Hub : Genes

TNFRSF10B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.256	0.0770	2.2e-03	0.233	NA	0.205	NA	0.221	5.0e-13	NA	1.7e-11	NA	2.1e-12
2	GTEx	Cells Transformed fibroblasts	0.243	0.0570	1.6e-05	0.021	NA	0.073	NA	0.048	9.5e-03	NA	3.8e-06	NA	1.7e-04
3	GTEx	Whole Blood	0.118	0.0390	2.4e-03	0.065	NA	0.058	NA	0.067	1.2e-06	NA	4.6e-06	NA	8.8e-07
4	NTR	Blood	0.147	0.0217	0.0e+00	0.108	0.090	0.117	0.117	0.106	5.6e-33	2.1e-27	1.1e-35	1.2e-35	2.7e-32
5	TCGA	Thyroid Carcinoma	0.093	0.0340	5.1e-05	0.051	0.051	0.051	NA	0.070	9.2e-06	1.1e-05	8.9e-06	NA	2.5e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.5	2.7	-1.5	-1.0	1.7	1.3	0.2
Bipolar Disorder or Schizophrenia	0.7	1.6	3.9	-0.1	-2.0	1.2	1.6	-0.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	-0.2	-0.0	1.0	0.3	0.7
Depression (Nagel 2018)	0.3	0.4	2.0	-1.4	0.2	-0.0	0.2	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.2	-1.1	-0.8	1.8	1.4	1.0
Neuroticism (Nagel 2018)	0.2	0.4	1.2	0.6	-0.8	0.2	0.0	1.1
Schizophrenia (2018)	0.4	0.9	2.9	1.0	-1.7	0.2	0.7	-0.4
Schizophrenia vs Biploar Disorder	0.6	0.7	1.8	0.2	1.3	-1.0	0.2	-0.9
Worry (Nagel 2018)	0.6	1.2	4.1	1.0	-2.0	0.2	0.2	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	0.5	-0.9	0.8	0.5	0.1
Alzheimer’s Disease (in father)	1.0	1.1	2.3	-1.5	0.2	0.9	1.4	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	-0.9	-0.1	0.9	1.1	0.3
Crohns Disease (2017)	0.6	1.2	1.7	-1.0	-0.9	1.3	1.2	1.0
Irritable Bowel Disease (IBD)	0.9	2.2	3.7	-1.7	-0.5	1.9	1.7	1.0
Ulcerative Colitis (UC)	1.1	2.0	4.4	-2.1	-0.1	1.7	1.6	0.6
Major Depression (MDD)	0.3	0.4	1.5	0.0	-0.4	-0.3	-0.1	-1.2
Reaction Time	0.3	0.6	1.5	0.1	1.1	-1.2	-0.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.5	-1.6	-0.9	1.9	1.6	-1.1
Breast Cancer	0.7	1.7	4.4	0.2	-1.3	1.5	2.1	0.2
Ovarian Cancer	0.2	0.2	0.5	0.0	-0.5	0.0	-0.6	0.7
Prostate Cancer	4.0	5.6	13.8	0.9	-2.9	-1.8	-1.4	-3.7
Age at First Birth	0.3	0.4	2.0	0.2	-1.4	0.3	0.1	-0.0
Bipolar Disorder (2011)	0.8	0.8	3.8	0.0	-2.0	0.0	-0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	3.5	-1.1	1.9	0.9	0.3	1.3
Coronary Artery Disease (CAD)	0.3	0.4	1.3	0.2	-0.1	0.0	-0.7	1.2
Crohns Disease (2012)	0.3	0.5	1.5	-0.7	0.1	0.7	1.2	0.3
Mean Putamen Volume	0.2	0.2	0.7	-0.1	0.4	0.5	0.2	-0.9
Fasting Glucose	0.7	0.8	3.1	0.0	-1.8	0.9	0.3	-0.4
HbA1C	1.3	1.4	2.0	1.4	-0.7	-1.3	-1.4	1.0
HDL Cholesterol	0.6	1.0	1.5	-1.2	1.1	1.0	1.1	0.1
LDL Cholesterol	0.6	1.0	2.9	1.2	0.2	-0.6	-1.7	-0.2
Lupus	0.3	0.5	1.4	-0.4	-0.3	-0.3	-1.2	-0.7
Neuroticism (2016)	0.2	0.3	1.1	-0.5	-1.1	-0.1	-0.1	0.3
Primary Biliary Cirrhosis	0.4	0.6	1.5	0.0	-0.1	-1.1	-1.2	-0.7
Rheumatoid Arthritis	0.4	0.6	1.5	-0.2	0.5	0.9	1.2	0.6
Schizophrenia (2014)	0.2	0.4	1.1	0.5	-1.0	-0.1	0.6	-0.5
Triglycerides	0.1	0.1	0.4	0.2	0.2	-0.1	0.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.1	0.5	0.1	0.6	0.6
Ulcerative Colitis	0.5	0.7	2.6	-1.6	0.4	0.7	0.4	0.2
Blood Eosinophil Count	7.9	61.0	100.9	-8.7	6.5	9.2	10.0	-1.1
Blood Platelet Count	0.6	7.4	20.7	-0.9	-4.5	-0.5	-0.7	-3.8
Blood Red Count	0.5	4.4	12.0	-1.3	3.5	2.0	2.1	0.0
Blood White Count	6.6	48.8	106.1	-6.4	-1.0	10.3	9.7	-1.2
Heel T-Score	0.1	0.4	0.8	0.1	-0.9	0.1	-0.9	0.7
BMI	0.4	2.2	4.3	-1.5	-0.8	2.1	0.8	-1.8
Height	0.0	0.9	2.9	0.2	-1.2	-0.2	-1.7	0.3
Waist Hip Ratio (WHR)	0.6	2.7	7.3	0.3	-2.7	-0.9	-0.4	-2.2
Systolic Blood Pressure	0.2	0.8	2.9	0.3	-0.5	-0.5	-1.7	0.6
Smoking Status	0.5	1.1	2.3	1.5	-0.6	-0.2	-1.4	-0.9
Allergy or Eczema	0.9	2.5	5.7	-0.6	-0.1	1.2	2.4	-2.2
Cardiovascular Disease	1.3	4.5	12.8	0.5	-2.6	-0.3	-1.6	-3.6
Hypothyroidism (self reported)	1.2	2.7	5.9	-1.3	-1.2	2.4	1.6	-1.4
Respiratory disease	0.4	0.9	2.9	-0.5	0.1	1.1	1.7	0.5
Type 2 Diabetes (T2D) (2018)	2.2	4.1	11.7	-1.4	-2.5	0.7	0.5	-3.4
Lung FEV1/FVC ratio	1.1	5.4	16.4	-0.3	-2.8	-1.3	-1.1	-4.0
Lung FVC	0.7	3.4	7.9	2.2	-0.4	-1.7	-2.8	-1.1
Neuroticism	0.5	1.2	2.3	1.4	-1.1	-0.6	-1.5	0.3
Chronotype (morning person)	0.4	0.9	2.4	-0.2	-1.3	0.0	-0.5	-1.5
Hair Pigment	0.1	3.2	10.1	0.2	-1.5	1.5	1.1	-3.2
Tanning	0.0	0.4	1.0	0.5	0.6	-0.3	-1.0	0.4
Hand grip strength (left)	0.1	0.3	0.7	0.9	-0.3	-0.6	-0.4	0.5
Number of treatments/medications taken	1.8	3.3	14.2	-0.1	-1.5	-0.2	0.3	-3.8
Average weekly spirits intake	2.8	3.5	8.3	-2.0	-0.3	2.9	2.3	-0.2
Sensitivity / hurt feelings	0.5	0.8	1.5	1.0	0.5	-0.9	-0.6	1.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	-0.1	0.3	-0.6	-0.7	0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.0	-0.8	0.3	-0.3	-0.7
Relative age of first facial hair	0.4	0.9	2.3	0.7	-1.5	0.3	0.1	-1.3
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	10.3	0.7	-3.2	-0.7	-1.3	-2.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.7	0.4	0.2	-1.5	-1.6	-1.3
Ever had hysterectomy (womb removed)	0.7	0.8	3.1	-0.3	-0.8	0.3	0.1	-1.8
Systolic blood pressure, automated reading	0.7	2.2	4.3	1.6	-0.6	-2.0	-2.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	0.5	-0.9	-1.2	-0.8	-1.1
Angina	2.6	3.4	6.1	-0.7	-2.5	2.5	2.1	-0.3
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.5	-0.2	-0.4	-0.6	0.3
Vitamin and mineral supplements	0.7	0.9	2.5	0.6	0.6	-0.3	-1.6	1.2
Supplements: Zinc	0.7	0.8	1.9	0.3	-1.4	-0.3	-0.4	-1.3
Medication: Co-codamol	0.4	0.5	1.2	0.2	0.2	-1.0	-1.1	0.1
Medication: Metformin	1.5	2.2	5.0	-1.0	-2.2	-0.2	0.4	-2.1
Diabetes (father)	0.3	0.4	0.9	0.1	-0.6	1.0	0.1	0.9
Diabetes (mother)	0.8	1.0	2.0	-0.5	1.4	0.7	0.4	1.4
Severe depression (siblings)	0.1	0.1	0.4	-0.6	0.3	-0.1	0.0	-0.1
Pack years adult smoking proportion	0.7	1.0	1.8	-0.3	-1.2	0.9	1.3	-1.1
Impedance of leg (right)	0.1	0.6	1.3	0.1	1.1	0.2	0.6	1.1
Leg fat-free mass (left)	0.3	1.8	4.8	-0.8	-2.2	0.9	-0.7	-1.5
Trunk fat percentage	0.4	1.7	3.2	-0.8	-1.8	1.6	-0.5	-1.4
Hand grip strength (right)	0.3	0.7	2.9	1.7	-0.1	-0.7	-0.5	0.3
Townsend deprivation index at recruitment	0.5	0.7	1.4	-0.2	0.8	0.3	1.1	1.2
Current tobacco smoking	0.8	1.3	4.5	2.1	-0.5	-0.3	-1.3	0.4
Average weekly fortified wine intake	1.3	1.5	2.8	-1.7	-0.2	1.6	1.1	0.8
Maternal smoking around birth	0.1	0.2	0.5	-0.5	-0.3	0.7	0.3	-0.2
Fed-up feelings	0.5	0.8	1.9	1.3	-0.2	0.1	-0.8	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.3	-0.7	0.4	-0.7	-0.3	1.1
Relative age voice broke	0.4	0.6	1.7	0.4	-1.3	0.7	0.3	-0.7
Taking other prescription medications	1.8	2.8	7.1	0.1	-2.7	0.2	0.4	-2.6
Age when periods started (menarche)	0.6	1.3	4.6	0.1	0.5	2.1	1.3	-0.3
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.3	-0.2	-0.3	-1.4	-1.2	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.1	-1.1	0.7	1.1	1.3	1.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.7	-0.1	0.1	0.7	-0.4
Qualifications: CSEs or equivalent	1.1	1.5	4.0	-0.7	2.0	1.4	0.9	-0.4
Serious illness, injury or assault to yourself	0.9	1.1	1.8	0.9	-1.3	-0.7	-0.7	-1.3
High blood pressure	1.1	2.9	6.3	0.3	-2.5	0.4	-1.4	-2.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.7	0.3	-0.5	0.4	1.6	-1.6
Multivitamins +/- minerals	0.5	0.6	1.7	0.5	-0.8	-0.5	0.5	-1.3
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.8	-0.2	0.1	0.6	0.3
Supplements: Glucosamine	1.6	2.1	7.2	0.6	-2.7	-1.2	-0.9	-0.9
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	7.8	1.2	-2.8	-0.9	-0.9	0.1
Medication: Atenolol	2.1	2.6	8.2	-1.7	-0.7	2.9	0.9	-0.8
Medication: Levothyroxine sodium	0.7	1.2	3.0	-0.9	-0.4	1.7	1.3	-0.6
Sitting height	0.4	2.7	7.7	-2.8	-0.8	1.9	1.1	0.4
Chronic bronchitis/emphysema (father)	0.5	0.5	1.0	-0.1	0.4	1.0	0.9	-0.8
High blood pressure (mother)	0.9	1.3	2.6	1.0	0.0	-1.0	-1.4	-1.6
Body mass index (BMI)	0.6	2.5	6.7	0.0	-2.1	0.4	-1.3	-2.6
Impedance of leg (left)	0.1	0.4	1.4	0.3	0.6	0.0	0.2	1.2
Leg predicted mass (left)	0.3	1.8	4.8	-0.8	-2.2	0.9	-0.8	-1.5
Trunk fat mass	0.6	2.5	5.6	-0.9	-2.4	1.5	-0.8	-1.9
Waist circumference	1.3	4.8	10.8	-0.4	-3.1	-0.1	-1.9	-3.3
Number of incorrect matches in round	0.5	0.9	2.1	1.1	-0.5	-0.6	-1.4	-0.7
Past tobacco smoking	1.2	2.2	8.9	-0.6	1.2	0.1	0.4	3.0
Alcohol usually taken with meals	1.1	1.8	3.5	-1.3	-1.9	1.6	0.9	0.6
Nervous feelings	0.3	0.6	0.9	-1.0	-0.8	0.6	0.9	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.7	1.6	-1.4	-1.0	-1.5	0.5
Hearing difficulty/problems with background noise	0.6	0.9	3.7	-0.8	-1.9	0.5	-0.2	-0.2
Hair/balding pattern: Pattern 2	0.9	1.1	3.5	0.0	-1.9	-0.7	-0.4	-1.2
Had menopause	1.6	2.0	2.9	1.0	-1.5	-1.4	-1.7	-1.4
Had other major operations	2.0	2.5	9.9	0.2	-3.2	0.4	-0.2	-1.4
Forced vital capacity (FVC)	0.2	0.6	2.2	-0.4	-0.4	0.6	-0.1	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.5	-0.3	0.4	1.0	0.9	1.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	2.9	1.3	-1.1	-1.7	-1.4	-0.2
Qualifications: None of the above	0.7	1.6	3.8	0.6	-0.5	-1.0	-2.0	-1.6
Financial difficulties in last 2 years	0.9	1.2	2.5	1.6	1.3	-1.2	-0.0	0.6
Mouth/teeth dental problems	0.3	0.4	1.0	0.6	1.0	-0.0	-0.5	0.6
Heart attack	0.1	0.1	0.4	0.2	-0.2	0.6	-0.1	-0.3
Allergy	0.4	0.9	2.8	-0.6	0.1	-0.1	-1.7	1.1
Pain all over the body in last month	1.3	1.4	4.0	-2.0	-1.1	1.0	0.6	-0.7
Diabetes (self-reported)	1.2	1.9	5.7	-0.7	-1.7	-0.3	-0.3	-2.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.1	0.6	0.8	0.7	0.3
Medication: Ramipril	1.5	2.0	4.6	1.6	-1.1	-0.6	-1.0	-2.1
Medication: Simvastatin	0.8	1.2	2.6	0.9	0.2	-1.6	-1.0	-1.4
Fluid intelligence score	2.8	5.7	8.4	-1.8	-2.2	2.9	2.8	-2.1
Illnesses of siblings	2.0	2.8	6.1	2.5	1.7	-0.9	-0.4	2.0
Neuroticism score	0.3	0.7	1.5	0.9	-0.3	-0.4	-0.9	1.2
Weight	0.7	3.5	7.6	-0.4	-2.8	0.7	-1.5	-2.6
Impedance of arm (right)	1.3	6.0	9.8	-1.7	2.3	2.3	2.6	3.1
Arm fat percentage (right)	0.4	1.4	2.6	-0.8	-1.4	1.4	0.0	-1.6
Trunk fat-free mass	0.6	3.5	8.0	-0.0	-2.8	0.1	-1.7	-2.6
Hip circumference	0.5	2.0	3.8	-1.1	-1.9	1.1	-0.8	-1.8
Time employed in main current job	0.2	0.3	0.8	0.3	0.0	-0.1	-0.9	-0.7
Alcohol intake versus 10 years previously	1.0	1.4	4.4	-1.5	0.5	-0.4	0.4	-2.1
Father’s age at death	1.8	2.4	4.6	2.1	0.2	-1.5	-2.1	-0.7
Worrier / anxious feelings	0.8	1.5	3.0	1.7	-0.6	-0.8	-0.8	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.2	-0.3	0.4	0.2	0.4
Falls in the last year	0.3	0.4	0.6	0.1	-0.8	0.8	0.6	0.6
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	0.2	1.3	-0.8	-0.9	0.7
Number of live births	2.8	4.0	5.8	1.6	-1.9	-1.9	-2.4	-2.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.9	-0.9	-1.0	0.3	-0.1	-1.7
Pulse rate	0.4	0.7	1.0	0.1	1.0	0.9	1.0	0.9
Happiness	0.8	1.0	3.8	0.1	-1.0	0.0	0.3	1.9
Noisy workplace	1.2	1.5	6.6	-0.1	-0.6	0.6	0.2	-2.6
Qualifications: A levels/AS levels or equivalent	2.3	5.1	9.8	-1.8	-0.5	3.0	3.1	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.7	-1.9	-0.3	1.4	1.7	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	2.0	0.2	-0.6	0.0	-0.3	-1.4
Asthma	0.2	0.4	1.9	0.2	-0.4	0.3	1.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.4	-1.2	0.8	0.0	0.2	-0.2
Medication: Cholesterol lowering	1.3	2.0	8.1	-0.6	-1.2	0.3	0.3	-2.9
Depression (self-reported)	0.9	1.1	4.5	-0.7	-2.1	0.1	0.2	-0.7
Medication: Lansoprazole	0.5	0.6	1.7	-0.3	0.1	-1.3	-0.8	-0.6
Prospective memory result	2.3	2.8	4.7	1.5	0.7	-2.2	-1.8	1.9
Lung cancer (father)	1.8	2.1	4.9	0.8	-1.7	-1.3	-2.2	-0.0
Illnesses of mother	0.2	0.3	1.3	0.0	-0.1	-0.3	0.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	6.5	-0.1	-1.1	-0.6	-1.1	-2.5
Pulse wave Arterial Stiffness index	3.3	3.8	7.2	1.3	-2.5	-1.8	-2.7	-0.9
Impedance of arm (left)	1.0	4.7	10.1	-1.3	1.8	1.9	2.1	3.2
Arm fat mass (right)	0.6	2.3	4.8	-0.3	-2.2	1.1	-0.8	-2.2
Trunk predicted mass	0.6	3.5	8.3	0.0	-2.9	0.1	-1.7	-2.5
Standing height	0.1	0.8	2.3	-0.7	-1.5	1.0	-0.5	0.1
Length of working week for main job	1.3	1.5	3.4	-0.8	-0.9	1.8	0.9	-1.3
Exposure to tobacco smoke at home	0.3	0.4	0.8	-0.9	-0.3	0.9	0.2	0.3
Breastfed as a baby	0.1	0.2	0.5	-0.2	-0.4	-0.1	-0.3	-0.7
Tense / ‘highly strung’	0.7	1.2	4.2	0.9	-2.0	-0.7	-0.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	4.1	0.8	-1.9	-1.8	-1.8	-2.0
Hair/balding pattern: Pattern 4	0.4	1.1	3.8	0.7	1.0	-0.1	-0.1	1.9
Birth weight of first child	1.5	2.7	4.6	1.1	-2.1	-1.6	-1.5	-1.8
Peak expiratory flow (PEF)	0.6	1.4	3.4	-1.2	-1.4	-0.3	-0.1	-1.9
Pulse wave reflection index	2.2	2.7	6.9	0.5	-2.6	-1.0	-1.9	-1.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.6	-0.1	0.5	-1.6	-1.0	-0.2
Loud music exposure frequency	0.7	0.8	1.5	0.1	-0.6	0.9	1.2	1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.9	0.7	1.1	0.3	1.2	1.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	2.0	-0.2	-0.5	-1.4	-0.6	-0.4
Blood clot in the leg (DVT)	0.3	0.4	0.9	0.6	0.0	-0.6	0.4	0.9
Medication: Paracetamol	0.5	0.9	3.9	-0.1	-0.3	-0.6	-0.4	-2.0
Headache pain in last month	0.2	0.4	1.2	1.1	-0.6	-0.6	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	5.2	0.7	0.9	-0.1	0.2	2.3
Glaucoma (self-reported)	0.8	0.9	1.9	1.2	0.1	1.1	-0.3	-1.4
Gout (self-reported)	3.7	5.0	10.9	2.5	-0.0	-2.8	-3.3	0.1
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	6.5	-1.6	-0.8	2.5	2.1	-0.6
Medication: Amlodipine	0.6	0.9	2.8	0.3	-1.7	0.2	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.4	-0.9	0.8	1.6	1.8	0.1
Birth weight	0.4	0.8	3.3	-0.6	-0.3	0.1	0.3	-1.8
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.3	-0.7	0.8	0.4	1.1	-0.3
High blood pressure (siblings)	1.5	2.2	4.2	-2.1	-1.5	1.2	0.7	-1.7
Forced vital capacity (FVC), Best measure	0.3	1.3	4.7	0.4	-0.6	-0.5	-0.9	-2.2
Body fat percentage	0.5	2.0	4.2	-0.5	-2.1	1.0	-0.9	-1.9
Leg fat percentage (right)	0.8	2.8	7.5	-0.2	-2.1	0.2	-1.4	-2.7
Arm fat-free mass (right)	0.8	3.8	9.3	0.1	-3.0	-0.2	-2.0	-2.4
Exposure to tobacco smoke outside home	0.2	0.3	0.8	-0.9	-0.4	0.4	-0.5	-0.4
Comparative body size at age 10	0.4	1.1	3.5	0.8	-0.6	-0.9	-1.9	-0.1
Number of full brothers	0.4	0.5	1.6	0.2	-0.8	-0.1	-0.3	-1.3
Worry too long after embarrassment	0.4	0.7	1.2	0.9	0.1	-0.9	-0.7	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.6	0.2	1.0	-1.9	-1.2	-0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	1.2	0.0	0.3	0.7	0.8
Number of children fathered	1.3	1.4	4.6	-0.4	-1.5	0.1	-0.2	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.7	-1.4	1.1	-0.1	0.4	1.6
Age at first live birth	0.3	0.5	0.8	0.5	-0.2	0.7	0.9	0.8
Pulse wave peak to peak time	2.7	3.2	6.4	-0.9	2.3	1.8	2.5	0.8
Health satisfaction	2.5	3.2	9.5	0.6	-3.1	-0.5	-1.5	-2.0
Shortness of breath walking on level ground	1.9	2.2	4.5	1.0	-0.5	-2.0	-2.1	-1.2
Qualifications: College or University degree	1.0	3.2	5.4	-2.1	-0.7	2.0	2.3	1.3
Eye problems/disorders: None of the above	2.1	2.5	4.7	1.3	1.0	-2.2	-0.6	2.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.2	0.0	-0.4	-0.3	-0.2	-1.1
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.5	-0.4	0.2	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.4	0.6	2.3	0.9	-0.0	-0.1	-0.3	1.5
Neck or shoulder pain in last month	0.5	0.8	2.6	0.2	0.4	-1.6	-0.9	-0.4
Medication: Blood pressure	0.4	0.7	1.2	-0.9	-1.1	0.9	0.3	-0.8
Angina (self-reported)	2.5	3.3	6.6	-0.6	-2.3	2.6	2.0	-0.6
Migraine (self-reported)	1.3	1.6	3.9	2.0	-0.3	-1.7	-0.9	-0.5
Medication: Ibuprofen	0.7	0.8	2.9	-1.7	0.8	0.4	0.6	0.1
Medication: Allopurinol	2.0	2.7	5.8	1.6	0.1	-2.1	-2.4	-0.7
Medication: Omeprazole	1.4	1.7	3.4	-1.0	-1.9	1.0	1.2	-1.1
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.2	0.5	0.4	0.6	-0.3
Mean time to correctly identify matches	0.5	1.0	2.3	0.3	0.6	-1.5	-1.1	-0.9
Heart disease (mother)	0.4	0.5	0.8	-0.6	-0.8	0.7	0.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.1	0.9	-0.6	-1.1	-0.9	-1.8
Whole body fat mass	0.6	2.6	5.5	-0.5	-2.3	0.8	-1.3	-2.2
Leg fat mass (right)	0.9	3.5	8.7	-0.3	-2.5	0.5	-1.5	-2.9
Arm predicted mass (right)	0.8	4.3	9.2	0.5	-3.0	-0.5	-2.3	-2.6
Pulse rate, automated reading	0.4	1.4	2.4	1.5	1.0	-1.6	-0.6	0.9
Alcohol intake frequency.	0.6	1.4	4.0	0.9	0.0	-2.0	-1.5	-0.0
Comparative height size at age 10	0.3	1.7	4.2	-0.1	-1.4	-0.3	-1.5	-2.0
Number of full sisters	1.4	1.7	4.6	0.0	-2.1	0.8	0.0	-1.7
Suffer from ‘nerves’	0.9	1.4	4.1	0.2	-2.0	1.1	1.0	0.8
Overall health rating	0.5	1.0	1.8	-1.2	-1.1	0.6	-0.4	-1.3
Chest pain or discomfort	1.1	1.7	2.7	-0.9	-1.3	1.4	1.7	-1.0
Had major operations	0.1	0.2	0.6	-0.1	0.1	-0.4	-0.8	-0.3
Age at last live birth	0.4	0.6	1.7	1.3	-0.2	-0.3	0.1	-1.0
Family relationship satisfaction	0.9	1.1	3.3	-1.3	-1.8	-0.1	0.7	0.2
Leg pain on walking	1.6	1.9	4.6	1.3	-1.5	-0.9	-2.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.1	1.4	1.3	-0.6	-0.6	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.8	0.0	-1.4	0.4	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.2	0.5	0.1	-0.3	-0.1
Medication: Aspirin	0.4	0.5	1.8	0.1	-0.6	0.6	0.5	-1.3
Supplements: Vitamin C	2.4	2.9	7.6	-1.5	0.8	1.6	2.8	-1.2
Knee pain experienced in last month	0.3	0.4	1.4	-0.7	-0.1	0.5	0.2	-1.2
Hypertension (Self-reported)	1.0	2.8	7.0	0.4	-2.2	0.3	-1.4	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.4	-0.7	-1.9	0.7	0.5	-1.1
Illnesses of father: Heart disease	0.0	0.1	0.2	-0.4	-0.0	0.1	-0.0	0.3
Illnesses of siblings: Diabetes	1.2	1.5	5.9	-0.5	-2.4	0.2	-0.6	-0.9
Smoking status: Previous	1.3	2.0	8.7	-0.1	-0.4	-0.7	-0.7	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.7	0.1	0.4	0.7	-0.0
Whole body fat-free mass	0.5	3.1	7.8	-0.3	-2.8	0.4	-1.5	-2.3
Leg fat-free mass (right)	0.4	1.9	5.5	-0.9	-2.3	0.8	-0.8	-1.4
Arm fat percentage (left)	0.3	1.3	2.3	-0.7	-1.5	1.3	-0.3	-1.5
Average weekly red wine intake	0.3	0.4	0.7	-0.9	-0.8	-0.1	0.6	0.3
Handedness (chirality/laterality): Left-handed	1.3	1.5	5.0	-2.2	0.5	1.3	0.7	-0.1
Mood swings	0.1	0.2	0.3	-0.4	0.4	0.6	0.5	0.5
Loneliness, isolation	0.2	0.2	0.6	-0.2	0.2	0.5	0.5	0.8
Long-standing illness, disability or infirmity	4.2	6.4	11.9	0.8	-3.4	-1.9	-2.0	-3.4
Ever had bowel cancer screening	2.6	3.0	6.8	1.7	-1.2	-1.5	-2.6	-1.3
Diabetes diagnosed by doctor	2.0	3.3	8.8	-0.7	-2.6	-0.6	-0.8	-3.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.5	1.2	0.7	-0.1	-0.3	-0.9
Friendships satisfaction	0.1	0.2	0.6	-0.3	-0.2	-0.1	0.2	0.8
Qualifications: nursing, teaching	0.6	0.9	2.5	0.9	-1.6	0.8	0.4	-0.4
Commuting to job workplace: Walk	3.0	3.3	8.4	2.5	-0.5	-2.9	-1.2	-0.3
Eye problems/disorders: Cataract	0.5	0.5	1.2	-0.7	-0.2	1.1	0.4	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.0	-0.7	-2.0	0.6	0.9	-0.3
Medication for cholesterol	2.3	3.5	8.4	-0.6	2.4	0.0	1.8	2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	4.5	0.2	-2.1	0.9	1.3	-1.0
Back pain experienced in last month	1.3	1.9	3.0	0.4	-1.4	-1.5	-1.6	-1.7
Mineral and other dietary supplements	0.9	1.2	4.6	-0.5	0.8	0.3	0.4	2.2
Breast cancer (self-reported)	0.2	0.2	1.0	0.3	-0.2	1.0	0.3	-0.1
Asthma (self-reported)	0.2	0.5	1.7	0.3	-0.4	0.5	1.3	-0.2
Osteoporosis (self-reported)	3.2	4.0	11.0	-1.7	-0.1	2.2	3.3	-1.0
Osteoarthritis (self-reported)	0.3	0.5	1.1	-1.1	-0.8	0.1	0.7	-0.2
Medication: Aspirin	0.7	0.9	2.9	0.4	-1.0	0.5	0.5	-1.7
Medication: Gliclazide	0.5	0.5	1.0	0.9	-0.0	-0.5	-1.0	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	0.2	0.8	-1.2	-0.3	0.9
Smoking status: Current	0.6	1.0	3.7	1.9	-0.4	0.2	-0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	6.2	-0.8	-1.4	-1.9	-1.6	-2.5
Whole body water mass	0.5	3.0	7.6	-0.3	-2.8	0.4	-1.4	-2.2
Leg predicted mass (right)	0.4	2.0	5.7	-0.9	-2.4	0.9	-0.7	-1.4
Arm fat mass (left)	0.5	2.1	4.7	-0.3	-2.2	1.0	-0.9	-2.0
Number of self-reported non-cancer illnesses	2.8	4.8	12.5	1.7	-3.5	-0.7	-0.8	-2.7
Average weekly champagne plus white wine intake	0.5	0.7	1.9	-1.4	-0.9	0.1	1.0	0.2
Miserableness	0.5	0.9	1.7	0.9	1.3	1.1	0.1	0.8
Guilty feelings	0.6	1.0	1.8	1.3	0.2	-1.1	-1.3	0.1
Wears glasses or contact lenses	0.4	0.4	1.4	-0.4	1.2	-0.4	-0.6	0.0
Ever taken oral contraceptive pill	0.9	1.0	2.3	-0.2	-0.6	-0.9	-1.2	-1.5
Hearing aid user	0.8	0.9	3.7	0.1	-1.9	0.6	0.4	-0.1
Mother’s age at death	0.2	0.3	0.8	-0.9	0.1	0.0	-0.9	0.0
Financial situation satisfaction	0.1	0.1	0.1	0.4	-0.4	0.3	-0.4	-0.1
Tinnitus: Yes, now most or all of the time	2.5	2.9	4.2	-2.0	-1.4	1.9	1.8	-1.3
Commuting to job workplace: Public transport	0.2	0.3	0.9	0.4	-0.0	-1.0	-0.5	0.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.5	0.9	0.5	-0.3	-0.6
Medication: Blood pressure	2.1	4.0	9.4	0.5	-2.3	-0.3	-2.2	-3.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.6	-0.1	0.2	0.3	0.8	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	-0.4	-0.2	-0.3	0.3	-1.0
High cholesterol (Self-reported)	1.8	3.2	10.0	0.7	-1.2	-1.5	-1.3	-3.2
Medication: Bendroflumethiazide	0.6	1.0	3.0	0.8	-0.6	-0.8	-1.7	-0.3
Medication: Paracetamol	0.4	0.7	1.8	0.2	-0.6	-1.0	-0.5	-1.3
Medication: Lisinopril	0.9	1.1	2.8	-0.4	-1.7	1.1	-0.3	-1.2
Medication: Atorvastatin	5.1	6.3	16.2	-0.5	-4.0	1.6	-0.4	-3.6
Illnesses of father: High blood pressure	0.1	0.2	0.5	0.2	0.7	-0.1	-0.3	-0.3
Alcohol drinker status: Never	0.3	0.3	0.7	-0.8	-0.2	-0.8	-0.2	0.4
Ever smoked	0.7	1.3	3.9	1.0	-1.2	0.3	0.0	-2.0
Basal metabolic rate	0.6	3.1	7.9	-0.4	-2.8	0.5	-1.4	-2.2
Leg fat percentage (left)	0.9	3.2	7.4	-0.1	-2.5	0.2	-1.6	-2.7
Arm fat-free mass (left)	0.8	3.9	8.6	0.3	-2.9	0.0	-2.0	-2.6
Number of operations (self-reported)	1.8	2.7	3.9	1.5	-1.6	-1.3	-1.7	-2.0
Average weekly beer plus cider intake	1.4	2.0	4.6	-1.8	0.7	2.1	1.2	-0.8
Irritability	1.5	2.6	4.7	-2.2	-0.3	1.9	2.1	0.4
Risk taking	1.2	1.8	2.7	1.2	0.3	-1.5	-1.7	-1.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.1	0.1	-0.6	-0.3	-0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.8	-0.1	0.4	0.6	1.1
Age started oral contraceptive pill	1.1	1.4	4.0	-0.1	-1.4	-1.0	-2.0	-0.4
Diastolic blood pressure, automated reading	0.1	0.2	0.4	-0.3	0.7	0.3	0.5	0.4
Ever depressed for a whole week	0.4	0.5	2.0	-0.2	-1.4	-0.4	-0.1	-0.2
Unable to work because of sickness or disability	0.2	0.3	0.8	0.0	0.9	0.3	0.8	-0.2
Commuting to job workplace: Cycle	0.7	0.9	2.5	0.3	1.6	0.8	0.7	0.9
Myopia	0.2	0.2	0.8	-0.5	-0.9	-0.1	-0.2	0.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.4	-0.6	2.1	-0.3	1.4	2.5
Cholesterol lowering medication	1.9	2.7	7.3	0.8	-2.7	-0.5	-1.1	-2.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.1	-1.7	-1.0	1.1	1.3	-0.0
Pain experienced in last month	1.9	3.2	6.9	-0.6	2.1	1.4	1.5	2.6
Supplements: Calcium	1.3	1.4	4.5	1.5	-0.1	0.1	0.6	-2.1
Basal cell carcinoma (self-reported)	4.0	4.8	13.8	-1.5	-1.5	2.1	1.1	-3.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.3	-0.0	0.2	-0.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	0.6	0.5	-0.5	0.5	1.3
Heart disease (siblings)	1.2	1.4	3.9	0.2	-0.6	-2.0	-1.5	-0.6
Alcohol drinker status: Previous	1.2	1.4	2.8	1.6	-0.3	-1.3	-1.7	0.0
Pack years of smoking	0.6	0.9	1.6	-0.3	-1.1	0.6	1.1	-1.3
Impedance of whole body	0.5	2.7	7.1	-0.5	1.3	1.3	1.5	2.7
Leg fat mass (left)	1.0	4.1	9.1	-0.3	-2.9	0.5	-1.6	-3.0
Arm predicted mass (left)	0.7	3.6	8.1	0.3	-2.8	-0.0	-1.9	-2.5