Hub : Genes

CCNE2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.157 0.053 0.00021 0.083 NA 0.058 NA 0.020 4.5e-05 NA 0.00058 NA 3.2e-02
2 GTEx Heart Atrial Appendage 0.125 0.051 0.00280 0.148 NA 0.100 NA 0.146 3.7e-07 NA 0.00003 NA 4.2e-07
3 GTEx Testis 0.152 0.055 0.00096 0.094 NA 0.086 NA 0.100 5.6e-05 NA 0.00012 NA 3.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.4 1.0 1.0 0.5 -0.1
Bipolar Disorder or Schizophrenia 0.3 0.8 1.7 0.7 1.3 0.3
Depressed Affect (Nagel 2018) 0.4 0.9 1.7 -1.3 -0.2 0.9
Depression (Nagel 2018) 0.3 0.5 1.1 -0.6 -0.1 1.1
Intelligence (Savage-Jansen 2018) 0.6 1.9 3.1 1.0 1.7 -1.2
Neuroticism (Nagel 2018) 0.1 0.3 0.7 -0.8 0.5 -0.0
Schizophrenia (2018) 0.3 0.6 1.6 0.2 1.3 0.4
Schizophrenia vs Biploar Disorder 0.9 1.2 3.2 -1.8 0.4 0.2
Worry (Nagel 2018) 0.2 0.5 1.1 -0.3 1.1 -0.5
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 0.3 0.7 -0.9
Alzheimer’s Disease (in father) 1.2 1.3 2.0 1.4 0.3 -1.4
Alzheimer’s Disease (including proxy) 3.1 4.5 9.9 3.1 1.1 -1.6
Crohns Disease (2017) 0.4 0.8 1.4 0.2 1.2 -0.9
Irritable Bowel Disease (IBD) 0.4 0.9 1.5 0.3 1.2 -1.1
Ulcerative Colitis (UC) 0.3 0.6 1.1 0.7 1.1 -0.6
Major Depression (MDD) 0.4 0.5 0.9 0.6 0.5 0.9
Reaction Time 1.1 2.1 2.7 -1.4 -1.6 1.2
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.7 0.8 -0.0 0.2
Breast Cancer 0.2 0.5 1.4 -0.0 -0.5 -1.2
Ovarian Cancer 0.2 0.3 0.8 0.4 -0.9 0.0
Prostate Cancer 0.3 0.4 1.0 -0.2 -0.5 -1.0
Age at First Birth 0.2 0.3 0.4 -0.3 -0.6 0.6
Bipolar Disorder (2011) 0.4 0.4 0.5 0.6 -0.7 0.5
Body Mass Index (BMI) (2010) 0.8 1.1 1.7 -1.1 -1.3 0.8
Coronary Artery Disease (CAD) 3.1 3.7 5.4 -2.2 -2.3 1.0
Crohns Disease (2012) 0.4 0.6 1.4 -0.1 0.6 -1.2
Mean Putamen Volume 0.1 0.1 0.3 0.2 0.5 0.0
Fasting Glucose 3.4 4.1 6.1 -1.9 -2.5 1.6
HbA1C 0.5 0.5 0.6 -0.8 -0.6 0.8
HDL Cholesterol 0.4 0.6 0.7 0.7 0.8 -0.9
LDL Cholesterol 0.3 0.5 1.2 -0.5 -0.3 -1.1
Lupus 0.4 0.7 1.2 0.8 1.1 -0.1
Neuroticism (2016) 0.7 1.0 1.6 -0.7 1.0 -1.3
Primary Biliary Cirrhosis 0.3 0.4 0.9 1.0 0.1 0.5
Rheumatoid Arthritis 0.7 1.0 2.4 1.6 0.4 -0.6
Schizophrenia (2014) 0.2 0.5 1.5 -0.1 1.2 0.0
Triglycerides 2.4 3.9 5.9 -2.4 -2.3 0.9
Type 2 Diabetes (T2D) (2012) 10.7 12.3 14.4 -3.8 -3.6 3.0
Ulcerative Colitis 0.3 0.4 0.9 -0.3 -1.0 0.4
Blood Eosinophil Count 2.8 21.8 27.4 5.2 4.3 -4.4
Blood Platelet Count 1.2 14.5 16.8 4.1 4.1 -3.2
Blood Red Count 5.3 50.8 66.7 -8.2 -7.6 5.3
Blood White Count 0.1 0.9 2.4 -0.6 0.0 1.5
Heel T-Score 0.5 3.6 6.2 1.5 2.5 -1.6
BMI 0.2 1.3 2.5 -1.1 -1.6 -0.6
Height 0.0 0.7 1.1 -0.6 -0.9 1.0
Waist Hip Ratio (WHR) 0.2 0.9 1.2 -1.1 -0.9 0.9
Systolic Blood Pressure 2.8 13.9 17.1 -3.8 -3.2 4.1
Smoking Status 0.2 0.5 0.6 -0.8 -0.8 -0.4
Allergy or Eczema 0.4 1.1 2.1 1.0 0.4 1.4
Cardiovascular Disease 5.3 17.4 26.7 -5.2 -4.2 2.8
Hypothyroidism (self reported) 0.5 1.1 2.4 0.9 -0.3 -1.5
Respiratory disease 1.1 2.3 4.5 0.6 1.5 -2.1
Type 2 Diabetes (T2D) (2018) 9.3 17.5 27.7 -5.3 -3.6 3.5
Lung FEV1/FVC ratio 2.0 10.3 13.8 3.7 3.3 -2.5
Lung FVC 0.4 1.9 5.3 0.5 2.3 -0.3
Neuroticism 0.0 0.1 0.2 -0.4 -0.1 0.1
Chronotype (morning person) 0.4 1.0 1.7 -0.6 -0.9 1.3
Hair Pigment 0.1 3.6 6.9 -2.6 -1.5 1.3
Tanning 0.0 0.1 0.4 0.1 -0.6 0.1
Hand grip strength (left) 1.0 2.6 3.8 -0.8 -1.8 2.0
Number of treatments/medications taken 1.7 3.0 8.5 -2.9 -0.6 -0.3
Average weekly spirits intake 1.1 1.4 1.8 -1.3 -1.3 0.8
Sensitivity / hurt feelings 2.2 3.8 6.7 0.7 2.1 -2.6
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.0 -1.1 -0.5 1.7
Hearing difficulty/problems: Yes 1.9 2.9 4.4 0.4 2.1 -2.1
Relative age of first facial hair 0.2 0.4 0.6 0.8 0.4 -0.8
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 3.6 -1.9 -0.1 0.3
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.2 -0.7 1.1 -0.5
Ever had hysterectomy (womb removed) 0.1 0.2 0.4 -0.6 0.0 -0.3
Systolic blood pressure, automated reading 1.2 3.6 4.5 -2.0 -1.6 2.1
Eye problems/disorders: Diabetes related eye disease 2.8 3.1 4.1 -2.0 -1.8 1.5
Angina 1.9 2.5 4.5 -1.5 -2.1 1.0
Medication for hormone replacement therapy 0.3 0.3 0.7 -0.5 0.8 0.1
Vitamin and mineral supplements 0.2 0.2 0.7 0.1 0.1 -0.8
Supplements: Zinc 0.3 0.3 0.7 0.8 0.3 0.3
Medication: Co-codamol 0.6 0.7 1.9 1.4 0.3 -0.4
Medication: Metformin 3.9 5.5 11.2 -3.4 -1.3 1.9
Diabetes (father) 1.7 2.1 2.6 -1.6 -1.5 1.3
Diabetes (mother) 5.1 6.5 7.5 -2.7 -2.7 2.2
Severe depression (siblings) 0.3 0.3 0.7 0.8 0.1 0.5
Pack years adult smoking proportion 0.2 0.4 1.0 -1.0 -0.3 0.2
Impedance of leg (right) 1.8 8.5 14.3 -2.3 -2.5 3.8
Leg fat-free mass (left) 0.3 1.7 5.2 -0.0 -0.2 -2.3
Trunk fat percentage 0.5 1.9 3.6 -1.4 -1.9 0.3
Hand grip strength (right) 1.2 3.3 4.9 -0.9 -2.2 2.1
Townsend deprivation index at recruitment 0.4 0.5 1.3 -1.1 -0.3 -0.3
Current tobacco smoking 0.3 0.5 1.2 -1.1 -0.2 -0.4
Average weekly fortified wine intake 2.6 3.1 5.3 0.7 1.9 -2.3
Maternal smoking around birth 0.5 0.8 1.9 -1.4 -0.6 0.3
Fed-up feelings 0.1 0.2 0.4 -0.3 -0.6 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.1 -0.2 0.3 0.4
Relative age voice broke 0.2 0.3 0.6 -0.4 -0.7 0.5
Taking other prescription medications 0.3 0.4 0.6 -0.7 0.5 -0.8
Age when periods started (menarche) 0.1 0.2 0.3 0.6 0.4 0.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.3 -0.2 1.1 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 -0.2 0.2 -0.4
Tinnitus: Yes, but not now, but have in the past 3.7 4.0 4.3 -2.0 -1.9 2.1
Qualifications: CSEs or equivalent 0.2 0.3 0.6 0.1 -0.8 -0.5
Serious illness, injury or assault to yourself 1.6 2.0 5.0 -2.2 -1.0 0.2
High blood pressure 3.9 11.0 18.7 -4.3 -3.1 2.2
Hayfever, allergic rhinitis or eczema 0.5 1.2 2.2 1.5 0.9 0.7
Multivitamins +/- minerals 0.3 0.4 1.2 0.2 0.2 1.1
Stomach or abdominal pain in last month 0.7 0.8 1.4 -1.2 0.7 -0.7
Supplements: Glucosamine 0.2 0.3 0.5 0.4 0.3 -0.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 -0.4 -0.9 0.7
Medication: Atenolol 0.7 0.9 1.3 -1.1 -0.7 0.9
Medication: Levothyroxine sodium 0.2 0.4 0.6 0.5 -0.5 -0.8
Sitting height 0.3 2.0 3.6 -1.4 -1.9 0.6
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 -0.3 -0.0 -0.3
High blood pressure (mother) 2.3 3.3 7.6 -2.8 -1.2 0.9
Body mass index (BMI) 0.4 1.6 3.8 -0.7 -0.6 -2.0
Impedance of leg (left) 2.2 10.7 18.7 -2.7 -2.5 4.3
Leg predicted mass (left) 0.3 1.7 5.1 0.0 -0.2 -2.2
Trunk fat mass 0.5 2.0 3.4 -1.6 -1.9 -0.3
Waist circumference 0.8 3.0 4.4 -2.1 -2.1 -0.6
Number of incorrect matches in round 0.7 1.1 2.6 -0.9 0.2 -1.6
Past tobacco smoking 0.4 0.7 2.0 0.1 1.4 0.2
Alcohol usually taken with meals 0.3 0.5 1.1 -0.1 -1.1 0.7
Nervous feelings 0.5 0.9 1.6 0.6 1.3 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.6 0.3 1.3 -0.2
Hearing difficulty/problems with background noise 0.1 0.2 0.6 -0.8 0.0 -0.3
Hair/balding pattern: Pattern 2 0.2 0.3 0.4 -0.6 0.6 -0.0
Had menopause 0.0 0.1 0.1 0.2 0.3 0.2
Had other major operations 0.2 0.3 0.8 -0.9 -0.0 -0.0
Forced vital capacity (FVC) 0.1 0.2 0.5 0.3 0.7 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.5 0.1 0.9 -1.2
Ever unenthusiastic/disinterested for a whole week 2.8 3.4 3.8 -1.9 -1.9 1.7
Qualifications: None of the above 0.7 1.6 2.7 0.2 1.7 -1.4
Financial difficulties in last 2 years 0.1 0.2 0.5 -0.2 0.2 -0.7
Mouth/teeth dental problems 2.2 3.3 5.3 2.3 2.0 -0.8
Heart attack 3.3 4.2 6.3 -2.4 -2.5 0.8
Allergy 1.9 4.5 6.5 -2.1 -2.5 1.5
Pain all over the body in last month 0.5 0.6 1.7 -0.1 1.3 0.1
Diabetes (self-reported) 7.3 11.2 18.4 -4.3 -2.8 2.8
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 1.5 1.2 -0.2 1.2
Medication: Ramipril 1.2 1.6 2.3 -1.5 -1.5 0.2
Medication: Simvastatin 1.9 2.8 4.9 -2.2 -1.3 1.3
Fluid intelligence score 0.2 0.3 0.7 0.9 -0.2 0.5
Illnesses of siblings 2.6 3.7 4.8 1.8 1.8 -2.2
Neuroticism score 0.2 0.5 1.0 0.2 1.0 -0.7
Weight 0.4 1.8 2.1 -1.5 -1.4 -1.2
Impedance of arm (right) 0.4 1.9 4.8 0.3 -0.9 2.2
Arm fat percentage (right) 0.3 1.3 1.7 -0.8 -1.3 -1.2
Trunk fat-free mass 0.2 1.4 2.0 -1.4 -0.9 -1.1
Hip circumference 0.5 2.0 3.1 -1.7 -1.8 -0.4
Time employed in main current job 2.1 2.4 3.6 -1.5 -1.2 1.9
Alcohol intake versus 10 years previously 0.9 1.3 2.3 -1.2 -1.5 0.4
Father’s age at death 0.6 0.8 1.1 1.0 -0.5 1.1
Worrier / anxious feelings 1.2 2.2 3.5 1.1 1.9 -1.4
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 4.8 -1.7 -0.8 2.2
Falls in the last year 0.7 0.9 2.7 0.1 -0.1 1.6
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 0.9 0.2 -0.4
Number of live births 0.6 0.9 1.5 -1.0 -1.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.2 1.8 1.1 1.4 -0.6
Pulse rate 0.6 1.1 2.1 -1.0 -1.5 0.1
Happiness 1.0 1.2 1.4 -1.2 -0.9 1.2
Noisy workplace 0.4 0.5 1.3 -1.2 0.4 -0.2
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.3 1.1 1.1 0.4
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.5 -0.5 -0.9 1.9
Mouth/teeth dental problems: Dentures 1.8 3.0 5.5 -2.4 -1.8 0.3
Asthma 0.8 1.6 3.0 0.7 1.1 -1.7
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 1.7 -0.7 0.6 -1.3
Medication: Cholesterol lowering 1.8 2.8 5.5 -2.3 -1.3 1.2
Depression (self-reported) 0.3 0.3 0.9 0.1 1.0 -0.0
Medication: Lansoprazole 0.7 0.8 1.5 -0.7 1.2 -0.6
Prospective memory result 2.5 3.0 4.4 -2.1 -0.9 2.0
Lung cancer (father) 4.2 4.9 6.7 1.4 2.6 -2.5
Illnesses of mother 4.4 5.5 8.9 3.0 2.2 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.0 0.8 1.4 -0.5
Pulse wave Arterial Stiffness index 0.2 0.2 0.6 0.3 -0.3 -0.8
Impedance of arm (left) 0.3 1.6 4.1 0.8 -0.2 2.0
Arm fat mass (right) 0.4 1.6 2.4 -1.1 -1.1 -1.5
Trunk predicted mass 0.2 1.3 1.8 -1.4 -0.8 -1.2
Standing height 0.3 2.7 3.1 -1.7 -1.7 1.4
Length of working week for main job 1.1 1.2 1.5 0.9 1.1 -1.2
Exposure to tobacco smoke at home 0.0 0.0 0.0 -0.2 -0.2 0.0
Breastfed as a baby 1.2 1.5 1.9 -1.4 -1.0 1.3
Tense / ‘highly strung’ 0.1 0.2 0.3 -0.4 0.3 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.1 0.4 1.4 0.2
Hair/balding pattern: Pattern 4 2.8 6.7 12.8 3.6 1.8 -2.0
Birth weight of first child 1.5 2.8 4.0 1.0 1.9 -2.0
Peak expiratory flow (PEF) 0.1 0.1 0.4 -0.1 -0.6 -0.0
Pulse wave reflection index 1.3 1.6 3.2 0.9 1.0 -1.8
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.4 0.1 0.1
Loud music exposure frequency 2.5 2.7 4.8 -2.2 -1.4 1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.2 0.1 -0.2 1.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.2 -0.8 -1.1 0.2
Blood clot in the leg (DVT) 3.0 3.9 5.0 1.6 2.0 -2.2
Medication: Paracetamol 1.8 3.0 5.0 0.4 2.2 -1.9
Headache pain in last month 0.9 1.6 4.0 -2.0 0.7 0.4
Medication for cholesterol, blood pressure or diabetes 4.9 8.1 13.9 3.7 2.5 -2.1
Glaucoma (self-reported) 4.1 4.9 6.9 2.6 2.4 -1.5
Gout (self-reported) 0.6 0.9 1.8 0.6 0.7 -1.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.1 1.3 0.2 -1.5
Medication: Amlodipine 1.1 1.6 2.6 -0.6 -1.6 1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.1 -1.0 -0.2 0.1
Birth weight 4.6 9.9 14.5 3.8 3.1 -2.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.7 -0.9 -0.4 0.4
High blood pressure (siblings) 2.5 3.6 4.2 -1.8 -2.1 1.8
Forced vital capacity (FVC), Best measure 0.1 0.4 1.3 0.1 1.1 0.1
Body fat percentage 0.5 2.1 3.7 -1.7 -1.9 -0.1
Leg fat percentage (right) 1.2 4.3 6.8 -2.6 -2.5 -0.2
Arm fat-free mass (right) 0.3 1.5 2.2 -1.5 -0.7 -1.4
Exposure to tobacco smoke outside home 0.2 0.3 0.5 -0.6 0.1 -0.7
Comparative body size at age 10 0.1 0.2 0.3 -0.2 -0.6 0.5
Number of full brothers 0.5 0.7 1.3 1.1 0.5 -0.7
Worry too long after embarrassment 0.1 0.2 0.3 0.2 0.5 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.7 -0.2 0.8 -0.0
Wheeze or whistling in the chest in last year 0.9 1.6 4.2 0.2 0.8 -2.0
Number of children fathered 0.2 0.3 0.4 -0.4 -0.6 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.2 1.0 1.1 -0.4
Age at first live birth 1.6 2.8 5.2 0.1 -1.8 2.3
Pulse wave peak to peak time 0.5 0.6 1.4 -0.6 -0.1 1.2
Health satisfaction 0.3 0.4 0.6 0.3 0.6 -0.8
Shortness of breath walking on level ground 0.0 0.0 0.1 -0.1 0.2 -0.3
Qualifications: College or University degree 0.1 0.3 0.6 0.8 -0.0 0.6
Eye problems/disorders: None of the above 0.7 0.8 1.2 -1.1 -1.1 0.3
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.0 1.0 0.1 -0.1
Emphysema/chronic bronchitis 1.6 1.8 3.0 0.0 1.5 -1.7
Medication for pain relief, constipation, heartburn 0.5 0.8 1.0 0.7 -1.0 1.0
Neck or shoulder pain in last month 0.1 0.2 0.5 -0.1 -0.7 -0.2
Medication: Blood pressure 3.1 5.5 9.3 -3.1 -2.1 1.6
Angina (self-reported) 1.6 2.1 3.5 -1.3 -1.9 0.9
Migraine (self-reported) 0.1 0.2 0.3 0.5 0.2 -0.4
Medication: Ibuprofen 1.0 1.2 2.8 -0.1 0.9 -1.7
Medication: Allopurinol 0.4 0.5 1.2 0.1 0.6 -1.1
Medication: Omeprazole 0.4 0.5 0.9 -0.9 -0.2 0.8
Medication: Seretide 50 evohaler 0.9 1.1 1.6 1.3 1.2 -0.5
Mean time to correctly identify matches 0.8 1.5 2.5 -0.6 -1.6 1.3
Heart disease (mother) 3.7 4.5 6.9 -2.2 -2.6 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.0 -0.4 -1.4 0.9
Whole body fat mass 0.4 1.9 2.5 -1.6 -1.6 -0.7
Leg fat mass (right) 0.7 2.7 3.8 -1.9 -1.9 -0.9
Arm predicted mass (right) 0.3 1.5 2.3 -1.5 -0.8 -1.2
Pulse rate, automated reading 0.3 0.8 2.0 -0.6 -1.4 -0.3
Alcohol intake frequency. 0.7 1.7 3.6 -1.9 -0.9 0.8
Comparative height size at age 10 0.4 2.0 4.7 -2.2 -0.9 0.6
Number of full sisters 0.0 0.0 0.1 0.2 0.0 -0.2
Suffer from ‘nerves’ 0.4 0.6 1.2 -0.0 0.7 -1.1
Overall health rating 0.7 1.6 3.4 -1.0 0.4 -1.9
Chest pain or discomfort 1.3 1.9 3.2 0.1 1.5 -1.8
Had major operations 0.3 0.3 0.7 -0.2 0.8 -0.6
Age at last live birth 1.8 2.7 4.9 0.2 -2.2 1.7
Family relationship satisfaction 1.6 2.0 2.5 -1.0 -1.6 1.6
Leg pain on walking 0.3 0.4 0.8 0.2 0.7 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.2 0.2 -0.5
Commuting to job workplace: Car/motor vehicle 1.9 2.1 3.9 -1.0 -1.2 2.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.9 0.8 0.2 -0.9
Medication: Aspirin 1.3 1.7 4.0 -0.7 -2.0 0.7
Supplements: Vitamin C 0.4 0.5 0.7 0.0 -0.8 0.8
Knee pain experienced in last month 0.2 0.2 0.4 -0.1 -0.7 0.5
Hypertension (Self-reported) 4.8 13.3 21.5 -4.6 -3.5 2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.5 3.5 1.1 1.7 -1.9
Illnesses of father: Heart disease 0.3 0.4 0.6 -0.4 0.7 0.6
Illnesses of siblings: Diabetes 2.1 2.5 4.2 -2.1 -1.1 1.5
Smoking status: Previous 0.4 0.5 1.5 -0.1 -1.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.2 0.3 -0.4 0.2
Whole body fat-free mass 0.2 1.3 3.0 -0.9 -0.5 -1.7
Leg fat-free mass (right) 0.3 1.5 4.5 0.0 0.1 -2.1
Arm fat percentage (left) 0.3 1.1 2.1 -0.6 -0.9 -1.4
Average weekly red wine intake 0.3 0.4 0.7 0.8 -0.6 0.3
Handedness (chirality/laterality): Left-handed 0.0 0.1 0.1 0.3 -0.0 0.3
Mood swings 0.0 0.1 0.2 0.4 -0.0 0.2
Loneliness, isolation 0.2 0.2 0.6 -0.8 0.1 -0.1
Long-standing illness, disability or infirmity 2.5 3.8 10.3 -3.2 -1.0 0.5
Ever had bowel cancer screening 2.0 2.3 3.9 -2.0 -0.8 1.5
Diabetes diagnosed by doctor 5.9 9.7 18.3 -4.3 -2.3 2.3
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 -0.6 1.0 0.2
Friendships satisfaction 0.1 0.2 0.4 0.1 -0.6 0.3
Qualifications: nursing, teaching 0.6 0.9 2.3 -0.6 -0.2 1.5
Commuting to job workplace: Walk 1.0 1.1 1.2 1.1 1.0 -1.1
Eye problems/disorders: Cataract 3.4 4.0 6.8 1.5 2.6 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.0 -1.4 -0.0 0.1
Medication for cholesterol 1.0 1.6 3.2 1.8 1.2 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.1 -1.4 1.4 0.6
Back pain experienced in last month 1.1 1.6 3.7 -1.0 0.3 -1.9
Mineral and other dietary supplements 0.4 0.6 1.3 -0.4 0.4 -1.2
Breast cancer (self-reported) 0.6 0.7 2.1 -0.0 -0.1 1.5
Asthma (self-reported) 0.8 1.5 3.1 0.5 1.0 -1.8
Osteoporosis (self-reported) 0.8 0.9 1.5 -0.6 -1.2 1.0
Osteoarthritis (self-reported) 1.7 2.2 3.7 1.5 1.9 -0.9
Medication: Aspirin 1.3 1.7 3.9 -1.0 -2.0 0.6
Medication: Gliclazide 2.3 2.6 5.7 -2.4 -1.2 0.8
Illnesses of father: None of the above (group 1) 1.1 1.4 3.3 1.8 0.4 -0.8
Smoking status: Current 0.3 0.5 1.3 -1.1 -0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.0 0.1 -0.2 0.2 0.2
Whole body water mass 0.2 1.3 2.8 -0.9 -0.6 -1.7
Leg predicted mass (right) 0.3 1.4 4.2 -0.1 -0.0 -2.1
Arm fat mass (left) 0.3 1.4 2.4 -0.9 -1.0 -1.5
Number of self-reported non-cancer illnesses 0.4 0.7 2.1 -1.4 -0.2 -0.0
Average weekly champagne plus white wine intake 0.9 1.2 3.3 1.8 0.6 -0.3
Miserableness 0.5 0.9 1.8 -1.4 0.8 0.5
Guilty feelings 0.2 0.3 0.6 0.4 0.3 -0.8
Wears glasses or contact lenses 2.1 2.4 3.7 -1.9 -1.6 0.9
Ever taken oral contraceptive pill 0.4 0.5 0.6 0.8 0.6 0.7
Hearing aid user 0.1 0.1 0.2 -0.0 0.4 -0.4
Mother’s age at death 1.3 1.7 3.2 -0.1 -1.8 1.3
Financial situation satisfaction 0.1 0.1 0.2 -0.1 -0.4 -0.1
Tinnitus: Yes, now most or all of the time 3.4 3.9 4.0 1.9 2.0 -2.0
Commuting to job workplace: Public transport 0.1 0.1 0.3 0.5 0.1 -0.3
Eye problems/disorders: Glaucoma 3.0 3.5 6.2 2.5 2.0 -0.7
Medication: Blood pressure 1.9 3.6 6.1 -2.5 -2.0 0.9
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.6 -1.6 0.1 -0.7
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.3 0.2 -0.9 1.5
High cholesterol (Self-reported) 0.5 0.8 1.1 -0.9 -0.8 1.0
Medication: Bendroflumethiazide 1.5 2.2 4.6 -2.1 -1.2 0.7
Medication: Paracetamol 3.7 5.7 9.2 0.4 2.8 -3.0
Medication: Lisinopril 0.7 1.0 2.1 -1.5 -0.8 0.0
Medication: Atorvastatin 0.1 0.1 0.2 0.1 -0.4 0.3
Illnesses of father: High blood pressure 2.3 2.8 5.5 -2.3 -1.2 1.2
Alcohol drinker status: Never 2.7 3.2 3.8 -1.9 -1.6 1.9
Ever smoked 0.1 0.2 0.2 0.5 -0.4 -0.5
Basal metabolic rate 0.3 1.5 2.4 -1.1 -0.9 -1.6
Leg fat percentage (left) 1.2 4.3 7.4 -2.7 -2.4 0.1
Arm fat-free mass (left) 0.3 1.7 2.7 -1.6 -1.2 -1.0
Number of operations (self-reported) 1.1 1.6 3.6 0.9 1.9 -0.7
Average weekly beer plus cider intake 0.1 0.2 0.4 -0.2 0.4 -0.6
Irritability 0.0 0.1 0.1 0.3 0.2 0.3
Risk taking 0.1 0.1 0.3 0.0 -0.5 0.0
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.2 0.2 -0.4
Fractured/broken bones in last 5 years 1.5 1.9 3.3 -1.1 -1.1 1.8
Age started oral contraceptive pill 0.8 1.0 1.8 -0.3 -1.0 1.4
Diastolic blood pressure, automated reading 2.0 6.1 10.9 -2.7 -3.3 -0.0
Ever depressed for a whole week 0.3 0.4 1.2 -1.1 -0.1 -0.1
Unable to work because of sickness or disability 2.3 3.0 5.7 -2.4 -0.5 1.8
Commuting to job workplace: Cycle 1.9 2.3 3.7 0.6 -1.7 1.9
Myopia 1.2 1.8 3.6 -1.3 -1.9 0.3
Vascular/heart problems diagnosed by doctor 5.0 13.7 21.6 4.6 3.7 -2.5
Cholesterol lowering medication 0.1 0.1 0.2 -0.4 -0.4 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 -0.7 0.3 0.5
Pain experienced in last month 0.5 0.9 2.3 0.3 -0.5 1.5
Supplements: Calcium 0.5 0.5 0.8 0.9 0.6 0.7
Basal cell carcinoma (self-reported) 1.3 1.6 4.0 2.0 0.7 -0.5
Heart attack/myocardial infarction (self-reported) 3.0 3.9 6.1 -2.3 -2.5 0.7
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 3.5 1.4 1.6 -1.9
Heart disease (siblings) 1.1 1.4 1.8 -1.3 -1.1 1.0
Alcohol drinker status: Previous 1.6 1.8 3.5 -1.9 -1.1 1.0
Pack years of smoking 0.2 0.3 0.7 -0.9 -0.2 -0.1
Impedance of whole body 0.9 4.7 11.6 -0.7 -1.4 3.4
Leg fat mass (left) 0.7 2.6 3.9 -2.0 -1.8 -0.8
Arm predicted mass (left) 0.3 1.7 2.8 -1.7 -1.0 -1.2