Best TWAS P=1.2e-10 · Best GWAS P=3.21e-11 conditioned to 0.029
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NDUFAF6 | 0.10 | 0.02 | lasso | 8 | 0.04 | 1.4e-04 | -6.0 | 6.0 | 2.5e-09 | -0.85 | 0.03 | 0.89 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CCNE2 | 0.16 | 0.08 | enet | 20 | 0.06 | 5.8e-04 | -6.0 | 5.2 | 1.7e-07 | -0.87 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Brain Cerebellum | NDUFAF6 | 0.28 | 0.13 | lasso | 7 | 0.14 | 5.8e-05 | -6.0 | 5.7 | 9.0e-09 | -0.87 | 0.05 | 0.93 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | NDUFAF6 | 0.07 | 0.03 | enet | 9 | 0.01 | 7.6e-02 | -6.0 | 5.7 | 1.3e-08 | -0.79 | 0.08 | 0.83 | FALSE |
| 5 | GTEx | Ovary | NDUFAF6 | 0.24 | 0.12 | enet | 9 | 0.12 | 6.7e-04 | -4.5 | 5.5 | 4.8e-08 | -0.77 | 0.05 | 0.88 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | TP53INP1 | 0.09 | 0.06 | enet | 13 | 0.07 | 3.3e-06 | -6.0 | 5.4 | 5.6e-08 | -0.87 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Testis | TP53INP1 | 0.12 | 0.10 | enet | 13 | 0.04 | 6.1e-03 | -6.6 | 6.1 | 9.4e-10 | -0.92 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Whole Blood | TP53INP1 | 0.07 | 0.04 | enet | 13 | 0.02 | 2.9e-03 | -6.0 | -6.4 | 1.2e-10 | 0.85 | 0.05 | 0.94 | TRUE |
| 9 | YFS | Blood | TP53INP1 | 0.03 | 0.02 | lasso | 5 | 0.02 | 8.0e-07 | -4.7 | -6.1 | 8.4e-10 | 0.88 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TP53INP1 | 0.04 | 0.05 | blup | 56 | 0.06 | 4.2e-07 | -6.0 | -5.8 | 7.3e-09 | 0.92 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TP53INP1 | 0.06 | 0.02 | lasso | 3 | 0.03 | 2.8e-03 | -6.0 | -6.0 | 2.2e-09 | 0.88 | 0.04 | 0.84 | FALSE |