Best TWAS P=9.7e-11 · Best GWAS P=1.67e-10 conditioned to 0.226
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | SAMD12 | 0.32 | 0.11 | lasso | 7 | 0.16 | 1.6e-06 | 6.3 | 6.4 | 1.6e-10 | 0.95 | 0.01 | 0.99 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | NOV | 0.37 | 0.10 | enet | 17 | 0.20 | 9.9e-06 | 5.9 | -6.3 | 3.4e-10 | -0.06 | 0.05 | 0.94 | TRUE |
3 | GTEx | Pancreas | SAMD12 | 0.32 | 0.13 | enet | 17 | 0.15 | 4.9e-07 | 5.7 | 6.5 | 9.7e-11 | 0.82 | 0.03 | 0.96 | TRUE |
4 | GTEx | Skin Not Sun Exposed Suprapubic | SAMD12 | 0.42 | 0.30 | lasso | 2 | 0.29 | 3.1e-16 | 6.4 | 6.4 | 1.5e-10 | 1.00 | 0.01 | 0.99 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | SAMD12 | 0.26 | 0.22 | lasso | 8 | 0.21 | 1.4e-17 | 6.3 | 6.5 | 9.8e-11 | 0.98 | 0.01 | 0.99 | FALSE |
6 | METSIM | Adipose | SAMD12 | 0.13 | 0.11 | enet | 12 | 0.11 | 7.1e-16 | 6.3 | 6.3 | 3.5e-10 | 0.92 | 0.01 | 0.99 | FALSE |
7 | NTR | Blood | SAMD12 | 0.19 | 0.17 | lasso | 5 | 0.18 | 3.7e-55 | 6.3 | 6.3 | 2.3e-10 | 0.96 | 0.01 | 0.99 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | TNFRSF11B | 0.06 | 0.04 | bslmm | 499 | 0.04 | 2.5e-06 | 4.9 | -5.2 | 2.2e-07 | -0.04 | 0.83 | 0.10 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SAMD12 | 0.07 | 0.06 | enet | 6 | 0.06 | 4.2e-07 | 6.4 | 6.0 | 2.5e-09 | 0.91 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SAMD12 | 0.11 | 0.04 | blup | 277 | 0.05 | 4.9e-06 | 5.9 | 6.0 | 1.6e-09 | 0.79 | 0.01 | 0.99 | FALSE |