	-0.5	0.1	-1.1	-1.7	-1.1	2.2	-1.1
Had menopause	0.4	0.5	4.2	-0.0	0.1	-0.2	2.1	-0.6	0.1	0.1	0.3	0.0	0.2
Had other major operations	1.4	1.7	4.5	0.8	-0.9	1.2	-0.8	1.6	-2.1	0.6	-1.7	1.1	-1.4
Forced vital capacity (FVC)	0.9	3.3	6.1	-2.1	1.0	-1.8	1.6	0.2	2.0	2.0	1.9	-2.5	2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	16.8	2.8	-0.3	1.1	-1.5	1.2	-1.0	-4.1	-1.5	2.9	-2.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	0.3	-0.5	-0.5	0.2	-0.2	-1.2	0.1	-1.0	0.4	-1.2
Qualifications: None of the above	0.1	0.3	1.5	-0.6	0.4	-0.1	-0.3	0.1	0.2	1.2	0.4	-0.5	0.4
Financial difficulties in last 2 years	1.0	1.3	3.8	1.4	-0.5	1.3	-0.0	-0.3	-1.2	-1.1	-1.1	2.0	-1.3
Mouth/teeth dental problems	1.1	1.7	4.4	-0.7	1.0	-1.2	-0.9	0.2	2.0	0.3	2.1	-0.7	1.9
Heart attack	1.1	1.4	4.2	0.1	0.1	-0.2	-1.0	0.9	1.4	2.1	1.7	-0.9	1.4
Allergy	0.8	1.7	3.3	-1.5	-1.8	-1.8	-0.7	-1.3	1.0	0.4	1.2	-1.1	1.6
Pain all over the body in last month	1.6	1.7	5.4	1.0	0.8	2.3	1.5	1.5	-1.1	-0.3	-1.2	1.1	-1.1
Diabetes (self-reported)	0.6	1.0	3.9	0.4	-0.3	1.5	0.7	-2.0	-0.6	-0.2	-0.9	1.0	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.1	-0.2	0.4	-0.6	-0.4	-0.4	1.1	-0.1	0.5	-0.5	0.5
Medication: Ramipril	0.6	0.8	3.8	-0.6	-1.3	-0.9	0.6	-2.0	0.6	0.6	0.1	-0.7	0.4
Medication: Simvastatin	0.6	0.8	5.3	-0.5	0.1	-1.0	2.3	0.4	-0.0	0.9	-0.4	-0.7	-0.2
Fluid intelligence score	0.5	1.1	4.0	-1.0	-1.3	-1.6	-1.0	-2.0	0.1	0.6	-0.0	-0.5	0.2
Illnesses of siblings	1.8	2.5	7.7	-0.2	0.6	-0.5	-2.8	0.4	2.6	-0.1	2.3	-0.2	2.0
Neuroticism score	0.8	1.7	6.3	0.8	-0.2	0.9	0.2	-0.5	-2.5	0.8	-1.9	0.7	-2.0
Weight	0.5	2.4	7.1	1.9	2.7	1.7	-1.4	-1.1	0.9	-2.1	0.6	1.4	0.2
Impedance of arm (right)	1.0	4.6	18.0	3.2	-0.9	1.2	1.4	-0.5	-0.1	-4.2	-0.5	3.3	-1.2
Arm fat percentage (right)	1.6	6.2	23.6	3.8	2.5	2.6	-0.5	-0.3	1.4	-4.9	0.7	2.9	-0.1
Trunk fat-free mass	0.4	2.2	6.0	-1.4	2.1	-0.6	-2.5	-1.5	0.1	2.0	0.5	-1.4	0.8
Hip circumference	0.5	2.3	7.1	2.7	1.9	1.7	-0.8	1.3	0.8	-2.0	0.2	1.7	-0.2
Time employed in main current job	0.7	0.8	2.1	0.2	1.4	0.9	0.2	0.8	0.8	-1.1	0.9	-0.2	1.0
Alcohol intake versus 10 years previously	2.1	3.2	7.1	2.3	-0.2	1.2	-0.8	-2.3	-2.1	0.4	-1.7	2.7	-2.1
Father’s age at death	1.3	1.8	4.3	1.6	0.7	1.6	-0.4	1.8	-0.9	-2.1	-0.5	1.6	-0.7
Worrier / anxious feelings	0.5	1.0	4.1	-0.3	0.8	-1.2	-0.2	-2.0	-1.0	1.3	-0.6	-0.8	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.6	1.6	0.7	0.9	-0.5	-0.3	-1.4	-0.4	-1.1	1.2	-1.4
Falls in the last year	0.4	0.6	4.2	-0.0	0.6	0.2	2.1	-1.0	-0.4	0.1	0.1	0.1	0.3
Hair/balding pattern: Pattern 3	1.5	2.3	6.4	-2.0	0.3	-1.8	0.5	1.5	1.0	1.4	1.2	-2.5	1.4
Number of live births	0.7	1.0	5.2	0.2	0.8	-0.1	-0.9	2.3	0.5	1.2	0.6	-0.8	0.4
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	9.8	-1.9	1.8	-1.7	1.0	0.8	3.1	2.0	3.0	-2.5	2.9
Pulse rate	0.4	0.7	3.2	0.6	-0.1	-0.1	1.0	1.8	-1.2	0.2	-0.9	0.3	-0.3
Happiness	0.5	0.6	4.2	-0.4	-0.1	-0.7	0.4	-2.0	-0.0	0.6	0.2	-0.8	0.4
Noisy workplace	2.1	2.6	5.8	1.8	0.1	1.6	0.5	-0.1	-1.6	-1.7	-2.0	2.1	-2.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	4.1	0.8	1.4	0.4	2.0	-0.5	-0.3	-0.2	-0.2	1.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.4	-0.3	1.6	-0.1	0.7	-0.9	1.4	-1.8	0.7	-0.4	0.8
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	1.2	0.6	1.4	1.4	-0.2	0.8	-0.5	0.2	0.7	-0.1
Asthma	0.6	1.3	2.8	1.2	1.6	1.7	1.0	1.0	-1.0	0.1	-1.1	1.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	0.6	0.8	1.5	1.4	-0.8	-0.5	-0.5	-0.3	1.2	-0.1
Medication: Cholesterol lowering	0.2	0.4	1.7	0.5	-0.4	0.4	1.3	0.3	-0.4	0.3	-0.5	0.3	-0.8
Depression (self-reported)	0.2	0.2	1.0	-0.1	-0.2	-0.6	-0.5	-1.0	0.4	0.1	0.1	-0.3	-0.2
Medication: Lansoprazole	0.6	0.6	1.6	1.2	1.2	0.3	-1.2	0.3	-0.2	-0.3	-0.3	1.0	-0.7
Prospective memory result	0.3	0.3	2.1	-0.0	1.5	-0.3	0.0	-0.6	0.7	-0.3	0.5	-0.4	-0.0
Lung cancer (father)	0.5	0.5	1.5	-0.4	1.2	0.1	0.4	0.9	0.7	-0.1	1.0	-0.6	1.0
Illnesses of mother	0.4	0.5	1.5	-0.6	0.3	-0.5	-1.2	0.8	0.5	-0.3	0.7	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	9.2	-1.4	1.5	-1.2	0.9	0.5	3.0	2.1	2.8	-2.2	2.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.9	0.4	0.9	-0.8	0.2	0.4	0.2	0.4	0.1	0.0	0.3
Impedance of arm (left)	1.4	6.3	21.0	3.7	-1.0	1.6	1.6	-0.3	-0.9	-4.6	-1.4	3.9	-2.1
Arm fat mass (right)	1.1	4.7	14.8	2.9	3.1	2.2	-1.2	-0.5	1.5	-3.9	0.9	2.2	0.3
Trunk predicted mass	0.4	2.1	5.7	-1.4	2.2	-0.6	-2.4	-1.5	0.1	1.9	0.5	-1.4	0.8
Standing height	0.1	1.1	6.2	0.1	1.3	-0.2	-1.2	-2.5	-0.7	-0.1	-0.5	0.7	-0.4
Length of working week for main job	0.5	0.6	1.3	-1.1	-1.2	-0.5	0.7	-1.1	0.3	0.5	0.3	-0.6	0.6
Exposure to tobacco smoke at home	0.4	0.5	2.1	-0.6	-1.5	-0.4	0.3	0.8	-0.7	-0.4	-0.6	0.1	-0.4
Breastfed as a baby	0.4	0.4	1.7	-0.2	0.2	-0.5	-0.4	1.3	0.2	1.1	0.4	-0.8	0.4
Tense / ‘highly strung’	1.2	2.0	3.9	0.3	-1.7	0.2	-1.8	-1.1	-2.0	1.4	-1.6	0.6	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.0	1.3	0.8	1.1	0.5	-0.8	-0.6	0.9	-0.4	1.7	-1.3
Hair/balding pattern: Pattern 4	1.2	2.8	17.6	-1.7	-4.2	-1.7	-0.4	-0.5	-0.4	1.9	-0.4	-0.8	-0.1
Birth weight of first child	0.9	1.6	5.5	-0.4	-1.5	0.8	-0.8	0.5	-2.3	1.0	-1.8	1.0	-1.0
Peak expiratory flow (PEF)	2.2	5.1	18.9	-0.4	2.1	-0.6	0.5	1.0	4.3	0.7	3.8	-1.0	3.1
Pulse wave reflection index	0.4	0.5	1.2	-0.4	1.1	-0.8	0.5	-0.4	1.1	0.4	0.7	-0.8	0.6
Ever highly irritable/argumentative for 2 days	1.0	1.3	2.7	0.8	1.6	0.8	-0.6	1.4	-1.1	-1.1	-1.1	0.7	-1.4
Loud music exposure frequency	1.9	2.0	5.4	2.0	0.5	2.2	1.2	-0.4	-0.2	-1.9	-0.4	2.3	-0.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.9	1.0	-1.1	1.1	1.1	0.5	-1.7	-0.8	-1.8	1.3	-2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.1	0.1	-1.2	0.4	1.1	-0.4	-1.6	-0.1	-1.8	0.4	-1.5
Blood clot in the leg (DVT)	0.6	0.8	5.0	1.0	0.2	0.5	-0.7	2.2	-0.0	-0.6	-0.1	0.8	-0.4
Medication: Paracetamol	0.6	1.0	2.9	0.1	-0.7	0.1	0.4	1.1	-1.7	1.5	-1.2	0.9	-1.1
Headache pain in last month	0.1	0.2	0.7	0.8	-0.3	-0.1	0.1	-0.5	-0.1	-0.1	0.3	0.8	0.3
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	7.3	0.4	2.7	0.3	-1.8	1.6	2.4	-1.1	2.2	-0.1	2.0
Glaucoma (self-reported)	0.6	0.7	3.1	-0.4	-1.0	-0.2	-1.8	1.6	0.1	-0.2	0.2	-0.5	0.6
Gout (self-reported)	0.5	0.6	2.7	-0.2	-1.1	0.4	-1.6	-0.3	-0.9	0.5	-0.9	-0.1	-0.6
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	13.0	2.9	1.3	3.6	1.2	-0.4	-0.8	-0.8	-0.5	2.7	-1.2
Medication: Amlodipine	0.8	1.1	4.7	-0.3	-1.1	-0.3	1.0	-2.2	-1.0	0.3	-1.2	-0.2	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.4	-0.0	-0.9	0.8	-0.1	-0.3	-1.5	0.3	-1.5	0.5	-1.3
Birth weight	0.9	1.9	11.9	-0.6	-1.8	-1.5	-3.5	0.3	0.2	-0.7	-0.2	-0.3	0.1
Chronic bronchitis/emphysema (mother)	2.1	2.4	5.1	-1.1	0.4	-1.6	-0.3	-1.1	2.0	1.7	2.1	-1.5	2.3
High blood pressure (siblings)	1.5	2.1	9.5	-0.4	-0.7	-0.5	3.1	-0.4	-2.1	-0.6	-1.8	-0.1	-1.6
Forced vital capacity (FVC), Best measure	1.0	3.7	6.9	-2.1	0.6	-2.1	1.0	0.1	2.3	2.4	2.1	-2.6	2.1
Body fat percentage	1.3	5.2	21.2	3.4	1.8	2.4	-0.5	0.3	1.2	-4.6	0.4	2.8	-0.3
Leg fat percentage (right)	0.6	2.3	7.5	1.8	1.5	1.7	-0.6	1.0	1.7	-2.7	1.2	1.2	0.7
Arm fat-free mass (right)	0.3	1.7	4.8	-1.4	2.2	-0.6	-2.0	-0.8	0.4	1.6	0.4	-1.4	0.8
Exposure to tobacco smoke outside home	0.9	1.3	2.8	0.1	0.7	0.8	1.6	-1.7	-1.5	-0.6	-1.3	0.4	-1.3
Comparative body size at age 10	1.1	3.1	6.2	2.1	1.1	2.2	1.9	-1.1	-1.5	-2.5	-1.3	1.9	-1.4
Number of full brothers	2.0	2.5	4.9	0.1	-2.1	1.4	1.7	0.3	-2.2	1.3	-2.2	0.4	-2.0
Worry too long after embarrassment	0.3	0.5	2.3	0.8	-0.1	0.7	1.5	-0.8	-0.6	-0.3	-0.2	0.5	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	6.5	0.3	-0.5	-0.0	-2.5	-1.0	-1.1	-0.3	-0.9	0.5	-1.3
Wheeze or whistling in the chest in last year	0.4	0.8	1.5	1.2	0.3	1.1	-0.3	0.8	-0.9	-0.3	-1.2	1.0	-1.0
Number of children fathered	1.7	1.9	7.5	0.2	0.1	0.4	-2.7	1.7	2.2	-0.6	1.6	-0.6	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	-0.6	-0.2	-0.4	-0.3	-0.4	-0.8	0.6	-0.6	-0.5	-0.6
Age at first live birth	0.6	1.0	2.6	-1.4	-0.5	-1.2	-0.9	-1.6	0.1	0.7	0.5	-1.3	0.5
Pulse wave peak to peak time	0.2	0.3	0.7	-0.4	-0.8	0.8	-0.7	-0.7	-0.2	-0.5	-0.1	0.1	-0.3
Health satisfaction	1.1	1.5	4.9	0.6	-0.4	0.7	-0.3	-1.1	-2.2	-0.3	-1.9	0.9	-1.7
Shortness of breath walking on level ground	2.0	2.3	4.7	2.0	-1.0	1.0	-0.6	0.3	-1.7	-0.8	-2.1	2.1	-2.2
Qualifications: College or University degree	0.3	1.1	2.6	0.7	1.4	-0.7	-1.6	-1.1	1.1	-1.0	1.1	0.5	0.6
Eye problems/disorders: None of the above	2.8	3.2	6.9	-2.6	-1.1	-2.5	0.2	1.3	1.4	1.9	1.4	-2.4	1.8
Mouth/teeth dental problems: Loose teeth	2.2	2.6	8.0	-2.3	-1.7	-1.0	-1.4	0.2	0.4	2.8	1.0	-2.1	1.3
Emphysema/chronic bronchitis	0.3	0.3	1.0	-0.9	-0.5	-0.8	-0.3	-0.4	-0.1	-0.4	-0.4	-1.0	-0.3
Medication for pain relief, constipation, heartburn	1.7	2.9	7.0	-1.2	0.4	-1.8	-2.0	-0.0	2.6	-0.5	2.1	-2.1	2.1
Neck or shoulder pain in last month	0.4	0.6	1.7	0.8	-0.3	1.3	-0.4	0.4	-0.8	-0.9	-0.8	1.1	-0.6
Medication: Blood pressure	2.0	3.5	8.2	-1.7	-2.9	-1.6	2.3	-2.7	-1.3	1.6	-1.3	-1.2	-0.8
Angina (self-reported)	0.1	0.1	0.4	0.3	-0.6	0.2	0.0	-0.3	0.0	0.7	-0.0	-0.1	-0.1
Migraine (self-reported)	0.3	0.4	1.7	-0.4	-0.6	-0.5	1.1	-0.5	-0.2	-1.3	-0.2	-0.1	-0.1
Medication: Ibuprofen	0.4	0.5	1.7	-0.0	1.0	0.9	1.3	-0.4	-0.2	-0.5	-0.1	0.8	0.2
Medication: Allopurinol	0.7	1.0	2.5	-0.3	-1.4	0.7	-0.7	-0.6	-1.6	0.3	-1.5	0.0	-1.2
Medication: Omeprazole	1.2	1.5	3.5	1.4	-1.1	0.9	-0.4	1.0	-1.9	-0.2	-1.5	1.5	-1.3
Medication: Seretide 50 evohaler	1.1	1.2	4.5	0.4	0.4	0.6	0.7	-1.6	-2.1	-0.2	-1.4	0.8	-1.3
Mean time to correctly identify matches	0.7	1.4	3.4	-1.8	0.2	-0.8	0.2	0.8	1.3	0.6	1.3	-1.8	1.6
Heart disease (mother)	0.8	0.9	3.8	-0.4	1.2	-0.4	-1.9	-0.6	0.7	-1.2	0.7	-0.8	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.2	0.6	1.8	0.3	-0.8	-1.7	1.6	-0.6	1.1	0.3	0.4
Whole body fat mass	0.9	3.9	13.6	2.7	2.3	2.1	-1.2	-0.5	1.1	-3.7	0.5	2.3	-0.1
Leg fat mass (right)	0.6	2.4	8.0	1.9	1.8	1.8	-1.2	-0.2	1.1	-2.8	0.7	1.6	0.2
Arm predicted mass (right)	0.4	2.0	5.6	-1.4	2.2	-0.7	-2.4	-0.8	0.3	1.9	0.4	-1.4	0.8
Pulse rate, automated reading	0.2	0.6	1.8	0.8	0.5	1.3	-0.6	0.5	-1.3	0.5	-0.5	0.4	-0.4
Alcohol intake frequency.	1.0	2.3	7.3	0.7	-2.7	1.0	1.0	0.1	-1.8	1.1	-1.7	1.8	-1.7
Comparative height size at age 10	0.4	2.2	3.8	-1.2	1.7	-1.5	-1.1	-1.9	1.7	0.4	1.7	-1.2	1.6
Number of full sisters	0.7	0.9	2.0	0.7	-0.4	1.4	-1.4	0.9	-0.9	-0.1	-0.8	1.3	-0.5
Suffer from ‘nerves’	1.5	2.3	6.1	1.0	-0.2	1.2	0.9	-0.1	-2.5	0.7	-2.3	1.6	-2.4
Overall health rating	0.9	1.8	6.7	0.3	-1.0	0.1	0.1	-1.7	-2.6	-0.3	-2.0	0.5	-1.8
Chest pain or discomfort	3.2	4.6	10.4	2.7	0.3	2.4	-0.5	0.6	-2.4	-0.7	-2.8	2.9	-3.2
Had major operations	0.4	0.5	2.5	0.0	-0.8	0.6	-0.1	-0.7	-0.9	1.6	-0.3	0.2	-0.3
Age at last live birth	0.3	0.5	1.6	-0.5	0.5	-0.4	-1.0	-1.3	0.4	0.3	0.6	-0.8	0.3
Family relationship satisfaction	1.0	1.2	4.9	-1.2	-0.2	-0.6	2.2	-1.0	0.9	-0.2	0.7	-1.2	0.9
Leg pain on walking	0.8	1.1	2.0	1.1	-0.7	1.4	-0.6	1.3	-0.7	-0.6	-1.0	1.4	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	3.4	0.4	1.9	0.6	-0.0	1.1	0.2	0.3	0.4	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.3	-0.9	0.3	-0.6	-1.1	0.1	0.9	0.4	1.0	-1.1	1.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.9	-0.8	0.8	-0.2	-0.4	0.2	1.9	1.1	1.8	-1.7	2.0
Medication: Aspirin	0.3	0.4	1.1	1.0	0.3	1.1	0.8	0.3	0.2	0.2	0.3	0.7	0.1
Supplements: Vitamin C	0.4	0.5	4.1	-0.1	-0.1	0.4	0.2	2.0	0.3	-0.6	0.3	0.4	0.5
Knee pain experienced in last month	0.8	1.2	3.2	1.5	-0.1	0.3	-1.8	0.8	-0.8	-0.1	-0.8	1.6	-1.3
Hypertension (Self-reported)	1.3	3.6	19.0	-1.7	-1.1	-1.0	2.0	-4.4	-0.8	2.0	-0.5	-1.6	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	0.6	0.3	0.3	-0.1	-0.1	0.8	-1.0	0.7	0.2	0.5
Illnesses of father: Heart disease	2.5	3.5	8.8	0.5	-1.2	0.2	2.5	-2.4	-3.0	0.0	-2.5	1.0	-2.3
Illnesses of siblings: Diabetes	4.2	5.1	9.7	2.6	-1.5	3.1	0.3	-0.4	-2.8	-0.9	-2.8	2.8	-2.9
Smoking status: Previous	0.7	1.0	3.5	-0.1	1.7	0.5	0.6	0.3	1.9	0.0	1.4	-0.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.4	-1.0	0.8	-1.0	-0.7	-1.8	-0.2	1.8	0.2	-0.7	0.3
Whole body fat-free mass	0.3	1.6	6.0	-0.6	2.5	-0.1	-2.3	-1.6	0.2	0.9	0.3	-0.7	0.6
Leg fat-free mass (right)	0.3	1.6	6.9	0.8	2.6	0.5	-1.7	-2.0	0.1	-0.9	-0.1	0.6	-0.1
Arm fat percentage (left)	1.6	6.3	25.1	3.8	2.4	2.6	-0.5	-0.2	1.1	-5.0	0.3	3.1	-0.5
Average weekly red wine intake	0.8	1.2	3.9	1.2	1.1	0.7	2.0	-1.9	0.5	-0.9	0.5	0.5	0.1
Handedness (chirality/laterality): Left-handed	3.0	3.6	8.0	-2.8	0.5	-2.3	-0.6	0.1	1.7	1.9	1.8	-2.8	2.1
Mood swings	0.3	0.6	2.3	0.5	0.1	0.8	-0.6	0.7	-0.9	0.5	-0.9	0.5	-1.5
Loneliness, isolation	0.5	0.7	1.6	1.0	0.4	-0.1	1.2	-0.8	-1.3	-0.5	-0.9	0.6	-0.7
Long-standing illness, disability or infirmity	0.8	1.2	3.6	1.1	-0.5	1.9	0.4	-0.5	-1.2	-1.4	-1.0	1.2	-1.1
Ever had bowel cancer screening	0.8	1.0	2.5	-0.6	-0.9	-1.2	-1.1	-0.5	-1.6	0.9	-1.2	-0.1	-0.9
Diabetes diagnosed by doctor	0.4	0.6	1.9	0.2	-0.2	1.4	0.0	-1.2	-0.7	-0.0	-0.8	1.0	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.2	0.2	-0.5	0.4	0.4	-0.7	0.9	-0.4	0.1	-0.5
Friendships satisfaction	0.7	0.8	2.4	-0.5	-0.0	-0.9	1.1	-0.8	1.1	-0.1	1.1	-0.7	1.6
Qualifications: nursing, teaching	0.3	0.5	2.2	-0.2	-1.0	0.1	-0.9	1.5	-0.0	-0.7	-0.1	-0.0	0.1
Commuting to job workplace: Walk	1.2	1.3	4.2	-0.3	-2.0	-0.6	1.4	0.2	-1.2	1.2	-1.4	0.0	-1.3
Eye problems/disorders: Cataract	1.2	1.4	3.9	1.6	0.2	1.6	2.0	-0.7	-0.7	-1.1	-0.5	1.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	3.9	1.7	0.5	1.3	0.9	-0.4	-2.0	0.4	-1.7	1.6	-1.7
Medication for cholesterol	0.9	1.4	4.0	-0.6	-0.8	-0.8	-1.4	2.0	1.4	0.2	1.5	-0.4	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.0	-0.2	0.6	0.6	-2.2	-0.5	-1.9	0.2	-1.8	0.7	-1.4
Back pain experienced in last month	0.3	0.5	1.2	0.4	1.1	-0.2	-1.1	0.2	0.8	-0.4	0.8	0.2	0.9
Mineral and other dietary supplements	0.5	0.7	2.0	-1.2	-0.6	-1.4	0.4	-1.2	-0.1	-0.1	-0.5	-0.9	-0.1
Breast cancer (self-reported)	0.8	1.0	2.6	0.6	0.5	1.1	0.9	-0.6	-1.5	-0.7	-1.3	0.5	-1.6
Asthma (self-reported)	0.9	1.8	3.5	1.4	1.3	1.9	1.1	1.3	-1.4	-0.4	-1.5	1.3	-1.5
Osteoporosis (self-reported)	1.9	2.3	5.4	-1.5	-0.6	-1.5	-0.4	-0.3	1.5	1.8	1.9	-1.8	2.3
Osteoarthritis (self-reported)	0.4	0.5	1.2	1.1	-0.5	0.7	-0.1	-0.1	-1.1	-0.4	-0.8	0.6	-0.8
Medication: Aspirin	0.3	0.4	1.1	1.1	0.6	1.0	-0.3	0.2	0.5	-0.0	0.6	0.6	0.3
Medication: Gliclazide	0.4	0.5	1.3	0.2	0.3	-0.1	-1.1	0.3	0.8	0.3	1.1	0.5	0.9
Illnesses of father: None of the above (group 1)	3.0	3.6	10.0	0.1	2.1	0.0	-3.2	1.7	2.9	-1.0	2.5	-0.7	1.9
Smoking status: Current	1.0	1.6	5.2	-0.6	-2.1	-1.9	-2.3	0.1	-0.9	0.7	-0.5	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	8.4	-0.8	2.9	-0.8	1.2	1.5	2.9	1.2	2.4	-1.6	2.0
Whole body water mass	0.3	1.6	6.8	-0.6	2.6	-0.1	-2.2	-1.6	0.4	0.8	0.4	-0.7	0.7
Leg predicted mass (right)	0.3	1.6	7.1	0.8	2.7	0.5	-1.8	-2.0	0.2	-0.9	-0.0	0.5	-0.1
Arm fat mass (left)	1.2	4.9	14.4	3.0	3.2	2.4	-1.1	-0.5	1.6	-3.8	1.0	2.2	0.3
Number of self-reported non-cancer illnesses	2.1	3.7	7.5	2.7	-0.3	2.5	-1.2	-0.6	-2.1	-1.1	-2.2	2.3	-2.4
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.2	0.2	-0.5	0.6	0.7	0.3	-0.3	0.2	-0.1	0.2
Miserableness	0.8	1.5	4.5	1.5	1.0	2.1	0.1	0.0	-1.5	0.2	-0.8	1.5	-1.2
Guilty feelings	0.3	0.4	1.6	0.2	-0.0	-1.1	-0.6	-0.6	-0.3	1.3	0.3	-0.4	0.2
Wears glasses or contact lenses	0.5	0.6	3.4	-1.0	-0.3	-1.8	0.4	0.4	-0.3	0.3	-0.1	-1.1	0.2
Ever taken oral contraceptive pill	1.2	1.3	4.6	-0.6	-0.1	-1.4	-2.1	0.1	1.1	0.9	1.3	-1.0	1.1
Hearing aid user	1.5	1.7	4.7	-1.7	-2.0	-2.2	-1.4	0.8	-0.4	1.0	0.1	-1.4	0.4
Mother’s age at death	0.3	0.4	1.3	0.1	-0.7	0.6	-0.8	1.1	-0.2	-0.9	0.1	0.6	0.4
Financial situation satisfaction	2.1	2.6	4.9	2.1	-0.1	1.2	-0.2	-1.3	-1.4	-2.2	-1.8	2.0	-1.9
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.9	2.6	0.6	1.5	1.8	-0.5	-0.8	-0.8	-0.9	2.3	-1.3
Commuting to job workplace: Public transport	1.4	1.7	5.7	1.1	0.5	0.8	2.4	-0.2	-1.7	0.9	-1.6	1.2	-1.3
Eye problems/disorders: Glaucoma	2.0	2.4	4.6	2.1	0.2	1.8	-2.1	1.4	-0.4	-1.9	-0.8	1.9	-1.0
Medication: Blood pressure	1.1	2.1	8.0	0.7	1.7	1.7	2.5	-2.8	0.2	-0.0	0.2	0.1	0.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.4	2.0	1.5	1.0	-2.1	2.0	1.1	-0.4	0.9	1.1	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	0.5	-0.3	0.9	-1.2	1.2	0.1	0.7	0.5	0.4	0.1
High cholesterol (Self-reported)	0.2	0.4	2.6	0.4	1.6	0.2	0.8	0.2	0.2	0.0	0.4	-0.1	0.1
Medication: Bendroflumethiazide	1.8	2.7	7.3	-1.9	0.7	-1.6	1.7	-1.8	0.1	2.7	0.5	-2.3	0.9
Medication: Paracetamol	0.5	0.8	2.3	0.3	-1.1	0.2	0.1	0.5	-1.5	0.7	-1.1	1.1	-0.9
Medication: Lisinopril	1.1	1.4	5.4	0.5	-0.5	0.9	2.3	-0.5	-1.5	-0.3	-1.5	0.8	-1.3
Medication: Atorvastatin	0.7	0.8	4.5	1.3	1.0	2.1	0.4	0.1	0.1	-0.5	-0.0	0.8	-0.3
Illnesses of father: High blood pressure	0.5	0.6	2.6	-0.3	0.4	-0.8	0.9	-1.6	0.7	-0.3	0.7	-0.3	0.7
Alcohol drinker status: Never	0.6	0.7	2.5	0.5	0.3	1.4	1.0	0.2	0.1	-1.6	0.3	0.8	-0.0
Ever smoked	0.3	0.6	1.8	-1.4	-0.5	-0.9	-0.8	0.3	0.1	0.5	0.3	-1.2	0.7
Basal metabolic rate	0.3	1.5	7.3	0.2	2.7	0.5	-2.1	-1.6	0.5	-0.1	0.4	0.0	0.5
Leg fat percentage (left)	0.7	2.6	7.8	1.9	1.9	1.6	-0.1	0.8	1.8	-2.8	1.3	1.3	0.7
Arm fat-free mass (left)	0.4	2.1	8.5	-1.0	2.9	-0.1	-1.8	-0.9	1.1	1.2	1.1	-1.2	1.3
Number of operations (self-reported)	0.6	0.8	2.5	-0.1	-1.0	0.5	-1.6	1.1	-1.2	1.2	-0.5	-0.2	-0.4
Average weekly beer plus cider intake	0.9	1.2	3.0	-1.1	-1.5	-0.7	-1.7	-0.1	-1.7	0.7	-1.1	-0.7	-0.5
Irritability	0.9	1.5	3.6	0.8	-0.4	1.2	-0.1	-0.1	-1.7	1.3	-1.8	1.1	-1.9
Risk taking	1.1	1.6	4.4	1.3	-0.6	1.1	-0.8	-0.7	-1.1	-1.1	-1.2	2.1	-1.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.5	0.2	1.4	0.3	1.6	1.0	0.2	0.4	0.5	0.2	0.5
Fractured/broken bones in last 5 years	1.7	2.2	4.9	-0.9	1.1	-1.3	-1.1	-0.9	1.9	1.0	2.2	-1.4	2.2
Age started oral contraceptive pill	0.3	0.4	0.7	0.9	0.7	0.7	0.1	0.8	0.6	-0.5	0.4	0.8	0.1
Diastolic blood pressure, automated reading	1.8	5.5	15.3	2.7	0.6	1.9	3.7	-3.9	-1.1	-1.9	-1.5	2.4	-1.6
Ever depressed for a whole week	0.2	0.2	0.6	0.2	0.7	0.0	0.4	0.3	-0.6	-0.2	-0.7	0.2	-0.8
Unable to work because of sickness or disability	3.5	4.6	11.4	1.4	-2.2	1.4	1.7	-0.6	-3.4	-0.6	-3.1	2.0	-2.9
Commuting to job workplace: Cycle	0.5	0.6	1.4	-0.1	1.2	-0.2	-0.8	0.6	1.0	0.5	1.1	-0.6	1.0
Myopia	0.2	0.3	2.9	0.0	0.3	-0.1	-1.7	-0.1	-0.2	-0.0	-0.0	0.2	0.2
Vascular/heart problems diagnosed by doctor	1.1	2.9	15.3	1.4	0.9	0.9	-1.8	3.9	0.6	-2.0	0.4	1.5	-0.1
Cholesterol lowering medication	0.5	0.8	4.2	0.8	2.0	1.1	0.9	-0.9	-0.0	-0.3	-0.1	0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	2.3	2.9	6.0	2.3	-0.8	2.2	0.5	0.7	-2.1	-0.4	-1.8	2.5	-1.7
Pain experienced in last month	1.0	1.7	5.1	-1.7	-0.7	-2.2	0.0	0.1	1.0	0.7	0.9	-2.2	1.0
Supplements: Calcium	0.6	0.6	2.9	0.2	-0.0	-0.2	-1.7	0.7	0.2	1.6	0.3	0.1	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	-1.0	0.4	-1.0	0.4	-0.8	-0.8	1.1	-0.4	-0.9	0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.2	0.3	0.0	-0.0	-1.1	1.1	1.2	1.8	1.5	-0.7	1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	5.4	0.6	0.3	0.2	-0.8	2.3	0.3	-0.1	0.3	0.3	0.1
Heart disease (siblings)	0.8	1.0	2.4	-1.0	-0.7	-0.5	1.1	-0.2	-1.6	1.5	-1.1	-0.8	-0.9
Alcohol drinker status: Previous	1.1	1.3	5.6	-0.5	-2.4	-0.6	0.1	0.8	-0.8	1.7	-1.0	-0.7	-0.9
Pack years of smoking	0.5	0.7	1.3	0.9	0.5	0.4	-0.1	-0.9	-1.0	-1.1	-0.9	0.9	-1.1
Impedance of whole body	0.6	2.8	8.0	2.1	-1.6	0.8	2.0	0.6	-0.4	-2.8	-0.7	2.4	-1.2
Leg fat mass (left)	0.6	2.3	7.5	1.9	2.0	1.6	-0.9	-0.4	1.2	-2.7	0.8	1.5	0.3
Arm predicted mass (left)	0.4	1.8	7.3	-0.8	2.7	-0.0	-1.9	-0.9	0.8	1.4	0.9	-1.0	1.1