Hub : Genes

CCNE2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.157	0.053	0.00021	0.083	NA	0.058	NA	0.020	4.5e-05	NA	0.00058	NA	3.2e-02
2	GTEx	Heart Atrial Appendage	0.125	0.051	0.00280	0.148	NA	0.100	NA	0.146	3.7e-07	NA	0.00003	NA	4.2e-07
3	GTEx	Testis	0.152	0.055	0.00096	0.094	NA	0.086	NA	0.100	5.6e-05	NA	0.00012	NA	3.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	1.0	1.0	0.5	-0.1
Bipolar Disorder or Schizophrenia	0.3	0.8	1.7	0.7	1.3	0.3
Depressed Affect (Nagel 2018)	0.4	0.9	1.7	-1.3	-0.2	0.9
Depression (Nagel 2018)	0.3	0.5	1.1	-0.6	-0.1	1.1
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.1	1.0	1.7	-1.2
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.8	0.5	-0.0
Schizophrenia (2018)	0.3	0.6	1.6	0.2	1.3	0.4
Schizophrenia vs Biploar Disorder	0.9	1.2	3.2	-1.8	0.4	0.2
Worry (Nagel 2018)	0.2	0.5	1.1	-0.3	1.1	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	0.3	0.7	-0.9
Alzheimer’s Disease (in father)	1.2	1.3	2.0	1.4	0.3	-1.4
Alzheimer’s Disease (including proxy)	3.1	4.5	9.9	3.1	1.1	-1.6
Crohns Disease (2017)	0.4	0.8	1.4	0.2	1.2	-0.9
Irritable Bowel Disease (IBD)	0.4	0.9	1.5	0.3	1.2	-1.1
Ulcerative Colitis (UC)	0.3	0.6	1.1	0.7	1.1	-0.6
Major Depression (MDD)	0.4	0.5	0.9	0.6	0.5	0.9
Reaction Time	1.1	2.1	2.7	-1.4	-1.6	1.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.7	0.8	-0.0	0.2
Breast Cancer	0.2	0.5	1.4	-0.0	-0.5	-1.2
Ovarian Cancer	0.2	0.3	0.8	0.4	-0.9	0.0
Prostate Cancer	0.3	0.4	1.0	-0.2	-0.5	-1.0
Age at First Birth	0.2	0.3	0.4	-0.3	-0.6	0.6
Bipolar Disorder (2011)	0.4	0.4	0.5	0.6	-0.7	0.5
Body Mass Index (BMI) (2010)	0.8	1.1	1.7	-1.1	-1.3	0.8
Coronary Artery Disease (CAD)	3.1	3.7	5.4	-2.2	-2.3	1.0
Crohns Disease (2012)	0.4	0.6	1.4	-0.1	0.6	-1.2
Mean Putamen Volume	0.1	0.1	0.3	0.2	0.5	0.0
Fasting Glucose	3.4	4.1	6.1	-1.9	-2.5	1.6
HbA1C	0.5	0.5	0.6	-0.8	-0.6	0.8
HDL Cholesterol	0.4	0.6	0.7	0.7	0.8	-0.9
LDL Cholesterol	0.3	0.5	1.2	-0.5	-0.3	-1.1
Lupus	0.4	0.7	1.2	0.8	1.1	-0.1
Neuroticism (2016)	0.7	1.0	1.6	-0.7	1.0	-1.3
Primary Biliary Cirrhosis	0.3	0.4	0.9	1.0	0.1	0.5
Rheumatoid Arthritis	0.7	1.0	2.4	1.6	0.4	-0.6
Schizophrenia (2014)	0.2	0.5	1.5	-0.1	1.2	0.0
Triglycerides	2.4	3.9	5.9	-2.4	-2.3	0.9
Type 2 Diabetes (T2D) (2012)	10.7	12.3	14.4	-3.8	-3.6	3.0
Ulcerative Colitis	0.3	0.4	0.9	-0.3	-1.0	0.4
Blood Eosinophil Count	2.8	21.8	27.4	5.2	4.3	-4.4
Blood Platelet Count	1.2	14.5	16.8	4.1	4.1	-3.2
Blood Red Count	5.3	50.8	66.7	-8.2	-7.6	5.3
Blood White Count	0.1	0.9	2.4	-0.6	0.0	1.5
Heel T-Score	0.5	3.6	6.2	1.5	2.5	-1.6
BMI	0.2	1.3	2.5	-1.1	-1.6	-0.6
Height	0.0	0.7	1.1	-0.6	-0.9	1.0
Waist Hip Ratio (WHR)	0.2	0.9	1.2	-1.1	-0.9	0.9
Systolic Blood Pressure	2.8	13.9	17.1	-3.8	-3.2	4.1
Smoking Status	0.2	0.5	0.6	-0.8	-0.8	-0.4
Allergy or Eczema	0.4	1.1	2.1	1.0	0.4	1.4
Cardiovascular Disease	5.3	17.4	26.7	-5.2	-4.2	2.8
Hypothyroidism (self reported)	0.5	1.1	2.4	0.9	-0.3	-1.5
Respiratory disease	1.1	2.3	4.5	0.6	1.5	-2.1
Type 2 Diabetes (T2D) (2018)	9.3	17.5	27.7	-5.3	-3.6	3.5
Lung FEV1/FVC ratio	2.0	10.3	13.8	3.7	3.3	-2.5
Lung FVC	0.4	1.9	5.3	0.5	2.3	-0.3
Neuroticism	0.0	0.1	0.2	-0.4	-0.1	0.1
Chronotype (morning person)	0.4	1.0	1.7	-0.6	-0.9	1.3
Hair Pigment	0.1	3.6	6.9	-2.6	-1.5	1.3
Tanning	0.0	0.1	0.4	0.1	-0.6	0.1
Hand grip strength (left)	1.0	2.6	3.8	-0.8	-1.8	2.0
Number of treatments/medications taken	1.7	3.0	8.5	-2.9	-0.6	-0.3
Average weekly spirits intake	1.1	1.4	1.8	-1.3	-1.3	0.8
Sensitivity / hurt feelings	2.2	3.8	6.7	0.7	2.1	-2.6
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.0	-1.1	-0.5	1.7
Hearing difficulty/problems: Yes	1.9	2.9	4.4	0.4	2.1	-2.1
Relative age of first facial hair	0.2	0.4	0.6	0.8	0.4	-0.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.6	-1.9	-0.1	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.2	-0.7	1.1	-0.5
Ever had hysterectomy (womb removed)	0.1	0.2	0.4	-0.6	0.0	-0.3
Systolic blood pressure, automated reading	1.2	3.6	4.5	-2.0	-1.6	2.1
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	4.1	-2.0	-1.8	1.5
Angina	1.9	2.5	4.5	-1.5	-2.1	1.0
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.5	0.8	0.1
Vitamin and mineral supplements	0.2	0.2	0.7	0.1	0.1	-0.8
Supplements: Zinc	0.3	0.3	0.7	0.8	0.3	0.3
Medication: Co-codamol	0.6	0.7	1.9	1.4	0.3	-0.4
Medication: Metformin	3.9	5.5	11.2	-3.4	-1.3	1.9
Diabetes (father)	1.7	2.1	2.6	-1.6	-1.5	1.3
Diabetes (mother)	5.1	6.5	7.5	-2.7	-2.7	2.2
Severe depression (siblings)	0.3	0.3	0.7	0.8	0.1	0.5
Pack years adult smoking proportion	0.2	0.4	1.0	-1.0	-0.3	0.2
Impedance of leg (right)	1.8	8.5	14.3	-2.3	-2.5	3.8
Leg fat-free mass (left)	0.3	1.7	5.2	-0.0	-0.2	-2.3
Trunk fat percentage	0.5	1.9	3.6	-1.4	-1.9	0.3
Hand grip strength (right)	1.2	3.3	4.9	-0.9	-2.2	2.1
Townsend deprivation index at recruitment	0.4	0.5	1.3	-1.1	-0.3	-0.3
Current tobacco smoking	0.3	0.5	1.2	-1.1	-0.2	-0.4
Average weekly fortified wine intake	2.6	3.1	5.3	0.7	1.9	-2.3
Maternal smoking around birth	0.5	0.8	1.9	-1.4	-0.6	0.3
Fed-up feelings	0.1	0.2	0.4	-0.3	-0.6	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	-0.2	0.3	0.4
Relative age voice broke	0.2	0.3	0.6	-0.4	-0.7	0.5
Taking other prescription medications	0.3	0.4	0.6	-0.7	0.5	-0.8
Age when periods started (menarche)	0.1	0.2	0.3	0.6	0.4	0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	-0.2	1.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.2	0.2	-0.4
Tinnitus: Yes, but not now, but have in the past	3.7	4.0	4.3	-2.0	-1.9	2.1
Qualifications: CSEs or equivalent	0.2	0.3	0.6	0.1	-0.8	-0.5
Serious illness, injury or assault to yourself	1.6	2.0	5.0	-2.2	-1.0	0.2
High blood pressure	3.9	11.0	18.7	-4.3	-3.1	2.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.2	1.5	0.9	0.7
Multivitamins +/- minerals	0.3	0.4	1.2	0.2	0.2	1.1
Stomach or abdominal pain in last month	0.7	0.8	1.4	-1.2	0.7	-0.7
Supplements: Glucosamine	0.2	0.3	0.5	0.4	0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	-0.4	-0.9	0.7
Medication: Atenolol	0.7	0.9	1.3	-1.1	-0.7	0.9
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.5	-0.5	-0.8
Sitting height	0.3	2.0	3.6	-1.4	-1.9	0.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	-0.3	-0.0	-0.3
High blood pressure (mother)	2.3	3.3	7.6	-2.8	-1.2	0.9
Body mass index (BMI)	0.4	1.6	3.8	-0.7	-0.6	-2.0
Impedance of leg (left)	2.2	10.7	18.7	-2.7	-2.5	4.3
Leg predicted mass (left)	0.3	1.7	5.1	0.0	-0.2	-2.2
Trunk fat mass	0.5	2.0	3.4	-1.6	-1.9	-0.3
Waist circumference	0.8	3.0	4.4	-2.1	-2.1	-0.6
Number of incorrect matches in round	0.7	1.1	2.6	-0.9	0.2	-1.6
Past tobacco smoking	0.4	0.7	2.0	0.1	1.4	0.2
Alcohol usually taken with meals	0.3	0.5	1.1	-0.1	-1.1	0.7
Nervous feelings	0.5	0.9	1.6	0.6	1.3	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	0.3	1.3	-0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.6	-0.8	0.0	-0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.4	-0.6	0.6	-0.0
Had menopause	0.0	0.1	0.1	0.2	0.3	0.2
Had other major operations	0.2	0.3	0.8	-0.9	-0.0	-0.0
Forced vital capacity (FVC)	0.1	0.2	0.5	0.3	0.7	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.5	0.1	0.9	-1.2
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	3.8	-1.9	-1.9	1.7
Qualifications: None of the above	0.7	1.6	2.7	0.2	1.7	-1.4
Financial difficulties in last 2 years	0.1	0.2	0.5	-0.2	0.2	-0.7
Mouth/teeth dental problems	2.2	3.3	5.3	2.3	2.0	-0.8
Heart attack	3.3	4.2	6.3	-2.4	-2.5	0.8
Allergy	1.9	4.5	6.5	-2.1	-2.5	1.5
Pain all over the body in last month	0.5	0.6	1.7	-0.1	1.3	0.1
Diabetes (self-reported)	7.3	11.2	18.4	-4.3	-2.8	2.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.5	1.2	-0.2	1.2
Medication: Ramipril	1.2	1.6	2.3	-1.5	-1.5	0.2
Medication: Simvastatin	1.9	2.8	4.9	-2.2	-1.3	1.3
Fluid intelligence score	0.2	0.3	0.7	0.9	-0.2	0.5
Illnesses of siblings	2.6	3.7	4.8	1.8	1.8	-2.2
Neuroticism score	0.2	0.5	1.0	0.2	1.0	-0.7
Weight	0.4	1.8	2.1	-1.5	-1.4	-1.2
Impedance of arm (right)	0.4	1.9	4.8	0.3	-0.9	2.2
Arm fat percentage (right)	0.3	1.3	1.7	-0.8	-1.3	-1.2
Trunk fat-free mass	0.2	1.4	2.0	-1.4	-0.9	-1.1
Hip circumference	0.5	2.0	3.1	-1.7	-1.8	-0.4
Time employed in main current job	2.1	2.4	3.6	-1.5	-1.2	1.9
Alcohol intake versus 10 years previously	0.9	1.3	2.3	-1.2	-1.5	0.4
Father’s age at death	0.6	0.8	1.1	1.0	-0.5	1.1
Worrier / anxious feelings	1.2	2.2	3.5	1.1	1.9	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	4.8	-1.7	-0.8	2.2
Falls in the last year	0.7	0.9	2.7	0.1	-0.1	1.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.9	0.2	-0.4
Number of live births	0.6	0.9	1.5	-1.0	-1.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	1.8	1.1	1.4	-0.6
Pulse rate	0.6	1.1	2.1	-1.0	-1.5	0.1
Happiness	1.0	1.2	1.4	-1.2	-0.9	1.2
Noisy workplace	0.4	0.5	1.3	-1.2	0.4	-0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.3	1.1	1.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.5	-0.5	-0.9	1.9
Mouth/teeth dental problems: Dentures	1.8	3.0	5.5	-2.4	-1.8	0.3
Asthma	0.8	1.6	3.0	0.7	1.1	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.7	-0.7	0.6	-1.3
Medication: Cholesterol lowering	1.8	2.8	5.5	-2.3	-1.3	1.2
Depression (self-reported)	0.3	0.3	0.9	0.1	1.0	-0.0
Medication: Lansoprazole	0.7	0.8	1.5	-0.7	1.2	-0.6
Prospective memory result	2.5	3.0	4.4	-2.1	-0.9	2.0
Lung cancer (father)	4.2	4.9	6.7	1.4	2.6	-2.5
Illnesses of mother	4.4	5.5	8.9	3.0	2.2	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.0	0.8	1.4	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.3	-0.3	-0.8
Impedance of arm (left)	0.3	1.6	4.1	0.8	-0.2	2.0
Arm fat mass (right)	0.4	1.6	2.4	-1.1	-1.1	-1.5
Trunk predicted mass	0.2	1.3	1.8	-1.4	-0.8	-1.2
Standing height	0.3	2.7	3.1	-1.7	-1.7	1.4
Length of working week for main job	1.1	1.2	1.5	0.9	1.1	-1.2
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.2	-0.2	0.0
Breastfed as a baby	1.2	1.5	1.9	-1.4	-1.0	1.3
Tense / ‘highly strung’	0.1	0.2	0.3	-0.4	0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	0.4	1.4	0.2
Hair/balding pattern: Pattern 4	2.8	6.7	12.8	3.6	1.8	-2.0
Birth weight of first child	1.5	2.8	4.0	1.0	1.9	-2.0
Peak expiratory flow (PEF)	0.1	0.1	0.4	-0.1	-0.6	-0.0
Pulse wave reflection index	1.3	1.6	3.2	0.9	1.0	-1.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.4	0.1	0.1
Loud music exposure frequency	2.5	2.7	4.8	-2.2	-1.4	1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.2	0.1	-0.2	1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	-0.8	-1.1	0.2
Blood clot in the leg (DVT)	3.0	3.9	5.0	1.6	2.0	-2.2
Medication: Paracetamol	1.8	3.0	5.0	0.4	2.2	-1.9
Headache pain in last month	0.9	1.6	4.0	-2.0	0.7	0.4
Medication for cholesterol, blood pressure or diabetes	4.9	8.1	13.9	3.7	2.5	-2.1
Glaucoma (self-reported)	4.1	4.9	6.9	2.6	2.4	-1.5
Gout (self-reported)	0.6	0.9	1.8	0.6	0.7	-1.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.1	1.3	0.2	-1.5
Medication: Amlodipine	1.1	1.6	2.6	-0.6	-1.6	1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-1.0	-0.2	0.1
Birth weight	4.6	9.9	14.5	3.8	3.1	-2.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.9	-0.4	0.4
High blood pressure (siblings)	2.5	3.6	4.2	-1.8	-2.1	1.8
Forced vital capacity (FVC), Best measure	0.1	0.4	1.3	0.1	1.1	0.1
Body fat percentage	0.5	2.1	3.7	-1.7	-1.9	-0.1
Leg fat percentage (right)	1.2	4.3	6.8	-2.6	-2.5	-0.2
Arm fat-free mass (right)	0.3	1.5	2.2	-1.5	-0.7	-1.4
Exposure to tobacco smoke outside home	0.2	0.3	0.5	-0.6	0.1	-0.7
Comparative body size at age 10	0.1	0.2	0.3	-0.2	-0.6	0.5
Number of full brothers	0.5	0.7	1.3	1.1	0.5	-0.7
Worry too long after embarrassment	0.1	0.2	0.3	0.2	0.5	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.2	0.8	-0.0
Wheeze or whistling in the chest in last year	0.9	1.6	4.2	0.2	0.8	-2.0
Number of children fathered	0.2	0.3	0.4	-0.4	-0.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.2	1.0	1.1	-0.4
Age at first live birth	1.6	2.8	5.2	0.1	-1.8	2.3
Pulse wave peak to peak time	0.5	0.6	1.4	-0.6	-0.1	1.2
Health satisfaction	0.3	0.4	0.6	0.3	0.6	-0.8
Shortness of breath walking on level ground	0.0	0.0	0.1	-0.1	0.2	-0.3
Qualifications: College or University degree	0.1	0.3	0.6	0.8	-0.0	0.6
Eye problems/disorders: None of the above	0.7	0.8	1.2	-1.1	-1.1	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.0	1.0	0.1	-0.1
Emphysema/chronic bronchitis	1.6	1.8	3.0	0.0	1.5	-1.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.0	0.7	-1.0	1.0
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.1	-0.7	-0.2
Medication: Blood pressure	3.1	5.5	9.3	-3.1	-2.1	1.6
Angina (self-reported)	1.6	2.1	3.5	-1.3	-1.9	0.9
Migraine (self-reported)	0.1	0.2	0.3	0.5	0.2	-0.4
Medication: Ibuprofen	1.0	1.2	2.8	-0.1	0.9	-1.7
Medication: Allopurinol	0.4	0.5	1.2	0.1	0.6	-1.1
Medication: Omeprazole	0.4	0.5	0.9	-0.9	-0.2	0.8
Medication: Seretide 50 evohaler	0.9	1.1	1.6	1.3	1.2	-0.5
Mean time to correctly identify matches	0.8	1.5	2.5	-0.6	-1.6	1.3
Heart disease (mother)	3.7	4.5	6.9	-2.2	-2.6	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	-0.4	-1.4	0.9
Whole body fat mass	0.4	1.9	2.5	-1.6	-1.6	-0.7
Leg fat mass (right)	0.7	2.7	3.8	-1.9	-1.9	-0.9
Arm predicted mass (right)	0.3	1.5	2.3	-1.5	-0.8	-1.2
Pulse rate, automated reading	0.3	0.8	2.0	-0.6	-1.4	-0.3
Alcohol intake frequency.	0.7	1.7	3.6	-1.9	-0.9	0.8
Comparative height size at age 10	0.4	2.0	4.7	-2.2	-0.9	0.6
Number of full sisters	0.0	0.0	0.1	0.2	0.0	-0.2
Suffer from ‘nerves’	0.4	0.6	1.2	-0.0	0.7	-1.1
Overall health rating	0.7	1.6	3.4	-1.0	0.4	-1.9
Chest pain or discomfort	1.3	1.9	3.2	0.1	1.5	-1.8
Had major operations	0.3	0.3	0.7	-0.2	0.8	-0.6
Age at last live birth	1.8	2.7	4.9	0.2	-2.2	1.7
Family relationship satisfaction	1.6	2.0	2.5	-1.0	-1.6	1.6
Leg pain on walking	0.3	0.4	0.8	0.2	0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.2	0.2	-0.5
Commuting to job workplace: Car/motor vehicle	1.9	2.1	3.9	-1.0	-1.2	2.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.8	0.2	-0.9
Medication: Aspirin	1.3	1.7	4.0	-0.7	-2.0	0.7
Supplements: Vitamin C	0.4	0.5	0.7	0.0	-0.8	0.8
Knee pain experienced in last month	0.2	0.2	0.4	-0.1	-0.7	0.5
Hypertension (Self-reported)	4.8	13.3	21.5	-4.6	-3.5	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	3.5	1.1	1.7	-1.9
Illnesses of father: Heart disease	0.3	0.4	0.6	-0.4	0.7	0.6
Illnesses of siblings: Diabetes	2.1	2.5	4.2	-2.1	-1.1	1.5
Smoking status: Previous	0.4	0.5	1.5	-0.1	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.3	-0.4	0.2
Whole body fat-free mass	0.2	1.3	3.0	-0.9	-0.5	-1.7
Leg fat-free mass (right)	0.3	1.5	4.5	0.0	0.1	-2.1
Arm fat percentage (left)	0.3	1.1	2.1	-0.6	-0.9	-1.4
Average weekly red wine intake	0.3	0.4	0.7	0.8	-0.6	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	0.3	-0.0	0.3
Mood swings	0.0	0.1	0.2	0.4	-0.0	0.2
Loneliness, isolation	0.2	0.2	0.6	-0.8	0.1	-0.1
Long-standing illness, disability or infirmity	2.5	3.8	10.3	-3.2	-1.0	0.5
Ever had bowel cancer screening	2.0	2.3	3.9	-2.0	-0.8	1.5
Diabetes diagnosed by doctor	5.9	9.7	18.3	-4.3	-2.3	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-0.6	1.0	0.2
Friendships satisfaction	0.1	0.2	0.4	0.1	-0.6	0.3
Qualifications: nursing, teaching	0.6	0.9	2.3	-0.6	-0.2	1.5
Commuting to job workplace: Walk	1.0	1.1	1.2	1.1	1.0	-1.1
Eye problems/disorders: Cataract	3.4	4.0	6.8	1.5	2.6	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.0	-1.4	-0.0	0.1
Medication for cholesterol	1.0	1.6	3.2	1.8	1.2	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.1	-1.4	1.4	0.6
Back pain experienced in last month	1.1	1.6	3.7	-1.0	0.3	-1.9
Mineral and other dietary supplements	0.4	0.6	1.3	-0.4	0.4	-1.2
Breast cancer (self-reported)	0.6	0.7	2.1	-0.0	-0.1	1.5
Asthma (self-reported)	0.8	1.5	3.1	0.5	1.0	-1.8
Osteoporosis (self-reported)	0.8	0.9	1.5	-0.6	-1.2	1.0
Osteoarthritis (self-reported)	1.7	2.2	3.7	1.5	1.9	-0.9
Medication: Aspirin	1.3	1.7	3.9	-1.0	-2.0	0.6
Medication: Gliclazide	2.3	2.6	5.7	-2.4	-1.2	0.8
Illnesses of father: None of the above (group 1)	1.1	1.4	3.3	1.8	0.4	-0.8
Smoking status: Current	0.3	0.5	1.3	-1.1	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	-0.2	0.2	0.2
Whole body water mass	0.2	1.3	2.8	-0.9	-0.6	-1.7
Leg predicted mass (right)	0.3	1.4	4.2	-0.1	-0.0	-2.1
Arm fat mass (left)	0.3	1.4	2.4	-0.9	-1.0	-1.5
Number of self-reported non-cancer illnesses	0.4	0.7	2.1	-1.4	-0.2	-0.0
Average weekly champagne plus white wine intake	0.9	1.2	3.3	1.8	0.6	-0.3
Miserableness	0.5	0.9	1.8	-1.4	0.8	0.5
Guilty feelings	0.2	0.3	0.6	0.4	0.3	-0.8
Wears glasses or contact lenses	2.1	2.4	3.7	-1.9	-1.6	0.9
Ever taken oral contraceptive pill	0.4	0.5	0.6	0.8	0.6	0.7
Hearing aid user	0.1	0.1	0.2	-0.0	0.4	-0.4
Mother’s age at death	1.3	1.7	3.2	-0.1	-1.8	1.3
Financial situation satisfaction	0.1	0.1	0.2	-0.1	-0.4	-0.1
Tinnitus: Yes, now most or all of the time	3.4	3.9	4.0	1.9	2.0	-2.0
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.5	0.1	-0.3
Eye problems/disorders: Glaucoma	3.0	3.5	6.2	2.5	2.0	-0.7
Medication: Blood pressure	1.9	3.6	6.1	-2.5	-2.0	0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.6	-1.6	0.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.3	0.2	-0.9	1.5
High cholesterol (Self-reported)	0.5	0.8	1.1	-0.9	-0.8	1.0
Medication: Bendroflumethiazide	1.5	2.2	4.6	-2.1	-1.2	0.7
Medication: Paracetamol	3.7	5.7	9.2	0.4	2.8	-3.0
Medication: Lisinopril	0.7	1.0	2.1	-1.5	-0.8	0.0
Medication: Atorvastatin	0.1	0.1	0.2	0.1	-0.4	0.3
Illnesses of father: High blood pressure	2.3	2.8	5.5	-2.3	-1.2	1.2
Alcohol drinker status: Never	2.7	3.2	3.8	-1.9	-1.6	1.9
Ever smoked	0.1	0.2	0.2	0.5	-0.4	-0.5
Basal metabolic rate	0.3	1.5	2.4	-1.1	-0.9	-1.6
Leg fat percentage (left)	1.2	4.3	7.4	-2.7	-2.4	0.1
Arm fat-free mass (left)	0.3	1.7	2.7	-1.6	-1.2	-1.0
Number of operations (self-reported)	1.1	1.6	3.6	0.9	1.9	-0.7
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.2	0.4	-0.6
Irritability	0.0	0.1	0.1	0.3	0.2	0.3
Risk taking	0.1	0.1	0.3	0.0	-0.5	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	0.2	-0.4
Fractured/broken bones in last 5 years	1.5	1.9	3.3	-1.1	-1.1	1.8
Age started oral contraceptive pill	0.8	1.0	1.8	-0.3	-1.0	1.4
Diastolic blood pressure, automated reading	2.0	6.1	10.9	-2.7	-3.3	-0.0
Ever depressed for a whole week	0.3	0.4	1.2	-1.1	-0.1	-0.1
Unable to work because of sickness or disability	2.3	3.0	5.7	-2.4	-0.5	1.8
Commuting to job workplace: Cycle	1.9	2.3	3.7	0.6	-1.7	1.9
Myopia	1.2	1.8	3.6	-1.3	-1.9	0.3
Vascular/heart problems diagnosed by doctor	5.0	13.7	21.6	4.6	3.7	-2.5
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	-0.4	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.7	0.3	0.5
Pain experienced in last month	0.5	0.9	2.3	0.3	-0.5	1.5
Supplements: Calcium	0.5	0.5	0.8	0.9	0.6	0.7
Basal cell carcinoma (self-reported)	1.3	1.6	4.0	2.0	0.7	-0.5
Heart attack/myocardial infarction (self-reported)	3.0	3.9	6.1	-2.3	-2.5	0.7
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	3.5	1.4	1.6	-1.9
Heart disease (siblings)	1.1	1.4	1.8	-1.3	-1.1	1.0
Alcohol drinker status: Previous	1.6	1.8	3.5	-1.9	-1.1	1.0
Pack years of smoking	0.2	0.3	0.7	-0.9	-0.2	-0.1
Impedance of whole body	0.9	4.7	11.6	-0.7	-1.4	3.4
Leg fat mass (left)	0.7	2.6	3.9	-2.0	-1.8	-0.8
Arm predicted mass (left)	0.3	1.7	2.8	-1.7	-1.0	-1.2