Best TWAS P=9.59e-24 · Best GWAS P=2.63e-28 conditioned to 0.0359
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TNFRSF10B | 0.26 | 0.23 | lasso | 2 | 0.22 | 2.1e-12 | 7.965 | -8.7 | 3.6e-18 | -0.76 | 0.95 | 0.05 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | TNFRSF10B | 0.24 | 0.02 | enet | 24 | 0.07 | 3.8e-06 | -1.611 | 6.5 | 8.2e-11 | 0.21 | 0.76 | 0.04 | TRUE |
| 3 | GTEx | Whole Blood | TNFRSF10B | 0.12 | 0.07 | lasso | 6 | 0.07 | 8.7e-07 | 10.979 | 9.2 | 2.9e-20 | 0.87 | 0.00 | 1.00 | TRUE |
| 4 | NTR | Blood | TNFRSF10B | 0.15 | 0.11 | enet | 36 | 0.12 | 1.1e-35 | 10.979 | 10.0 | 9.6e-24 | 0.91 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNFRSF10C | 0.02 | 0.00 | blup | 53 | 0.01 | 3.9e-04 | -0.079 | -8.6 | 9.2e-18 | -0.38 | 0.07 | 0.17 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TNFRSF10C | 0.13 | 0.09 | blup | 53 | 0.09 | 6.6e-10 | 10.979 | -7.9 | 3.1e-15 | -0.79 | 0.00 | 1.00 | FALSE |